Advanced search
Publication Cover
Scandinavian Journal of Urology and Nephrology Volume 21, 1987 - Issue 4
Submit an article Journal homepage
79
Views
87
CrossRef citations to date
0
Altmetric
Original Article

A Randomized Trial of Postoperative Radiotherapy Versus Observation in Stage II and III Renal Adenocarcinoma

A Study by the Copenhagen Renal Cancer Study Group

Mogens Kjaer Department of Oncology II, Finsen Institute, Copenhagen, Denmark
,
Peter Iversen Department of Urology, Hvidovre Hospital, Copenhagen, Denmark
,
Valdemar Hvidt Urological Surgery D, Bispebjerg Hospital, Copenhagen, Denmark
,
Eywin Bruun Urology, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
,
Poul Skaarup Urological Surgery H, Copenhagen County Hospital, Herlev, Denmark
,
Jørgen Bech Hansen Surgery K, Frederiksberg Hospital, Copenhagen, Denmark
&
Peter L. Frederiksen Oncology and Radiotherapy R, Copenhagen County Hospital, Herlev, Denmark
 show all
Pages 285-289 | Received 01 Jul 1986, Published online: 15 Feb 2010

Citations (87)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Dylan M Buller, Maria Antony & Benjamin T Ristau. (2023) Adjuvant Therapy for High-Risk Localized Renal Cell Carcinoma: Current Landscape and Future Direction. OncoTargets and Therapy 16, pages 49-64.
Read now
Eliana M C Tacconi, Mark Tuthill & Andrew Protheroe. (2020) Review of Adjuvant Therapies in Renal Cell Carcinoma: Evidence to Date. OncoTargets and Therapy 13, pages 12301-12316.
Read now
Sabine Brookman-May, Matthias May, Christian Gilfrich, Wolf Ferdinand Wieland & Maximilian Burger. (2010) Can vaccination or tyrosine kinase inhibitor therapy play a role in the adjuvant treatment of renal cell carcinoma?. Expert Review of Anticancer Therapy 10:6, pages 813-823.
Read now
Alejandro R Rodriguez & Mayer N Fishman. (2007) Growing opportunities for adjuvant therapy of renal cell carcinoma: targeted drugs and vaccines. Expert Opinion on Pharmacotherapy 8:17, pages 2979-2990.
Read now
John S Lam, Arie S Belldegrun & Robert A Figlin. (2006) Adjuvant treatment for renal cell carcinoma. Expert Opinion on Pharmacotherapy 7:6, pages 705-720.
Read now

Articles from other publishers (82)

Jonathan E. Leeman. (2023) Role of Radiation in Treatment of Renal Cell Carcinoma. Hematology/Oncology Clinics of North America 37:5, pages 921-924.
Crossref
Kendrick Yim & Jonathan E. Leeman. (2023) Radiation Therapy in the Treatment of Localized and Advanced Renal Cancer. Urologic Clinics of North America 50:2, pages 325-334.
Crossref
Yongqiang Huang, Hong Sun & Pu Guo. (2023) Research Progress of Tumor Microenvironment Targeted Therapy for Clear Cell Renal Cell Carcinoma. Cancer Control 30, pages 107327482311557.
Crossref
Laura MARANDINO, Chiara CICCARESE, Giulio FRANCOLINI, Daniele AMPARORE & Riccardo CAMPI. (2023) The role of stereotactic ablative body radiotherapy in renal cell carcinoma: focus on oligometastatic and oligoprogressive disease. Minerva Urology and Nephrology 75:2.
Crossref
Simon Kirste, Alexander Rühle, Stefan Zschiedrich, Wolfgang Schultze-Seemann, Cordula A. Jilg, Elke Neumann-Haefelin, Simon S. Lo, Anca-Ligia Grosu & Emily Kim. (2022) Stereotactic Body Radiotherapy for Renal Cell Carcinoma in Patients with Von Hippel–Lindau Disease—Results of a Prospective Trial. Cancers 14:20, pages 5069.
Crossref
Justin CohenMDMD, Gregory AlexanderMDMD & Mark V. MishraMDMD. 2022. Principles and Practice of Particle Therapy. Principles and Practice of Particle Therapy 411 423 .
Alec Sundet, Jodi McConnell, Kyle Walker & Bennie Lindeque. (2021) Intraoperative Cryotherapy in the Treatment of Metastatic Renal Cell Carcinoma of the Bone. Orthopedics 44:5.
Crossref
Maria Levitin, Joel Ofori, Woo Jae Shin, Jiayi Huang, Mackenzie Daly, Dengfeng Cao & Russell Pachynski. (2020) Radiation and Checkpoint Inhibitor Immunotherapy Lead to Long Term Disease Control in a Metastatic RCC patient With Brain Metastases. Frontiers in Oncology 10.
Crossref
Michael Dohopolski, Raquibul Hannan, Zabi Wardak, Hans Hammers & Aurelie Garant. (2020) The Reintroduction of Radiotherapy Into the Integrated Management of Kidney Cancer. The Cancer Journal 26:5, pages 448-459.
Crossref
Landon C. Brown, Tian Zhang & Daniel J. George. (2020) The Role of Targeted Therapy in the Management of High-Risk Resected Kidney Cancer. The Cancer Journal 26:5, pages 376-381.
Crossref
Joseph A. Miccio, Oluwadamilola T. Oladeru, Sung Jun Ma & Kimberly L. Johung. (2020) Radiation Therapy for Patients with Advanced Renal Cell Carcinoma. Urologic Clinics of North America 47:3, pages 399-411.
Crossref
Fadil Hassan, Shahid Lambe, Kiran Sharma & Anil Kapoor. 2020. Evolving Trends in Kidney Cancer. Evolving Trends in Kidney Cancer.
Junichi Inokuchi, Akira Yokomizo, Naotaka Nishiyama, Hiroshi Kitamura, Masatoshi Eto, Hiroyuki Nishiyama & Yoshihiko Tomita. (2020) Perioperative therapies for urological cancers. Japanese Journal of Clinical Oncology 50:4, pages 357-367.
Crossref
Alejandro Abello & Patrick A. Kenney. 2020. Renal Cancer. Renal Cancer 411 435 .
Alexander Rühle, Nicolaus Andratschke, Shankar Siva & Matthias Guckenberger. (2019) Is there a role for stereotactic radiotherapy in the treatment of renal cell carcinoma?. Clinical and Translational Radiation Oncology 18, pages 104-112.
Crossref
Camillo Porta, Laura Cosmai, Bradley C. Leibovich, Thomas Powles, Maurizio Gallieni & Axel Bex. (2019) The adjuvant treatment of kidney cancer: a multidisciplinary outlook. Nature Reviews Nephrology 15:7, pages 423-433.
Crossref
Iván A. Rodríguez-Fernández, Laura Rodríguez-Romo, David Hernandez-Barajas, Galileo A. Gonzalez-Conchas, Adrian Verdines-Perez, Arnoud J. Templeton, Alberto Ocana, Bostjan Seruga, Ian F. Tannock, Eitan Amir & Francisco E. Vera-Badillo. (2019) Adjuvant Radiation Therapy After Radical Nephrectomy in Patients with Localized Renal Cell Carcinoma: A Systematic Review and Meta-analysis. European Urology Oncology 2:4, pages 448-455.
Crossref
Yasuyoshi Okamura, Nobuyuki Hinata, Tomoaki Terakawa, Junya Furukawa, Kenichi Harada, Yuzo Nakano, Ichiro Nakamura, Takaaki Inoue, Takayoshi Ogawa & Masato Fujisawa. (2019) External validation of nomograms for prediction of progression-free survival and liver toxicity in patients with advanced renal cell carcinoma treated with pazopanib. International Journal of Clinical Oncology 24:6, pages 698-705.
Crossref
Nikolaos Tselis & Georgios Chatzikonstantinou. (2019) Treating the Chameleon: Radiotherapy in the management of Renal Cell Cancer. Clinical and Translational Radiation Oncology 16, pages 7-14.
Crossref
Rachel Choi & James B. Yu. (2019) Radiation Therapy for Renal Cell Carcinoma. Kidney Cancer 3:1, pages 1-6.
Crossref
Nicholas G. Zaorsky, Daniel M. Trifiletti & Katherine Tzou. 2019. Absolute Clinical Radiation Oncology Review. Absolute Clinical Radiation Oncology Review 313 359 .
James L. Liu, Mohamad E. Allaf & Michael A. Gorin. 2019. Diagnosis and Surgical Management of Renal Tumors. Diagnosis and Surgical Management of Renal Tumors 263 269 .
Osama Mohamad, Robert D. Timmerman & Raquibul Hannan. 2019. Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy. Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy 307 317 .
Won Kim, Mamta Parikh, Christopher Ryan & Primo Lara. (2018) Reconciling the Role of Vascular Endothelial Growth Factor-Targeted Therapies in Adjuvant Renal Cell Carcinoma Treatment. Kidney Cancer 2:2, pages 95-102.
Crossref
Francesca De Felice & Vincenzo Tombolini. (2018) Radiation therapy in renal cell carcinoma. Critical Reviews in Oncology/Hematology 128, pages 82-87.
Crossref
Sameer Jhavar, Gregory Swanson & Jessica Pruszynski. (2018) Risk factors for locoregional relapse after radical nephrectomy. Asia-Pacific Journal of Clinical Oncology 14:3, pages 192-197.
Crossref
Waqar Haque, Vivek Verma, Gary D Lewis, Simon S Lo, Edward Brian Butler & Bin S Teh. (2018) Utilization of radiotherapy and stereotactic body radiation therapy for renal cell cancer in the USA. Future Oncology 14:9, pages 819-827.
Crossref
R.A. Figlin, B.C. Leibovich, G.D. Stewart & S. Negrier. (2018) Adjuvant therapy in renal cell carcinoma: does higher risk for recurrence improve the chance for success?. Annals of Oncology 29:2, pages 324-331.
Crossref
Xiang-Rong Zhao, Guang-Lian Shan, Yong Zhang & Yong-Hua Yu. (2018) Hypofractionated postoperative irradiation in localized renal cell cancer. Journal of Cancer Research and Therapeutics 14:Suppl 1, pages S260-S262.
Crossref
Nikolaos Tselis & Georgios Chatzikonstantinou. 2018. Radiation Oncology. Radiation Oncology 1 14 .
Alfredo I. Urdaneta & Mitchell S. Anscher. 2018. Urothelial Malignancies of the Upper Urinary Tract. Urothelial Malignancies of the Upper Urinary Tract 323 336 .
Francesco Massari, Vincenzo Di Nunno, Chiara Ciccarese, Jeffrey Graham, Camillo Porta, Francesca Comito, Marta Cubelli, Roberto Iacovelli & Daniel Y.C. Heng. (2017) Adjuvant therapy in renal cell carcinoma. Cancer Treatment Reviews 60, pages 152-157.
Crossref
Shankar Siva, Gargi Kothari, Alexander Muacevic, Alexander V. Louie, Ben J. Slotman, Bin S. Teh & Simon S. Lo. (2017) Radiotherapy for renal cell carcinoma: renaissance of an overlooked approach. Nature Reviews Urology 14:9, pages 549-563.
Crossref
Anthony L. Zietman, Jonathan J. Paly & Jason A. Efstathiou. 2017. Clinical Radiation Oncology. Clinical Radiation Oncology 531 538 .
Natalia Dengina, Ilya Tsimafeyeu & Timur Mitin. (2017) Current Role of Radiotherapy for Renal-Cell Carcinoma: Review. Clinical Genitourinary Cancer 15:2, pages 183-187.
Crossref
Satoru Taguchi, Sebastiano Buti, Hiroshi Fukuhara, Masafumi Otsuka, Melissa Bersanelli, Teppei Morikawa, Hideyo Miyazaki, Tohru Nakagawa, Tetsuya Fujimura, Haruki Kume, Yasuhiko Igawa & Yukio Homma. (2017) Benefit of adjuvant immunotherapy in renal cell carcinoma: A myth or a reality?. PLOS ONE 12:2, pages e0172341.
Crossref
Reza Mehrazin, Che-Kai Tsao, John Sfakianos & Matthew D. Galsky. (2016) Systemic adjuvant therapy for renal cell carcinoma: Any hope for future clinical trials?. Urologic Oncology: Seminars and Original Investigations 34:5, pages 221-224.
Crossref
Jose A. Karam & Surena F. Matin. (2016) Positive Margins after Radical Nephrectomy with Venous Thrombectomy: Controversies and Treatment Options. Journal of Urology 195:2, pages 241-242.
Crossref
Anatoly Nikolaev & Rashmi Benda. (2016) Palliative Radiation Therapy for Symptomatic Control of Inoperable Renal Cell Carcinoma. Urology Case Reports 4, pages 51-52.
Crossref
William W. Wong, Jennifer L. Peterson, Winston W. Tan, Michael G. Haddock, Alexander S. Parker, Michael J. Wehle & Ryan C. Hutchinson. 2016. Clinical Radiation Oncology. Clinical Radiation Oncology 1139 1159.e5 .
Talha Shaikh, Elizabeth A. Handorf, Colin T. Murphy, Alexander Kutikov, Robert G. Uzzo, Mark Hallman, Eric M. Horwitz & Marc C. Smaldone. (2015) Contemporary Trends in the Utilization of Radiotherapy in Patients With Renal Cell Carcinoma. Urology 86:6, pages 1165-1173.
Crossref
Irving D. Kaplan, Anand Mahadevan & Andrew A. Wagner. 2015. Stereotactic Body Radiotherapy. Stereotactic Body Radiotherapy 225 232 .
Matthew J. Maurice, Gino J. Vricella & Lee E. Ponsky. 2013. Percutaneous Renal Surgery. Percutaneous Renal Surgery 276 270 .
Francesco Massari, Emilio Bria, Francesca Maines, Michele Milella, Diana Giannarelli, Francesco Cognetti, Giovanni Pappagallo, Giampaolo Tortora & Camillo Porta. (2013) Adjuvant Treatment for Resected Renal Cell Carcinoma: Are All Strategies Equally Negative? Potential Implications for Trial Design With Targeted Agents. Clinical Genitourinary Cancer 11:4, pages 471-476.
Crossref
Tobias Janowitz, Sarah J. Welsh, Kamarul Zaki, Peter Mulders & Tim Eisen. (2013) Adjuvant Therapy in Renal Cell Carcinoma—Past, Present, and Future. Seminars in Oncology 40:4, pages 482-491.
Crossref
Roberto Bortolus. (2013) Ruolo Della Radioterapia Nei Tumori Urologici Localmente Avanzati e/o Recidivati. Urologia Journal 80:3, pages 212-224.
Crossref
Reham Abdulmoniem, Tarek Haikal & Hossam Darwiesh. (2013) Is Post Operative Radiotherapy Justified for Completely Resected Locally Advanced Renal Cell Cancers?. Journal of Cancer Therapy 04:09, pages 1429-1434.
Crossref
Patrick A. Kenney & Christopher G. Wood. 2013. Renal Cancer. Renal Cancer 155 177 .
Ying Li, Gregory P. Swanson & Chul S. Ha. 2013. Image-Guided Cancer Therapy. Image-Guided Cancer Therapy 689 697 .
Shankar Siva, Daniel Pham, Suki Gill, Niall M. Corcoran & Farshad Foroudi. (2012) A systematic review of stereotactic radiotherapy ablation for primary renal cell carcinoma. BJU International 110:11b.
Crossref
Tanja Hüsch, Michael A. Reiter, Rene Mager, Martin Kurosch & Axel Haferkamp. (2012) Treatment of Locally Advanced Renal Cell Carcinoma. European Urology Supplements 11:3, pages 66-72.
Crossref
Patrick A. Kenney & Christopher G. Wood. (2012) Integration of Surgery and Systemic Therapy for Renal Cell Carcinoma. Urologic Clinics of North America 39:2, pages 211-231.
Crossref
Alessandro Sciarra, Susanna Cattarino, Stefano Salciccia, Andrea Alfarone, Alessandro Gentilucci, Ulderico Parente, Gianna Mariotti, Michele Innocenzi & Vincenzo Gentile. (2012) The emerging role of targeted therapy in renal cell carcinoma (RCC): Is it time for a neoadjuvant or an adjuvant approach?. Critical Reviews in Oncology/Hematology 81:2, pages 151-162.
Crossref
In-Chang ChoJinsoo Chung. (2012) Current Status of Targeted Therapy for Advanced Renal Cell Carcinoma. Korean Journal of Urology 53:4, pages 217.
Crossref
Lee E. Ponsky & Gino Vricella. 2012. Robotic Radiosurgery. Treating Prostate Cancer and Related Genitourinary Applications. Robotic Radiosurgery. Treating Prostate Cancer and Related Genitourinary Applications 179 184 .
Bin S. Teh, Hiromichi Ishiyama, Angel I. Blanco, Lee E. Ponsky, Simon S. Lo, Bo Xu, E. Brian Butler, Robert J. Amato & Rodney J. Ellis. 2012. Stereotactic Body Radiation Therapy. Stereotactic Body Radiation Therapy 197 209 .
Angel I. Blanco, Bin S. Teh & Robert J. Amato. (2011) Role of Radiation Therapy in the Management of Renal Cell Cancer. Cancers 3:4, pages 4010-4023.
Crossref
Eric A Singer, Gopal N Gupta & Ramaprasad Srinivasan. (2011) Update on targeted therapies for clear cell renal cell carcinoma. Current Opinion in Oncology 23:3, pages 283-289.
Crossref
M.A. Tunio, A. Hashmi & M. Rafi. (2010) Need for a new trial to evaluate postoperative radiotherapy in renal cell carcinoma: a meta-analysis of randomized controlled trials. Annals of Oncology 21:9, pages 1839-1845.
Crossref
Thean Hsiang TAN, Ganesalingam PRANAVAN, Hodo Z HAXHIMOLLA & Desmond YIP. (2010) New systemic treatment options for metastatic renal-cell carcinoma in the era of targeted therapies. Asia-Pacific Journal of Clinical Oncology 6:1, pages 5-18.
Crossref
Gino J. Vricella, Nicholas A. Boncher & Lee E. Ponsky. (2010) Extracorporeal Stereotactic Radiosurgery for Small Renal Masses. Current Urology Reports 11:1, pages 33-37.
Crossref
David M. Hartke & Lee E. Ponsky. 2010. New Technologies in Urology. New Technologies in Urology 155 159 .
Joaquim Bellmunt, Emiliano Calvo, Daniel Castellano, Miguel Ángel Climent, Emilio Esteban, Xavier García del Muro, José Luis González-Larriba, Pablo Maroto & José Manuel Trigo. (2009) Recommendations from the Spanish Oncology Genitourinary Group for the treatment of metastatic renal cancer. Cancer Chemotherapy and Pharmacology 63:S1, pages 1-13.
Crossref
Vitaly Margulis, Surena F. Matin, Nizar Tannir, Pheroze Tamboli, Yu Shen, Marisa Lozano, David A. Swanson, Eric Jonasch & Christopher G. Wood. (2009) Randomized Trial of Adjuvant Thalidomide Versus Observation in Patients With Completely Resected High-Risk Renal Cell Carcinoma. Urology 73:2, pages 337-341.
Crossref
Naomi B. Haas & Robert Uzzo. (2008) Adjuvant therapy for renal cell carcinoma. Current Oncology Reports 10:3, pages 245-252.
Crossref
Shen Fu. 2008. Radiation Oncology. Radiation Oncology 271 282 .
Brant A. Inman & Bradley C. Leibovich. 2008. Renal Cell Cancer. Renal Cell Cancer 515 534 .
R. Longo, M.R. D'Andrea, R. Sarmiento, F. Salerno & G. Gasparini. (2007) Integrated therapy of kidney cancer. Annals of Oncology 18, pages vi141-vi148.
Crossref
Eric C. Nelson, Christopher P. Evans & Primo N. LaraJr.Jr.. (2007) Renal cell carcinoma: Current status and emerging therapies. Cancer Treatment Reviews 33:3, pages 299-313.
Crossref
Tim Eisen. (2007) Adjuvant Therapy in Renal Cell Carcinoma: Where Are We?. European Urology Supplements 6:7, pages 492-498.
Crossref
Tai Lahans. 2007. Integrating Conventional and Chinese Medicine in Cancer Care. Integrating Conventional and Chinese Medicine in Cancer Care 215 228 .
David A. Kunkle, Naomi B. Haas & Robert G. Uzzo. (2007) Adjuvant therapy for high-risk renal cell carcinoma patients. Current Urology Reports 8:1, pages 19-30.
Crossref
Timothy A. Yap & Tim G. Eisen. (2006) Adjuvant Therapy of Renal Cell Carcinoma. Clinical Genitourinary Cancer 5:2, pages 120-130.
Crossref
John S. Lam, John T. Leppert, Arie S. Belldegrun & Robert A. Figlin. (2005) Adjuvant therapy of renal cell carcinoma: patient selection and therapeutic options. BJU International 96:4, pages 483-488.
Crossref
Jonathan J. Beitler, Denise Makara, Phillip Silverman & Gil Lederman. (2004) Definitive, High-Dose-Per-Fraction, Conformal, Stereotactic External Radiation for Renal Cell Carcinoma. American Journal of Clinical Oncology 27:6, pages 646-648.
Crossref
Hyung L. Kim, John S. Lam & Arie S. Belldegrun. (2004) The role of lymphadenectomy in renal cell carcinoma. Current Urology Reports 5:1, pages 25-29.
Crossref
Chris Coppin & Franz Porzsolt. 2003. Evidence‐based Oncology. Evidence‐based Oncology 333 345 .
Eliahu Gez, Michael Libes, Raquel Bar-Deroma, Rafael Rubinov, Moshe Stein & Abraham Kuten. (2018) Postoperative Irradiation in Localized Renal Cell Carcinoma: The Rambam Medical Center Experience. Tumori Journal 88:6, pages 500-502.
Crossref
Ibrahim Aref, R.Gregory Bociek & Douglas Salhani. (1997) Is post-operative radiation for renal cell carcinoma justified?. Radiotherapy and Oncology 43:2, pages 155-157.
Crossref
Steven C. Campbell & Andrew C. Novick. (1994) MANAGEMENT OF LOCAL RECURRENCE FOLLOWING RADICAL NEPHRECTOMY OR PARTIAL NEPHRECTOMY. Urologic Clinics of North America 21:4, pages 593-599.
Crossref
M. Goepel & T. Otto. 1993. Immuntherapie in der Uroonkologie. Immuntherapie in der Uroonkologie 326 336 .
Moshe Stein, Abraham Kuten, Joshua Halpern, Noreen M. Coachman, Yoram Cohen & Eliezer Robinson. (1992) The value of postoperative irradiation in renal cell cancer. Radiotherapy and Oncology 24:1, pages 41-44.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.