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Original Article

Mechanisms of Mucosal Injury and Healing: the Role of Non-steroidal Anti-inflammatory Drugs

Pages 24-29 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

T.T. Priya, M.C. Sabu & C.I. Jolly. (2011) Role of Mangifera indica bark polyphenols on rat gastric mucosa against ethanol and cold-restraint stress. Natural Product Research 25:8, pages 815-826.
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Denis M. McCarthy. (2001) Helicobacter pylori and NSAIDs - What Interaction. The European Journal of Surgery 167:586, pages 56-65.
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Jane C. Chandramouli & Keith G. Tolman. (2000) Prevention and Management of NSAID-Induced Gastropathy. Journal of Pharmaceutical Care in Pain & Symptom Control 8:4, pages 27-40.
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B. L. Slomiany, A. Slomiany. (2000) Role of Endothelin-converting Enzyme-1 in the Suppression of Constitutive Nitric Oxide Synthase in Rat Gastric Mucosal Injury by Indomethacin. Scandinavian Journal of Gastroenterology 35:11, pages 1131-1136.
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J. Piotrowski, A. Slomiany, B. L. Slomiany. (1999) Activation of Apoptotic Caspase-3 and Nitric Oxide Synthase-2 in Gastric Mucosal Injury Induced by Indomethacin. Scandinavian Journal of Gastroenterology 34:2, pages 129-134.
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B. L. Slomiany, J. Piotrowski & A. Slomiany. (1997) Induction of Tumor Necrosis Factor-α and Apoptosis in Gastric Mucosal Injury by Indomethacin: Effect of Omeprazole and Ebrotidine. Scandinavian Journal of Gastroenterology 32:7, pages 638-642.
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Articles from other publishers (37)

KM Diksha SinghVikram SinghAdity SinghVipin Kesharwani. (2021) Evaluation of Oxidative Stress potential of some Nsaıds against Hydrogen Peroxide in experimental animal. Research Journal of Pharmacy and Technology, pages 6194-6200.
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Anna SEIDENARI, Dajana CUICCHI, Aly YOUSSEF, Emily A. OLIVER, Elisa MONTAGUTI & Federica BELLUSSI. (2021) Obstetric anal sphincter injuries: strategies for prevention, diagnosis, and management. Minerva Obstetrics and Gynecology 73:1.
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Samuel L. Jones, Gilles Fecteau, Pamela J. Hullinger, Danelle A. Bickett-Weddle, Guy St. Jean, Sylvain Nichols, N. James Maclachlan, Christie E. Mayo, Paul Walz, Sébastien Buczinski, Franklyn Garry, Craig McConnel, David Francoz, André Desrochers, Raymond W. Sweeney, Spring K. Halland, Robert Bascom Sager, Bradford P. Smith, Michelle H. Barton, Jack Easley, Anthony T. Blikslager, Gayle D. Hallowell, Liara M. Gonzalez, Kelsey A. Hart, Jennifer L. Davis, Nicola Pusterla, John F. Marshall, Tiffany L. Hall, Chris Sanchez, Robert J. Callan, Nimet Browne & Francisco A. Uzal. 2020. Large Animal Internal Medicine. Large Animal Internal Medicine 702 920.e35 .
Marie-Andrée Harvey & Marianne Pierce. (2016) Lésions obstétricales du sphincter anal (LOSA) : Prévention, identification et réparation. Journal of Obstetrics and Gynaecology Canada 38:12, pages S740-S761.
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Marie-Andrée Harvey, Marianne Pierce, Jens-Erik Walter, Queena Chou, Phaedra Diamond, Annette Epp, Roxana Geoffrion, Marie-Andrée Harvey, Annick Larochelle, Kenny Maslow, Grace Neustaedter, Dante Pascali, Marianne Pierce, Jane Schulz, David Wilkie, Abdul Sultan & Ranee Thakar. (2015) Obstetrical Anal Sphincter Injuries (OASIS): Prevention, Recognition, and Repair. Journal of Obstetrics and Gynaecology Canada 37:12, pages 1131-1148.
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Juan Rodríguez-Silverio, María Elena Sánchez-Mendoza, Jesús Arrieta-Valencia, Héctor Isaac Rocha-Gonzalez & Francisco Javier Flores-Murrieta. (2013) Tizanidine Increases Antinociceptive Effect and Prevents Gastric Damage Induced by Ketorolac in the Rat. Drug Development Research 74:1, pages 38-42.
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Smeeta M Mohod & Subhash L Bodhankar. (2013) Antiulcer activity of aqueous extract of leaves of Madhuca indica J. F. Gmel against naproxen induced gastric mucosal injury in rats. Journal of Acute Disease 2:2, pages 127-133.
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Yasin TuluceHalil Ozkol, Ismail Koyuncu & Hatice Ine. (2011) Gastroprotective effect of small centaury ( Centaurium erythraea L) on aspirin-induced gastric damage in rats . Toxicology and Industrial Health 27:8, pages 760-768.
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C Hernández, E Santamatilde, KJ McCreath, AM Cervera, I Díez, D Ortiz-Masiá, N Martínez, S Calatayud, JV Esplugues & MD Barrachina. (2009) Induction of trefoil factor (TFF)1, TFF2 and TFF3 by hypoxia is mediated by hypoxia inducible factor-1: implications for gastric mucosal healing. British Journal of Pharmacology 156:2, pages 262-272.
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Takahiro Suzuki, Norimasa Yoshida, Nami Nakabe, Yutaka Isozaki, Hirokazu Kajikawa, Tomohisa Takagi, Osamu Handa, Satoshi Kokura, Hiroshi Ichikawa, Yuji Naito, Hirofumi Matsui & Toshikazu Yoshikawa. (2008) Prophylactic Effect of Rebamipide on Aspirin-Induced Gastric Lesions and Disruption of Tight Junctional Protein Zonula Occludens-1 Distribution. Journal of Pharmacological Sciences 106:3, pages 469-477.
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M. Kirkova, A. Alexandova, M. Kesiova & S. Todorov. (2007) In vivo effects of amtolmetin guacyl on lipid peroxidation and antioxidant defence systems. Comparison with non-selective and COX-2 selective NSAIDs. Autonomic & Autacoid Pharmacology 27:2, pages 99-104.
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M. Kirkova, A. Alexandova, M. Kesiova, E. Tsvetanova, A. Georgieva & S. Todorov. (2007) Potential antioxidant activity of celecoxib and amtolmetin guacyl: in vitro studies. Autonomic & Autacoid Pharmacology 27:1, pages 13-18.
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Jae Youl Cho. (2007) Immunomodulatory effect of nonsteroidal anti-inflammatory drugs (NSAIDs) at the clinically available doses. Archives of Pharmacal Research 30:1, pages 64-74.
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T. NARITA, N. OKABE, M. HANE, Y. YAMAMOTO, K. TANI, Y. NAITO & S. HARA. (2006) Nonsteroidal anti-inflammatory drugs induce hypermotilinemia and disturbance of interdigestive migrating contractions in instrumented dogs. Journal of Veterinary Pharmacology and Therapeutics 29:6, pages 569-577.
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Mehrafarin Fesharaki, Ali Nasimi, Saloomeh Mokhtari, Roozbeh Mokhtari, Raana Moradian & Nooshin Amirpoor. (2006) Reactive oxygen metabolites and anti-oxidative defenses in aspirin-induced gastric damage in rats: Gastroprotection by Vitamin E. Pathophysiology 13:4, pages 237-243.
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Martijn G. H. van Oijen, Robert J. F. Laheij, Marjolein Koetsier, Evelien de Kleine, René H. M. te Morsche, Lieke A. S. van Kerkhoven, Jan B. M. J. Jansen & Joost P. H. Drenth. (2006) Effect of a Specific Cyclooxygenase-Gene Polymorphism (A-842G/C50T) on the Occurrence of Peptic Ulcer Hemorrhage. Digestive Diseases and Sciences 51:12, pages 2348-2352.
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Jeong-Hwan Kim, Young-Sik Kim, Gwan-Gyu Song, Jong-Jae Park & Hyo-Ihl Chang. (2005) Protective effect of astaxanthin on naproxen-induced gastric antral ulceration in rats. European Journal of Pharmacology 514:1, pages 53-59.
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C. M. Hotz-Behofsits, M. J. M. Walley, R. Simpson & I. T. Bjarnason. (2003) COX-1, COX-2 and the topical effect in NSAID-induced enteropathy. InflammoPharmacology 11:4-6, pages 363-370.
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Naveen K Jain, Shrinivas K Kulkarni & Amarjit Singh. (2002) Modulation of NSAID-induced antinociceptive and anti-inflammatory effects by α2-adrenoceptor agonists with gastroprotective effects. Life Sciences 70:24, pages 2857-2869.
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Ludmila Filaretova, Tatiana Podvigina, Tatiana Bagaeva & Gabor Makara. (2001) Gastroprotective action of glucocorticoids during the formation and the healing of indomethacin-induced gastric erosions in rats. Journal of Physiology-Paris 95:1-6, pages 201-208.
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Angel Lanas, Eduardo Bajador, Pedro Serrano, Javier Fuentes, Sofía Carreño, Jesusa Guardia, Mercedes Sanz, Miguel Montoro & Ricardo Sáinz. (2000) Nitrovasodilators, Low-Dose Aspirin, Other Nonsteroidal Antiinflammatory Drugs, and the Risk of Upper Gastrointestinal Bleeding. New England Journal of Medicine 343:12, pages 834-839.
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B. L. Slomiany & A. Slomiany. (2000) Suppression of endothelin-converting enzyme-1 by sucralfate, a factor in gastric mucosal resistance to indomethacin injury in rats. InflammoPharmacology 8:2, pages 207-218.
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Bronislaw L. Slomiany & Amalia Slomiany. (2000) Induction of Endothelin-Converting Enzyme-1 in Gastric Mucosal Injury by Idomethacin. Biochemical and Biophysical Research Communications 269:2, pages 377-381.
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