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Scandinavian Journal of Gastroenterology Volume 31, 1996 - Issue 11
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Original Article

Disturbed Motilin and Cholecystokinin Release in the Irritable Bowel Syndrome

K. Sjölund Dept. of Internal Medicine, University Hospital of Lund, Lund, Sweden; Dept. of Internal Medicine, University of Lund, General Hospital, Malmö, Sweden; Division of Neurochemistry, Department of Psychiatry and Clinical Chemistry, University of Gothenburg, Mölndal, Sweden; Dept. of Clinical Big Chemistry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
,
R. Ekman Dept. of Internal Medicine, University Hospital of Lund, Lund, Sweden; Dept. of Internal Medicine, University of Lund, General Hospital, Malmö, Sweden; Division of Neurochemistry, Department of Psychiatry and Clinical Chemistry, University of Gothenburg, Mölndal, Sweden; Dept. of Clinical Big Chemistry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
,
S. Lindgren Dept. of Internal Medicine, University Hospital of Lund, Lund, Sweden; Dept. of Internal Medicine, University of Lund, General Hospital, Malmö, Sweden; Division of Neurochemistry, Department of Psychiatry and Clinical Chemistry, University of Gothenburg, Mölndal, Sweden; Dept. of Clinical Big Chemistry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
&
J. F. Rehfeld Dept. of Internal Medicine, University Hospital of Lund, Lund, Sweden; Dept. of Internal Medicine, University of Lund, General Hospital, Malmö, Sweden; Division of Neurochemistry, Department of Psychiatry and Clinical Chemistry, University of Gothenburg, Mölndal, Sweden; Dept. of Clinical Big Chemistry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
Pages 1110-1114 | Received 04 Mar 1996, Accepted 03 Jun 1996, Published online: 08 Jul 2009

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Samin Alihosseini, Farzaneh Khodaei, Mehran Jaberinezhad, Mojtaba Azari, Maghsoud Ezzati Khatab, Hedieh Akhlaghi, Nima Ghanini, Mohammad Kazem Tarzamni & Elham Eghbali. (2023) Evaluation of gallbladder contractility and Doppler findings in patients with irritable bowel syndrome; a case-control study. Scandinavian Journal of Gastroenterology 0:0, pages 1-8.
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Salman Nusrat & Philip B. Miner$suffix/text()$suffix/text(). (2015) New pharmacological treatment options for irritable bowel syndrome with constipation. Expert Opinion on Emerging Drugs 20:4, pages 625-636.
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Sanjoy Banerjee & Yvette Colón. (2010) Irritable Bowel Syndrome. Journal of Pain & Palliative Care Pharmacotherapy 24:3, pages 271-274.
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Rickard Ekesbo, Peter M. Nilsson & Kristina Sjölund. (2008) Effects of anti-secretory factor (ASF) on irritable bowel syndrome (IBS). Scandinavian Journal of Primary Health Care 26:2, pages 106-110.
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Patrick P. J. Van Der Veek, Izäk Biemond & Ad A. M. Masclee. (2006) Proximal and distal gut hormone secretion in irritable bowel syndrome. Scandinavian Journal of Gastroenterology 41:2, pages 170-177.
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Ashkan Farhadi, Keith Bruninga, Jeremy Fields & Ali Keshavarzian. (2001) Irritable bowel syndrome: an update on therapeutic modalities. Expert Opinion on Investigational Drugs 10:7, pages 1211-1222.
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M. Peracchi, G. Basilisco, R. Tagliabue, C. Terrani, A. Locati, P. A. Bianchi, P. Velio. (1999) Postprandial Gut Peptide Plasma Levels in Women with Idiopathic Slow-Transit Constipation. Scandinavian Journal of Gastroenterology 34:1, pages 25-28.
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Massimo D'Amato & Lucio C Rovati. (1997) Cholecystokinin-A receptor antagonists: therapies for gastrointestinal disorders. Expert Opinion on Investigational Drugs 6:7, pages 819-836.
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Sakine Atila Karaca, Tuncer Temel & Duygu Yeniceli Uğur. (2023) Development of a sensitive HPLC method with fluorescence detection for the determination of motilin in human plasma. Bioanalysis 15:4, pages 219-229.
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Ravi Philip Rajkumar. (2021) Gut Hormones as Potential Therapeutic Targets or Biomarkers of Response in Depression: The Case of Motilin. Life 11:9, pages 892.
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Mohamed Farid, Sameh Hany Emile, Magdy Haleem & Nabil Gad El-Hak. (2018) A pilot study on disturbed gastric myoelectric activity in obstructed defecation syndrome. Journal of Surgical Research 227, pages 95-100.
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Yeon-Ji Kim, Woo Chul Chung, Byung Wook Kim, Sung Soo Kim, Jin Il Kim, Na Jin Kim, Jinho Yoo & Soo Hwan Kim. (2017) Is Helicobacter pylori Associated Functional Dyspepsia Correlated With Dysbiosis? . Journal of Neurogastroenterology and Motility 23:4, pages 504-516.
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Marie C. M. Halliez & André G. Buret. (2015) Gastrointestinal Parasites and the Neural Control of Gut Functions. Frontiers in Cellular Neuroscience 9.
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E. M. Wang, W. T. Li, X. J. Yan, X. Chen, Q. Liu, C. C. Feng, Z. J. Cao, J. Y. Fang & S. L. Chen. (2015) Vagal afferent‐dependent cholecystokinin modulation of visceral pain requires central amygdala NMDA ‐ NR 2B receptors in rats . Neurogastroenterology & Motility 27:9, pages 1333-1343.
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Ulrich Cuntz, Paul Enck, Erich Frühauf, Peter Lehnert, Rudolf L. Riepl, Manfred M. Fichter & Bärbel Otto. (2013) Cholecystokinin Revisited: CCK and the Hunger Trap in Anorexia Nervosa. PLoS ONE 8:1, pages e54457.
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P. J. van der Schaar, E. van Hoboken, S Ludidi & A. A. M. Masclee. (2012) Effect of cholecystokinin on rectal motor and sensory function in patients with irritable bowel syndrome and healthy controls. Colorectal Disease 15:1.
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Marcel Mazur, Agata Furgała, Konrad Jabłoński, Tomasz Mach & Piotr Thor. (2012) Autonomic nervous system activity in constipation-predominant irritable bowel syndrome patients. Medical Science Monitor 18:8, pages CR493-CR499.
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Konstantinos Kalafatakis & Konstantinos Triantafyllou. (2011) Contribution of neurotensin in the immune and neuroendocrine modulation of normal and abnormal enteric function. Regulatory Peptides 170:1-3, pages 7-17.
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Kristina Sjölund, Rolf Ekman & Nils Wierup. (2010) Covariation of plasma ghrelin and motilin in irritable bowel syndrome. Peptides 31:6, pages 1109-1112.
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V. DIZDAR, R. SPILLER, G. SINGH, K. HANEVIK, O. H. GILJA, M. EL‐SALHY & T. HAUSKEN. (2010) Relative importance of abnormalities of CCK and 5‐HT (serotonin) in Giardia ‐induced post‐infectious irritable bowel syndrome and functional dyspepsia . Alimentary Pharmacology & Therapeutics 31:8, pages 883-891.
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Erin E Cawston & Laurence J Miller. (2010) Therapeutic potential for novel drugs targeting the type 1 cholecystokinin receptor. British Journal of Pharmacology 159:5, pages 1009-1021.
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Ashraf MORCOS, Ted DINAN & Eamonn MM QUIGLEY. (2009) Irritable bowel syndrome: Role of food in pathogenesis and management. Journal of Digestive Diseases 10:4, pages 237-246.
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Hillevi Pendleton, Rolf Ekman, Rolf Olsson, Olle Ekberg & Bodil Ohlsson. (2009) Motilin concentrations in relation to gastro intestinal dysmotility in diabetes mellitus. European Journal of Internal Medicine 20:6, pages 654-659.
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M Fornai, R Colucci, L Antonioli, F Crema, P Buccianti, M Chiarugi, F Baschiera, N Ghisu, M Tuccori, C Blandizzi & M Del Tacca. (2007) Cholecystokinin CCK 2 receptors mediate the peptide's inhibitory actions on the contractile activity of human distal colon via the nitric oxide pathway . British Journal of Pharmacology 151:8, pages 1246-1253.
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Eric Marsault, Hamid R. Hoveyda, Mark L. Peterson, Carl Saint-Louis, Annick Landry, Martin Vézina, Luc Ouellet, Zhigang Wang, Mahesh Ramaseshan, Sylvie Beaubien, Kamel Benakli, Sophie Beauchemin, Robert Déziel, Theo Peeters & Graeme L. Fraser. (2006) Discovery of a New Class of Macrocyclic Antagonists to the Human Motilin Receptor. Journal of Medicinal Chemistry 49:24, pages 7190-7197.
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Marlène Dufresne, Catherine Seva & Daniel Fourmy. (2006) Cholecystokinin and Gastrin Receptors. Physiological Reviews 86:3, pages 805-847.
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Lawrence R. Schiller. (2006) Nutrition Management of Chronic Diarrhea and Malabsorption. Nutrition in Clinical Practice 21:1, pages 34-39.
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Kristina Sj??lund, Izabella Bartosik, Greger Lindberg, Agneta Scheja, Marie Wildt & Anita ??kesson. (2005) Small intestinal manometry in patients with systemic sclerosis. European Journal of Gastroenterology & Hepatology 17:11, pages 1205-1212.
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Albena Halpert & Douglas Drossman. (2005) Biopsychosocial Issues in Irritable Bowel Syndrome. Journal of Clinical Gastroenterology 39:8, pages 665-669.
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M. Simren, E. S. Bjornsson & H. Abrahamsson. (2005) High interdigestive and postprandial motilin levels in patients with the irritable bowel syndrome. Neurogastroenterology and Motility 17:1, pages 51-57.
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Kathy AbascalEric Yarnell. (2005) Combining Herbs in a Formula for Irritable Bowel Syndrome. Alternative and Complementary Therapies 11:1, pages 17-23.
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D. Lesbros-Pantoflickova, P. Michetti, M. Fried, C. Beglinger & A. L. Blum. (2004) Meta-analysis: the treatment of irritable bowel syndrome. Alimentary Pharmacology & Therapeutics 20:11-12, pages 1253-1269.
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Gábor Varga, András Bálint, Beáta Burghardt & Massimo D'Amato. (2004) Involvement of endogenous CCK and CCK 1 receptors in colonic motor function . British Journal of Pharmacology 141:8, pages 1275-1284.
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I. M. C. Kamerling, J. Burggraaf, A. D. Van Haarst, M. F. Oppenhuizen-Duinker, H. C. Schoemaker, I. Biemond, R. Jones, H. Heinzerling, A. F. Cohen & A. A. M. Masclee. (2003) The effect of motilin on the rectum in healthy volunteers. British Journal of Clinical Pharmacology 55:6, pages 538-543.
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Adriane I Budavari & Kevin W Olden. (2003) Psychosocial aspects of functional gastrointestinal disorders. Gastroenterology Clinics of North America 32:2, pages 477-506.
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Piero Portincasa. (2003) Pan-enteric dysmotility, impaired quality of life and alexithymia in a large group of patients meeting ROME II criteria for irritable bowel syndrome . World Journal of Gastroenterology 9:10, pages 2293.
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Magnus Simrén, Per-Ove Stotzer, Henrik Sjövall, Hasse Abrahamsson & Einar S Björnsson. (2003) Abnormal levels of neuropeptide Y and peptide YY in the colon in irritable bowel syndrome. European Journal of Gastroenterology & Hepatology 15:1, pages 55-62.
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J-M. Sabate, C. Gorbatchef, B. Flourie, R. Jian & B. Coffin. (2002) Cholecystokinin octapeptide increases rectal sensitivity to pain in healthy subjects. Neurogastroenterology and Motility 14:6, pages 689-695.
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Robert T. Jensen. (2003) Involvement of Cholecystokinin/Gastrin‐Related Peptides and their Receptors in Clinical Gastrointestinal Disorders. Pharmacology & Toxicology 91:6, pages 333-350.
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Richard B Birrer. (2002) Irritable bowel syndrome. Disease-a-Month 48:2, pages 101-143.
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I. M. C. Kamerling, A. D. Van Haarst, J. Burggraaf, H. C. Schoemaker, I. Biemond, R. Jones, A. F. Cohen & A. A. M. Masclee. (2002) Dose‐related effects of motilin on proximal gastrointestinal motility. Alimentary Pharmacology & Therapeutics 16:1, pages 129-135.
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Bo H. Jonsson & Per M. Hellström. (2000) Motilin-and neuropeptide Y-like immunoreactivity in a psychophysiological stress experiment on patients with functional dyspepsia. Integrative Physiological and Behavioral Science 35:4, pages 256-265.
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Massimo D’Amato, Francesco Makovec & Lucio C. Rovati. 2000. Drug Development. Drug Development 147 176 .
Allan D. Shaw, Jillian L. Brooks, John W.T. Dickerson & G. Jill Davies. (2007) Dietary triggers in irritable bowel syndrome. Nutrition Research Reviews 11:2, pages 279-309.
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