Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 26, 1991 - Issue 2
Submit an article Journal homepage
46
Views
82
CrossRef citations to date
0
Altmetric
Original Article

Evidence of Intracellular Activation of Serine Proteases in Acute Cerulein-Induced Pancreatitis in Rats

R. Bialek Dept. of Pediatrics, University of Bonn, Bonn, Germany; Dept. of Internal Medicine, Philipps-University Marburg, Marburg, Germany
,
S. Willemer Dept. of Pediatrics, University of Bonn, Bonn, Germany; Dept. of Internal Medicine, Philipps-University Marburg, Marburg, Germany
,
R. Arnold Dept. of Pediatrics, University of Bonn, Bonn, Germany; Dept. of Internal Medicine, Philipps-University Marburg, Marburg, Germany
&
G. Adler Dept. of Pediatrics, University of Bonn, Bonn, Germany; Dept. of Internal Medicine, Philipps-University Marburg, Marburg, Germany
Pages 190-196 | Received 17 Apr 1990, Accepted 28 Aug 1990, Published online: 08 Jul 2009

Citations (82)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

S. Schmid, W. Uhl & M. W. Büchler. (1996) Protease-Antiprotease Interactions and the Rationale for Therapeutic Protease Inhibitors. Scandinavian Journal of Gastroenterology 31:sup219, pages 47-50.
Read now
S. D. Leach, F. S. Gorelick & I. M. Modlin. (1992) New Perspectives on Acute Pancreatitis. Scandinavian Journal of Gastroenterology 27:sup192, pages 29-38.
Read now
T. Hirano & T. Manabe. (1992) Effect of short-termed pancreatic duct obstruction on the pancreatic subcellular organellar fragility and pancreatic lysosomal enzyme secretion in rabbits. Scandinavian Journal of Clinical and Laboratory Investigation 52:6, pages 523-535.
Read now

Articles from other publishers (79)

Günter Klöppel. 2023. The Pancreas. The Pancreas 164 169 .
Günter Klöppel & Giuseppe Zamboni. (2023) Acute and Chronic Alcoholic Pancreatitis, Including Paraduodenal Pancreatitis. Archives of Pathology & Laboratory Medicine 147:3, pages 294-303.
Crossref
Filip Vlavcheski, Eric J. O’Neill, Filip Gagacev & Evangelia Tsiani. (2022) Effects of Berberine against Pancreatitis and Pancreatic Cancer. Molecules 27:23, pages 8630.
Crossref
Umasankar Mathuram Thiyagarajan, Amirthavarshini Ponnuswamy & Rhys Thomas. (2021) Can Inflammatory Markers Foretell Aetiology and Prolonged Hospitalisation in Acute Pancreatitis?. Cureus.
Crossref
Won Suk Park, Kyuhyun Paik, Keum Jin Yang & Jong Ok Kim. (2020) Eupatilin Ameliorates Cerulein-Induced Pancreatitis Via Inhibition of the Protein Kinase D1 Signaling Pathway In Vitro. Pancreas 49:2, pages 281-289.
Crossref
Fu Gui, Yuebo Zhang, Jianhua Wan, Xianbao Zhan, Yao Yao, Yinghua Li, Ashley N. Haddock, Ji Shi, Jia Guo, Jiaxiang Chen, Xiaohui Zhu, Brandy H. Edenfield, Lu Zhuang, Cheng Hu, Ying Wang, Debabrata Mukhopadhyay, Evette S. Radisky, Lizhi Zhang, Aurelia Lugea, Stephen J. Pandol, Yan Bi & Baoan Ji. (2019) Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H. Journal of Clinical Investigation 130:1, pages 189-202.
Crossref
Julia Mayerle, Matthias Sendler, Eszter Hegyi, Georg Beyer, Markus M. Lerch & Miklós Sahin-Tóth. (2019) Genetics, Cell Biology, and Pathophysiology of Pancreatitis. Gastroenterology 156:7, pages 1951-1968.e1.
Crossref
Vikas Dudeja, Rajinder Dawra & Ashok K. Saluja. 2018. The Pancreas. The Pancreas 63 74 .
Julia Mayerle, Frank Ulrich Weiss, Walter Halangk & Markus M. Lerch. 2018. The Pancreas. The Pancreas 178 192 .
Matthias Sendler, Julia Mayerle & Markus M. Lerch. 2018. Molecular Pathology. Molecular Pathology 457 476 .
Jingzhen Yuan & Stephen J. Pandol. (2016) PKD signaling and pancreatitis. Journal of Gastroenterology 51:7, pages 651-659.
Crossref
Sivalingam Jayaveni, Kamaraj Nithyanandham & Chellan Rose. (2016) In vitro secretion of zymogens by bovine pancreatic acini and ultra-structural analysis of exocytosis. Biochemistry and Biophysics Reports 5, pages 237-245.
Crossref
Ahmed Bettaieb, Yannan Xi, Ellen Hosein, Nicole Coggins, Santana Bachaalany, Florian Wiede, Salvador Perez, Stephen M Griffey, Juan Sastre, Tony Tiganis & Fawaz G Haj. (2014) Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis. Cell Communication and Signaling 12:1.
Crossref
Ahmed Bettaieb, Samah Chahed, George Tabet, Jun Yang, Christophe Morisseau, Stephen Griffey, Bruce D. Hammock & Fawaz G. Haj. (2014) Effects of Soluble Epoxide Hydrolase Deficiency on Acute Pancreatitis in Mice. PLoS ONE 9:11, pages e113019.
Crossref
Xiaoguang Lu, Weiqiang Xiao, Xin Kang, Jie Yu & Zhiwei Fan. (2014) The effect of Chinese herbal medicine on non-biliogenic severe acute pancreatitis: A systematic review and meta-analysis. Journal of Ethnopharmacology 155:1, pages 21-29.
Crossref
James R. Myer, Elizabeth H. Romach & Chandikumar S. Elangbam. (2013) Species- and Dose-Specific Pancreatic Responses and Progression in Single- and Repeat-Dose Studies with GI181771X. Toxicologic Pathology 42:1, pages 260-274.
Crossref
Sara Yubero, Manuel A. Manso, Laura Ramudo, Secundino Vicente & Isabel De Dios. (2012) Dexamethasone down-regulates the inflammatory mediators but fails to reduce the tissue injury in the lung of acute pancreatitis rat models. Pulmonary Pharmacology & Therapeutics 25:4, pages 319-324.
Crossref
Sara Yubero, Laura Ramudo, Manuel A. Manso, Francisco Collía & Isabel De Dios. (2012) Evaluation of N-acetylcysteine treatment in acute pancreatitis-induced lung injury. Inflammation Research 61:7, pages 699-705.
Crossref
Alexander A Aghdassi, Julia Mayerle, Sandra Christochowitz, Frank U Weiss, Matthias Sendler & Markus M Lerch. (2011) Animal models for investigating chronic pancreatitis. Fibrogenesis & Tissue Repair 4:1.
Crossref
Laura Ramudo, Sara Yubero, Manuel A. Manso, Javier Sanchez-Recio, Eduardo Weruaga & Isabel De Dios. (2010) Effects of Dexamethasone on Intercellular Adhesion Molecule 1 Expression and Inflammatory Response in Necrotizing Acute Pancreatitis in Rats. Pancreas 39:7, pages 1057-1063.
Crossref
Olivier LassoutCatherine M. PastorVanessa Fétaud-LapierreDenis F. HochstrasserJean-Louis FrossardPierre Lescuyer. (2010) Analysis of the Pancreatic Low Molecular Weight Proteome in an Animal Model of Acute Pancreatitis. Journal of Proteome Research 9:9, pages 4535-4544.
Crossref
Laura Ramudo, Sara Yubero, Manuel A. Manso, Javier S. Recio, Eduardo Weruaga & Isabel De Dios. (2010) Effect of dexamethasone on peripheral blood leukocyte immune response in bile-pancreatic duct obstruction-induced acute pancreatitis. Steroids 75:4-5, pages 362-367.
Crossref
Jaimie D. Nathan, Joelle Romac, Ruth Y. Peng, Michael Peyton, Don C. Rockey & Rodger A. Liddle. (2010) Protection Against Chronic Pancreatitis and Pancreatic Fibrosis in Mice Overexpressing Pancreatic Secretory Trypsin Inhibitor. Pancreas 39:1, pages e24-e30.
Crossref
Baoan Ji, Sebastian Gaiser, Xueqing Chen, Stephen A. Ernst & Craig D. Logsdon. (2009) Intracellular Trypsin Induces Pancreatic Acinar Cell Death but Not NF-κB Activation. Journal of Biological Chemistry 284:26, pages 17488-17498.
Crossref
S. Yubero, L. Ramudo, M.A. Manso & I. De Dios. (2009) The role of redox status on chemokine expression in acute pancreatitis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1792:2, pages 148-154.
Crossref
Matthias Sendler, Julia Mayerle & Markus M. Lerch. 2009. Molecular Pathology. Molecular Pathology 421 433 .
Hiroharu Yamashita, Hidehiro Shinozaki & Taiichi Otani. (2008) Generation of Trypsinogen Activation Peptide Activity in Rat Isolated Pancreatic Acini Under Bombesin Stimulation. Pancreas 36:2, pages 208-209.
Crossref
Mohammed Elfar, Lillian W. Gaber, Omaima Sabek, Craig P. Fischer & A. Osama Gaber. (2007) The Inflammatory Cascade in Acute Pancreatitis: Relevance to Clinical Disease. Surgical Clinics of North America 87:6, pages 1325-1340.
Crossref
Stephen J. Pandol, Ashok K. Saluja, Clement W. Imrie & Peter A. Banks. (2007) Acute Pancreatitis: Bench to the Bedside. Gastroenterology 133:3, pages 1056.e1-1056.e25.
Crossref
Hana Algül, Matthias Treiber, Marina Lesina, Hassan Nakhai, Dieter Saur, Fabian Geisler, Alexander Pfeifer, Stephan Paxian & Roland M. Schmid. (2007) Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis. Journal of Clinical Investigation 117:6, pages 1490-1501.
Crossref
Ashok K. SalujaMarkus M. Lerch, Phoebe A. PhillipsVikas Dudeja. (2007) Why Does Pancreatic Overstimulation Cause Pancreatitis?. Annual Review of Physiology 69:1, pages 249-269.
Crossref
Stephen J. Pandol, Ashok K. Saluja, Clement W. Imrie & Peter A. Banks. (2007) Acute Pancreatitis: Bench to the Bedside. Gastroenterology 132:3, pages 1127-1151.
Crossref
Rodger A. Liddle. (2006) Pathophysiology of SPINK Mutations in Pancreatic Development and Disease. Endocrinology and Metabolism Clinics of North America 35:2, pages 345-356.
Crossref
Manuel Ruthenbürger, Julia Mayerle & Markus M. Lerch. (2006) Cell Biology of Pancreatic Proteases. Endocrinology and Metabolism Clinics of North America 35:2, pages 313-331.
Crossref
Akira Matsukura, Taiichi Otani, Takeshi Takamoto, Hiroshi Usui, Yuka Goto & Masatoshi Makuuchi. (2006) Intracellular Activation of Trypsinogen in Rat Pancreatic Acini After Supramaximal Secretagogue Stimulation. Pancreas 32:2, pages 197-204.
Crossref
D M Kelly, G P McEntee, C Delaney, K F McGeeney & J M Fitzpatrick. (1993) Temporal relationship of acinar and microvascular changes in caerulein-induced pancreatitis. British Journal of Surgery 80:9, pages 1174-1176.
Crossref
L J Formela, S W Galloway & A N Kingsnorth. (1995) Inflammatory mediators in acute pancreatitis. British Journal of Surgery 82:1, pages 6-13.
Crossref
Laura Ramudo, Manuel A Manso, Sara Sevillano & Isabel de Dios. (2005) Kinetic study of TNF-α production and its regulatory mechanisms in acinar cells during acute pancreatitis induced by bile–pancreatic duct obstruction. The Journal of Pathology 206:1, pages 9-16.
Crossref
Jaimie D. Nathan, Joelle Romac, Ruth Y. Peng, Michael Peyton, Raymond J. MacDonald & Rodger A. Liddle. (2005) Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology 128:3, pages 717-727.
Crossref
Walter Halangk & Markus M. Lerch. (2005) Early Events in Acute Pancreatitis. Clinics in Laboratory Medicine 25:1, pages 1-15.
Crossref
J. Mayerle, F. U. Weiss & M. M. Lerch. 2005. Pancreatitis: Advances in Pathobiology, Diagnosis and Treatment. Pancreatitis: Advances in Pathobiology, Diagnosis and Treatment 13 27 .
Sakhawat H. Rahman, Gwyneth Salter, John H. M. Holmfield, Michael Larvin & Michael J. McMahon. (2004) Soluble CD14 receptor expression and monocyte heterogeneity but not the C-260T CD14 genotype are associated with severe acute pancreatitis. Critical Care Medicine 32:12, pages 2457-2463.
Crossref
Rodger A. Liddle. (2004) Susceptibility to pancreatitis related to PSTI/SPINK1 expression. Gastroenterology Clinics of North America 33:4, pages 807-816.
Crossref
Walter Halangk & Markus M. Lerch. (2004) Early events in acute pancreatitis. Gastroenterology Clinics of North America 33:4, pages 717-731.
Crossref
C. D. Johnson & C. W. ImrieMarkus M. Lerch, Manuel Ruthenbürger, Frank Ch. Mooren, Verena Hlouschek, Julia Mayerle, Peter Simon & F. Ulrich Weiss. 2004. Pancreatic Disease. Pancreatic Disease 324 339 .
Markus M. Lerch, Elke Albrecht, Manuel Ruthenbürger, Julia Mayerle, Walter Halangk & Burkhard Krüger. (2003) Pathophysiology of Alcohol-Induced Pancreatitis. Pancreas 27:4, pages 291-296.
Crossref
Ana M de la Mano, Sara Sevillano, Manuel A Manso & Isabel de Dios. (2003) Effect of long-term CCK blockade on the pancreatic acinar cell renewal in rats with acute pancreatitis. Peptides 24:4, pages 535-541.
Crossref
Isabel de Dios, Martin Perez, Ana de La Mano, Sara Sevillano, Alberto Orfao, Laura Ramudo & Manuel Antonio Manso. (2002) CONTRIBUTION OF CIRCULATING LEUKOCYTES TO CYTOKINE PRODUCTION IN PANCREATIC DUCT OBSTRUCTION-INDUCED ACUTE PANCREATITIS IN RATS. Cytokine 20:6, pages 295-303.
Crossref
Yoshio Sogame, Keisho Kataoka, Masato Kato, Junichi Sakagami, Saori Osawa, Ami Takatera, Mayuko Mitsuyoshi, Noriko Usui, Shinichi Mitsui & Nozomi Yamaguchi. (2002) Molecular Cloning and Characterization of Chymopasin, a Novel Serine Protease from Rat Pancreas. Pancreas 25:4, pages 378-386.
Crossref
A Uruñuela, S Sevillano, A.M de la Mano, M.A Manso, A Orfao & I de Dios. (2002) Time-course of oxygen free radical production in acinar cells during acute pancreatitis induced by pancreatic duct obstruction. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1588:2, pages 159-164.
Crossref
Michael Steer. (2002) Pancreatitis severity: Who calls the shots?. Gastroenterology 122:4, pages 1168-1172.
Crossref
Jens M. Mayer, Michael Raraty, John Slavin, Esko Kemppainen, John Fitzpatrick, Antti Hietaranta, Pauli Puolakkainen, Hans G. Beger & John P. Neoptolemos. (2002) Severe acute pancreatitis is related to increased early urinary levels of the activation peptide of pancreatic phospholipase A2. Pancreatology 2:6, pages 535-542.
Crossref
Markus M. Lerch, Walter Halangk & Burkhard Krüger. 2002. Cellular Peptidases in Immune Functions and Diseases 2. Cellular Peptidases in Immune Functions and Diseases 2 403 410 .
Charles D. UlrichIIII, Elizabeth Kopras, Ying Wu & Susan Ward. (2000) Hereditary pancreatitis: Epidemiology, molecules, mutations, and models. Journal of Laboratory and Clinical Medicine 136:4, pages 260-274.
Crossref
Z ??ledzi??ski, M Wo??niak, A Brunelli, E Lezoche, G Scutti, E Kossowska, K Jankowski, A Stanek & E Bertoli. (2000) Experimental Pancreatitis Induced by Synthetic Prooxidant Tert-butyl Hydroperoxide. Pancreas 20:2, pages 146-151.
Crossref
Rosa M. Pinto, Isabel de Dios, Aránzazu Uruñuela, Alberto Orfao & Manuel Antonio Manso. (2000) Alterations in the glycoconjugates of pancreatic cell membrane induced by acute pancreatitis. European Journal of Cell Biology 79:1, pages 62-69.
Crossref
Werner Hartwig, Ramon E. Jimenez, Jens Werner, Kent B. Lewandrowski, Andrew L. Warshaw & Carlos Fernández–del Castillo. (1999) Interstitial trypsinogen release and its relevance to the transformation of mild into necrotizing pancreatitis in rats. Gastroenterology 117:3, pages 717-725.
Crossref
Suresh Karne & Fred S. Gorelick. (1999) ETIOPATHOGENESIS OF ACUTE PANCREATITIS. Surgical Clinics of North America 79:4, pages 699-710.
Crossref
J. B. Ward, O. H. Petersen & R. Sutton. 1999. Pancreatic Disease. Pancreatic Disease 3 13 .
Reinhard Lüthen, James H. Grendell, Claus Niederau & Dieter Häussinger. (1998) Trypsinogen activation and glutathione content are linked to pancreatic injury in models of biliary acute pancreatitis. International journal of pancreatology 24:3, pages 193-202.
Crossref
T. Grady, M. Mah’Moud, T. Otani, S. Rhee, M. M. Lerch & F. S. Gorelick. (1998) Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury. American Journal of Physiology-Gastrointestinal and Liver Physiology 275:5, pages G1010-G1017.
Crossref
B. HofbauerA. K. SalujaM. M. Lerch, L. BhagatM. BhatiaH. S. LeeJ. L. FrossardG. Adler & M. L. Steer. (1998) Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats. American Journal of Physiology-Gastrointestinal and Liver Physiology 275:2, pages G352-G362.
Crossref
Kai Mithöfer, Carlos Fernández-Del Castillo, David Rattner & Andrew L. Warshaw. (1998) Subcellular kinetics of early trypsinogen activation in acute rodent pancreatitis. American Journal of Physiology-Gastrointestinal and Liver Physiology 274:1, pages G71-G79.
Crossref
Walter Halangk, Jörg Stürzebecher, Rainer Matthias, Hans-Ulrich Schulz & Hans Lippert. (1997) Trypsinogen activation in rat pancreatic acinar cells hyperstimulated by caerulein. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1362:2-3, pages 243-251.
Crossref
PAUL S HABER, ROMANO C PIROLA & JEREMY S WILSON. (2008) CLINICAL UPDATE: Management of acute pancreatitis. Journal of Gastroenterology and Hepatology 12:3, pages 189-197.
Crossref
Wataru Kimura & Joachim Mössner. (1996) Role of hypertriglyceridemia in the pathogenesis of experimental acute pancreatitis in rats. International Journal of Gastrointestinal Cancer 20:3, pages 177-184.
Crossref
Naohiro Sata, Wataru Kimura, Tetsuichiro Muto & Chieko Mineo. (1996) Exocrine function of caerulein-induced acute pancreatitis in anesthetized rats. Journal of Gastroenterology 31:1, pages 94-99.
Crossref
K. W. Simpson, N. Beechey-Newman, C. R. Lamb, J. B. A. Smyth, G. Hughes, K. Coombe, N. Sumar & J. Hermon-Taylor. (1995) Cholecystokinin-8 induces edematous pancreatitis in dogs associated with short burst of trypsinogen activation. Digestive Diseases and Sciences 40:10, pages 2152-2161.
Crossref
J. Melrose, P. Ghosh & M. Patel. (1995) Biotinylated aprotinin: a versatile probe for the detection of serine proteinases on western blots. The International Journal of Biochemistry & Cell Biology 27:9, pages 891-904.
Crossref
Fred S. Gorelick & Lisa M. Matovcik. (1995) Lysosomal enzymes and pancreatitis. Gastroenterology 109:2, pages 620-625.
Crossref
Mark A. Korsten, Paul S. Haber, Jeremy S. Wilson & Charles S. Lieber. (1995) The effect of chronic alcohol administration on cerulein-induced pancreatitis. International journal of pancreatology 18:1, pages 25-31.
Crossref
Thomas W. Frick, Kai Mithöfer, Carlos Fernández-del Castillo, David W. Rattner & Andrew L. Warshaw. (1995) Hypercalcemia causes acute pancreatitis by pancreatic secretory block, intracellular zymogen accumulation, and acinar cell injury. The American Journal of Surgery 169:1, pages 167-172.
Crossref
Naohiro Sata, Yutaka Atomi, Wataru Kimura, Akira Kuroda, Tetsuichiro Muto & Chieko Mineo. (1994) Intracellular action of an exogenous low-molecular-weight synthetic protease inhibitor, E3123, in cerulein-induced acute pancreatitis in rats. International journal of pancreatology 15:2, pages 119-127.
Crossref
M. M. Lerch & G. Adler. 1994. Facing the Pancreatic Dilemma. Facing the Pancreatic Dilemma 487 497 .
Markus M. Lerch, Ashok K. Saluja, Rajinder Dawra, Manju Saluja & Michael L. Steer. (1993) The effect of chloroquine administration on two experimental models of acute pancreatitis. Gastroenterology 104:6, pages 1768-1779.
Crossref
Andrew L. Warshaw. (1993) Damage prevention versus damage control in acute pancreatitis. Gastroenterology 104:4, pages 1216-1219.
Crossref
Markus Büchler, Peter Malfertheiner, Waldemar Uhl, Jürgen Schölmerich, Fritz Stöckmann, Guido Adler, Wilhelm Gaus, Klaus Rolle & Hans G. Beger. (1993) Gabexate mesilate in human acute pancreatitis. Gastroenterology 104:4, pages 1165-1170.
Crossref
Tetsuya Hirano, Tadao Manabe & Takayoshi Tobe. (1992) Cytoprotective Effects of Prostaglandins and a New Potent Protease Inhibitor in Acute Pancreatitis. The American Journal of the Medical Sciences 304:3, pages 154-163.
Crossref
S. Willemer, R. Bialek, R. Arnold & G. Adler. (1990) Cerulein-induced acute pancreatitis in rats: evidence for reduced calcium affinity of secretory granule membranes. Research in Experimental Medicine 190:1, pages 413-421.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.