54
Views
80
CrossRef citations to date
0
Altmetric
Original Article

In vitro Activities of A-Gliadin-Related Synthetic Peptides Damaging Effect on the Atrophic Coeliac Mucosa and Activation of Mucosal Immune Response in the Treated Coeliac Mucosa

, , , , , , & show all
Pages 247-253 | Received 28 Apr 1995, Accepted 24 Jul 1995, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Paolo D’Avino, Gloria Serena, Victoria Kenyon & Alessio Fasano. (2021) An updated overview on celiac disease: from immuno-pathogenesis and immuno-genetics to therapeutic implications. Expert Review of Clinical Immunology 17:3, pages 269-284.
Read now
NorbertoE. Pogna, Laura Gazza, Olimpia Vincentini & Massimo De Vincenzi. (2008) Variation in noxiousness of different wheat species for celiac patients. Journal of Plant Interactions 3:1, pages 57-67.
Read now
Mauro Rossi, Francesco Maurano & Diomira Luongo. (2005) Immunomodulatory Strategies for Celiac Disease. International Reviews of Immunology 24:5-6, pages 479-499.
Read now

Articles from other publishers (77)

Miriam Marín-Sanz, Francisco Barro & Susana Sánchez-León. (2023) Unraveling the celiac disease-related immunogenic complexes in a set of wheat and tritordeum genotypes: implications for low-gluten precision breeding in cereal crops. Frontiers in Plant Science 14.
Crossref
Ritu Tomer, Sumeet Patiyal, Anjali Dhall & Gajendra P. S. Raghava. (2023) Prediction of celiac disease associated epitopes and motifs in a protein. Frontiers in Immunology 14.
Crossref
Plaimein Amnuaycheewa, Mohamed Abdelmoteleb, John Wise, Barbara Bohle, Fatima Ferreira, Afua O. Tetteh, Steve L. Taylor & Richard E. Goodman. (2022) Development of a Sequence Searchable Database of Celiac Disease-Associated Peptides and Proteins for Risk Assessment of Novel Food Proteins. Frontiers in Allergy 3.
Crossref
Susan Swee-Shan Hue, Siok-Bian Ng, Shi Wang & Soo-Yong Tan. (2022) Cellular Origins and Pathogenesis of Gastrointestinal NK- and T-Cell Lymphoproliferative Disorders. Cancers 14:10, pages 2483.
Crossref
Martin A. Lauxmann, Diego S. Vazquez, Hanna M. Schilbert, Pia R. Neubauer, Karen M. Lammers & Veronica I. Dodero. (2021) From celiac disease to coccidia infection and vice‐versa: The polyQ peptide CXCR3‐interaction axis. BioEssays 43:12, pages 2100101.
Crossref
Jordan Voisine & Valérie Abadie. (2021) Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac Disease. Frontiers in Immunology 12.
Crossref
Jan G. Schaart, Elma M. J. Salentijn, Svetlana V. Goryunova, Charity Chidzanga, Danny G. Esselink, Nick Gosman, Alison R. Bentley, Luud J. W. J. Gilissen & Marinus J. M. Smulders. (2021) Exploring the alpha‐gliadin locus: the 33‐mer peptide with six overlapping coeliac disease epitopes in Triticum aestivum is derived from a subgroup of Aegilops tauschii . The Plant Journal 106:1, pages 86-94.
Crossref
Xuechen Yu, Justin Vargas, Peter H.R. Green & Govind Bhagat. (2021) Innate Lymphoid Cells and Celiac Disease: Current Perspective. Cellular and Molecular Gastroenterology and Hepatology 11:3, pages 803-814.
Crossref
Fernando Gabriel Chirdo, Salvatore Auricchio, Riccardo Troncone & Maria Vittoria Barone. 2021. Immunopathology of Celiac Disease. Immunopathology of Celiac Disease 165 205 .
Josep Penuelas, Albert Gargallo-Garriga, Ivan A. Janssens, Philippe Ciais, Michael Obersteiner, Karel Klem, Otmar Urban, Yong-Guan Zhu & Jordi Sardans. (2020) Could Global Intensification of Nitrogen Fertilisation Increase Immunogenic Proteins and Favour the Spread of Coeliac Pathology?. Foods 9:11, pages 1602.
Crossref
María Georgina Herrera, María Florencia Gómez Castro, Eduardo Prieto, Exequiel Barrera, Veronica Isabel Dodero, Sergio Pantano & Fernando Chirdo. (2019) Structural conformation and self‐assembly process of p31‐43 gliadin peptide in aqueous solution. Implications for celiac disease. The FEBS Journal 287:10, pages 2134-2149.
Crossref
Sandra Dedrick, Bharathi Sundaresh, Qian Huang, Claudia Brady, Tessa Yoo, Catherine Cronin, Caitlin Rudnicki, Michael Flood, Babak Momeni, Johnny Ludvigsson & Emrah Altindis. (2020) The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis. Frontiers in Endocrinology 11.
Crossref
Hyemin Min, Ji-Sun Kim, Jiyun Ahn & Yhong-Hee Shim. (2019) Gliadin Intake Causes Disruption of the Intestinal Barrier and an Increase in Germ Cell Apoptosis in A Caenorhabditis Elegans Model. Nutrients 11:11, pages 2587.
Crossref
Shakira Yoosuf & Govind K. Makharia. (2019) Evolving Therapy for Celiac Disease. Frontiers in Pediatrics 7.
Crossref
María Florencia Gómez Castro, Emanuel Miculán, María Georgina Herrera, Carolina Ruera, Federico Perez, Eduardo Daniel Prieto, Exequiel Barrera, Sergio Pantano, Paula Carasi & Fernando Gabriel Chirdo. (2019) p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine. Frontiers in Immunology 10.
Crossref
Martin Haupt-Jorgensen, Laurits Holm, Knud Josefsen & Karsten Buschard. (2018) Possible Prevention of Diabetes with a Gluten-Free Diet. Nutrients 10:11, pages 1746.
Crossref
Karen M. Lammers, Maria G. Herrera & Veronica I. Dodero. (2018) Translational Chemistry Meets Gluten-Related Disorders. ChemistryOpen 7:3, pages 217-232.
Crossref
Karla A Bascuñán, Leda Roncoroni, Federica Branchi, Luisa Doneda, Alice Scricciolo, Francesca Ferretti, Magdalena Araya & Luca Elli. (2018) The 5 Ws of a gluten challenge for gluten-related disorders. Nutrition Reviews 76:2, pages 79-87.
Crossref
Elisabetta Gerace, Francesco Resta, Elisa Landucci, Daniela Renzi, Alessio Masi, Domenico E. Pellegrini-Giampietro, Antonio Calabrò & Guido Mannaioni. (2017) The gliadin peptide 31-43 exacerbates kainate neurotoxicity in epilepsy models. Scientific Reports 7:1.
Crossref
Bilgin Vatansever, Amalia Muñoz, Christoph L. Klein & Knut Reinert. (2016) Development and optimisation of a generic micro LC-ESI-MS method for the qualitative and quantitative determination of 30-mer toxic gliadin peptides in wheat flour for food analysis. Analytical and Bioanalytical Chemistry 409:4, pages 989-997.
Crossref
Serena Vitale, Stefania Picascia & Carmen Gianfrani. (2016) The cross-talk between enterocytes and intraepithelial lymphocytes. Molecular and Cellular Pediatrics 3:1.
Crossref
Giuseppe Iacomino, Luigia Di Stasio, Olga Fierro, Gianluca Picariello, Antonella Venezia, Laura Gazza, Pasquale Ferranti & Gianfranco Mamone. (2016) Protective effects of ID331 Triticum monococcum gliadin on in vitro models of the intestinal epithelium. Food Chemistry 212, pages 537-542.
Crossref
Verena Knorr, Roland Kerpes, Herbert Wieser, Martin Zarnkow, Thomas Becker & Peter Koehler. (2015) Production and application of barley malt extract with high peptidase activity for the degradation of gluten in wort. European Food Research and Technology 242:4, pages 585-597.
Crossref
Carmen V. Ozuna, Julio C. M. Iehisa, María J. Giménez, Juan B. Alvarez, Carolina Sousa & Francisco Barro. (2015) Diversification of the celiac disease α-gliadin complex in wheat: a 33-mer peptide with six overlapping epitopes, evolved following polyploidization. The Plant Journal 82:5, pages 794-805.
Crossref
Linda Monaci, Rosa Pilolli, Elisabetta De Angelis & Gianfranco Mamone. 2015. Advanced Mass Spectrometry for Food Safety and Quality. Advanced Mass Spectrometry for Food Safety and Quality 359 393 .
Maria Barone, Riccardo Troncone & Salvatore Auricchio. (2014) Gliadin Peptides as Triggers of the Proliferative and Stress/Innate Immune Response of the Celiac Small Intestinal Mucosa. International Journal of Molecular Sciences 15:11, pages 20518-20537.
Crossref
Marco Silano, Elena Penas Pozo, Francesca Uberti, Sara Manferdelli, Tamara Del Pinto, Cristina Felli, Andrea Budelli, Olimpia Vincentini & Patrizia Restani. (2013) Diversity of oat varieties in eliciting the early inflammatory events in celiac disease. European Journal of Nutrition 53:5, pages 1177-1186.
Crossref
Peter Koehler, Herbert Wieser & Katharina Konitzer. 2014. Celiac Disease and Gluten. Celiac Disease and Gluten 97 148 .
Peter Koehler, Herbert Wieser & Katharina Konitzer. 2014. Celiac Disease and Gluten. Celiac Disease and Gluten 1 96 .
Karen M. Lammers, Brintha Vasagar & Alessio Fasano. 2014. Celiac Disease. Celiac Disease 13 25 .
Peng-Fei Qi, Qing Chen, Thérèse Ouellet, Zhao Wang, Cheng-Xing Le, Yu-Ming Wei, Xiu-Jin Lan & You-Liang Zheng. (2013) The molecular diversity of α-gliadin genes in the tribe Triticeae. Genetica 141:7-9, pages 303-310.
Crossref
Giuseppe Iacomino, Olga Fierro, Sabato D’Auria, Gianluca Picariello, Pasquale Ferranti, Claudia Liguori, Francesco Addeo & Gianfranco Mamone. (2013) Structural Analysis and Caco-2 Cell Permeability of the Celiac-Toxic A-Gliadin Peptide 31–55. Journal of Agricultural and Food Chemistry 61:5, pages 1088-1096.
Crossref
Gianna Ferretti, Tiziana Bacchetti, Simona Masciangelo & Letizia Saturni. (2012) Celiac Disease, Inflammation and Oxidative Damage: A Nutrigenetic Approach. Nutrients 4:4, pages 243-257.
Crossref
Cynthia Grant, Francesco Cubadda, Marina Carcea, Norberto E. Pogna & Laura Gazza. 2012. Durum Wheat. Durum Wheat 125 137 .
Karen M. Lammers, Sunaina Khandelwal, Fatima Chaudhry, Debby Kryszak, Elaine L. Puppa, Vincenzo Casolaro & Alessio Fasano. (2011) Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease. Immunology 132:3, pages 432-440.
Crossref
Alessio Fasano. (2011) Zonulin and Its Regulation of Intestinal Barrier Function: The Biological Door to Inflammation, Autoimmunity, and Cancer. Physiological Reviews 91:1, pages 151-175.
Crossref
J. R. Mujico, T. Pozo, A. Marcos & E. Nova. (2011) Cytokine balance of an intestinal in vitro model stimulated with different gliadin peptides involved in caeliac disease . Proceedings of the Nutrition Society 70:OCE2.
Crossref
Riccardo Troncone & Salvatore Auricchio. 2011. Pediatric Gastrointestinal and Liver Disease. Pediatric Gastrointestinal and Liver Disease 366 373.e3 .
Ivana Caputo, Marilena Lepretti, Stefania Martucciello & Carla Esposito. (2010) Enzymatic Strategies to Detoxify Gluten: Implications for Celiac Disease. Enzyme Research 2010, pages 1-9.
Crossref
Ivana Caputo, Maria Vittoria Barone, Marilena Lepretti, Stefania Martucciello, Ivan Nista, Riccardo Troncone, Salvatore Auricchio, Daniele Sblattero & Carla Esposito. (2010) Celiac anti-tissue transglutaminase antibodies interfere with the uptake of alpha gliadin peptide 31–43 but not of peptide 57–68 by epithelial cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1802:9, pages 717-727.
Crossref
Maria Vittoria Barone, Merlin Nanayakkara, Giovanni Paolella, Mariantonia Maglio, Virginia Vitale, Raffaele Troiano, Maria Teresa Silvia Ribecco, Giuliana Lania, Delia Zanzi, Sara Santagata, Renata Auricchio, Riccardo Troncone & Salvatore Auricchio. (2010) Gliadin Peptide P31-43 Localises to Endocytic Vesicles and Interferes with Their Maturation. PLoS ONE 5:8, pages e12246.
Crossref
Olimpia Vincentini, Osvaldo Borrelli, Marco Silano, Laura Gazza, Norberto Pogna, Roberto Luchetti & Massimo De Vincenzi. (2009) T-cell response to different cultivars of farro wheat, Triticum turgidum ssp. dicoccum, in celiac disease patients. Clinical Nutrition 28:3, pages 272-277.
Crossref
Les Lang. (2009) Second Annual William K. Warren, Jr Prize for Excellence in Celiac Disease Research Awarded to Professor Salvatore Auricchio of Naples, Italy. Gastroenterology 136:3, pages 739-740.
Crossref
B Meresse, J Ripoche, M Heyman & N Cerf-Bensussan. (2009) Celiac disease: from oral tolerance to intestinal inflammation, autoimmunity and lymphomagenesis. Mucosal Immunology 2:1, pages 8-23.
Crossref
Herbert Wieser & Peter Koehler. (2008) The Biochemical Basis of Celiac Disease. Cereal Chemistry Journal 85:1, pages 1-13.
Crossref
Olimpia Vincentini, Francesca Maialetti, Laura Gazza, Marco Silano, Mariarita Dessi, Massimo De Vincenzi & Norberto Edgardo Pogna. (2007) Environmental factors of celiac disease: Cytotoxicity of hulled wheat species Triticum monococcum, T. turgidum ssp. dicoccum and T. aestivum ssp. spelta. Journal of Gastroenterology and Hepatology 22:11, pages 1816-1822.
Crossref
Daniela De Stefano, Maria Chiara Maiuri, Vittorio Simeon, Gianluca Grassia, Antonio Soscia, Maria Pia Cinelli & Rosa Carnuccio. (2007) Lycopene, quercetin and tyrosol prevent macrophage activation induced by gliadin and IFN-γ. European Journal of Pharmacology 566:1-3, pages 192-199.
Crossref
Daniela De Stefano, Maria Chiara Maiuri, Barbara Iovine, Armando Ialenti, Maria Assunta Bevilacqua & Rosa Carnuccio. (2005) The role of NF-κB, IRF-1, and STAT-1α transcription factors in the iNOS gene induction by gliadin and IFN-γ in RAW 264.7 macrophages. Journal of Molecular Medicine 84:1, pages 65-74.
Crossref
Frits Koning. (2005) Celiac Disease: Caught Between a Rock and a Hard Place. Gastroenterology 129:4, pages 1294-1301.
Crossref
Tamara Matysiak–Budnik, Celine Candalh, Christophe Cellier, Christophe Dugave, Abdelkader Namane, Teresita Vidal–Martinez, Nadine Cerf–Bensussan & Martine Heyman. (2005) Limited Efficiency of Prolyl-Endopeptidase in the Detoxification of Gliadin Peptides in Celiac Disease. Gastroenterology 129:3, pages 786-796.
Crossref
Carmen Gianfrani, Salvatore Auricchio & Riccardo Troncone. (2005) Adaptive and innate immune responses in celiac disease. Immunology Letters 99:2, pages 141-145.
Crossref
Frits Koning, Luud Gilissen & Cisca Wijmenga. (2005) Gluten: a two-edged sword. Immunopathogenesis of celiac disease. Springer Seminars in Immunopathology 27:2, pages 217-232.
Crossref
R Ciccocioppo, A Di Sabatino & G R Corazza. (2005) The immune recognition of gluten in coeliac disease. Clinical and Experimental Immunology 140:3, pages 408-416.
Crossref
Marco Silano, Olimpia Vincentini, Riccardo A.A. Muzzarelli, Corrado Muzzarelli & Massimo De Vincenzi. (2004) MP-Chitosan protects Caco-2 cells from toxic gliadin peptides. Carbohydrate Polymers 58:2, pages 215-219.
Crossref
Raffaella Di Cagno, Maria De Angelis, Salvatore Auricchio, Luigi Greco, Charmaine Clarke, Massimo De Vincenzi, Claudio Giovannini, Massimo D'Archivio, Francesca Landolfo, Giampaolo Parrilli, Fabio Minervini, Elke Arendt & Marco Gobbetti. (2004) Sourdough Bread Made from Wheat and Nontoxic Flours and Started with Selected Lactobacilli Is Tolerated in Celiac Sprue Patients. Applied and Environmental Microbiology 70:2, pages 1088-1096.
Crossref
Susi Martucci, Jocelyn Sophie Fraser, Federico Biagi, Gino Roberto Corazza, Paul Jonathan Ciclitira & Heather Julia Ellis. (2003) Characterizing one of the DQ2 candidate epitopes in coeliac disease. European Journal of Gastroenterology & Hepatology 15:12, pages 1293-1298.
Crossref
Tamara Matysiak-Budnik, Celine Candalh, Christophe Dugave, Abdelkader Namane, Christophe Cellier, Nadine Cerf-Bensussan & Martine Heyman. (2003) Alterations of the intestinal transport and processing of gliadin peptides in celiac disease. Gastroenterology 125:3, pages 696-707.
Crossref
Carla Esposito, Francesco Paparo, Ivana Caputo, Raffaele Porta, Virginia M. Salvati, Giuseppe Mazzarella, Salvatore Auricchio & Riccardo Troncone. (2003) Expression and enzymatic activity of small intestinal tissue transglutaminase in celiac disease. The American Journal of Gastroenterology 98:8, pages 1813-1820.
Crossref
Tricia Thompson. (2003) Oats and the gluten-free diet. Journal of the American Dietetic Association 103:3, pages 376-379.
Crossref
Raffaella Di Cagno, Maria De Angelis, Paola Lavermicocca, Massimo De Vincenzi, Claudio Giovannini, Michele Faccia & Marco Gobbetti. (2002) Proteolysis by Sourdough Lactic Acid Bacteria: Effects on Wheat Flour Protein Fractions and Gliadin Peptides Involved in Human Cereal Intolerance. Applied and Environmental Microbiology 68:2, pages 623-633.
Crossref
M Ten Dam, Y Van DE Wal, M L Mearin, Y Kooy, S PEñA, J W Drijfhout, F Koning & M Van Tol. (1998) Anti-α-gliadin antibodies (AGA) in the serum of coeliac children and controls recognize an identical collection of linear epitopes of α-gliadin. Clinical and Experimental Immunology 114:2, pages 189-195.
Crossref
Awad A. Osman, Holm H. Uhlig, Israel Valdes, Mona Amin, Enrique Méndez & Thomas Mothes. (2001) A monoclonal antibody that recognizes a potential coeliac-toxic repetitive pentapeptide epitope in gliadins. European Journal of Gastroenterology & Hepatology 13:10, pages 1189-1193.
Crossref
Linda Feighery, Sara Lynch, Claire Kilmartin, Mohamed Abuzakouk, Donald Weir, John Jackson & Conleth Feighery. (2001) Flow-cytometric detection of lactase expression in normal and coeliac intestinal epithelium. European Journal of Gastroenterology & Hepatology 13:8, pages 897-902.
Crossref
Martin Stern, Paul J. Ciclitira, Renate van Eckert, Conleth Feighery, Frederik W. Janssen, Enrique Méndez, Thomas Mothes, Riccardo Troncone & Herbert Wieser. (2001) Analysis and clinical effects of gluten in coeliac disease. European Journal of Gastroenterology & Hepatology 13:6, pages 741-747.
Crossref
Gerburg M. Spiekermann & W. Allan Walker. (2001) Oral Tolerance and Its Role in Clinical Disease. Journal of Pediatric Gastroenterology and Nutrition 32:3, pages 237-255.
Crossref
Hannu Lähteenoja, Markku Mäki, Markku Viander, Ismo Räihä, Pekka Vilja, Immo Rantala, Auli Toivanen & Stina Syrjänen. (2000) Local Challenge on Oral Mucosa With An α-Gliadin Related Synthetic Peptide in Patients With Celiac Disease. American Journal of Gastroenterology 95:10, pages 2880-2887.
Crossref
Elza M. B. T. Silva, Maria I. M. Fernandes, Livia C. Galvão, Regina Sawamura & Eduardo A. Donadi. (2000) Human Leukocyte Antigen Class II Alleles in White Brazilian Patients With Celiac Disease. Journal of Pediatric Gastroenterology and Nutrition 31:4, pages 391-394.
Crossref
Rajesh Kumar, Angela Lumsden, Paul J Ciclitira, H.Julia Ellis & Gordon W Laurie. (2000) Human genome search in celiac disease using gliadin cDNA as probe11Edited by J. Karn. Journal of Molecular Biology 300:5, pages 1155-1167.
Crossref
C Giovannini, M Sanchez, E Straface, B Scazzocchio, M Silano & M De Vincenzi. (2000) Induction of apoptosis in Caco-2 cells by wheat gliadin peptides. Toxicology 145:1, pages 63-71.
Crossref
Robert P. Anderson, Pilar Degano, Andrew J. Godkin, Derek P. Jewell & Adrian V.S. Hill. (2000) In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope. Nature Medicine 6:3, pages 337-342.
Crossref
Gabriele Bolte, Werner Seilmeier, Herbert Wieser, Kati Holm, Karin Beuermann, Beate Newport & Martin Stern. (1999) Enhanced Peptide-Binding Capacities of Small Intestinal Brush Border Membranes in Celiac Disease. Pediatric Research 46:6, pages 666-666.
Crossref
Biagi, Ellis, Parnell, Shidrawi, Thomas, O’reilly, Corazza & Ciclitira. (2001) A non‐toxic analogue of a coeliac‐activating gliadin peptide: a basis for immunomodulation?. Alimentary Pharmacology & Therapeutics 13:7, pages 945-950.
Crossref
Marco Silano & Massimo De Vincenzi. (1999) In vitro screening of food peptides toxic for coeliac and other gluten-sensitive patients: a review. Toxicology 132:2-3, pages 99-110.
Crossref
David Branski & Riccardo Troncone. (1998) Celiac disease: A reappraisal. The Journal of Pediatrics 133:2, pages 181-187.
Crossref
Massimo De Vincenzi, Annalaura Stammati, Roberto Luchetti, Marco Silano, Giovanni Gasbarrini & Vittorio Silano. (1998) Structural specificities and significance for coeliac disease of wheat gliadin peptides able to agglutinate or to prevent agglutination of K562(S) cells. Toxicology 127:1-3, pages 97-106.
Crossref
Claudio Giovannini, Roberto Luchetti & Massimo De Vincenzi. (2020) The activities of peptides “31–43”, “44–55” and “56–68” of A-gliadin on In Vitro Cultures of CaCo-2 Cells . Alternatives to Laboratory Animals 25:4, pages 437-443.
Crossref
William E. Barbeau, Mary Ann Novascone & Klaus D. Elgert. (1997) Is celiac disease due to molecular mimicry between gliadin peptide-HLA class II molecule-T cell interactions and those of some unidentified superantigen?. Molecular Immunology 34:7, pages 535-541.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.