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Original Article

Cholecystokinin and the Regulation of Insulin Secretion

Pages 161-165 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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J. W. Konturek, R. Stoll, M. Gutwinska-Konturek, S. J. Konturek & W. Domschke. (1993) Cholecystokinin in the Regulation of Gastric Acid and Endocrine Pancreatic Secretion in Humans. Scandinavian Journal of Gastroenterology 28:5, pages 401-407.
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Articles from other publishers (39)

Battuvshin Lkhagvasuren, Onanong Mee-inta, Zi-Wei Zhao, Tetsuya Hiramoto, Damdindorj Boldbaatar & Yu-Min Kuo. (2021) Pancreas-Brain Crosstalk. Frontiers in Neuroanatomy 15.
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Dawood Khan, Srividya Vasu, R. Charlotte Moffett, Nigel Irwin & Peter R. Flatt. (2018) Expression of Gastrin Family Peptides in Pancreatic Islets and Their Role in β-Cell Function and Survival. Pancreas 47:2, pages 190-199.
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Shang-lei Ning, Wen-shuai Zheng, Jing Su, Nan Liang, Hui Li, Dao-lai Zhang, Chun-hua Liu, Jun-hong Dong, Zheng-kui Zhang, Min Cui, Qiao-Xia Hu, Chao-chao Chen, Chang-hong Liu, Chuan Wang, Qi Pang, Yu-xin Chen, Xiao Yu & Jin-peng Sun. (2015) Different downstream signalling of CCK 1 receptors regulates distinct functions of CCK in pancreatic beta cells . British Journal of Pharmacology 172:21, pages 5050-5067.
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B. Ahrén. (2011) The future of incretin-based therapy: novel avenues-novel targets. Diabetes, Obesity and Metabolism 13, pages 158-166.
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Kazumi TANIGUCHI, Atsushi YAMASHITA & Ken-ichiro MUTOH. (2011) Morphological Changes in the Endocrine and Exocrine Pancreas of Rats after Experimental Obstructive Jaundice. Journal of Veterinary Medical Science 73:2, pages 161-168.
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Mateu Serra-Prat, Elisabet Palomera, Pere Clave & Manel Puig-Domingo. (2009) Effect of age and frailty on ghrelin and cholecystokinin responses to a meal test. The American Journal of Clinical Nutrition 89:5, pages 1410-1417.
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Maria Sörhede Winzell & Bo Ahrén. (2007) G-protein-coupled receptors and islet function—Implications for treatment of type 2 diabetes. Pharmacology & Therapeutics 116:3, pages 437-448.
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Przemyslaw J. Tomasik, Krystyna Sztefko, Jerzy Starzyk, Iwona Rogatko & Zdzisław Szafran. (2005) Entero-insular axis in children with anorexia nervosa. Psychoneuroendocrinology 30:4, pages 364-372.
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Haruaki Kageyama, Tetsuro Kita, Shigeru Horie, Fumiko Takenoya, Hisayuki Funahashi, Sachi Kato, Masami Hirayama, Eun Young Lee, Junko Sakurai, Shuji Inoue & Seiji Shioda. (2005) Immunohistochemical analysis of cholecystokinin A receptor distribution in the rat pancreas. Regulatory Peptides 126:1-2, pages 137-143.
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Jean Morisset, Sophie Julien & Jean Lainé. (2016) Localization of Cholecystokinin Receptor Subtypes in the Endocine Pancreas. Journal of Histochemistry & Cytochemistry 51:11, pages 1501-1513.
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Masanori Iwase, Yuji Uchizono, Udai Nakamura, Sakae Nohara & Mitsuo Iida. (2003) Effect of exogenous cholecystokinin on islet blood flow in anesthetized rats. Regulatory Peptides 116:1-3, pages 87-93.
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Bo Ahr��n. 2003. International Textbook of Diabetes Mellitus. International Textbook of Diabetes Mellitus.
L. Hidalgo, P. Clave, M. Estorch, J. Rodriguez-Espinosa, L. Rovati, G. H. Greeley, G. Capella & F. Lluis. (2002) Effect of cholecystokinin-A receptor blockade on postprandial insulinaemia and gastric emptying in humans. Neurogastroenterology and Motility 14:5, pages 519-525.
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Anna Maria Bucceri, Aldo E Calogero & Alfio Brogna. (2002) Gallbladder and gastric emptying: relationship to cholecystokininemia in diabetics. European Journal of Internal Medicine 13:2, pages 123-128.
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Sophie Marchal-Victorion, Nathalie Vionnet, Chantal Escrieut, Frédérique Dematos, Christian Dina, Marlène Dufresne, Nicole Vaysse, Lucien Pradayrol, Philippe Froguel & Daniel Fourmy. (2002) Genetic, pharmacological and functional analysis of cholecystokinin-1 and cholecystokinin-2 receptor polymorphism in type 2 diabetes and obese patients. Pharmacogenetics 12:1, pages 23-30.
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Bo Ahrén. 2002. Encyclopedia of the Human Brain. Encyclopedia of the Human Brain 525 540 .
Patrick Gilon & Jean-Claude Henquin. (2001) Mechanisms and Physiological Significance of the Cholinergic Control of Pancreatic β-Cell Function. Endocrine Reviews 22:5, pages 565-604.
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Giovanni Pacini, Karl Thomaseth & Bo Ahrén. (2001) Contribution to glucose tolerance of insulin-independent vs. insulin-dependent mechanisms in mice. American Journal of Physiology-Endocrinology and Metabolism 281:4, pages E693-E703.
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Amel Guenifi, Bo Ahr??n & Samy M. Abdel-Halim. (2001) Differential Effects of Glucagon-like Peptide-1 (7-36)Amide Versus Cholecystokinin on Arginine-Induced Islet Hormone Release In Vivo and In Vitro. Pancreas 22:1, pages 58-64.
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M. Schweiger, M. H. Erhard & W. M. Amselgruber. (2008) Cell‐specific Localization of the Cholecystokinin A Receptor in the Porcine Pancreas . Anatomia, Histologia, Embryologia 29:6, pages 357-361.
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B.-R Choi, D.L Palmquist & M.S Allen. (2000) Cholecystokinin mediates depression of feed intake in dairy cattle fed high fat diets☆. Domestic Animal Endocrinology 19:3, pages 159-175.
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Jean Morisset, Helen Wong, John H. Walsh, J. Lainé & Judith Bourassa. (2000) Pancreatic CCK B receptors: their potential roles in somatostatin release and δ-cell proliferation . American Journal of Physiology-Gastrointestinal and Liver Physiology 279:1, pages G148-G156.
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Bo Ahrén, Jens Juul Holst & Suad Efendic. (2000) Antidiabetogenic Action of Cholecystokinin-8 in Type 2 Diabetes*. The Journal of Clinical Endocrinology & Metabolism 85:3, pages 1043-1048.
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Erik Simonsson, Sven Karlsson & Bo Ahrén. (2000) The Cyclic AMP–Protein Kinase A Pathway Restrains Islet Phospholipase A2 Activation. Biochemical and Biophysical Research Communications 269:1, pages 242-246.
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Bo Ahrén & Peter J. Havel. (1999) Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line (INS-1 cells). American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 277:4, pages R959-R966.
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Bo Ahrén. 1999. The Biology of the Pancreatic β-Cell. The Biology of the Pancreatic β-Cell 175 197 .
Nadya Tarasova. 1999. Gastrointestinal Endocrinology. Gastrointestinal Endocrinology 101 123 .
Sven Karlsson, Frank Sundler & Bo Ahrén. (1998) CCK receptor subtype in insulin-producing cells: a combined functional and in situ hybridization study in rat islets and a rat insulinoma cell line. Regulatory Peptides 78:1-3, pages 95-103.
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Erik Simonsson & Bo Ahrén. (1998) Potentiated β-cell response to non-glucose stimuli in insulin-resistant C57BL/6J mice. European Journal of Pharmacology 350:2-3, pages 243-250.
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H. Mineo, N. Iwaki, K. Kogishi, T. Onaga, S. Kato & R. Zabielski. (1997) Effects of proglumide on cholecystokinin-8-induced exocrine and endocrine pancreatic responses in conscious sheep. Comparative Biochemistry and Physiology Part A: Physiology 118:3, pages 759-764.
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H Mimeo, H Kamita, H Muto, M Ito, H.S Hyun, T Onaga & N Yanaihara. (1997) Effects of C-terminal fragments of cholecystokinin on plasma insulin and glucagon concentrations in sheep. Research in Veterinary Science 62:2, pages 171-174.
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Yoshinobu Yamazaki, Masuo Akahane, Mamoru Kobayashi, Hiroo Takeda & Yukiyoshi Ajisawa. (1996) Effects of KSG-504, a New Cholecystokinin-A-Receptor Antagonist, on Pancreatic Exocrine and Endocrine Secretions in Rats. Japanese Journal of Pharmacology 70:2, pages 183-190.
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S. Karlsson & B. Ahrén. (1996) Gastrin-releasing peptide mobilizes calcium from intracellular stores in HIT-T15 cells. Peptides 17:6, pages 909-916.
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Michael P.M. van der Burg, Onno R. Guicherit, Marijke Frölich & Hein G. Gooszen. (1995) Insulinotropic effects of cholecystokinin, gastric inhibitory polypeptide and glucagon-like peptide-1 during perifusion of short-term cultured canine isolated islets. Regulatory Peptides 60:1, pages 61-67.
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Stefan G. Pierzynowski, Björn R. Weström, Jorgen Svendsen, Lorraine Svendsen & Börje W. Karlsson. (1995) Development and regulation of porcine pancreatic function. International journal of pancreatology 18:2, pages 81-94.
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H. Mineo, N. Iwaki, K. Kogishi, R. Zabielski, T. Onaga & S. Kato. (1995) Effects of intravenous infusions of cholecystokinin (CCK)-8 on exocrine and endocrine pancreatic secretion in conscious sheep. Comparative Biochemistry and Physiology Part A: Physiology 111:1, pages 133-138.
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Robert C. Backus, Grace L. Rosenquist, Quinton R. Rogers, John Calam & James G. Morris. (1995) Elevation of plasma cholecystokinin (CCK) immunoreactivity by fat, protein, and amino acids in the cat, a carnivore. Regulatory Peptides 57:2, pages 123-131.
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H. Mimeo, N. Iwaki, T. Onaga & S. Kato. (1994) Effects of intravenous infusions of cholecystokinin-8 and pentagastrin on plasma concentrations of insulin and glucagon in sheep. Research in Veterinary Science 56:3, pages 298-302.
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Yoshinobu Yamazaki, Masuo Akahane, Mamoru Kobayashi, Makio Kitazawa, Yoshikazu Kurashina & Kinji Iizuka. (1993) Pharmacological Profile of KSG-504, a New Cholecystokinin-A-Receptor Antagonist. Japanese Journal of Pharmacology 63:2, pages 219-225.
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