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Original Article

Glucagon-Like Peptide-1 7-36 Amide and Peptide YY Have Additive Inhibitory Effect on Gastric Acid Secretion in Man

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Pages 552-555 | Received 28 Aug 1996, Accepted 13 Feb 1997, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Anne-Barbara Witte, Per Grybäck, Hans Jacobsson, Erik Näslund, Per Martin Hellström, Jens Juul Holst, Linda Hilsted & Peter Thelin Schmidt. (2011) Involvement of endogenous glucagon-like peptide-1 in regulation of gastric motility and pancreatic endocrine secretion. Scandinavian Journal of Gastroenterology 46:4, pages 428-435.
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E. Näslund, J. Bogefors, P. Grybäck, P. Bjellerup, H. Jacobsson, J. J. Holst, P. M. Hellström. (2001) GLP-1 Inhibits Gastric Emptying of Water but Does Not Influence Plasma Vasopressin, Sodium, or Osmolality. Scandinavian Journal of Gastroenterology 36:2, pages 156-162.
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F. Hoentjen, W. P. M. Hopman, M. I. M. Maas, J. B. M. J. Jansen. (2000) Role of Circulating Peptide YY in the Inhibition of Gastric Acid Secretion by Dietary Fat in Humans. Scandinavian Journal of Gastroenterology 35:2, pages 166-171.
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Articles from other publishers (46)

Mark M. Smits & Jens J. Holst. (2023) Endogenous glucagon‐like peptide (GLP)‐1 as alternative for GLP‐1 receptor agonists: Could this work and how?. Diabetes/Metabolism Research and Reviews 39:8.
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鑫 李. (2022) Advances in Biological and Clinical Research of GLP-1 Receptor Agonists. Advances in Clinical Medicine 12:04, pages 2979-2988.
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Amy C. Engevik, Izumi Kaji & James R. Goldenring. (2020) The Physiology of the Gastric Parietal Cell. Physiological Reviews 100:2, pages 573-602.
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Jens J. Holst, Nicolai J. Wewer Albrechtsen, Mette M. Rosenkilde & Carolyn F. Deacon. 2011. Comprehensive Physiology. Comprehensive Physiology 1339 1381 .
Alessandra Rotondo, Imke Masuy, Wout Verbeure, Jessica R. Biesiekierski, Eveline Deloose & Jan Tack. (2019) Randomised clinical trial: the DPP-4 inhibitor, vildagliptin, inhibits gastric accommodation and increases glucagon-like peptide-1 plasma levels in healthy volunteers. Alimentary Pharmacology & Therapeutics 49:8, pages 997-1004.
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Mark Hvistendahl, Christopher Filtenborg Brandt, Siri Tribler, Rahim Mohammad Naimi, Bolette Hartmann, Jens Juul Holst, Jens Frederik Rehfeld, Mads Hornum, Jens Rikardt Andersen, Birthe Merete Henriksen, Per Brøbech Mortensen & Palle Bekker Jeppesen. (2017) Effect of Liraglutide Treatment on Jejunostomy Output in Patients With Short Bowel Syndrome: An Open‐Label Pilot Study. Journal of Parenteral and Enteral Nutrition 42:1, pages 112-121.
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Daniela Guarino, Monica Nannipieri, Giorgio Iervasi, Stefano Taddei & Rosa Maria Bruno. (2017) The Role of the Autonomic Nervous System in the Pathophysiology of Obesity. Frontiers in Physiology 8.
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Chris de Graaf, Dan Donnelly, Denise Wootten, Jesper Lau, Patrick M. Sexton, Laurence J. Miller, Jung-Mo Ahn, Jiayu Liao, Madeleine M. Fletcher, Dehua Yang, Alastair J. H. Brown, Caihong Zhou, Jiejie Deng & Ming-Wei Wang. (2016) Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes. Pharmacological Reviews 68:4, pages 954-1013.
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H. Poudyal. (2016) Mechanisms for the cardiovascular effects of glucagon-like peptide-1. Acta Physiologica 216:3, pages 277-313.
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J. Luttikhold, F. M. de Ruijter, K. van Norren, M. Diamant, R. F. Witkamp, P. A. M. van Leeuwen & M. A. R. Vermeulen. (2013) Review article: the role of gastrointestinal hormones in the treatment of delayed gastric emptying in critically ill patients. Alimentary Pharmacology & Therapeutics 38:6, pages 573-583.
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H.S. Shin, J.R. Ingram, A.-T. McGill & S.D. Poppitt. (2013) Lipids, CHOs, proteins: Can all macronutrients put a ‘brake’ on eating?. Physiology & Behavior 120, pages 114-123.
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Anita Belza, Christian Ritz, Mejse Q Sørensen, Jens J Holst, Jens F Rehfeld & Arne Astrup. (2013) Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety. The American Journal of Clinical Nutrition 97:5, pages 980-989.
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A Rotondo, P Janssen, F Mulè & J Tack. (2012) Effect of the GLP-1 analog liraglutide on satiation and gastric sensorimotor function during nutrient-drink ingestion. International Journal of Obesity 37:5, pages 693-698.
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Charlotte X. Dong & Patricia L. Brubaker. (2012) Ghrelin, the proglucagon-derived peptides and peptide YY in nutrient homeostasis. Nature Reviews Gastroenterology & Hepatology 9:12, pages 705-715.
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Shenghao LiuRui LiuYu-Ting ChiangLifang SongXiaoming LiTianru Jin & Qinghua Wang. (2012) Insulin detemir enhances proglucagon gene expression in the intestinal L cells via stimulating β-catenin and CREB activities. American Journal of Physiology-Endocrinology and Metabolism 303:6, pages E740-E751.
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Asadullah Hamid Pyarokhil, Miyuki Ishihara, Motoki Sasaki & Nobuo Kitamura. (2012) Immunohistochemical study on the ontogenetic development of the regional distribution of peptide YY, pancreatic polypeptide, and glucagon-like peptide 1 endocrine cells in bovine gastrointestinal tract. Regulatory Peptides 175:1-3, pages 15-20.
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Ashok R. Gunawardene, Bernard M. Corfe & Carolyn A. Staton. (2011) Classification and functions of enteroendocrine cells of the lower gastrointestinal tract. International Journal of Experimental Pathology 92:4, pages 219-231.
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Remy Burcelin, Cendrine Cabou, Christophe Magnan & Pierre Gourdy. 2011. Metabolic Syndrome. Metabolic Syndrome 279 325 .
Manabu Sato, Chikashi Shibata, Daisuke Kikuchi, Fumie Ikezawa, Hirofumi Imoto & Iwao Sasaki. (2010) Effects of biliary and pancreatic juice diversion into the ileum on gastrointestinal motility and gut hormone secretion in conscious dogs. Surgery 148:5, pages 1012-1019.
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E.J. Verspohl. (2009) Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors. Pharmacology & Therapeutics 124:1, pages 113-138.
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Tina Vilsbøll, Jens J. Holst & Filip K. Knop. (2009) The spectrum of antidiabetic actions of GLP-1 in patients with diabetes. Best Practice & Research Clinical Endocrinology & Metabolism 23:4, pages 453-462.
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Wook Kim & Josephine M. Egan. (2008) The Role of Incretins in Glucose Homeostasis and Diabetes Treatment. Pharmacological Reviews 60:4, pages 470-512.
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Kasper Aaboe, Thure Krarup, Sten Madsbad & Jens Juul Holst. (2008) GLP‐1: physiological effects and potential therapeutic applications. Diabetes, Obesity and Metabolism 10:11, pages 994-1003.
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P.W.J. Maljaars, H.P.F. Peters, D.J. Mela & A.A.M. Masclee. (2008) Ileal brake: A sensible food target for appetite control. A review. Physiology & Behavior 95:3, pages 271-281.
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R. Burcelin, M. Massebœuf & C. Cabou. (2008) GLP-1 et système nerveux : un mécanisme de son action antidiabétique. Médecine des Maladies Métaboliques 2:5, pages 502-508.
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Jens Juul Holst. (2007) The Physiology of Glucagon-like Peptide 1. Physiological Reviews 87:4, pages 1409-1439.
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Amosy E. M’Koma, Paul E. Wise, Roberta L. Muldoon, David A. Schwartz, Mary K. Washington & Alan J. Herline. (2007) Evolution of the restorative proctocolectomy and its effects on gastrointestinal hormones. International Journal of Colorectal Disease 22:10, pages 1143-1163.
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Owais Chaudhri, Caroline Small & Steve Bloom. (2006) Gastrointestinal hormones regulating appetite. Philosophical Transactions of the Royal Society B: Biological Sciences 361:1471, pages 1187-1209.
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Juris J Meier. (2006) Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls. World Journal of Gastroenterology 12:12, pages 1874.
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Nicola M. Neary, Caroline J. Small, Maralyn R. Druce, Adrian J. Park, Sandra M. Ellis, Nina M. Semjonous, Catherine L. Dakin, Karin Filipsson, Fang Wang, Aysha S. Kent, Gary S. Frost, Mohammad A. Ghatei & Stephen R. Bloom. (2005) Peptide YY3–36 and Glucagon-Like Peptide-17–36 Inhibit Food Intake Additively. Endocrinology 146:12, pages 5120-5127.
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Tanvi Talsania, Younes Anini, Stephanie Siu, Daniel J. Drucker & Patricia L. Brubaker. (2005) Peripheral Exendin-4 and Peptide YY3–36 Synergistically Reduce Food Intake through Different Mechanisms in Mice. Endocrinology 146:9, pages 3748-3756.
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Hongxiang Hui, Xiaoning Zhao & Riccardo Perfetti. (2005) Structure and function studies of glucagon‐like peptide‐1 (GLP‐1): the designing of a novel pharmacological agent for the treatment of diabetes. Diabetes/Metabolism Research and Reviews 21:4, pages 313-331.
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Xiaofa Qin, Hui Shen, Min Liu, Qing Yang, Shuqin Zheng, Mary Sabo, David A. D'Alessio & Patrick Tso. (2005) GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. American Journal of Physiology-Gastrointestinal and Liver Physiology 288:5, pages G943-G949.
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Juris J. Meier & Michael A. Nauck. (2005) Glucagon-like peptide 1(GLP-1) in biology and pathology. Diabetes/Metabolism Research and Reviews 21:2, pages 91-117.
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Kristine Mortensen, Louise Lundby Christensen, Jens Juul Holst & Cathrine Orskov. (2003) GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine. Regulatory Peptides 114:2-3, pages 189-196.
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Umberto Laforenza, Giulia Gastaldi, Guido Rindi, Andrew B Leiter, Emanuela Cova, Annalisa Marchetti, Maria Elena Candusso, Michele Autelli, Maria Novella Orsenigo & Ulderico Ventura. (2003) PYY-Tag Transgenic Mice Displaying Abnormal (H+-K+)ATPase Activity and Gastric Mucosal Barrier Impairment. Laboratory Investigation 83:1, pages 47-54.
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Hong Yang. (2002) Central and peripheral regulation of gastric acid secretion by peptide YY. Peptides 23:2, pages 349-358.
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Timothy J. Kieffer, Mehboob A. Hussain & Joel F. Habener. 2011. Comprehensive Physiology. Comprehensive Physiology 197 265 .
Mitchell L. Schubert. (2000) Gastric secretion. Current Opinion in Gastroenterology 16:6, pages 463-468.
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Mitchell L. Schubert. (1999) Regulation of gastric acid secretion. Current Opinion in Gastroenterology 15:6, pages 457.
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Erik Näslund, Jesper BogeforsStaffan SkogarPer Grybäck, Hans Jacobsson, Jens Juul Holst & Per M. Hellström. (1999) GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 277:3, pages R910-R916.
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A. E. M'Koma, K. Lindquist & L. Liljeqvist. (1999) Effect of restorative proctocolectomy on gastric acid secretion and serum gastrin levels. Diseases of the Colon & Rectum 42:3, pages 398-402.
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Xiao-Tuan Zhao, John H. Walsh, Helen Wong, Lijie Wang & Henry C. Lin. (1999) Intestinal fat-induced inhibition of meal-stimulated gastric acid secretion depends on CCK but not peptide YY. American Journal of Physiology-Gastrointestinal and Liver Physiology 276:2, pages G550-G555.
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Thomas P Mommsen & Svetlana Mojsov. (1998) Glucagon-like peptide-1 activates the adenylyl cyclase system in rockfish enterocytes and brain membranes. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 121:1, pages 49-56.
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A. Wettergren, M. Wøjdemann & J.J. Holst. (1998) The Inhibitory Effect of Glucagon-Like Peptide-1 (7-36)amide on Antral Motility is Antagonized by Its N-Terminally Truncated Primary Metabolite GLP-1 (9-36)amide. Peptides 19:5, pages 877-882.
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Leslie C. Fung, Connie Chisholm & Gordon R. Greenberg. (1998) Glucagon-Like Peptide-1-(7–36) Amide and Peptide YY Mediate Intraduodenal Fat-Induced Inhibition of Acid Secretion in Dogs*. Endocrinology 139:1, pages 189-194.
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