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Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 12
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Original

CYP3A4 and CYP3A5 catalyse the conversion of the N-methyl-D-aspartate (NMDA) antagonist CJ-036878 to two novel dimers

C. Emoto Department of Pharmacokinetics Dynamics Metabolism
,
H. Nishida Department of Medicinal Chemistry Technologies, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan, Inc., Taketoyo, Aichi, Japan
,
H. Hirai Department of Medicinal Chemistry Technologies, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan, Inc., Taketoyo, Aichi, Japan
&
K. Iwasaki Department of Pharmacokinetics Dynamics MetabolismCorrespondence[email protected]
Pages 1408-1420 | Received 30 Jul 2007, Accepted 31 Aug 2007, Published online: 12 Jul 2010

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Heng-Keang Lim, Min Yang, Wing Lam, Fran Xu, Jie Chen, Yaodong Xu, H. Umesha Shetty, Ke Yang, Jose Silva & David C. Evans. (2012) Free radical metabolism of raloxifene in human liver microsomes. Xenobiotica 42:8, pages 737-747.
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Articles from other publishers (3)

Ryan H. Takahashi, Jessica M. Grandner, Sudheer Bobba, Yanzhou Liu, Paul Beroza, Donglu Zhang & Shuguang Ma. (2020) Novel Homodimer Metabolites of GDC-0994 via Cytochrome P450–Catalyzed Radical Coupling. Drug Metabolism and Disposition 48:6, pages 521-527.
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Alexander V. LyubimovF. Peter Guengerich. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 23 .
Toshiro Niwa, Norie Murayama & Hiroshi Yamazaki. (2010) Comparison of the Contributions of Cytochromes P450 3A4 and 3A5 in Drug Oxidation Rates and Substrate Inhibition. Journal of Health Science 56:3, pages 239-256.
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