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Original Article

Evaluation of the Lactulose/Mannitol and 51Cr-Ethylenediaminetetraacetic Acid/14C-Mannitol Methods for Intestinal Permeability: Influence of Urinary Volume, Sex, Age, Smoking, and Intestinal Disease on Marker Excretion

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Pages 805-812 | Received 01 Nov 1996, Accepted 18 Apr 1997, Published online: 08 Jul 2009

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Fernando Navarro, Deborah A Pearson, Nicole Fatheree, Rosleen Mansour, S Shahrukh Hashmi & J Marc Rhoads. (2015) Are ‘leaky gut’ and behavior associated with gluten and dairy containing diet in children with autism spectrum disorders?. Nutritional Neuroscience 18:4, pages 177-185.
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Thomas W Leonard, John Lynch, Michael J McKenna & David J Brayden. (2006) Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET™. Expert Opinion on Drug Delivery 3:5, pages 685-692.
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L. Halme, U. Turunen, J. Tuominen, T. Forsström, U. Turpeinen. (2000) Comparison of iohexol and lactulose-mannitol tests as markers of disease activity in patients with inflammatory bowel disease. Scandinavian Journal of Clinical and Laboratory Investigation 60:8, pages 695-701.
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Articles from other publishers (15)

Elena Monfort Sánchez, James Avery, Jonathan Gan, Jingjing Qian, Mulima Mwiinga, Rosemary Banda, Jonathan Hoare, Hutan Ashranfian, Ara Darzi, Paul Kelly & Alex J. Thompson. (2023) A compact fluorescence sensor for low-cost non-invasive monitoring of gut permeability in undernutrition. A compact fluorescence sensor for low-cost non-invasive monitoring of gut permeability in undernutrition.
Jonathan Gan, Scarlet Nazarian, Julian Teare, Ara Darzi, Hutan Ashrafian & Alex J. Thompson. (2022) A case for improved assessment of gut permeability: a meta-analysis quantifying the lactulose:mannitol ratio in coeliac and Crohn’s disease. BMC Gastroenterology 22:1.
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Nikita Hanning, Adam L. Edwinson, Hannah Ceuleers, Stephanie A. Peters, Joris G. De Man, Leslie C. Hassett, Benedicte Y. De Winter & Madhusudan Grover. (2021) Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review. Therapeutic Advances in Gastroenterology 14, pages 175628482199358.
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Margaret N. Kosek, Gwenyth O. Lee, Richard L. Guerrant, Rashidul Haque, Gagandeep Kang, Tahmeed Ahmed, Pascal Bessong, Asad Ali, Estomih Mduma, Pablo Peñataro Yori, William A. Faubion, Aldo A.M. Lima, Maribel Paredes Olortegui, Carl Mason, Sudhir Babji, Ravinder Singh, Shahida Qureshi, Peter S. Kosek, Amidou Samie, John Pascal, Sanjaya Shrestha, Benjamin J.J. McCormick, Jessica C. Seidman, Dennis R. Lang, Anita Zaidi, Laura E. Caulfield & Michael Gottlieb. (2017) Age and Sex Normalization of Intestinal Permeability Measures for the Improved Assessment of Enteropathy in Infancy and Early Childhood: Results From the MAL-ED Study. Journal of Pediatric Gastroenterology & Nutrition 65:1, pages 31-39.
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Matthias Prager, Janine Büttner, Philip Grunert, David Ellinghaus & Carsten Büning. (2016) A Promoter Variant Within the Aryl Hydrocarbon Receptor Gene Is Associated with an Epithelial Barrier Defect in Smokers with Crohnʼs Disease. Inflammatory Bowel Diseases 22:10, pages 2356-2368.
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R. G. Lentle, I. R. Sequeira, A. K. Hardacre & G. Reynolds. (2016) A method for assessing real time rates of dissolution and absorption of carbohydrate and other food matrices in human subjects. Food & Function 7:6, pages 2820-2832.
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Klaus Michel & Sotirios G Zarogiannis. (2014) Clinical tests for intestinal permeability: ‘Sweet’ transition from clinical to basic physiology. Clinical and Experimental Pharmacology and Physiology 41:2, pages 105-106.
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Ivana R Sequeira, Roger G Lentle, Marlena C Kruger & Roger D Hurst. (2014) Differential trafficking of saccharidic probes following aspirin in clinical tests of intestinal permeability in young healthy women. Clinical and Experimental Pharmacology and Physiology 41:2, pages 107-117.
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James Claude Warrington & Martin Charron. (2007) Pediatric Gastrointestinal Nuclear Medicine. Seminars in Nuclear Medicine 37:4, pages 269-285.
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Jordan J. Feld, Jonathan Meddings & E. Jenny Heathcote. (2006) Abnormal Intestinal Permeability in Primary Biliary Cirrhosis. Digestive Diseases and Sciences 51:9, pages 1607-1613.
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P Monteleone, R Carratù, M Cartenì, M Generoso, M Lamberti, L De Magistris, F Brambilla, B Colurcio, M Secondulfo & M Maj. (2003) Intestinal permeability is decreased in anorexia nervosa. Molecular Psychiatry 9:1, pages 76-80.
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Xiao-Hua Jiang. (2003) Intestinal permeability in patients after surgical trauma and effect of enteral nutrition versus parenteral nutrition. World Journal of Gastroenterology 9:8, pages 1878.
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N.P. Breslin, C. Nash, R.J. Hilsden, N.B. Hershfield, L.M. Price, J.B. Meddings & L.R. Sutherland. (2001) Intestinal permeability is increased in a proportion of spouses of patients with Crohn's disease. The American Journal of Gastroenterology 96:10, pages 2934-2938.
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S. Pascual, J. Martínez & M. Pérez-Mateo. (2001) La barrera intestinal: trastornos funcionales en enfermedades digestivas y extradigestivas. Gastroenterología y Hepatología 24:5, pages 256-267.
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Suenaert, Bulteel, Den Hond, Hiele, Peeters, Monsuur, Ghoos & Rutgeerts. (2001) The effects of smoking and indomethacin on small intestinal permeability. Alimentary Pharmacology & Therapeutics 14:6, pages 819-822.
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