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Original Article

In Vitro Toxicity of Gluten Peptides in Coeliac Disease Assessed by Organ Culture

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Pages 758-763 | Received 06 Oct 1994, Accepted 05 Dec 1994, Published online: 08 Jul 2009

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Read on this site (4)

Suzanne C. Donnelly, Tanja Šuligoj, H. Julia Ellis & Paul J. Ciclitira. (2016) Identification of coeliac disease triggering glutenin peptides in adults. Scandinavian Journal of Gastroenterology 51:7, pages 819-826.
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Suzanne C Donnelly, H Julia Ellis & Paul J Ciclitira. (2011) Pharmacotherapy and management strategies for coeliac disease. Expert Opinion on Pharmacotherapy 12:11, pages 1731-1744.
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Daniela Pizzuti, Andrea Buda, Anna D'Odorico, Renata D'Incà, Silvia Chiarelli, Andrea Curioni & Diego Martines. (2006) Lack of intestinal mucosal toxicity of Triticum monococcum in celiac disease patients. Scandinavian Journal of Gastroenterology 41:11, pages 1305-1311.
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A. Picarelli. (1999) 31-43 Amino Acid Sequence of the a-Gliadin Induces Anti-Endomysial Antibody Production during in Vitro Challenge. Scandinavian Journal of Gastroenterology 34:11, pages 1099-1102.
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David Díaz-Regañón, Vojtech Gabriel, Vanessa Livania, Dongjie Liu, Basant H. Ahmed, Addison Lincoln, Hannah Wickham, Abigail Ralston, Maria M. Merodio, Dipak K. Sahoo, Christopher Zdyrski, David K. Meyerholz, Jonathan P. Mochel & Karin Allenspach. (2023) Changes of Enterocyte Morphology and Enterocyte: Goblet Cell Ratios in Dogs with Protein-Losing and Non-Protein-Losing Chronic Enteropathies. Veterinary Sciences 10:7, pages 417.
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Brad A. Palanski, Nielson Weng, Lichao Zhang, Andrew J. Hilmer, Lalla A. Fall, Kavya Swaminathan, Bana Jabri, Carolina Sousa, Nielsen Q. Fernandez-Becker, Chaitan Khosla & Joshua E. Elias. (2022) An efficient urine peptidomics workflow identifies chemically defined dietary gluten peptides from patients with celiac disease. Nature Communications 13:1.
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Fernando Gabriel Chirdo, Salvatore Auricchio, Riccardo Troncone & Maria Vittoria Barone. 2021. Immunopathology of Celiac Disease. Immunopathology of Celiac Disease 165 205 .
Margaret R. Dunne, Greg Byrne, Fernando G. Chirdo & Conleth Feighery. (2020) Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder. Frontiers in Immunology 11.
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Bilgin Vatansever, Amalia Muñoz, Christoph L. Klein & Knut Reinert. (2016) Development and optimisation of a generic micro LC-ESI-MS method for the qualitative and quantitative determination of 30-mer toxic gliadin peptides in wheat flour for food analysis. Analytical and Bioanalytical Chemistry 409:4, pages 989-997.
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Tanja Šuligoj, Paul J. Ciclitira & Borut Božič. (2017) Diagnostic and Research Aspects of Small Intestinal Disaccharidases in Coeliac Disease. Journal of Immunology Research 2017, pages 1-8.
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Gianluca Picariello, Gianfranco Mamone, Adele Cutignano, Angelo Fontana, Lucia Zurlo, Francesco Addeo & Pasquale Ferranti. (2015) Proteomics, Peptidomics, and Immunogenic Potential of Wheat Beer (Weissbier). Journal of Agricultural and Food Chemistry 63:13, pages 3579-3586.
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Peter Koehler, Herbert Wieser & Katharina Konitzer. 2014. Celiac Disease and Gluten. Celiac Disease and Gluten 97 148 .
Lucinda A. Harris, Jason Y. Park, Lysandra Voltaggio & Dora Lam-Himlin. (2012) Celiac disease: clinical, endoscopic, and histopathologic review. Gastrointestinal Endoscopy 76:3, pages 625-640.
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M. Stella Colomba & Armando Gregorini. (2012) Are Ancient Durum Wheats Less Toxic to Celiac Patients? A Study of α -Gliadin from Graziella Ra and Kamut . The Scientific World Journal 2012, pages 1-8.
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Yvonne Reinke, Marc Behrendt, Sonja Schmidt, Klaus-Peter Zimmer & Hassan Y. Naim. (2011) Impairment of protein trafficking by direct interaction of gliadin peptides with actin. Experimental Cell Research 317:15, pages 2124-2135.
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R. van Eckert, J. Bond, P. Rawson, Ch.L. Klein, M. Stern & T.W. Jordan. (2010) Reactivity of gluten detecting monoclonal antibodies to a gliadin reference material. Journal of Cereal Science 51:2, pages 198-204.
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Richard J. Farrell & Ciarán P. Kelly. 2010. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. Sleisenger and Fordtran's Gastrointestinal and Liver Disease 1797 1820.e4 .
Armando Gregorini, Mariastella Colomba, H. Julia Ellis & Paul Ciclitira. (2009) Immunogenicity Characterization of Two Ancient Wheat α-Gliadin Peptides Related to Coeliac Disease. Nutrients 1:2, pages 276-290.
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Aleksandra Konic-Ristic, Dejan Dodig, Radmilo Krstic, Svetislav Jelic, Ivan Stankovic, Aleksandra Ninkovic, Jelena Radic, Irina Besu, Branka Bonaci-Nikolic, Njegica Jojic, Milica Djordjevic, Dragan Popovic & Zorica Juranic. (2009) Different levels of humoral immunoreactivity to different wheat cultivars gliadin are present in patients with celiac disease and in patients with multiple myeloma. BMC Immunology 10:1.
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Paul J. Ciclitira & Julia H. Ellis. 2009. Gluten‐Free Food Science and Technology. Gluten‐Free Food Science and Technology 28 41 .
Martine Heyman & Sandrine Menard. (2009) Pathways of Gliadin Transport in Celiac Disease. Annals of the New York Academy of Sciences 1165:1, pages 274-278.
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Satumarja M Stenman, Katri Lindfors, Ilma R Korponay-Szabo, Olli Lohi, Päivi Saavalainen, Jukka Partanen, Katri Haimila, Herbert Wieser, Markku Mäki & Katri Kaukinen. (2008) Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits. BMC Immunology 9:1.
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Herbert Wieser & Peter Koehler. (2008) The Biochemical Basis of Celiac Disease. Cereal Chemistry Journal 85:1, pages 1-13.
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Georg Hartmann, Peter Koehler & Herbert Wieser. (2006) Rapid degradation of gliadin peptides toxic for coeliac disease patients by proteases from germinating cereals. Journal of Cereal Science 44:3, pages 368-371.
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R. van Eckert, E. Berghofer, P.J. Ciclitira, F. Chirdo, S. Denery-Papini, H.J. Ellis, P. Ferranti, P. Goodwin, U. Immer, G. Mamone, E. Méndez, T. Mothes, S. Novalin, A. Osman, M. Rumbo, M. Stern, L. Thorell, A. Whim & H. Wieser. (2006) Towards a new gliadin reference material–isolation and characterisation. Journal of Cereal Science 43:3, pages 331-341.
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R.P. Anderson & H. Wieser. 2006. Gliadin and Glutenin: The Unique Balance of Wheat Quality. Gliadin and Glutenin: The Unique Balance of Wheat Quality 387 409 .
Paul J. Ciclitira, Mathew W. Johnson, David H. Dewar & H. Julia Ellis. (2005) The pathogenesis of coeliac disease. Molecular Aspects of Medicine 26:6, pages 421-458.
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Frits Koning. (2005) Celiac Disease: Caught Between a Rock and a Hard Place. Gastroenterology 129:4, pages 1294-1301.
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Bana Jabri, Donald D. Kasarda & Peter H. R. Green. (2005) Innate and adaptive immunity: the Yin and Yang of celiac disease. Immunological Reviews 206:1, pages 219-231.
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Frits Koning, Luud Gilissen & Cisca Wijmenga. (2005) Gluten: a two-edged sword. Immunopathogenesis of celiac disease. Springer Seminars in Immunopathology 27:2, pages 217-232.
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J. Fernndez Castroagudn, C. Durana Tonder & J.E. Domnguez Muoz. (2004) S?ndrome de malabsorci?n intestinal (2). Formas de afectaci?n intestinal primaria en el adulto. Medicine - Programa de Formaci?n M?dica Continuada Acreditado 9:3, pages 172-184.
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Susi Martucci, Jocelyn Sophie Fraser, Federico Biagi, Gino Roberto Corazza, Paul Jonathan Ciclitira & Heather Julia Ellis. (2003) Characterizing one of the DQ2 candidate epitopes in coeliac disease. European Journal of Gastroenterology & Hepatology 15:12, pages 1293-1298.
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Tamara Matysiak-Budnik, Celine Candalh, Christophe Dugave, Abdelkader Namane, Christophe Cellier, Nadine Cerf-Bensussan & Martine Heyman. (2003) Alterations of the intestinal transport and processing of gliadin peptides in celiac disease. Gastroenterology 125:3, pages 696-707.
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Luigi Maiuri, Carolina Ciacci, Ida Ricciardelli, Loredana Vacca, Valeria Raia, Salvatore Auricchio, Jean Picard, Mohamed Osman, Sonia Quaratino & Marco Londei. (2003) Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. The Lancet 362:9377, pages 30-37.
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S. Martucci, F. Biagi, A. Di Sabatino & G.R. Corazza. (2002) Coeliac disease. Digestive and Liver Disease 34, pages S150-S153.
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M Ten Dam, Y Van DE Wal, M L Mearin, Y Kooy, S PEñA, J W Drijfhout, F Koning & M Van Tol. (1998) Anti-α-gliadin antibodies (AGA) in the serum of coeliac children and controls recognize an identical collection of linear epitopes of α-gliadin. Clinical and Experimental Immunology 114:2, pages 189-195.
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R G Shidrawi, N D J Parnell, P J Ciclitira, P Travers, G Evan & S Rosen-Bronson. (1998) Binding of gluten-derived peptides to the HLA-DQ2 (α1*0501, β1*0201) molecule, assessed in a cellular assay. Clinical and Experimental Immunology 111:1, pages 158-165.
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Awad A. Osman, Holm H. Uhlig, Israel Valdes, Mona Amin, Enrique Méndez & Thomas Mothes. (2001) A monoclonal antibody that recognizes a potential coeliac-toxic repetitive pentapeptide epitope in gliadins. European Journal of Gastroenterology & Hepatology 13:10, pages 1189-1193.
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Martin Stern, Paul J. Ciclitira, Renate van Eckert, Conleth Feighery, Frederik W. Janssen, Enrique Méndez, Thomas Mothes, Riccardo Troncone & Herbert Wieser. (2001) Analysis and clinical effects of gluten in coeliac disease. European Journal of Gastroenterology & Hepatology 13:6, pages 741-747.
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Paul J. Ciclitira. (2001) AGA technical review on celiac sprue. Gastroenterology 120:6, pages 1526-1540.
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S. Moodie & P. Ciclitira. (2001) Maladie cœllaque: facteurs génétiques et présentation des antigènesCoeliac disease: genetic factors and antigen presentation. Acta Endoscopica 31:3, pages 255-264.
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P. J. Ciclitira, F. Biagi, H. J. Ellis & N. D. G. Parnell. (2001) Endomysial antibody production after in vitro gliadin challenge. European Journal of Gastroenterology & Hepatology 13:2, pages 214.
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Karoly Horvath & Devendra I. Mehta. (2000) Celiac disease—A worldwide problem. The Indian Journal of Pediatrics 67:10, pages 757-763.
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Allan Mcl Mowat. (2000) Coeliac disease—a future for peptide therapy?. The Lancet 356:9226, pages 270-271.
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Rajesh Kumar, Angela Lumsden, Paul J Ciclitira, H.Julia Ellis & Gordon W Laurie. (2000) Human genome search in celiac disease using gliadin cDNA as probe11Edited by J. Karn. Journal of Molecular Biology 300:5, pages 1155-1167.
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Gabriele Bolte, Werner Seilmeier, Herbert Wieser, Kati Holm, Karin Beuermann, Beate Newport & Martin Stern. (1999) Enhanced Peptide-Binding Capacities of Small Intestinal Brush Border Membranes in Celiac Disease. Pediatric Research 46:6, pages 666-666.
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Fernando G. Chirdo, Martín Rumbo, Patricia Carabajal, Norma Castagnino, Elizabeth Mavromatopulos, Vilma Cirincione, María-Christina Añón & Carlos Alberto Fossati. (1999) Analysis of Anti-Gliadin Antibodies by Immunoblot Analysis and Enzyme-Linked Immunosorbent Assay Using Gliadin Fractions As Antigens. Journal of Pediatric Gastroenterology and Nutrition 29:2, pages 171-177.
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Biagi, Ellis, Parnell, Shidrawi, Thomas, O’reilly, Corazza & Ciclitira. (2001) A non‐toxic analogue of a coeliac‐activating gliadin peptide: a basis for immunomodulation?. Alimentary Pharmacology & Therapeutics 13:7, pages 945-950.
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Harald Vogelsang, Maria Schwarzenhofer, Gerhard Granditsch & Georg Oberhuber. (1999) In Vitro Production of Endomysial Antibodies in Cultured Duodenal Mucosa From Patients With Celiac Disease. American Journal of Gastroenterology 94:4, pages 1057-1061.
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Marco Silano & Massimo De Vincenzi. (1999) In vitro screening of food peptides toxic for coeliac and other gluten-sensitive patients: a review. Toxicology 132:2-3, pages 99-110.
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PARNELL & CICLITIRA. (2001) Review article: coeliac disease and its management. Alimentary Pharmacology & Therapeutics 13:1, pages 1-13.
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Massimo De Vincenzi, Annalaura Stammati, Roberto Luchetti, Marco Silano, Giovanni Gasbarrini & Vittorio Silano. (1998) Structural specificities and significance for coeliac disease of wheat gliadin peptides able to agglutinate or to prevent agglutination of K562(S) cells. Toxicology 127:1-3, pages 97-106.
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