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Scandinavian Journal of Gastroenterology Volume 27, 1992 - Issue 11
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Original Article

Cyclosporin Pharmacokinetics after Intravenous and Oral Administration in Patients with Crohn's Disease

J. Brynskov Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Herlev, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Medicine, Dronninglund Hospital, Dronninglund; Dept. of Medicine P, Bispebjerg University Hospital, Copenhagen; Denmark; and Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
L. Freund Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Herlev, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Medicine, Dronninglund Hospital, Dronninglund; Dept. of Medicine P, Bispebjerg University Hospital, Copenhagen; Denmark; and Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
,
M. C. Campanini Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Herlev, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Medicine, Dronninglund Hospital, Dronninglund; Dept. of Medicine P, Bispebjerg University Hospital, Copenhagen; Denmark; and Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
&
J. P. Kampmann Dept. of Internal Medicine and Gastroenterology C, Herlev University Hospital, Herlev, Copenhagen; Dept. of Internal Medicine and Gastroenterology, Aalborg Hospital, Aalborg; Dept. of Medicine, Dronninglund Hospital, Dronninglund; Dept. of Medicine P, Bispebjerg University Hospital, Copenhagen; Denmark; and Dept. of Internal Medicine and Gastroenterology, Ospedale Maggiore, Milan, Italy
Pages 961-967 | Received 01 Mar 1992, Accepted 07 Jul 1992, Published online: 08 Jul 2009

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Teruo Murakami, Erik Bodor & Nicholas Bodor. (2020) Modulation of expression/function of intestinal P-glycoprotein under disease states. Expert Opinion on Drug Metabolism & Toxicology 16:1, pages 59-78.
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Jakob Hendel, Jørn Brynskov, Torben Særmark & Klaus Bendtzen. (1996) Section Review Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Experimental cytokine modulation therapy of inflammatory bowel disease (Crohn's disease and ulcerative colitis). Expert Opinion on Investigational Drugs 5:7, pages 843-850.
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J. Brynskov & S. Nørby Rasmussen. (1996) Clinical Pharmacology in Gastroenterology: Development of New Forms of Treatment of Inflammatory Bowel Disease. Scandinavian Journal of Gastroenterology 31:sup216, pages 175-180.
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J. Brynskov. (1993) Cyclosporin for Inflammatory Bowel Disease: Mechanisms and Possible Actions. Scandinavian Journal of Gastroenterology 28:10, pages 849-857.
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Articles from other publishers (21)

Nicole K. Wilson & Ann D. Kataria. (2023) Immunosuppression in solid organ–transplant recipients and impact on nutrition support. Nutrition in Clinical Practice.
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Angela EffingerMark McAllisterIrena TomaszewskaCaitriona M. O’Driscoll, Mark TaylorSteve GomersallJames HeatonKieran L. SmithInese SarcevicaSam L. YoungNikoletta Fotaki. (2021) Investigating the Impact of Crohn’s Disease on the Bioaccessibility of a Lipid-Based Formulation with an In Vitro Dynamic Gastrointestinal Model. Molecular Pharmaceutics 18:4, pages 1530-1543.
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Keshavamurthy Vinay, Akanksha Kaushik, Muthu Sendhil Kumaran & Davinder Parsad. (2019) Intravenous cyclosporine in treatment of Stevens–Johnson syndrome/toxic epidermal necrolysis: A case series. Dermatologic Therapy, pages e12957.
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Sophie E. Berends, Anne S. Strik, Mark Löwenberg, Geert R. D’Haens & Ron A. A. Mathôt. (2018) Clinical Pharmacokinetic and Pharmacodynamic Considerations in the Treatment of Ulcerative Colitis. Clinical Pharmacokinetics 58:1, pages 15-37.
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Luc J. J. Derijks, Dennis R. Wong, Daniel W. Hommes & Adriaan A. van Bodegraven. (2018) Clinical Pharmacokinetic and Pharmacodynamic Considerations in the Treatment of Inflammatory Bowel Disease. Clinical Pharmacokinetics 57:9, pages 1075-1106.
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E. G. Quetglas, A. Armuzzi, S. Wigge, G. Fiorino, L. Barnscheid, M. Froelich & Silvio Danese. (2015) Review article: The pharmacokinetics and pharmacodynamics of drugs used in inflammatory bowel disease treatment. European Journal of Clinical Pharmacology 71:7, pages 773-799.
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A. Schrauder, S. Saleh, K. W. Sykora, H. Hoy, K. Welte, J. Boos, G. Hempel & L. Grigull. (2009) Pharmacokinetic monitoring of intravenous cyclosporine A in pediatric stem-cell transplant recipients. The trough level is not enough. Pediatric Transplantation 13:4, pages 444-450.
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Robert J. Greenstein, Liya Su, Ramon A. Juste & Sheldon T. Brown. (2008) On the Action of Cyclosporine A, Rapamycin and Tacrolimus on M. avium Including Subspecies paratuberculosis. PLoS ONE 3:6, pages e2496.
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Laurence J. Egan & William J. Sandborn. 2005. Inflammatory Bowel Disease: From Bench to Bedside. Inflammatory Bowel Disease: From Bench to Bedside 495 521 .
Conor G Loftus, Laurence J Egan & William J Sandborn. (2004) Cyclosporine, tacrolimus, and mycophenolate mofetil in the treatment of inflammatory bowel disease. Gastroenterology Clinics of North America 33:2, pages 141-169.
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Laurence J. Egan & William J. Sandborn. 2003. Inflammatory Bowel Disease: From Bench to Bedside. Inflammatory Bowel Disease: From Bench to Bedside 495 521 .
G. Wu & S-M. Yan. (2001) Cyclosporine therapeutic and toxic effects may be related to different cyclosporine concentration zones in plasma. Medical Hypotheses 56:5, pages 691-692.
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Matthias Schwab & Ulrich Klotz. (2001) Pharmacokinetic Considerations in the Treatment of Inflammatory Bowel Disease. Clinical Pharmacokinetics 40:10, pages 723-751.
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A. C. F. Taylor, W. R. Connell, R. Elliott & A. J. F. D'Apice. (2008) Oral cyclosporin in refractory inflammatory bowel disease. Australian and New Zealand Journal of Medicine 28:2, pages 179-183.
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Laurence J Egan, William J Sandborn & William J Tremaine. (1998) Clinical Outcome Following Treatment of Refractory Inflammatory and Fistulizing Crohn's Disease With Intravenous Cyclosporine. American Journal of Gastroenterology 93:3, pages 442-448.
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E. ELTON & S. B. HANAUER. (2007) Review article: The medical management of Crohn's disease. Alimentary Pharmacology & Therapeutics 10:1, pages 1-22.
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Robert J. Greenstein & Adrian J. Greenstein. (1995) Is there clinical, epidemiological and molecular evidence for two forms of Crohn's disease?. Molecular Medicine Today 1:7, pages 343-348.
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William J. Sandborn. (1995) Cyclosporine therapy for inflammatory bowel disease: Definitive answers and remaining questions. Gastroenterology 109:3, pages 1001-1003.
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Simone S. Flückiger, Christoph Schmidt, Ansgar Meyer, Zoltan Kallay, Atholl Johnston & Klaus Kutz. (2013) Pharmacokinetics of Orally Administered Cyclosporine in Patients with Crohn's Disease. The Journal of Clinical Pharmacology 35:7, pages 681-687.
Crossref
William J. Sandborn. (1995) A Critical Review of Cyclosporine Therapy in Inflammatory Bowel Disease. Inflammatory Bowel Diseases 1:1, pages 48-63.
Crossref
A. B. R. Thomson. 1994. Inflammatory Bowel Disease. Inflammatory Bowel Disease 385 423 .

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