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Scandinavian Journal of Gastroenterology Volume 28, 1993 - Issue 4
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Original Article

The Enkephalinase Inhibitor, Acetorphan, in Acute Diarrhoea: A Double-Blind, Controlled Clinical Trial versus Loperamide

J. Roge Policlinic, Kremlin Bicětre University Hospital Centre; Laboratoire Bioprojet, Paul Broca Centre, National Institute of Health and Medical Research, Paris, France
,
P. Baumer Policlinic, Kremlin Bicětre University Hospital Centre; Laboratoire Bioprojet, Paul Broca Centre, National Institute of Health and Medical Research, Paris, France
,
H. Berard Policlinic, Kremlin Bicětre University Hospital Centre; Laboratoire Bioprojet, Paul Broca Centre, National Institute of Health and Medical Research, Paris, France
,
J.-C. Schwartz Policlinic, Kremlin Bicětre University Hospital Centre; Laboratoire Bioprojet, Paul Broca Centre, National Institute of Health and Medical Research, Paris, France
&
J.-M. Lecomte Policlinic, Kremlin Bicětre University Hospital Centre; Laboratoire Bioprojet, Paul Broca Centre, National Institute of Health and Medical Research, Paris, France
Pages 352-354 | Received 07 Jul 1992, Accepted 04 Nov 1992, Published online: 08 Jul 2009

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Thierry Monteil, Denis Danvy, Jean-Christophe Plaquevent, Lucette Duhamel, Pierre Duhamel, Claude Gros, Jean-Charles Schwartz & Jeanne-Marie Lecomte. (2001) NEW ASYMMETRIC SYNTHESIS OF DEXECADOTRIL AND ECADOTRIL STARTING FROM A SINGLE PRECURSOR. Synthetic Communications 31:2, pages 211-218.
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Agata Szymaszkiewicz, Martin Storr, Jakub Fichna & Marta Zielinska. (2018) Enkephalinase inhibitors, potential therapeutics for the future treatment of diarrhea predominant functional gastrointestinal disorders. Neurogastroenterology & Motility 31:4.
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Adam Fabisiak, Małgorzata Sobocińska, Elżbieta Kamysz, Jakub Fichna & Marta Zielińska. (2018) Antinociceptive potency of enkephalins and enkephalinase inhibitors in the mouse model of colorectal distension-proof-of-concept. Chemical Biology & Drug Design 92:1, pages 1387-1392.
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Luca Gallelli, Manuela Colosimo, Grazia A. Tolotta, Daniella Falcone, Laura Luberto, Lucia S. Curto, Pierandrea Rende, Francesca Mazzei, Norma M. Marigliano, Giovambattista De Sarro & Salvatore Cucchiara. (2009) Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes. European Journal of Clinical Pharmacology 66:2, pages 137-144.
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Guy De Bruyn & Alain Bouckenooghe. 2009. Evidence‐Based Infectious Diseases. Evidence‐Based Infectious Diseases 98 114 .
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Florence Noble, Nadia Benturquia, Andras Bilkei-Gorzo, Andreas Zimmer & Bernard P. Roques. (2007) Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours. Psychopharmacology 196:2, pages 327-335.
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Prarthana Thakurta, Poulami Bhowmik, Souryadeep Mukherjee, Tapas K. Hajra, Amarendra Patra & Prasanta K. Bag. (2007) Antibacterial, antisecretory and antihemorrhagic activity of Azadirachta indica used to treat cholera and diarrhea in India. Journal of Ethnopharmacology 111:3, pages 607-612.
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Hwang-Huei Wang. (2005) A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults. World Journal of Gastroenterology 11:10, pages 1540.
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H. U. De Schepper, F. Cremonini, M.-I. Park & M. Camilleri. (2004) Opioids and the gut: pharmacology and current clinical experience. Neurogastroenterology and Motility 16:4, pages 383-394.
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Enriqueta Román & María Luz Cilleruelo. (2003) Racecadotrilo en la gastroenteritis aguda infantil. Anales de Pediatría Continuada 1:3, pages 155-158.
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SATHAPORN MANATSATHIT, HERBERT L DUPONT, MICHAEL FARTHING, CHOMSRI KOSITCHAIWAT, SOMCHAI LEELAKUSOLVONG, BS RAMAKRISHNA, ADERBAL SABRA, PETER SPEELMAN & SURAPOL SURANGSRIRAT. (2002) Guideline for the management of acute diarrhea in adults. Journal of Gastroenterology and Hepatology 17, pages S54-S71.
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D. Turck, H. Berard, N. Fretault & J.M. Lecomte. (1999) Comparison of racecadotril and loperamide in children with acute diarrhoea. Alimentary Pharmacology & Therapeutics 13, pages 27-32.
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J.M. Vetel, H. Berard, N. Fretault & J.M. Lecomte. (1999) Comparison of racecadotril and loperamide in adults with acute diarrhoea. Alimentary Pharmacology & Therapeutics 13, pages 21-26.
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H. Hamza, H. Ben Khalifa, P. Baumer, H. Berard & J.M. Lecomte. (1999) Racecadotril versus placebo in the treatment of acute diarrhoea in adults. Alimentary Pharmacology & Therapeutics 13, pages 15-19.
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Lawrence R. Schiller. (1999) Secretory diarrhea. Current Gastroenterology Reports 1:5, pages 389-397.
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