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Scandinavian Journal of Infectious Diseases Volume 18, 1986 - Issue 5
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Original Article

The Use of Antibiotic Serum Levels to Predict Concentrations in Tissues

D. Michael Ryan Microbiology Division, Glaxo Group Research Ltd, Greenford, Middlesex, England
,
Otto Cars Department of Infectious Diseases, Akademiska sjukhuset, Uppsala University, Uppsala, Sweden
&
Björn Hoffstedt MSD Sharp & Dohme GmbH, Munich, FRG
Pages 381-388 | Published online: 08 Jul 2009

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M.J.B. Mengelers, H.A. Kuiper, A. Pijpers, J.H.M. Verheijden & A.S.J.P.A.M. van Miert. (2000) Prevention of pleuropneumonia in pigs by in‐feed medication with sulphadimethoxine and sulphamethoxazole in combination with trimethoprim. Veterinary Quarterly 22:3, pages 157-162.
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Otto Cars & William A. Craig. (1990) Pharmacodynamics of Antibiotics-Consequences for Dosing: Proceedings of a Symposium Held in Stockholm, June 7–9, 1990. Scandinavian Journal of Infectious Diseases 22:sup74, pages 1-284.
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Inga Odenholt-Tornqvist. (1988) Pharmacodynamics of Beta-Lactam Antibiotics: Studies on the Paradoxical and Postantibiotic Effects in Vitro and in an Animal Model. Scandinavian Journal of Infectious Diseases 20:sup58, pages 1-55.
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S. Ragnar Norrby, Kjell Alestig, Arne Forsgren & Carl Erik Nord. (1988) Doxycycline Revisited: Proceedings of a Symposium Held in New York, NY, 9 October 1987. Scandinavian Journal of Infectious Diseases 20:sup53, pages 1-79.
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Inga Odenholt, Stig E. Holm & Otto Cars. (1988) An in Vivo Model for Evaluation of the Postantibiotic Effect. Scandinavian Journal of Infectious Diseases 20:1, pages 97-103.
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Peter Gortvai, John De Louvois & Rosalinde Hurley. (1987) The Bacteriology and Chemotherapy of Acute Pyogenic Brain Abscess. British Journal of Neurosurgery 1:2, pages 189-203.
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Articles from other publishers (43)

Sandrine Marchand, Alexia Chauzy, Claire Dahyot-Fizelier & William Couet. (2016) Microdialysis as a way to measure antibiotics concentration in tissues. Pharmacological Research 111, pages 201-207.
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I.M. Ghoneim, A.M. Abdelghany, M.M. Waheed, A.M. Elmoslemany, A.K. Alhaider & M.M. Al-Eknah. (2015) Effect of oxytocin and PGF2α on chlortetracycline absorption from the uterus of early postpartum camels (Camelus dromedarius). Theriogenology 84:4, pages 645-649.
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Amelia N. Deitchman & Hartmut Derendorf. (2014) Measuring drug distribution in the critically ill patient. Advanced Drug Delivery Reviews 77, pages 22-26.
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Paul Skorup, Lisa Maudsdotter, Miklós Lipcsey, Markus Castegren, Anders Larsson, Ann-Beth Jonsson & Jan Sjölin. (2014) Beneficial Antimicrobial Effect of the Addition of an Aminoglycoside to a β-Lactam Antibiotic in an E. coli Porcine Intensive Care Severe Sepsis Model. PLoS ONE 9:2, pages e90441.
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Ursula Theuretzbacher. 2014. Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics. Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics 401 443 .
Stephen Castellino, M Reid Groseclose & David Wagner. (2011) MALDI imaging mass spectrometry: bridging biology and chemistry in drug development. Bioanalysis 3:21, pages 2427-2441.
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Anna Ciechanowska, Jan M. Wojcicki, Iwona Maruniak-Chudek, Piotr Ladyzynski & Janusz Krzymien. 2011. Applications of Microdialysis in Pharmaceutical Science. Applications of Microdialysis in Pharmaceutical Science 359 401 .
Yuh-Lih Chang, Shih-Hwa Chiou, Yueh-Ching Chou, Chih-Ju Yen & Tung-Hu Tsai. (2007) Quantitative determination of unbound cefoperazone in rat bile using microdialysis and liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 45:1, pages 158-163.
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Cornelia Buerger, Nele Plock, Pejman Dehghanyar, Christian Joukhadar & Charlotte Kloft. (2006) Pharmacokinetics of Unbound Linezolid in Plasma and Tissue Interstitium of Critically Ill Patients after Multiple Dosing Using Microdialysis. Antimicrobial Agents and Chemotherapy 50:7, pages 2455-2463.
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Pejman Dehghanyar, Cornelia Bürger, Markus Zeitlinger, Florian Islinger, Florian Kovar, Markus Müller, Charlotte Kloft & Christian Joukhadar. (2005) Penetration of Linezolid into Soft Tissues of Healthy Volunteers after Single and Multiple Doses. Antimicrobial Agents and Chemotherapy 49:6, pages 2367-2371.
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Lucy Sasongko, Kenneth M. Williams, Richard O. Day & Andrew J. McLachlan. (2003) Human subcutaneous tissue distribution of fluconazole: comparison of microdialysis and suction blister techniques. British Journal of Clinical Pharmacology 56:5, pages 551-561.
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F. Scaglione, D. Caronzolo, J. P. Pintucci & F. Fraschini. (2003) Measurement of Cefaclor and Amoxicillin-Clavulanic Acid Levels in Middle-Ear Fluid in Patients with Acute Otitis Media. Antimicrobial Agents and Chemotherapy 47:9, pages 2987-2989.
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Rodrigo J. Freddo & Teresa Dalla Costa. (2002) Determination of Norfloxacin Free Interstitial Levels in Skeletal Muscle by Microdialysis. Journal of Pharmaceutical Sciences 91:11, pages 2433-2440.
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Sheryl A. Zelenitsky, Robert E. Ariano, Godfrey K. M. Harding & Richard E. Silverman. (2002) Antibiotic Pharmacodynamics in Surgical Prophylaxis: an Association between Intraoperative Antibiotic Concentrations and Efficacy. Antimicrobial Agents and Chemotherapy 46:9, pages 3026-3030.
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Y.L Chang, M.H Chou, M.F Lin, C.F Chen & T.H Tsai. (2002) Determination and pharmacokinetic study of meropenem in rat bile using on-line microdialysis and liquid chromatography. Journal of Chromatography A 961:1, pages 119-124.
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Loretta M. Chiu & Guy W. Amsden. (2012) Intrapulmonary Pharmacokinetics of Antibacterial Agents. American Journal of Respiratory Medicine 1:3, pages 201-209.
Crossref
Jeffrey M. B. Musser, Kevin L. Anderson & Joe O. Boison. (2001) Tissue disposition and depletion of penicillin G after oral administration with milk in unweaned dairy calves. Journal of the American Veterinary Medical Association 219:3, pages 346-350.
Crossref
Cynthia A. Cox, Aaron B. Cullen, Marla R. Wolfson & Thomas H. Shaffer. (2001) Intratracheal administration of perfluorochemical-gentamicin suspension: A comparison to intravenous administration in normal and injured lungs. Pediatric Pulmonology 32:2, pages 142-151.
Crossref
Christian Joukhadar, Martin Frossard, Bernhard X. Mayer, Martin Brunner, Nikolas Klein, Peter Siostrzonek, Hans Georg Eichler & Markus Müller. (2001) Impaired target site penetration of β -lactams may account for therapeutic failure in patients with septic shock. Critical Care Medicine 29:2, pages 385-391.
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Markus Müller, Martin Brunner, Ursula Hollenstein, Christian Joukhadar, Rainer Schmid, Erich Minar, Herbert Ehringer & Hans Georg Eichler. (1999) Penetration of Ciprofloxacin into the Interstitial Space of Inflamed Foot Lesions in Non-Insulin-Dependent Diabetes Mellitus Patients. Antimicrobial Agents and Chemotherapy 43:8, pages 2056-2058.
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Scaglione, Demartini, Dugnani, Arcidiacono, Pintucci & Fraschini. (2001) Interpretation of middle ear fluid concentrations of antibiotics: comparison between ceftibuten, cefixime and azithromycin. British Journal of Clinical Pharmacology 47:3, pages 267-271.
Crossref
David E. Nix. (1998) INTRAPULMONARY CONCENTRATIONS OF ANTIMICROBIAL AGENTS. Infectious Disease Clinics of North America 12:3, pages 631-646.
Crossref
FRANCESCO SCAGLIONE. (1997) Predicting the clinical efficacy of antibiotics: toward definitive criteria. The Pediatric Infectious Disease Journal 16, pages S56-S59.
Crossref
M MüllerO HaagT BurgdorffA GeorgopoulosW WeningerB JansenG StanekH PehambergerE AgneterH G Eichler. (1996) Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans. Antimicrobial Agents and Chemotherapy 40:12, pages 2703-2709.
Crossref
Thomas J. Pallasch. (2007) Pharmacokinetic principles of antimicrobial therapy. Periodontology 2000 10:1, pages 5-11.
Crossref
G WoodnuttV BerryL Mizen. (1995) Effect of protein binding on penetration of beta-lactams into rabbit peripheral lymph. Antimicrobial Agents and Chemotherapy 39:12, pages 2678-2683.
Crossref
B.H. ANDERSON, E.C. FIRTH & T. WHITTEM. (2008) The disposition of gentamicin in equine plasma, synovial fluid and lymph. Journal of Veterinary Pharmacology and Therapeutics 18:2, pages 124-131.
Crossref
E. Bertazzoni Minelli. 1994. Facing the Pancreatic Dilemma. Facing the Pancreatic Dilemma 301 312 .
M. Dupon, G. Janvier, G. Vin�on, S. Winnock, F. Demotes-Mainard, O. Capeyron & J. Saric. (1993) Plasma levels of piperacillin and vancomycin used as prophylaxis in liver transplant patients. European Journal of Clinical Pharmacology 45:6, pages 529-534.
Crossref
U. Ganzinger & K. Neumann. (1992) Quantification of tissue distribution of antibiotics by kinetic hysteresis analysis. European Journal of Clinical Pharmacology 43:5, pages 517-522.
Crossref
D E NixS D GoodwinC A PeloquinD L RotellaJ J Schentag. (1991) Antibiotic tissue penetration and its relevance: impact of tissue penetration on infection response. Antimicrobial Agents and Chemotherapy 35:10, pages 1953-1959.
Crossref
D E NixS D GoodwinC A PeloquinD L RotellaJ J Schentag. (1991) Antibiotic tissue penetration and its relevance: models of tissue penetration and their meaning. Antimicrobial Agents and Chemotherapy 35:10, pages 1947-1952.
Crossref
I Odenholt-TornqvistE LöwdinO Cars. (1991) Pharmacodynamic effects of subinhibitory concentrations of beta-lactam antibiotics in vitro. Antimicrobial Agents and Chemotherapy 35:9, pages 1834-1839.
Crossref
B. Bengtsson, A. Franklin, S. Jacobsson, J. Luthman & M. Horn af Rantzien. (1991) Distribution of penicillin-G and spiramycin to tissue cages and subcutaneous tissue fluid in calves. Research in Veterinary Science 50:3, pages 301-307.
Crossref
J. Lumio. 1991. Rapid Methods and Automation in Microbiology and Immunology. Rapid Methods and Automation in Microbiology and Immunology 204 212 .
M. Erttmann, R. Krausse & U. Ullmann. (1990) Pharmacokinetics of imipenem in patients undergoing major colon surgeryPharmakokinetik von Imipenem bei größeren kolonchirurgischen Eingriffen. Infection 18:6, pages 367-371.
Crossref
J E ConnorsJ T DiPiroR G HayterK D HookerJ A StanfieldT R Young. (1990) Assessment of cefazolin and cefuroxime tissue penetration by using a continuous intravenous infusion. Antimicrobial Agents and Chemotherapy 34:6, pages 1128-1131.
Crossref
T HishikawaT KusunokiK TsuchiyaY UzukaT SakamotoT NagatakeK Matsumoto. (1990) Application of mathematical model to experimental chemotherapy of fatal murine pneumonia. Antimicrobial Agents and Chemotherapy 34:2, pages 326-331.
Crossref
V. Joly & C. Carbon. (1989) Pharmacocinetique tissulaire de la ceftriaxone. Médecine et Maladies Infectieuses 19, pages 57-62.
Crossref
Marc Lebel. (1989) Tissue and tissue fluid penetration of antibiotics. Antimicrobic Newsletter 6:9, pages 69-72.
Crossref
J. Renneberg & M. Walder. (1988) Mouse model for evaluation of antibiotic treatment of acute and chronic infections. European Journal of Clinical Microbiology & Infectious Diseases 7:6, pages 753-757.
Crossref
Claes Henning, Ann-Marie Bergholm & Stig Holm. (1988) Factors influencing the biological inactivation of high protein bound beta-lactam antibiotics in vitro . APMIS 96:7-12, pages 997-1001.
Crossref
A. Strömberg, U. Friberg & O. Cars. (1987) Concentrations of phenoxymethylpenicillin and cefadroxil in tonsillar tissue and tonsillar surface fluid. European Journal of Clinical Microbiology 6:5, pages 525-529.
Crossref

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