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Scandinavian Journal of Infectious Diseases Volume 44, 2012 - Issue 8
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Case Reports

Evaluation of the pharmacokinetics of linezolid in an obese Japanese patient

Yasuhiro TsujiDepartment of Pharmacy, Sasebo Chuo Hospital, NagasakiCorrespondence[email protected]
,
Yoichi HirakiDepartment of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto
,
Kana MatsumotoDepartment of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto
,
Akiko MizoguchiDepartment of Pharmacy, Sasebo Chuo Hospital, Nagasaki
,
Shinichi SadohDepartment of Pharmacy, Sasebo Chuo Hospital, Nagasaki
,
Tsutomu KobayashiDepartment of Internal Medicine, Sasebo Chuo Hospital, Nagasaki
,
Seisaburo SakamotoDepartment of Neurosurgery, Sasebo Chuo Hospital, Nagasaki
,
Kunihiko MoritaDepartment of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto
,
Eiji YukawaLaboratory of Evidence-Based Pharmacotherapy, Daiichi University of Pharmacy, Fukuoka
,
Hidetoshi KamimuraFaculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
&
Yoshiharu KarubeFaculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
 show all
Pages 626-629 | Received 06 Dec 2011, Accepted 10 Dec 2011, Published online: 21 Jan 2012

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Navaneeth Narayanan, Christopher D Adams, David W Kubiak, Serena Cheng, Robyn Stoianovici, Leonid Kagan & Luigi Brunetti. (2019) Evaluation of treatment options for methicillin-resistant Staphylococcus aureus infections in the obese patient. Infection and Drug Resistance 12, pages 877-891.
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Dario Cattaneo, Jan-Willem Alffenaar & Michael Neely. (2016) Drug monitoring and individual dose optimization of antimicrobial drugs: oxazolidinones. Expert Opinion on Drug Metabolism & Toxicology 12:5, pages 533-544.
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Articles from other publishers (21)

Meiling Zuo, Yuxuan Sun, Xianmei Zhao, Gaoqi Xu, Nan Wang, Jingtao Chen, Liqin Zhu, Wenjie Yang & Mingfeng Zhao. (2022) Evaluating linezolid dose regimens against methicillin‐resistant Staphylococcus aureus based on renal function in populations with different body weight . Journal of Clinical Pharmacy and Therapeutics 47:12, pages 2162-2169.
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Yasuhiro Tsuji. (2021) Hospital Pharmacometrics for Optimal Individual Administration of Antimicrobial Agents for Anti-methicillin-resistant <i>Staphylococcus aureus</i> Infected Patients. Biological and Pharmaceutical Bulletin 44:9, pages 1174-1183.
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Alison L. Blackman, Praneeth Jarugula, David P. Nicolau, Sai Ho Chui, Manjari Joshi, Emily L. Heil & Mathangi Gopalakrishnan. (2021) Evaluation of Linezolid Pharmacokinetics in Critically Ill Obese Patients with Severe Skin and Soft Tissue Infections. Antimicrobial Agents and Chemotherapy 65:2.
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Wenjun Zhao, Lingti Kong, Chenchen Wu & Xiaofei Wu. (2020) Prolonged infusion of linezolid is associated with improved pharmacokinetic/pharmacodynamic (PK/PD) profiles in patients with external ventricular drains. European Journal of Clinical Pharmacology 77:1, pages 79-86.
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Joseph I. Boullata. 2021. Nutrition and Infectious Diseases. Nutrition and Infectious Diseases 367 410 .
Feifan Xie, Konstantinos Mantzarlis, Polychronis Malliotakis, Vasileios Koulouras, Sophie Degroote, Despoina Koulenti, Stijn Blot, Koen Boussery, Jan Van Bocxlaer, Pieter Colin, Epameinondas Zakynthinos, Dimitrios Georgopoulos, Athanasios Papathanasiou, Kostoula Arvaniti, Dimitrios Matamis, Anna Spring, Vasileios Bekos, Apostolos Komnos, Tilemachos Zafeiridis & Dirk Vogelaers. (2019) Pharmacokinetic evaluation of linezolid administered intravenously in obese patients with pneumonia. Journal of Antimicrobial Chemotherapy 74:3, pages 667-674.
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Nuggehally R. Srinivas. (2018) Influence of Morbid Obesity on the Clinical Pharmacokinetics of Various Anti-Infective Drugs: Reappraisal Using Recent Case Studies—Issues, Dosing Implications, and Considerations. American Journal of Therapeutics 25:2, pages e224-e246.
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Maya Hites & Fabio Silvio Taccone. 2018. Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill. Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill 47 72 .
Alicia Galar, Maricela Valerio, Patricia Muñoz, Luis Alcalá, Xandra García-González, Almudena Burillo, María Sanjurjo, Santiago Grau & Emilio Bouza. (2017) Systematic Therapeutic Drug Monitoring for Linezolid: Variability and Clinical Impact. Antimicrobial Agents and Chemotherapy 61:10.
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Young Lee. (2016) Linezolid for Methicillin-Resistant Staphylococcus aureus Pneumonia: The Impact of Obesity on Clinical Outcomes. Journal of Pharmacy & Pharmaceutics 3:2, pages 1-4.
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Syed Tabish R. Zaidi & Brett Janson. 2016. Drug Dosing in Obesity. Drug Dosing in Obesity 63 76 .
Silvia Corcione, Nicole Pagani, Lorena Baietto, Vito Fanelli, Rosario Urbino, V. Marco Ranieri, Giovanni Di Perri, Antonio D'Avolio & Francesco G. De Rosa. (2015) Pharmacokinetics of high dosage of linezolid in two morbidly obese patients. Journal of Antimicrobial Chemotherapy 70:8, pages 2417-2418.
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M. Hites & F. S. Taccone. (2015) Optimization of antibiotic therapy in the obese, critically ill patientOptimisation de l’antibiothérapie chez le patient obèse en réanimation. Réanimation 24:3, pages 278-294.
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Gennaro De Pascale, Serena Fortuna, Mario Tumbarello, Salvatore Lucio Cutuli, MariaSole Vallecoccia, Teresa Spanu, Giuseppe Bello, Luca Montini, Mariano Alberto Pennisi, Pierluigi Navarra & Massimo Antonelli. (2014) Linezolid plasma and intrapulmonary concentrations in critically ill obese patients with ventilator-associated pneumonia: intermittent vs continuous administration. Intensive Care Medicine 41:1, pages 103-110.
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C. E. Tucker, A. M. Lockwood & N. H. Nguyen. (2014) Antibiotic dosing in obesity: the search for optimum dosing strategies. Clinical Obesity, pages n/a-n/a.
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B. Edwards, R. Andini, S. Esposito, P. Grossi, D. Lew, T. Mazzei, A. Novelli, A. Soriano & I.M. Gould. (2014) Treatment options for methicillin-resistant Staphylococcus aureus (MRSA) infection: Where are we now?. Journal of Global Antimicrobial Resistance 2:3, pages 133-140.
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Joseph I. Boullata. (2014) Comments on Linezolid in Morbid Obesity. Annals of Pharmacotherapy 48:3, pages 429-429.
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Ursula Theuretzbacher. 2014. Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics. Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics 401 443 .
Amira A. Bhalodi, Pavlos K. Papasavas, Darren S. Tishler, David P. Nicolau & Joseph L. Kuti. (2013) Pharmacokinetics of Intravenous Linezolid in Moderately to Morbidly Obese Adults. Antimicrobial Agents and Chemotherapy 57:3, pages 1144-1149.
Crossref
R. Hamilton, X. C. Thai, D. Ameri & M. P. Pai. (2012) Oral bioavailability of linezolid before and after Roux-en-Y gastric bypass surgery: is dose modification necessary in obese subjects?. Journal of Antimicrobial Chemotherapy 68:3, pages 666-673.
Crossref
Brett Janson & Karin Thursky. (2012) Dosing of antibiotics in obesity. Current Opinion in Infectious Diseases 25:6, pages 634-649.
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