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Original Article

Expression of Epidermal Growth Factor and Transforming Growth Factor Alpha during Ulcer Healing: Time Sequence Study

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Pages 6-15 | Received 02 Mar 1996, Accepted 03 Sep 1996, Published online: 08 Jul 2009

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Read on this site (6)

Tomasz Brzozowski, Malgorzata Zwolinska-Wcislo, Peter C. Konturek, Slawomir Kwiecien, Danuta Drozdowicz, Stanislaw J. Konturek, Jerzy Stachura, Alicja Budak, Józef Bogdal, Wieslaw W. Pawlik & Eckhart G. Hahn. (2005) Influence of gastric colonization with Candida albicans on ulcer healing in rats: Effect of ranitidine, aspirin and probiotic therapy. Scandinavian Journal of Gastroenterology 40:3, pages 286-296.
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U. Schiemann, J. W. Konturek, M. Osterhoff, R. Assert, K. Rembiasz, D. Pfeiffer, H. Schatz, W. Domschke, A. Pfeiffer. (2001) Decreased Expression of Epidermal Growth Factor Receptor and mRNA of Its Ligands in Helicobacter pylori-infected Gastric Mucosa. Scandinavian Journal of Gastroenterology 36:1, pages 23-31.
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S. Coerper, S. Wolf, S. Von Kiparski, S. Thomas, T. T. Zittel, M. B. Ranke, T. K. Hunt, H. D. Becker. (2001) Insulin-Like Growth Factor I Accelerates Gastric Ulcer Healing by Stimulating Cell Proliferation and by Inhibiting Gastric Acid Secretion. Scandinavian Journal of Gastroenterology 36:9, pages 921-927.
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Khadija Hormi, Guillaume Cadiot, Stéphanie Kermorgant, Valérie Dessirier, Muriel Le Romancer, Miguel J. M. Lewin, Michel Mignon & Thérése Lehy. (2000) Transforming Growth Factor-α and Epidermal Growth Factor Receptor in Colonic Mucosa in Active and Inactive Inflammatory Bowel Disease. Growth Factors 18:2, pages 79-91.
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P. CH. KONTUREK, A. BOBRZYNSKI, S. J. KONTUREK, W. BIELANSKI, G. FALLER, T. KIRCHNER, E. G. HAHN. (1998) Epidermal Growth Factor and Transforming Growth Factor Alpha in Duodenal Ulcer and Non-Ulcer Dyspepsia Patients before and after Helicobacter pylori Eradication. Scandinavian Journal of Gastroenterology 33:2, pages 143-151.
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S. Coerper, E. Sigloch, D. Cox, M. Starlinger, G. Köveker & H.D. Becker. (1997) Recombinant Human Transforming Growth Factor Beta 3 Accelerates Gastric Ulcer Healing in Rats. Scandinavian Journal of Gastroenterology 32:10, pages 985-990.
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Katarzyna Magierowska, Dominik Bakalarz, Dagmara Wójcik, Anna Chmura, Magdalena Hubalewska-Mazgaj, Sabina Licholai, Edyta Korbut, Slawomir Kwiecien, Zbigniew Sliwowski, Grzegorz Ginter, Tomasz Brzozowski & Marcin Magierowski. (2019) Time-dependent course of gastric ulcer healing and molecular markers profile modulated by increased gastric mucosal content of carbon monoxide released from its pharmacological donor. Biochemical Pharmacology 163, pages 71-83.
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Nana Liu, Shuo Guan, Hongyan Wang, Chen Li, Jyawei Cheng, Huiyuan Yu, Li Lin & Yaping Pan. (2018) The Antimicrobial Peptide Nal-P-113 Exerts a Reparative Effect by Promoting Cell Proliferation, Migration, and Cell Cycle Progression. BioMed Research International 2018, pages 1-10.
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Mohan Kumar, Manish Kumar Gautam, Amit Singh & Raj Kumar Goel. (2013) Healing effects of Musa sapientum var. paradisiaca in diabetic rats with co-occurring gastric ulcer: cytokines and growth factor by PCR amplification. BMC Complementary and Alternative Medicine 13:1.
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Sue Park, Kathryn B. Brown, Phyllis R. Bishop, Hua Liu, Zhi He, Charu Subramony & Michael J. Nowicki. (2013) Ménétrier Disease in Childhood. Clinical Pediatrics 52:11, pages 1059-1064.
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Olena V Bogdanova. (2010) Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes. World Journal of Biological Chemistry 1:11, pages 338.
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Yan Peng, Shou-xiang Yi, Xiao-rong Chang, Na Peng, Jie Yan & Ya-ping Lin. (2007) Effect and mechanism of moxibustion on acupoints Zusanli (ST 36) and Liangmen (ST 21) in the prevention and treatment of stress ulcer. Journal of Acupuncture and Tuina Science 5:1, pages 14-20.
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Tomasz Brzozowski, Peter C. Konturek, Krystyna Zwirska-Korczala, Stanislaw J. Konturek, Iwona Brzozowska, Danuta Drozdowicz, Zbigniew Sliwowski, Michal Pawlik, Wieslaw W. Pawlik & Eckhart G. Hahn. (2005) Importance of the pineal gland, endogenous prostaglandins and sensory nerves in the gastroprotective actions of central and peripheral melatonin against stress-induced damage. Journal of Pineal Research 39:4, pages 375-385.
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W. Grellner, S. Vieler & B. Madea. (2005) Transforming growth factors (TGF-α and TGF-β1) in the determination of vitality and wound age: immunohistochemical study on human skin wounds. Forensic Science International 153:2-3, pages 174-180.
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G.E Samonina, G.N Kopylova, G.V Lukjanzeva, S.E Zhuykova, E.A Smirnova, S.V German & A.A Guseva. (2004) Antiulcer effects of amylin: a review. Pathophysiology 11:1, pages 1-6.
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Hideaki Kazumori, Shunji Ishihara, Mohammad A. K. Rumi, Cesar F. Ortega-Cava, Yasunori Kadowaki & Yoshikazu Kinoshita. (2004) Transforming growth factor-α directly augments histidine decarboxylase and vesicular monoamine transporter 2 production in rat enterochromaffin-like cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 286:3, pages G508-G514.
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Igor A. Harsch, Tomasz Brzozowski, Karolina Bazela, Stanislaw J. Konturek, Vitaly Kukharsky, Teres Pawlik, Edward Pawlowski, Eckhart G. Hahn & Peter C. Konturek. (2003) Impaired gastric ulcer healing in diabetic rats: role of heat shock protein, growth factors, prostaglandins and proinflammatory cytokines. European Journal of Pharmacology 481:2-3, pages 249-260.
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Tomasz Brzozowski, Peter C. Konturek, Zbigniew Sliwowski, Stanislaw Konturek, Wladyslaw Bielanski, Robert Pajdo, Danuta Drozdowicz & Eckhart Hahn. (2002) Helicobacter pylori attenuates the delay in ulcer healing induced by aspirin and selective COX-2 inhibitor. InflammoPharmacology 10:4-6, pages 423-433.
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Peter C Konturek, Tomasz Brzozowski, Slawomir Kwiecień, Danuta Drozdowicz, Igor A Harsch, Holger Meixner, Jerzy Stachura, Eckhart G Hahn & Stanislaw J Konturek. (2002) Effect of Helicobacter pylori on delay in ulcer healing induced by aspirin in rats. European Journal of Pharmacology 451:2, pages 191-202.
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Teresa Pawlik, Peter C Konturek, Jan W Konturek, Stanislaw J Konturek, Tomasz Brzozowski, Marta Cześnikiewicz, Malgorzata Plonka, Władysław Bielanski & Hany Areny. (2002) Impact of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on gastric ulcerogenesis in experimental animals and in humans. European Journal of Pharmacology 449:1-2, pages 1-15.
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H. Kazumori, S. Ishihara, R. Fukuda & Y. Kinoshita. (2002) Time-course changes of ECL cell markers in acetic acid-induced gastric ulcers in rats. Alimentary Pharmacology & Therapeutics 16, pages 10-19.
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Iwona Brzozowska, Peter C. Konturek, Tomasz Brzozowski, Stanislaw J. Konturek, Slawomir Kwiecien, Robert Pajdo, Danuta Drozdowicz, Michal Pawlik, Agata Ptak & Eckhart G. Hahn. (2002) Role of prostaglandins, nitric oxide, sensory nerves and gastrin in acceleration of ulcer healing by melatonin and its precursor, L-tryptophan. Journal of Pineal Research 32:3, pages 149-162.
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Lu Xia. (2002) Effects of epidermal growth factor on the growth of human gastric cancer cell and the implanted tumor of nude mice. World Journal of Gastroenterology 8:3, pages 455.
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Stefano Milani & Antonio Calabrò. (2001) Role of growth factors and their receptors in gastric ulcer healing. Microscopy Research and Technique 53:5, pages 360-371.
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Tomasz Brzozowski, Peter C. Konturek, Stanislaw J. Konturek, Zbigniew Sliwowski, Robert Pajdo, Danuta Drozdowicz, Agata Ptak & Eckhart G. Hahn. (2001) Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers. Microscopy Research and Technique 53:5, pages 343-353.
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H.V SIMPSON. (2000) Pathophysiology of Abomasal Parasitism: Is the Host or Parasite Responsible?. The Veterinary Journal 160:3, pages 177-191.
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Susan N. ElliottJ. L. WallaceW. McKnightD. G. Gall, J. A. Hardin, M. Olson & A. Buret. (2000) Bacterial colonization and healing of gastric ulcers: the effects of epidermal growth factor. American Journal of Physiology-Gastrointestinal and Liver Physiology 278:1, pages G105-G112.
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Antonio Guglietta & Marija Veljača. 2000. Drug Development. Drug Development 89 112 .
H. Sawaoka, S. Tsuji, E.S. Gunawan, N. Kawai, Y. Sasaki, M. Hori & S. Kawano. (1999) Involvement of cyclooxygenase-2 in proliferation and morphogenesis induced by transforming growth factor α in gastric epithelial cells. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) 61:5, pages 315-322.
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Tomasz Brzozowski, Peter Ch. Konturek, Stanislaw J. Konturek, Robert Pajdo, Danuta Drozdowicz, Slawomir Kwiecień & Eckhart G. Hahn. (1999) Acceleration of ulcer healing by cholecystokinin (CCK): role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves. Regulatory Peptides 82:1-3, pages 19-33.
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Paul L. Beck & Daniel K. Podolsky. (1999) Growth Factors in Inflammatory Bowel Disease. Inflammatory Bowel Diseases 5:1, pages 44-60.
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Susan N. Elliott, André Buret, Webb McKnight, Mark J. S. Miller & John L. Wallace. (1998) Bacteria rapidly colonize and modulate healing of gastric ulcers in rats. American Journal of Physiology-Gastrointestinal and Liver Physiology 275:3, pages G425-G432.
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Konturek, Brzozowski, Pierzchalski, Kwiecien, Pajdo, Hahn & Konturek. (1998) Activation of genes for spasmolytic peptide, transforming growth factor alpha and for cyclooxygenase (COX)-1 and COX-2 during gastric adaptation to aspirin damage in rats. Alimentary Pharmacology & Therapeutics 12:8, pages 767-777.
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