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Case Reports

Decreased serum linezolid concentrations in two patients receiving linezolid and rifampicin due to bone infections

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Pages 548-550 | Received 17 Jan 2012, Accepted 21 Jan 2012, Published online: 04 Mar 2012

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Read on this site (6)

Marjan Wouthuyzen-Bakker & Henk Scheper. (2023) Rifampicin in periprosthetic joint infections: where do we stand and where are we headed?. Expert Review of Anti-infective Therapy 21:7, pages 695-701.
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Maria V. Golikova, Elena N. Strukova, Yury A. Portnoy, Svetlana A. Dovzhenko, Mikhail B. Kobrin, Stephen H. Zinner & Alexander A. Firsov. (2017) Predicting effects of antibiotic combinations using MICs determined at pharmacokinetically derived concentration ratios: in vitro model studies with linezolid- and rifampicin-exposed Staphylococcus aureus. Journal of Chemotherapy 29:5, pages 267-273.
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Alexander A. Firsov, Maria V. Golikova, Elena N. Strukova, Yury A. Portnoy, Svetlana A. Dovzhenko, Mikhail B. Kobrin & Stephen H. Zinner. (2017) Pharmacokinetically-based prediction of the effects of antibiotic combinations on resistant Staphylococcus aureus mutants: in vitro model studies with linezolid and rifampicin. Journal of Chemotherapy 29:4, pages 220-226.
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L. Morata, C. De la Calle, J. M. Gómez-Cerquera, L. Manzanedo, G. Casals, M. Brunet, N. Cobos-Trigueros, J. A. Martínez, J. Mensa & A. Soriano. (2016) Risk factors associated with high linezolid trough plasma concentrations. Expert Opinion on Pharmacotherapy 17:9, pages 1183-1187.
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Predrag Sazdanovic, Slobodan M. Jankovic, Marina Kostic, Aleksandra Dimitrijevic & Srdjan Stefanovic. (2016) Pharmacokinetics of linezolid in critically ill patients. Expert Opinion on Drug Metabolism & Toxicology 12:6, pages 595-600.
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Antonios Douros, Katja Grabowski & Ralf Stahlmann. (2015) Drug–drug interactions and safety of linezolid, tedizolid, and other oxazolidinones. Expert Opinion on Drug Metabolism & Toxicology 11:12, pages 1849-1859.
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Articles from other publishers (27)

Ruth Alexandra Corrigan & Bridget L Atkins. (2023) Controversies in the microbiological diagnosis and treatment of bone and joint infections. Orthopaedics and Trauma 37:6, pages 336-343.
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Pan Yan, Qun-Zhi Shi, Yi-Xing Hu, Ying Zeng & Hong Lu. (2023) Evaluation of the impact of rifampicin on the plasma concentration of linezolid in tuberculosis co-infected patients. Frontiers in Pharmacology 14.
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Manjunath P Pai, Pier Giorgio Cojutti, Valentina Gerussi, Paola Della Siega, Carlo Tascini & Federico Pea. (2023) Linezolid Population Pharmacokinetics to Improve Dosing in Cardiosurgical Patients: Factoring a New Drug–Drug Interaction Pathway. Clinical Infectious Diseases 76:7, pages 1173-1179.
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Cristina El Haj, Eva Benavent, Yanik Sierra, Laura Soldevila, Raul Rigo-Bonnin, Benjamin Torrejón, Joan Gomez-Junyent, Irantzu Rosselló & Oscar Murillo. (2022) Comparative efficacy of dalbavancin alone and with rifampicin against in vitro biofilms in a pharmacodynamic model with methicillin-resistant Staphylococcus aureus. International Journal of Antimicrobial Agents 60:4, pages 106664.
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Hitoshi Kawasuji, Yasuhiro Tsuji, Chika Ogami, Makito Kaneda, Yushi Murai, Kou Kimoto, Akitoshi Ueno, Yuki Miyajima, Yasutaka Fukui, Ippei Sakamaki & Yoshihiro Yamamoto. (2021) Initially Reduced Linezolid Dosing Regimen to Prevent Thrombocytopenia in Hemodialysis Patients. Antibiotics 10:5, pages 496.
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M. Depypere, M. Morgenstern, R. Kuehl, E. Senneville, T.F. Moriarty, W.T. Obremskey, W. Zimmerli, A. Trampuz, K. Lagrou & W-J. Metsemakers. (2020) Pathogenesis and management of fracture-related infection. Clinical Microbiology and Infection 26:5, pages 572-578.
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Kentaro Tsuji, Soichiro Kimura, Kazuhiro Tateda & Hiroshi Takahashi. (2020) Does Vitamin D3 Prevent the Inhibitory Effect of Vancomycin on Osteoblasts?. Clinical Orthopaedics & Related Research 478:2, pages 420-433.
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Melissa Depypere, Richard Kuehl, Willem-Jan Metsemakers, Eric Senneville, Martin A. McNally, William T. Obremskey, Werner Zimmerli, Bridget L. Atkins & Andrej Trampuz. (2020) Recommendations for Systemic Antimicrobial Therapy in Fracture-Related Infection: A Consensus From an International Expert Group. Journal of Orthopaedic Trauma 34:1, pages 30-41.
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Jose Lomas. (2019) Antimicrobial treatment in bone and joint infections. Orthopaedics and Trauma 33:3, pages 153-159.
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Rahul Kashyap, Aditya Shah, Taru Dutt, Patrick M Wieruszewski, Jaishid Ahdal & Rishi Jain. (2019) Treatments and limitations for methicillin-resistant Staphylococcus aureus : A review of current literature . World Journal of Clinical Infectious Diseases 9:1, pages 1-10.
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Satsuki Hashimoto, Kyoko Honda, Kohei Fujita, Yuka Miyachi, Kazuya Isoda, Ko Misaka, Yukio Suga, Satoshi Kato, Hiroyuki Tsuchiya, Yukio Kato, Masaki Okajima, Takumi Taniguchi, Tsutomu Shimada & Yoshimichi Sai. (2018) Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies. Journal of Pharmaceutical Health Care and Sciences 4:1.
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Jongtak Jung, Eunyoung Lee, Kyoung-Ho Song, Pyoeng Gyun Choe, Wan Beom Park, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sang Won Park, Nam Joong Kim & Myoung-don Oh. (2018) Efficacy and Tolerability of Linezolid for Treatment of Infectious Spondylitis. The Korean Journal of Medicine 93:5, pages 464-472.
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Cristina El Haj, Oscar Murillo, Alba Ribera, Nuria Lloberas, Joan Gómez-Junyent, Fe Tubau, Pere Fontova, Carme Cabellos & Javier Ariza. (2018) Evaluation of linezolid or trimethoprim/sulfamethoxazole in combination with rifampicin as alternative oral treatments based on an in vitro pharmacodynamic model of staphylococcal biofilm. International Journal of Antimicrobial Agents 51:6, pages 854-861.
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Claire Roger, Jason A. Roberts & Laurent Muller. (2017) Clinical Pharmacokinetics and Pharmacodynamics of Oxazolidinones. Clinical Pharmacokinetics 57:5, pages 559-575.
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Neeraj Gupta, Michael J. Hanley, Karthik Venkatakrishnan, Alberto Bessudo, Drew W. Rasco, Sunil Sharma, Bert H. O'Neil, Bingxia Wang, Guohui Liu, Alice Ke, Chirag Patel, Karen Rowland Yeo, Cindy Xia, Xiaoquan Zhang, Dixie-Lee Esseltine & John Nemunaitis. (2018) Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug-Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinetic Ana. The Journal of Clinical Pharmacology 58:2, pages 180-192.
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Federico Pea, Pier Giorgio Cojutti & Massimo Baraldo. (2017) A 10‐Year Experience of Therapeutic Drug Monitoring ( TDM ) of Linezolid in a Hospital‐wide Population of Patients Receiving Conventional Dosing: Is there Enough Evidence for Suggesting TDM in the Majority of Patients? . Basic & Clinical Pharmacology & Toxicology 121:4, pages 303-308.
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Adriana Macedo Dell'Aquila, Cesar Janovsky & Moises Cohen. (2017) Case Report - Infection of Total Knee Arthroplasty Treated with One-Stage Surgery and Linezolid. Journal of Bone and Joint Infection 2:3, pages 163-166.
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Eduard Tornero, Laura Morata, Juan C. Martínez-Pastor, Silvia Angulo, Andreu Combalia, Guillem Bori, Sebastián García-Ramiro, Jordi Bosch, Josep Mensa & Alex Soriano. (2016) Importance of selection and duration of antibiotic regimen in prosthetic joint infections treated with debridement and implant retention. Journal of Antimicrobial Chemotherapy 71:5, pages 1395-1401.
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T. Ichie, D. Suzuki, K. Yasui, H. Takahashi, M. Matsuda, H. Hayashi, Y. Sugiura & T. Sugiyama. (2015) The association between risk factors and time of onset for thrombocytopenia in Japanese patients receiving linezolid therapy: a retrospective analysis. Journal of Clinical Pharmacy and Therapeutics 40:3, pages 279-284.
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Cristina Gervasoni, Francesco R. Simonetti, Chiara Resnati, Nitin Charbe, Emilio Clementi & Dario Cattaneo. (2015) Prolonged inductive effect of rifampicin on linezolid exposure. European Journal of Clinical Pharmacology 71:5, pages 643-644.
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T. Dresbach, A. Müller & A. Simon. (2015) Infektionen mit Methicillin-resistentem Staphylococcus aureusInfections with methicillin-resistant Staphylococcus aureus. Monatsschrift Kinderheilkunde 163:5, pages 437-447.
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Lorenzo Castellani & Alberto Farese. 2015. Perioperative Medical Management for Total Joint Arthroplasty. Perioperative Medical Management for Total Joint Arthroplasty 315 325 .
Laura Morata, Eric Senneville, Louis Bernard, Sophie Nguyen, Rodolphe Buzel?J?rome Druon, Eduard Tornero, Josep Mensa & Alex Soriano. (2014) A Retrospective Review of the Clinical Experience of Linezolid with or Without Rifampicin in Prosthetic Joint Infections Treated with Debridement and Implant Retention. Infectious Diseases and Therapy 3:2, pages 235-243.
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L. Morata, E. Tornero, J. C. Martinez-Pastor, S. Garcia-Ramiro, J. Mensa & A. Soriano. (2014) Clinical experience with linezolid for the treatment of orthopaedic implant infections. Journal of Antimicrobial Chemotherapy 69:suppl 1, pages i47-i52.
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B. Edwards, R. Andini, S. Esposito, P. Grossi, D. Lew, T. Mazzei, A. Novelli, A. Soriano & I.M. Gould. (2014) Treatment options for methicillin-resistant Staphylococcus aureus (MRSA) infection: Where are we now?. Journal of Global Antimicrobial Resistance 2:3, pages 133-140.
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Yasuhiro Horita & Norio Doi. (2014) Comparative Study of the Effects of Antituberculosis Drugs and Antiretroviral Drugs on Cytochrome P450 3A4 and P-Glycoprotein. Antimicrobial Agents and Chemotherapy 58:6, pages 3168-3176.
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Laura Morata, Josep Mensa & Alex Soriano. (2013) Reply to “Breakthrough Bacteremia by Linezolid-Susceptible Enterococcus faecalis under Linezolid Treatment in a Severe Polytrauma Patient”. Antimicrobial Agents and Chemotherapy 57:12, pages 6413-6414.
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