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Original Article

Good outcome with trimethoprim 10 mg/kg/day-sulfamethoxazole 50 mg/kg/day for Pneumocystis jirovecii pneumonia in HIV infected patients

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Pages 862-868 | Received 06 May 2009, Published online: 18 Nov 2009

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Read on this site (3)

R. Benson Weyant, Dima Kabbani, Karen Doucette, Cecilia Lau & Carlos Cervera. (2021) Pneumocystis jirovecii: a review with a focus on prevention and treatment. Expert Opinion on Pharmacotherapy 22:12, pages 1579-1592.
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Jianlei Ji, Qinghai Wang, Tao Huang, Ziyu Wang, Pingli He, Chen Guo, Weijia Xu, Yanwei Cao, Zhen Dong & Hongyang Wang. (2021) Efficacy of Low-Dose Trimethoprim/Sulfamethoxazole for the Treatment of Pneumocystis jirovecii Pneumonia in Deceased Donor Kidney Recipients. Infection and Drug Resistance 14, pages 4913-4920.
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Yu-Shan Huang, Jen-Jia Yang, Nan-Yao Lee, Guan-Jhou Chen, Wen-Chien Ko, Hsin-Yun Sun & Chien-Ching Hung. (2017) Treatment of Pneumocystis jirovecii pneumonia in HIV-infected patients: a review. Expert Review of Anti-infective Therapy 15:9, pages 873-892.
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Articles from other publishers (26)

Zhun-Yong Gu, Wen-Jun Liu, Dan-Lei Huang, Yu-Jing Liu, Hong-Yu He, Cheng Yang, Yi-Mei Liu, Ming Xu, Rui-Ming Rong, Du-Ming Zhu, Zhe Luo & Min-Jie Ju. (2022) Preliminary Study on the Combination Effect of Clindamycin and Low Dose Trimethoprim-Sulfamethoxazole on Severe Pneumocystis Pneumonia After Renal Transplantation. Frontiers in Medicine 9.
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Yinqiu Huang, Xiaoqing He, Hui Chen, Vijay Harypursat, Yanqiu Lu, Jing Yuan, Jingmin Nie, Min Liu, Jianhua Yu, Yulin Zhang, Zhongsheng Jiang, Yingmei Qin, Lijun Xu, Guoqiang Zhou, Defa Zhang, Xiaohong Chen, Baisong Zheng & Yaokai Chen. (2022) No Statistically Apparent Difference in Antifungal Effectiveness Observed Among Trimethoprim/Sulfamethoxazole Plus Clindamycin or Caspofungin, and Trimethoprim/Sulfamethoxazole Monotherapy in HIV-Infected Patients with Moderate to Severe Pneumocystis Pneumonia: Results of an Observational Multicenter Cohort Study. Infectious Diseases and Therapy 11:1, pages 543-557.
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Brandon J. Tritle, Andre A. Hejazi & Tristan T. Timbrook. (2021) The effectiveness and safety of low dose trimethoprim‐sulfamethoxazole for the treatment of pneumocystis pneumonia: A systematic review and meta‐analysis. Transplant Infectious Disease 23:6.
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Emily G McDonald, Guillaume Butler-Laporte, Olivier Del Corpo, Jimmy M Hsu, Alexander Lawandi, Julien Senecal, Zahra N Sohani, Matthew P Cheng & Todd C Lee. (2021) On the Treatment of Pneumocystis jirovecii Pneumonia: Current Practice Based on Outdated Evidence . Open Forum Infectious Diseases 8:12.
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Tongli Zhang. 2021. Case Studies in Systems Biology. Case Studies in Systems Biology 229 243 .
Guillaume Butler-Laporte, Elizabeth Smyth, Alexandre Amar-Zifkin, Matthew P Cheng, Emily G McDonald & Todd C Lee. (2020) Low-Dose TMP-SMX in the Treatment of Pneumocystis jirovecii Pneumonia: A Systematic Review and Meta-analysis. Open Forum Infectious Diseases 7:5.
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Abdelbaset A. Elzagallaai, Elham A. Sultan, John R. Bend, Awatif M. Abuzgaia, Eman Loubani & Michael J. Rieder. (2019) Role of Oxidative Stress in Hypersensitivity Reactions to Sulfonamides. The Journal of Clinical Pharmacology 60:3, pages 409-421.
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Sadatomo Tasaka. (2020) Recent Advances in the Diagnosis and Management of Pneumocystis Pneumonia . Tuberculosis and Respiratory Diseases 83:2, pages 132.
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Shin-ichiro Ohmura, Taio Naniwa, Shin-ya Tamechika, Toshiaki Miyamoto, Daisuke Shichi, Nobukata Kazawa, Shiho Iwagaitsu, Shinji Maeda, Jun-ichi Wada & Akio Niimi. (2019) Effectiveness and safety of lower dose sulfamethoxazole/trimethoprim therapy for Pneumocystis jirovecii pneumonia in patients with systemic rheumatic diseases: A retrospective multicenter study. Journal of Infection and Chemotherapy 25:4, pages 253-261.
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Kemi Adeyanju, John R. Bend, Michael J. Rieder & Gregory A. Dekaban. (2018) HIV-1 tat expression and sulphamethoxazole hydroxylamine mediated oxidative stress alter the disulfide proteome in Jurkat T cells. Virology Journal 15:1.
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Guan-Sheng Liu, Richard Ballweg, Alan Ashbaugh, Yin Zhang, Joseph Facciolo, Melanie T. Cushion & Tongli Zhang. (2018) A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice. BMC Systems Biology 12:1.
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Kei Nakashima, Masahiro Aoshima, Tamao Nakashita, Masahiko Hara, Ayumu Otsuki, Satoshi Noma, Masafumi Misawa, Yoshihito Otsuka & Shinji Motojima. (2018) Low-dose trimethoprim-sulfamethoxazole treatment for pneumocystis pneumonia in non-human immunodeficiency virus-infected immunocompromised patients: A single-center retrospective observational cohort study. Journal of Microbiology, Immunology and Infection 51:6, pages 810-820.
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Jennifer M. Reinhart, Warren Rose, Daniel J. Panyard, Michael A. Newton, Tyler K. Liebenstein, Jeremiah Yee & Lauren A. Trepanier. (2018) RNA expression profiling in sulfamethoxazole-treated patients with a range of in vitro lymphocyte cytotoxicity phenotypes. Pharmacology Research & Perspectives 6:2, pages e00388.
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Makoto Kosaka, Atsuhito Ushiki, Yuichi Ikuyama, Kazuya Hirai, Akemi Matsuo, Tsutomu Hachiya & Masayuki Hanaoka. (2017) A Four-Center Retrospective Study of the Efficacy and Toxicity of Low-Dose Trimethoprim-Sulfamethoxazole for the Treatment of Pneumocystis Pneumonia in Patients without HIV Infection. Antimicrobial Agents and Chemotherapy 61:12.
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S. Blaas. (2017) Pneumocystis-jirovecii-Pneumonie bei Patienten mit AutoimmunerkrankungenPneumocystis jirovecii pneumonia in patients with autoimmune diseases. Zeitschrift für Rheumatologie 76:9, pages 761-766.
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Jennifer M. Reinhart, Alison Motsinger-Reif, Allison Dickey, Steven Yale & Lauren A. Trepanier. (2016) Genome-Wide Association Study in Immunocompetent Patients with Delayed Hypersensitivity to Sulfonamide Antimicrobials. PLOS ONE 11:6, pages e0156000.
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T. Fauchier, L. Hasseine, M. Gari-Toussaint, V. Casanova, P. M. Marty & C. Pomares. (2016) Detection of Pneumocystis jirovecii by Quantitative PCR To Differentiate Colonization and Pneumonia in Immunocompromised HIV-Positive and HIV-Negative Patients. Journal of Clinical Microbiology 54:6, pages 1487-1495.
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Dina Creemers-Schild, Frank P. Kroon, Ed. J. Kuijper & Mark G. J. de Boer. (2015) Treatment of Pneumocystis pneumonia with intermediate-dose and step-down to low-dose trimethoprim–sulfamethoxazole: lessons from an observational cohort study. Infection 44:3, pages 291-299.
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Tomohiko SHIBATA, Kumiko TONOOKA, Kosei TSUCHIDA, Hirofumi MITOMI, Toshiko SHIBATA & Naooki KATSUYAMA. (2016) Retrospective investigation of side effects and prognoses of moderate-dose trimethoprim-sulfamethoxazole treatment for pneumocystis pneumonia that developed in patients with autoimmune diseases. Japanese Journal of Clinical Immunology 39:3, pages 213-218.
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Sadatomo Tasaka. (2015) Pneumocystis Pneumonia in Human Immunodeficiency Virus–infected Adults and Adolescents: Current Concepts and Future Directions . Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine 9s1, pages CCRPM.S23324.
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Norihiko GotoKenta FutamuraManabu OkadaTakayuki YamamotoMakoto TsujitaTakahisa HiramitsuShunji NarumiYoshihiko Watarai. (2015) Management of Pneumocystis jirovecii Pneumonia in Kidney Transplantation to Prevent Further Outbreak . Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine 9s1, pages CCRPM.S23317.
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Heather M. Kling, Timothy W. Shipley, Siobhan Guyach, Rebecca Tarantelli, Alison Morris & Karen A. Norris. (2014) Trimethoprim–Sulfamethoxazole Treatment Does Not Reverse Obstructive Pulmonary Changes in Pneumocystis-Colonized Nonhuman Primates With SHIV Infection. JAIDS Journal of Acquired Immune Deficiency Syndromes 65:4, pages 381-389.
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Takahiro Takuma. (2014) 2. Recent Antifungal Drugs and the Usage. Nihon Naika Gakkai Zasshi 103:11, pages 2721-2727.
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Anthony P. Sinai, Edna S. Kaneshiro, Honorine Ward, Louis M. Weiss & Melanie T. Cushion. (2012) The State of Research for AIDS-Associated Opportunistic Infections and the Importance of Sustaining Smaller Research Communities. Eukaryotic Cell 11:2, pages 90-97.
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Sadatomo Tasaka & Hitoshi Tokuda. (2012) Pneumocystis jirovecii pneumonia in non-HIV-infected patients in the era of novel immunosuppressive therapies. Journal of Infection and Chemotherapy 18:6, pages 793-806.
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Rossana de Aguiar Cordeiro, Delia Jessica Astete-Medrano, Francisca Jakelyne de Farias Marques, Heuziwanne Tavares Leite Andrade, Lauro Vieira Perdigão Neto, Juliane Lira Tavares, Rita Amanda Chaves de Lima, Kharla Kharolyni Nobre Rabelo Patoilo, Andre Jalles Monteiro, Raimunda Sâmia Nogueira Brilhante, Marcos Fábio Gadelha Rocha, Zoilo Pires de Camargo & José Júlio Costa Sidrim. (2011) Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals. Memórias do Instituto Oswaldo Cruz 106:8, pages 1045-1048.
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