72
Views
70
CrossRef citations to date
0
Altmetric
Original Article

A New Pharmacologic Treatment of Functional Gastrointestinal Disorder: A Double-Blind Placebo-Controlled Study with Mianserin

&
Pages 318-325 | Received 21 Mar 1995, Accepted 24 Aug 1995, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

L. Tanum, U. F. Malt. (2000) Personality Traits Predict Treatment Outcome with an Antidepressant in Patients with Functional Gastrointestinal Disorder. Scandinavian Journal of Gastroenterology 35:9, pages 935-941.
Read now
Herdis Molinder. (1999) Dyspepsia?Acid or Stress? A Study of Controversy: Abandoned by Experts, Finalized in Clinical Practice?. Scandinavian Journal of Gastroenterology 34:11, pages 1057-1064.
Read now

Articles from other publishers (67)

Hollie Birkinshaw, Claire M Friedrich, Peter Cole, Christopher Eccleston, Marc Serfaty, Gavin Stewart, Simon White, R Andrew Moore, David Phillippo & Tamar Pincus. (2023) Antidepressants for pain management in adults with chronic pain: a network meta-analysis. Cochrane Database of Systematic Reviews 2023:5.
Crossref
Jeremy R. Glissen Brown, Ava Sanayei, Samantha Proctor, Ryan Flanagan, Sarah Ballou, Paul A. Bain & Judy Nee. (2023) Examining the Nocebo Effect in Trials of Neuromodulators for Use in Disorders of Gut-Brain Interaction. American Journal of Gastroenterology 118:4, pages 692-701.
Crossref
L Bosman, L Wauters & T Vanuytsel. (2023) Neuromodulating agents in functional dyspepsia: a comprehensive review. Acta Gastro Enterologica Belgica 86:1, pages 49-57.
Crossref
Shin Fukudo, Toshikatsu Okumura, Masahiko Inamori, Yusuke Okuyama, Motoyori Kanazawa, Takeshi Kamiya, Ken Sato, Akiko Shiotani, Yuji Naito, Yoshiko Fujikawa, Ryota Hokari, Tastuhiro Masaoka, Kazuma Fujimoto, Hiroshi Kaneko, Akira Torii, Kei Matsueda, Hiroto Miwa, Nobuyuki Enomoto, Tooru Shimosegawa & Kazuhiko Koike. (2021) Evidence-based clinical practice guidelines for irritable bowel syndrome 2020. Journal of Gastroenterology 56:3, pages 193-217.
Crossref
Andres Herane-Vives, Lorena Ortega, Rodrigo Sandoval, Allan H. Young, Anthony Cleare, Susana Espinoza, Alexander Hayes & Jan Benöhr. (2020) Measuring Earwax Cortisol Concentration using a non-stressful sampling method. Heliyon 6:11, pages e05124.
Crossref
Nana Xiong, Yanping Duan, Jing Wei, Ricarda Mewes & Rainer Leonhart. (2018) Antidepressants vs. Placebo for the Treatment of Functional Gastrointestinal Disorders in Adults: A Systematic Review and Meta-Analysis. Frontiers in Psychiatry 9.
Crossref
Christina M. van der Feltz-Cornelis, Iman Elfeddali, Ursula Werneke, Ulrik F. Malt, Omer Van den Bergh, Rainer Schaefert, Willem J. Kop, Antonio Lobo, Michael Sharpe, Wolfgang Söllner & Bernd Löwe. (2018) A European Research Agenda for Somatic Symptom Disorders, Bodily Distress Disorders, and Functional Disorders: Results of an Estimate-Talk-Estimate Delphi Expert Study. Frontiers in Psychiatry 9.
Crossref
Agnieszka Kułak-Bejda, Grzegorz Bejda & Napoleon Waszkiewicz. (2017) Antidepressants for irritable bowel syndrome—A systematic review. Pharmacological Reports 69:6, pages 1366-1379.
Crossref
Yuri A Saito, Richard G Locke, Ann E Almazar, Ernest P Bouras, Colin W Howden, Brian E Lacy, John K DiBaise, Charlene M Prather, Bincy P Abraham, Hashem B El-Serag, Paul Moayyedi, Linda M Herrick, Lawrence A Szarka, Michael Camilleri, Frank A Hamilton, Cathy D Schleck, Katherine E Tilkes, Alan R Zinsmeister & Nicholas J Talley. (2017) Polymorphisms of 5-HTT LPR and GNβ3 825C>T and Response to Antidepressant Treatment in Functional Dyspepsia: A Study from The Functional Dyspepsia Treatment Trial. American Journal of Gastroenterology 112:6, pages 903-909.
Crossref
Alexander C Ford, Pavit Luthra, Jan Tack, Guy E Boeckxstaens, Paul Moayyedi & Nicholas J Talley. (2017) Efficacy of psychotropic drugs in functional dyspepsia: systematic review and meta-analysis. Gut 66:3, pages 411-420.
Crossref
Mariko Hojo, Akihito Nagahara, Daisuke Asaoka, Yuji Shimada, Hitoshi Sasaki, Kohei Matsumoto, Tsutomu Takeda, Hiroya Ueyama, Kenshi Matsumoto & Sumio Watanabe. (2017) A Systematic Review of the Effectiveness of Antianxiety and Antidepressive Agents for Functional Dyspepsia. Internal Medicine 56:23, pages 3127-3133.
Crossref
Yaoyao Lu, Meng Chen, Zhiyin Huang & Chengwei Tang. (2016) Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis. PLOS ONE 11:6, pages e0157798.
Crossref
. 2016. Funktionelle Dyspepsie. Funktionelle Dyspepsie 109 120 .
Shin Fukudo, Hiroshi Kaneko, Hirotada Akiho, Masahiko Inamori, Yuka Endo, Toshikatsu Okumura, Motoyori Kanazawa, Takeshi Kamiya, Ken Sato, Toshimi Chiba, Kenji Furuta, Shigeru Yamato, Tetsuo Arakawa, Yoshihide Fujiyama, Takeshi Azuma, Kazuma Fujimoto, Tetsuya Mine, Soichiro Miura, Yoshikazu Kinoshita, Kentaro Sugano & Tooru Shimosegawa. (2014) Evidence-based clinical practice guidelines for irritable bowel syndrome. Journal of Gastroenterology 50:1, pages 11-30.
Crossref
Maria Kleinstäuber, Michael Witthöft, Andrés Steffanowski, Harm van Marwijk, Wolfgang Hiller & Michael J Lambert. (2014) Pharmacological interventions for somatoform disorders in adults. Cochrane Database of Systematic Reviews.
Crossref
Fei Dai, Yong Lei, Shiying Li, Gengqing Song & Jiande D. Z. Chen. (2013) Desvenlafaxine succinate ameliorates visceral hypersensitivity but delays solid gastric emptying in rats. American Journal of Physiology-Gastrointestinal and Liver Physiology 305:4, pages G333-G339.
Crossref
김지연 & ChongNak Son. (2012) The Effects of Mindfulness-based Cognitive Therapy(MBCT) on Symptoms, Worry, and Quality of Life for People with Functional Dyspepsia. Korean Journal of Health Psychology 17:1, pages 27-42.
Crossref
Lisa Ruepert, A Otto Quartero, Niek J de Wit, Geert J van der Heijden, Gregory Rubin & Jean WM Muris. (2011) Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome. Cochrane Database of Systematic Reviews 2013:3.
Crossref
P. Janssen, L. Van Oudenhove, R. Vos, K. Verbeke & J. Tack. (2011) Effect of mianserin on gastric sensorimotor function and gastric emptying: a randomized, placebo-controlled, double-blind, crossover study in healthy volunteers. Neurogastroenterology & Motility 23:5, pages 433-e174.
Crossref
T. Hattori, S. Watanabe, M. Kano, M. Kanazawa & S. Fukudo. (2010) Differential responding of autonomic function to histamine H1 antagonism in irritable bowel syndrome. Neurogastroenterology & Motility 22:12, pages 1284-e335.
Crossref
Heitham Abdul-Baki, Ihab I El Hajj, Lara ElZahabi, Cecilio Azar, Elie Aoun, Assaad Skoury, Hani Chaar & Ala I Sharara. (2009) A randomized controlled trial of imipramine in patients with irritable bowel syndrome. World Journal of Gastroenterology 15:29, pages 3636.
Crossref
r. s. choung, f. cremonini, p. thapa, a. r. zinsmeister & n. j. talley. (2008) The effect of short-term, low-dose tricyclic and tetracyclic antidepressant treatment on satiation, postnutrient load gastrointestinal symptoms and gastric emptying: a double-blind, randomized, placebo-controlled trial. Neurogastroenterology & Motility 20:3, pages 220-227.
Crossref
Bénédicte Verdu, Isabelle Decosterd, Thierry Buclin, Friedrich Stiefel & Alexandre Berney. (2008) Antidepressants for the Treatment of Chronic Pain. Drugs 68:18, pages 2611-2632.
Crossref
. 2006. Wiley Handbook of Current and Emerging Drug Therapies. Wiley Handbook of Current and Emerging Drug Therapies.
s. kindt & j. tack. (2007) Mechanisms of serotonergic agents for treatment of gastrointestinal motility and functional bowel disorders. Neurogastroenterology & Motility 19:s2, pages 32-39.
Crossref
Hidekazu Suzuki, Toshihiro Nishizawa & Toshifumi Hibi. (2006) Therapeutic strategies for functional dyspepsia and the introduction of the Rome III classification. Journal of Gastroenterology 41:6, pages 513-523.
Crossref
m. camilleri. (2006) Management of patients with chronic abdominal pain in clinical practice. Neurogastroenterology and Motility 18:7, pages 499-506.
Crossref
J. HAMMER & N. J. TALLEY. (2006) Disturbed bowel habits in patients with non-ulcer dyspepsia. Alimentary Pharmacology and Therapeutics 24:2, pages 405-410.
Crossref
T. Liebregts, B. Adam & G. Holtmann. (2006) Funktionelle Dyspepsie – eine Verlegenheitsdiagnose?Functional dyspepsia – diagnosis of desperation?. Der Internist 47:6, pages 568-577.
Crossref
v. andresen & m. camilleri. (2006) Challenges in drug development for functional gastrointestinal disorders. Part II: Visceral pain. Neurogastroenterology and Motility 18:5, pages 354-360.
Crossref
Nicholas J. Talley, Nimish B. Vakil & Paul Moayyedi. (2005) American Gastroenterological Association Technical Review on the Evaluation of Dyspepsia. Gastroenterology 129:5, pages 1756-1780.
Crossref
Mariko Hojo, Hiroto Miwa, Tetsuji Yokoyama, Toshifumi Ohkusa, Akihito Nagahara, Masato Kawabe, Daisuke Asaoka, Yuko Izumi & Nobuhiro Sato. (2005) Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review. Journal of Gastroenterology 40:11, pages 1036-1042.
Crossref
M. Bixquert-Jiménez & L. Bixquert-Pla. (2005) Tratamiento con antidepresivos en los trastornos funcionales digestivos. Gastroenterología y Hepatología 28:8, pages 485-492.
Crossref
Nicholas J. Talley & Nimish Vakil. (2005) Guidelines for the Management of Dyspepsia. The American Journal of Gastroenterology 100:10, pages 2324-2337.
Crossref
M. Lancaster Smith. (2005) Functional dyspepsia pathogenesis and therapeutic options—Implications for management. Digestive and Liver Disease 37:8, pages 547-558.
Crossref
M. Delvaux & G. Gay. (2005) Stratégie thérapeutique chez les patients atteints du syndrome de l’intestin irritableTherapeutic strategy in patients with irritable bowel syndrome. Acta Endoscopica 35:4, pages 649-661.
Crossref
Noel R. Fajardo, Filippo Cremonini & Nicholas J. Talley. (2005) Frontiers in functional dyspepsia. Current Gastroenterology Reports 7:4, pages 289-296.
Crossref
M. Otaka, M. Jin, M. Odashima, T. Matsuhashi, I. Wada, Y. Horikawa, K. Komatsu, R. Ohba, J. Oyake, N. Hatakeyama & S. Watanabe. (2005) New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline. Alimentary Pharmacology and Therapeutics 21:s2, pages 42-46.
Crossref
A Otto Quartero, Villy Meiniche-Schmidt, Jean Muris, Gregory Rubin & Niek de Wit. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Vincenzo Stanghellini, Elisabetta Poluzzi, Fabrizio De Ponti, Roberto De Giorgio, Giovanni Barbara & Roberto Corinaldesi. (2005) Idiopathic dyspepsia. Current Treatment Options in Gastroenterology 8:2, pages 175-183.
Crossref
S. D. Kuiken, G. N. Tytgat & G. E. Boeckxstaens. (2005) Review article: drugs interfering with visceral sensitivity for the treatment of functional gastrointestinal disorders - the clinical evidence. Alimentary Pharmacology and Therapeutics 21:6, pages 633-651.
Crossref
D. Lesbros-Pantoflickova, P. Michetti, M. Fried, C. Beglinger & A. L. Blum. (2004) Meta-analysis: the treatment of irritable bowel syndrome. Alimentary Pharmacology & Therapeutics 20:11-12, pages 1253-1269.
Crossref
Jan Tack, Raf Bisschops & Giovanni Sarnelli. (2004) Pathophysiology and treatment of functional dyspepsia. Gastroenterology 127:4, pages 1239-1255.
Crossref
Filippo Cremonini, Silvia Delgado-Aros & Nicholas J. Talley. (2004) Functional dyspepsia: drugs for new (and old) therapeutic targets. Best Practice & Research Clinical Gastroenterology 18:4, pages 717-733.
Crossref
B. J. P. CrulPatrick Onghena & Boudewijn Van Houdenhove. 2009. Pijn Info. Pijn Info 1008 1018 .
Robin C. Spiller. (2003) Treatment of irritable bowel syndrome. Current Treatment Options in Gastroenterology 6:4, pages 329-337.
Crossref
Ray E Clouse. (2003) Managing functional bowel disorders from the top down: lessons from a well-designed treatment trial. Gastroenterology 125:1, pages 249-253.
Crossref
William L Hasler. (2003) Pharmacotherapy for intestinal motor and sensory disorders. Gastroenterology Clinics of North America 32:2, pages 707-732.
Crossref
Magnus Simrén & Jan Tack. (2003) Functional dyspepsia: evaluation and treatment. Gastroenterology Clinics of North America 32:2, pages 577-599.
Crossref
Nicolas J. Talley. (2003) SSRIs in IBS: Sensing a dash of disappointment. Clinical Gastroenterology and Hepatology 1:3, pages 155-159.
Crossref
T. O. C. Kilkens, A. Honig, N. Rozendaal, M. A. Van Nieuwenhoven & R.-J. M. Brummer. (2003) Serotonergic modulators in the treatment of irritable bowel syndrome - influence on psychiatric and gastrointestinal symptoms. Alimentary Pharmacology & Therapeutics 17:1, pages 43-51.
Crossref
Richard B Birrer. (2002) Irritable bowel syndrome. Disease-a-Month 48:2, pages 101-143.
Crossref
G. Laux, J. Fritze, W. König, O. Dietmaier & F. König. 2002. Neuro-Psychopharmaka Ein Therapie-Handbuch. Neuro-Psychopharmaka Ein Therapie-Handbuch 103 221 .
Jan Tack, Raf Bisschops & Brunello DeMarchi. (2001) Causes and treatment of functional dyspepsia. Current Gastroenterology Reports 3:6, pages 503-508.
Crossref
Peter Holzer. (2001) Gastrointestinal afferents as targets of novel drugs for the treatment of functional bowel disorders and visceral pain. European Journal of Pharmacology 429:1-3, pages 177-193.
Crossref
Luiz Ernesto de Almeida TRONCON. (2001) Novas drogas no tratamento da dispepsia funcional. Arquivos de Gastroenterologia 38:3, pages 207-212.
Crossref
Lars Tanum & Ulrik Fredrik Malt. (2001) Personality and physical symptoms in nonpsychiatric patients with functional gastrointestinal disorder. Journal of Psychosomatic Research 50:3, pages 139-146.
Crossref
Maxwell A. Asante. (2001) Optimal Management of Patients With Non-Ulcer Dyspepsia. Drugs & Aging 18:11, pages 819-826.
Crossref
Pan Xiaoping, Li Yuyuan, Sha Weihong & Yang Fuying. (2008) Psychological factors in functional dyspepsia and its treatment. Chinese Journal of Digestive Diseases 1:1, pages 17-20.
Crossref
John E. Pandolfino, Colin W. Howden & Peter J. Kahrilas. (2000) Motility-modifying agents and management of disorders of gastrointestinal motility. Gastroenterology 118:2, pages S32-S47.
Crossref
Jeffrey L Jackson, Patrick G O’Malley, Glen Tomkins, Erin Balden, James Santoro & Kurt Kroenke. (2000) Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis11The opinions in this article represent those of the authors and are not to be construed, in any way, to represent those of the U.S. Army or the Department of Defense.. The American Journal of Medicine 108:1, pages 65-72.
Crossref
Lars Tanum, Kari Bråtveit-Johansen & Ulrik F. Malt. (1999) Fenfluramine challenge test predicts outcome in pharmacological treatment of patients with functional gastrointestinal disorder. Journal of Psychosomatic Research 47:6, pages 525-535.
Crossref
R.Bruce Lydiard & Sherry A Falsetti. (1999) Experience with anxiety and depression treatment studies: implications for designing irritable bowel syndrome clinical trials. The American Journal of Medicine 107:5, pages 65-73.
Crossref
Nicholas J Talley. (1999) Non-ulcer dyspepsia. Current Treatment Options in Gastroenterology 2:4, pages 307-312.
Crossref
Jack D. BurkeJr.Jr., Kimberly C. Burke & Glen Couchman. 1999. Somatoform Disorders. Somatoform Disorders 222 228 .
Fabrizio De Ponti & Juan-Ramon Malagelada. (1998) Functional Gut Disorders. Pharmacology & Therapeutics 80:1, pages 49-88.
Crossref
Patrick Onghena & Boudewijn Van Houdenhove. (1998) 2c The antidepressant-induced analgesic effect. Baillière's Clinical Anaesthesiology 12:1, pages 53-68.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.