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Scandinavian Journal of Urology and Nephrology Volume 27, 1993 - Issue 1
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Original Article

Doxazosin Treatment in Patients with Prostatic Obstruction

A Double-Blind Placebo-Controlled Study

Mads Mark ChristensenDepartment of Surgery K and Clinical Physiological Department, Randers Central Hospital and the Department of Surgery I, Aarhus County Hospital, Denmark
,
Jørgen Bendix HolmeDepartment of Surgery K and Clinical Physiological Department, Randers Central Hospital and the Department of Surgery I, Aarhus County Hospital, Denmark
,
Peter Christian RasmussenDepartment of Surgery K and Clinical Physiological Department, Randers Central Hospital and the Department of Surgery I, Aarhus County Hospital, Denmark
,
Flemming JacobsenDepartment of Surgery K and Clinical Physiological Department, Randers Central Hospital and the Department of Surgery I, Aarhus County Hospital, Denmark
,
Jørn NielsenDepartment of Surgery K and Clinical Physiological Department, Randers Central Hospital and the Department of Surgery I, Aarhus County Hospital, Denmark
,
Jens Peter NørgaardDepartment of Surgery K and Clinical Physiological Department, Randers Central Hospital and the Department of Surgery I, Aarhus County Hospital, Denmark
,
Sigurd OlesenDepartment of Surgery K and Clinical Physiological Department, Randers Central Hospital and the Department of Surgery I, Aarhus County Hospital, Denmark
,
Ivan NoerDepartment of Surgery K and Clinical Physiological Department, Randers Central Hospital and the Department of Surgery I, Aarhus County Hospital, Denmark
,
Hans WolfDepartment of Surgery K and Clinical Physiological Department, Randers Central Hospital and the Department of Surgery I, Aarhus County Hospital, Denmark
&
Steen Elkjær HustedDepartment of Surgery K and Clinical Physiological Department, Randers Central Hospital and the Department of Surgery I, Aarhus County Hospital, Denmark
 show all
Pages 39-44 | Received 07 Sep 1991, Accepted 27 Mar 1992, Published online: 15 Feb 2010

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Jeetesh Bhardwa, Miles Goldstraw, Sevasti Tzortzis & Roger Kirby. (2007) Finasteride and doxazosin alone or in combination for the treatment of benign prostatic hyperplasia. Expert Opinion on Pharmacotherapy 8:9, pages 1337-1344.
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Timothy J Wilt & Roderick MacDonald. (2006) Doxazosin in the treatment of benign prostatic hypertrophy: an update. Clinical Interventions in Aging 1:4, pages 389-401.
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Sheila A Doggrell. (2004) After ALLHAT: doxazosin for the treatment of benign prostatic hyperplasia. Expert Opinion on Pharmacotherapy 5:9, pages 1957-1964.
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PER LUND-JOHANSEN & ROGER S. KIRBY. (2003) Effect of Doxazosin GITS on Blood Pressure in Hypertensive and Normotensive Patients: A Review of Hypertension and BPH Studies. Blood Pressure 12:sup1, pages 5-13.
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Jørgen Bendix Holme, Mads Mark Christensen, Peter Christian Rasmussen, Flemming Jacobsen, Jørn Nielsen, Jens Peter Nørgaard, Sigurd Olesen, Ivan Noer, Hans Wolf & Steen Elkjær Husted. (1994) 29-Week Doxazosin Treatment in Patients with Symptomatic Benign Prostatic Hyperplasia. Scandinavian Journal of Urology and Nephrology 28:1, pages 77-82.
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Articles from other publishers (40)

. (2019) Harninkontinenz bei geriatrischen Patienten, Diagnostik und Therapie. Aktuelle Urologie 50:S 01, pages s11-s59.
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Xinghuan Wang, Xiao Wang, Sheng Li, Zhe Meng, Tao Liu & Xinhua Zhang. (2014) Comparative Effectiveness of Oral Drug Therapies for Lower Urinary Tract Symptoms due to Benign Prostatic Hyperplasia: A Systematic Review and Network Meta-Analysis. PLoS ONE 9:9, pages e107593.
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J. C. Nickel, S. Sander & T. D. Moon. (2008) A meta-analysis of the vascular-related safety profile and efficacy of α-adrenergic blockers for symptoms related to benign prostatic hyperplasia. International Journal of Clinical Practice 62:10, pages 1547-1559.
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Luis Zegarra, Abraham Vaisberg, Cesar Loza, Roxana L. Aguirre, Miguel Campos, Irma Fernandez, Oscar Talla & Leon Villegas. (2007) Double-blind randomized placebo-controlled study of bixa orellana in patients with lower urinary tract symptoms associated to benign prostatic hyperplasia. International braz j urol 33:4, pages 493-501.
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Zhaoying Xue, Yuanfang Zhang, Qiang Ding, Zhishong He, Jiangong Wang & Ke Xu. (2007) Doxazosin gastrointestinal therapeutic system versus tamsulosin for the treatment of benign prostatic hyperplasia: A study in Chinese patients. International Journal of Urology 14:2, pages 118-122.
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Atif Awad & Peter Bradford. 2005. Nutrition and Cancer Prevention. Nutrition and Cancer Prevention.
Rosebud O. Roberts, Michael M. Lieber, Debra J. Jacobson, Cynthia J. Girman & Steven J. Jacobsen. (2005) Limitations of Using Outcomes in the Placebo Arm of a Clinical Trial of Benign Prostatic Hyperplasia to Quantify Those in the Community. Mayo Clinic Proceedings 80:6, pages 759-764.
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Shirin Milani & Bob Djavan. (2005) Lower urinary tract symptoms suggestive of benign prostatic hyperplasia: latest update on alpha1-adrenoceptor antagonists. BJU International 95:s4, pages 29-36.
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Roderick MacDonald, Timothy J. Wilt & R. William Howe. (2004) Doxazosin for treating lower urinary tract symptoms compatible with benign prostatic obstruction: a systematic review of efficacy and adverse effects. BJU International 94:9, pages 1263-1270.
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Bob Djavan, Chris Chapple, Shirin Milani & Michael Marberger. (2004) State of the art on the efficacy and tolerability of alpha1-adrenoceptor antagonists in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Urology 64:6, pages 1081-1088.
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Bob Djavan. (2004) α1-Adenoceptor Antagonists for the Treatment of Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia (LUTS/BPH): State of the Art. European Urology Supplements 3:4, pages 23-30.
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R.S. Kirby, S. Quinn, S. Mallen & D. Jensen. (2004) Doxazosin controlled release vs tamsulosin in the management of benign prostatic hyperplasia: an efficacy analysis. International Journal of Clinical Practice 58:1, pages 6-10.
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R.S. Kirby. (2003) A randomized, double-blind crossover study of tamsulosin and controlled-release doxazosin in patients with benign prostatic hyperplasia. BJU International 91:1, pages 41-44.
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Roger S Kirby, Claus Roehrborn, Peter Boyle, Georg Bartsch, Alain Jardin, Margaret M Cary, Michael Sweeney & Eric B Grossman. (2003) Efficacy and tolerability of doxazosin and finasteride, alone or in combination, in treatment of symptomatic benign prostatic hyperplasia: the Prospective European Doxazosin and Combination Therapy (PREDICT) trial. Urology 61:1, pages 119-126.
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R. Berges. 2002. Pharmakotherapie in der Urologie. Pharmakotherapie in der Urologie 269 284 .
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K. Höfner. 2000. Klinische Geriatrie. Klinische Geriatrie 666 684 .
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Robert M. Guthrie & Richard L. Siegel. (1999) A multicenter, community-based study of doxazosin in the treatment of concomitant hypertension and symptomatic benign prostatic hyperplasia: the hypertension and BPH intervention trial (HABIT). Clinical Therapeutics 21:10, pages 1732-1748.
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Ahmed Fawzy, Angela Hendry, Eileen Cook & Francisco Gonzalez. (2002) Long‐term (4 year) efficacy and tolerability of doxazosin for the treatment of concurrent benign prostatic hyperplasia and hypertension. International Journal of Urology 6:7, pages 346-354.
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Ahmed Fawzy, Vijay Vashi, Menger Chung, Norma Dias & Michael Gaffney. (1999) Clinical correlation of maximal urinary flow rate and plasma doxazosin concentrations in the treatment of benign prostatic hyperplasia. Urology 53:2, pages 329-335.
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Vijay Vashi, Menger Chung, James Hilbert, Victor Lawrence & Kern Phillips. (2013) Pharmacokinetic Interaction between Finasteride and Terazosin, but not Finasteride and Doxazosin. The Journal of Clinical Pharmacology 38:11, pages 1072-1076.
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Mario C Beduschi, Ricardo Beduschi & Joseph E Oesterling. (1998) Alpha-Blockade Therapy for Benign Prostatic Hyperplasia: from a Nonselective to a More Selective Alpha1A-Adrenergic Antagonist. Urology 51:6, pages 861-872.
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RS Kirby. (1998) MORNING VERSUS EVENING DOSING WITH DOXAZOSIN IN BENIGN PROSTATIC HYPERPLASIA: PHARMACOKINETICS, EFFICACY AND SAFETY. International Journal of Clinical Practice 52:2, pages 75-77.
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Chapple. (1998) Pharmacotherapy for benign prostatic hyperplasia - the potential for α 1 -adrenoceptor subtype-specific blockade . British Journal of Urology 81:S1, pages 34-47.
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Scott M. Sech, Juan D. Montoya, Pablo A. Bernier, Emma Barnboym, Sherril Brown, Allison Gregory & Claus G. Roehrborn. (1998) The so-called “placebo effect” in benign prostatic hyperplasia treatment trials represents partially a conditional regression to the mean induced by censoring. Urology 51:2, pages 242-250.
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Claus G. Roehrborn, Joseph E. Oesterling, Peggy J. Olson & Robert J. Padley. (1997) Serial prostate-specific antigen measurements in men with clinically benign prostatic hyperplasia during a 12-month placebo-controlled study with terazosin. Urology 50:4, pages 556-561.
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Steven A. Kaplan & Norman M. Kaplan. (1996) Alpha-blockade: Monotherapy for hypertension and benign prostatic hyperplasia. Urology 48:4, pages 541-550.
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JL Pool. (1996) DOXAZOSIN: A NEW APPROACH TO HYPERTENSION AND BENIGN PROSTATIC HYPERPLASIA. International Journal of Clinical Practice 50:3, pages 154-163.
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Claus G. Roehrborn, Joseph E. Oesterling, Stephen Auerbach, Stephen A. Kaplan, L. Keith Lloyd, Douglas F. Milam & Robert J. Padley. (1996) The hytrin community assessment trial study: A one-year study of terazosin versus placebo in the treatment of men with symptomatic benign prostatic hyperplasia. Urology 47:2, pages 159-168.
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Andrew G. Ramage & Michael G. Wyllie. (1995) A comparison of the effects of doxazosin and terazosin on the spontaneous sympathetic drive to the bladder and related organs in anaesthetized cats. European Journal of Pharmacology 294:2-3, pages 645-650.
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Roger S. Kirby. (1995) Doxazosin in benign prostatic hyperplasia: Effects on blood pressure and urinary flow in normotensive and hypertensive men. Urology 46:2, pages 182-186.
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Jay Y. GillenwaterRichard L. ConnSteven G. ChrysantJohnny RoyMichael GaffneyKathleen IceNorma Dias. (1995) Doxazosin for the Treatment of Benign Prostatic Hyperplasia in Patients with Mild to Moderate Essential Hypertension: A Double-Blind, Placebo-Controlled, Dose-Response Multicenter Study. Journal of Urology 154:1, pages 110-115.
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R.R. Berges, J. Windeler, H.J. Trampisch, Th Senge & β-sitosterol study group. (1995) Randomised, placebo-controlled, double-blind clinical trial of β-sitosterol in patients with benign prostatic hyperplasia. The Lancet 345:8964, pages 1529-1532.
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Joseph E. Oesterling. (1995) Benign Prostatic Hyperplasia — Medical and Minimally Invasive Treatment Options. New England Journal of Medicine 332:2, pages 99-110.
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Rudolf Foglar, Katsushi Shibata, Kuniko Horie, Akira Hirasawa & Gozoh Tsujimoto. (1995) Use of recombinant α1-adrenoceptors to characterize subtype selectivity of drugs for the treatment of prostatic hypertrophy. European Journal of Pharmacology: Molecular Pharmacology 288:2, pages 201-207.
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Steven A. Kaplan, Katherine A. Soldo & Carl A. Olsson. (1994) Effect of dosing regimen on efficacy and safety of doxazosin in normotensive men with symptomatic prostatism: A pilot study. Urology 44:3, pages 348-352.
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Arie T. J. Lavrijssen & Peter W. De Leeuw. 1994. Hypertension in the Elderly. Hypertension in the Elderly 51 69 .

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