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Original Article

Plasma Kinetics and Biliary Excretion of Colchicine in Patients with Chronic Liver Disease after Oral Administration of a Single Dose and after Long-Term Treatment

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Pages 346-351 | Received 11 Jun 1993, Accepted 21 Sep 1993, Published online: 08 Jul 2009

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Thilini Madushanka Wijerathna, Indika Bandara Gawarammana, Fahim Mohamed, Dhammika Menike Dissanayaka, Paul I Dargan, Umesh Chathuranga, Chamila Jayathilaka & Nicholas Alan Buckley. (2019) Epidemiology, toxicokinetics and biomarkers after self-poisoning with Gloriosa superba. Clinical Toxicology 57:11, pages 1080-1086.
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Shukry Zawahir, Indika Gawarammana, Paul I. Dargan, Mahfoudh Abdulghni & Andrew H. Dawson. (2017) Activated charcoal significantly reduces the amount of colchicine released from Gloriosa superba in simulated gastric and intestinal media. Clinical Toxicology 55:8, pages 914-918.
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Yaron Finkelstein, Steven E. Aks, Janine R. Hutson, David N. Juurlink, Patricia Nguyen, Gal Dubnov-Raz, Uri Pollak, Gideon Koren & Yedidia Bentur. (2010) Colchicine poisoning: the dark side of an ancient drug. Clinical Toxicology 48:5, pages 407-414.
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Articles from other publishers (24)

Zeyuan Wang, Xiaoman Zu, Shanshan Xiong, Ren Mao, Yun Qiu, Baili Chen, Zhirong Zeng, Minhu Chen & Yao He. (2023) The Role of Colchicine in Different Clinical Phenotypes of Behcet Disease. Clinical Therapeutics 45:2, pages 162-176.
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Tanveer A. Wani, Ahmed H. Bakheit, Seema Zargar & Salman Alamery. (2022) Mechanistic competitive binding interaction study between olmutinib and colchicine with model transport protein using spectroscopic and computer simulation approaches. Journal of Photochemistry and Photobiology A: Chemistry 426, pages 113794.
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Tanveer A. Wani, Nawaf A. Alsaif, Mohammed M. Alanazi, Ahmed H. Bakheit, Azmat Ali Khan & Seema Zargar. (2021) Binding of colchicine and ascorbic acid (vitamin C) to bovine serum albumin: An in-vitro interaction study using multispectroscopic, molecular docking and molecular dynamics simulation study. Journal of Molecular Liquids 342, pages 117542.
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Tanveer A. Wani, Ahmed H. Bakheit, Abdulrahman A. Al-Majed, Nojood Altwaijry, Anwar Baquaysh, Ashwaq Aljuraisy & Seema Zargar. (2021) Binding and drug displacement study of colchicine and bovine serum albumin in presence of azithromycin using multispectroscopic techniques and molecular dynamic simulation. Journal of Molecular Liquids 333, pages 115934.
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Jingcheng Xiao, Doanh Tran, Xinyuan Zhang, Tao Zhang, Shirley Seo, Haojie Zhu & Peng Zou. (2020) Biliary Excretion–Mediated Food Effects and Prediction. The AAPS Journal 22:6.
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Aernoud T. L. Fiolet, Max J. M. Silvis, Tjerk S. J. Opstal, Willem A. Bax, Frans A. L. van der Horst, Arend Mosterd, Dominique de Kleijn & Jan H. Cornel. (2020) Short-term effect of low-dose colchicine on inflammatory biomarkers, lipids, blood count and renal function in chronic coronary artery disease and elevated high-sensitivity C-reactive protein. PLOS ONE 15:8, pages e0237665.
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Leo F. Buckley & Peter Libby. (2019) Inhibiting NLRP3 Inflammasome Activity in Acute Myocardial Infarction. Journal of Cardiovascular Pharmacology 74:4, pages 297-305.
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Gwo‐Ching Sun, Hsin‐Hung Chen, Wei-Zhe Liang & Chung-Ren Jan. (2019) Exploration of the effect of the alkaloid colchicine on Ca2+ handling and its related physiology in human oral cancer cells. Archives of Oral Biology 102, pages 179-185.
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Leslie Z. Benet, Chelsea M. Hosey, Oleg Ursu & Tudor I. Oprea. (2016) BDDCS, the Rule of 5 and drugability. Advanced Drug Delivery Reviews 101, pages 89-98.
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Samer Alabed, Juan B Cabello, Greg J Irving, Mohammed Qintar & Amanda Burls. (2014) Colchicine for pericarditis. Cochrane Database of Systematic Reviews 2014:8.
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Samer Alabed, Juan B Cabello, Greg J Irving, Mohammed Qintar & Massimo Imazio. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Sameer Sapra, Yashika Bhalla, Nandani, Sahil Sharma, Gagandip Singh, Kunal Nepali, Abhishek Budhiraja & Kanaya L. Dhar. (2012) Colchicine and its various physicochemical and biological aspects. Medicinal Chemistry Research 22:2, pages 531-547.
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M. Imazio, A. Brucato, R. Trinchero, D. Spodick & Y. Adler. (2009) Colchicine for pericarditis: hype or hope?. European Heart Journal 30:5, pages 532-539.
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George Nuki. (2008) Colchicine: Its mechanism of action and efficacy in crystal-induced inflammation. Current Rheumatology Reports 10:3, pages 218-227.
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Elisabeth Niel & Jean-Michel Scherrmann. (2006) Actualité de la colchicine. Revue du Rhumatisme 73:12, pages 1338-1345.
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Elisabeth Niel & Jean-Michel Scherrmann. (2006) Colchicine today. Joint Bone Spine 73:6, pages 672-678.
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Erwin Kuntz. 2006. Hepatology Principles and Practice. Hepatology Principles and Practice 843 891 .
Miran Brvar, Gordana Koželj, Martin Možina & Matjaž Bunc. (2004) Acute poisoning with autumn crocus (Colchicum autumnale L.). Wiener Klinische Wochenschrift 116:5-6, pages 205-208.
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Miran Brvar, Tom Ploj, Gordana Kozelj, Martin Mozina, Marko Noc & Matjaz Bunc. (2004) Case report: fatal poisoning with Colchicum autumnale. Critical Care 8:1.
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Fernando Perez-Ruiz, Francisco Javier MielgoGonzalezGonzalez & Ana Maria Herrero Beites. (2000) Optimisation of the Treatment of Acute Gout. BioDrugs 13:6, pages 415-423.
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Tomonori Tateishi, Pavel Soucek, Yoseph Caraco, F.Peter Guengerich & Alastair J.J. Wood. (1997) Colchicine biotransformation by human liver microsomes. Biochemical Pharmacology 53:1, pages 111-116.
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Stephen W Borron, JM Scherrmann & Frédéric J Baud. (2016) Markedly altered colchicine kinetics in a fatal intoxication: Examination of contributing factors. Human & Experimental Toxicology 15:11, pages 885-890.
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C.A. Palmerini, C. Saccardi, A. Floridi & G. Arienti. (1996) Formylcolchicine bound to lactosaminated serum albumin is a more active antifibrotic agent than free colchicine. Clinica Chimica Acta 254:2, pages 149-157.
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O Chappey & JM Scherrmann. (1995) La colchicine: données récentes sur sa pharmacocinétique et sa pharmacologie clinique. La Revue de Médecine Interne 16:10, pages 782-789.
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