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Xenobiotica
the fate of foreign compounds in biological systems
Volume 40, 2010 - Issue 5
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Topics in Xenobiochemistry

Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives

Pages 357-367 | Received 03 Jan 2010, Accepted 29 Jan 2010, Published online: 15 Mar 2010

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Bao Zheng, Xiwei Zhou, Lujun Pang, Yanjun Che & Xin Qi. (2021) Baicalin suppresses autophagy-dependent ferroptosis in early brain injury after subarachnoid hemorrhage. Bioengineered 12:1, pages 7794-7804.
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Hyung-Ip Kim, Ji-Ae Kim, Eun-Jin Choi, Jason B. Harris, Seong-Yeop Jeong, Seok-Jun Son, Younghoon Kim & Ok Sarah Shin. (2015) In vitro and in vivo antimicrobial efficacy of natural plant-derived compounds against Vibrio cholerae of O1 El Tor Inaba serotype. Bioscience, Biotechnology, and Biochemistry 79:3, pages 475-483.
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Yumeng Wei, Jianmin Guo, Xiaoli Zheng, Jun Wu, Yang Zhou, Yu Yu, Yun Ye, Liangke Zhang & Ling Zhao. (2014) Preparation, pharmacokinetics and biodistribution of baicalin-loaded liposomes. International Journal of Nanomedicine 9, pages 3623-3630.
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Sung Jae Yang, Hyoung Jo, June-Gone Kim & Sang Hoon Jung. (2014) Baicalin Attenuates Laser-Induced Choroidal Neovascularization. Current Eye Research 39:7, pages 745-751.
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Ling Zhao, Yumeng Wei, Yu Huang, Bing He, Yang Zhou & Junjiang Fu. (2013) Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation. International Journal of Nanomedicine 8, pages 3769-3779.
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Nikolaus J Sucher. (2013) The application of Chinese medicine to novel drug discovery. Expert Opinion on Drug Discovery 8:1, pages 21-34.
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Articles from other publishers (89)

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Shuai Yan, Yahui Wang, Yunhui Gu, Mingyue Zhou, Lianlin Su, Tianpeng Yin, Wei Zhang & Yinzi Yue. (2023) Baicalin suppresses colorectal cancer cell proliferation, potentially via ARRDC4: Bioinformatics and experimental analysis. Arabian Journal of Chemistry 16:10, pages 105141.
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Xin Liu, Wei Niu, Jiamin Liu, Zhao Cui, Jiazheng Li, Zhenhai Zhang & Jianming Ju. (2023) Preparation of β-cyclodextrin and hydroxypropyl-β-cyclodextrin inclusion complexes of baicalein and evaluation of their effects on dextran sulfate sodium-induced acute ulcerative colitis in mice. Journal of Drug Delivery Science and Technology 87, pages 104714.
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Dongli Qi, Bei Jia, Hui Peng, Jiachen He, Jiaxin Pi, Pan Guo, Ying Zhang, Xiuping Deng, Jiawei Li & Zhidong Liu. (2023) Baicalin/ambroxol hydrochloride combined dry powder inhalation formulation targeting lung delivery for treatment of idiopathic pulmonary fibrosis: Fabrication, characterization, pharmacokinetics, and pharmacodynamics. European Journal of Pharmaceutics and Biopharmaceutics 188, pages 243-253.
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Haizhou Liu, Hui Liu, Zhiyi Zhou, Jessica Chung, Guojing Zhang, Jin Chang, Robert A. Parise, Edward Chu & John C. Schmitz. (2023) Scutellaria baicalensis enhances 5-fluorouracil-based chemotherapy via inhibition of proliferative signaling pathways. Cell Communication and Signaling 21:1.
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Renhong Wan, Yue Ji, Yihua Fan, Chen Yang, Hong Yang, Xiaoping Gou, Xinyuan Zhang & Wei Liu. (2023) Efficacy and safety of Duhuo Jisheng decoction combined with Western medicine in the treatment of ankylosing spondylitis: A systematic review and meta-analysis. Complementary Therapies in Clinical Practice 51, pages 101739.
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Syeda Nashvia Adin, Isha Gupta, Mohd. Aqil & Mohd. Mujeeb. (2023) Baicalin loaded transethosomes for rheumatoid arthritis: Development, characterization, pharmacokinetic and pharmacodynamic evaluation. Journal of Drug Delivery Science and Technology 81, pages 104209.
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Na Li, Yanhong Wang, Anqing Wang, Jing Zhang, Chaoran Jia, Chunlei Yu, Zhenbo Song, Shuyue Wang, Lei Liu, Jingwen Yi, Yongli Bao, Yanxin Huang & Luguo Sun. (2023) STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression. International Journal of Molecular Sciences 24:3, pages 2987.
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Zhuo-yuan Wang, Ming-zhe Li, Wen-jie Li, Jing-feng Ouyang, Xiao-jun Gou & Ying Huang. (2023) Mechanism of action of Daqinjiao decoction in treating cerebral small vessel disease explored using network pharmacology and molecular docking technology. Phytomedicine 108, pages 154538.
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Xu Li, Jian Liu, Yanyan Fang, Dan Huang, Mingyu He, Fanfan Wang & Qi Han. (2022) Potential Therapeutic Mechanism of Scutellaria baicalensis Georgi against Ankylosing Spondylitis Based on a Comprehensive Pharmacological Model. BioMed Research International 2022, pages 1-14.
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Jiafeng Li, Huixin Liu, Qiwang Lin, Huajiao Chen, Liya Liu, Hongjuan Liao, Ying Cheng, Xiuli Zhang, Zhenlong Wang, Aling Shen & Guolong Chen. (2022) Baicalin suppresses the migration and invasion of breast cancer cells via the TGF-β/lncRNA-MALAT1/miR-200c signaling pathway. Medicine 101:46, pages e29328.
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Muhammad Umar Ijaz, Sabahat Shahzadi, Asma Ashraf, Shahid Mahboob, K.A. Al-Ghanim, Mian N. Riaz, F. Al-Misned & Salma Sultana. (2022) Protective effect of baicalin on methotrexate-induced mitochondrial damage in testicular tissues of rats. Journal of King Saud University - Science 34:8, pages 102343.
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Ali Ahmadi, Zoha Mortazavi, Soghra Mehri & Hossein Hosseinzadeh. (2022) Scutellaria baicalensis and its constituents baicalin and baicalein as antidotes or protective agents against chemical toxicities: a comprehensive review. Naunyn-Schmiedeberg's Archives of Pharmacology 395:11, pages 1297-1329.
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Xin Zhang. (2022) Exploration of Gancao Xiexin decoction for treatment of Behcet disease based on network pharmacology and molecular docking. Medicine 101:42, pages e31277.
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Chenxiang Wang, Yibin Sun, Wenjing Liu, Yang Liu, Sualiha Afzal, Jahnavi Grover, Dennis Chang, Gerald Münch, Chun Guang Li, Shiling Lin, Jianyu Chen, Yiping Zhang, Zaixing Cheng, Yanxiang Lin, Yanfang Zheng, Mingqing Huang & Xian Zhou. (2022) Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy. Frontiers in Endocrinology 13.
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Ali Ahmadi, Zoha Mortazavi, Soghra Mehri & Hossein Hosseinzadeh. (2022) Protective and therapeutic effects of Scutellaria baicalensis and its main active ingredients baicalin and baicalein against natural toxicities and physical hazards: a review of mechanisms. DARU Journal of Pharmaceutical Sciences 30:2, pages 351-366.
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Alaa Ibrahim, Maha Nasr & Ibrahim M. El-Sherbiny. (2022) Baicalin as an emerging magical nutraceutical molecule: Emphasis on pharmacological properties and advances in pharmaceutical delivery. Journal of Drug Delivery Science and Technology 70, pages 103269.
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Ruo-Song AiKun XingXin DengJuan-Juan HanDong-Xia HaoWen-Hui QiBing HanYa-Na YangXing LiYuan Zhang. (2022) Baicalin Promotes CNS Remyelination via PPARγ Signal Pathway. Neurology Neuroimmunology & Neuroinflammation 9:2.
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Xiaolei Zheng, Ping Wang, Mengqi Jia, Qing Li, Anna Zhang & Qingbo Zhou. (2022) Baicalin Alleviates Thrombin-Induced Inflammation in Vascular Smooth Muscle Cells. BioMed Research International 2022, pages 1-10.
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舒文 罗. (2022) Exploring the Mechanism of Action of Scutellaria baicalensis-Huanglian in the Treatment of Atherosclerosis Based on Network Pharmacology. Advances in Clinical Medicine 12:05, pages 4154-4165.
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Jiří Patočka, Zdeňka Navrátilová, Kamil Kuča, Patrik Olekšák & Uday Kumar Killi. (2021) CAN BAICALEIN BECOME A NEW DRUG FOR COVID-19?. Military Medical Science Letters 90:4, pages 198-207.
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Jia-jia Li, Qing Liang & Guang-chun Sun. (2021) Traditional Chinese medicine for prevention and treatment of hepatocellular carcinoma: A focus on epithelial-mesenchymal transition. Journal of Integrative Medicine 19:6, pages 469-477.
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Samar A Rizk, Manal A Elsheikh, Yosra S R Elnaggar & Ossama Y Abdallah. (2021) Novel bioemulsomes for baicalin oral lymphatic targeting: development, optimization and pharmacokinetics. Nanomedicine 16:22, pages 1983-1998.
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Yu Liu, Xiaoyi Li, Zhaoran Zhang, Jiacheng Zhang, Jianfeng Xu, Yinsheng Qiu, Chun Ye, Shulin Fu, Zhongyuan Wu & Chien-An Andy Hu. (2021) Baicalin Protects Vascular Tight Junctions in Piglets During Glaesserella parasuis Infection. Frontiers in Veterinary Science 8.
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Yasuko Yoshioka, Yayoi Kamata, Mitsutoshi Tominaga, Yoshie Umehara, Ikuyo Yoshida, Nobuya Matsuoka & Kenji Takamori. (2021) Extract of Scutellaria baicalensis induces semaphorin 3A production in human epidermal keratinocytes. PLOS ONE 16:4, pages e0250663.
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Laiyun Xin, Jialiang Gao, Hongchen Lin, Yi Qu, Chang Shang, Yuling Wang, Yingdong Lu & Xiangning Cui. (2020) Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review. Frontiers in Pharmacology 11.
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Li Qiao, Maosen Han, Shijie Gao, Xinxin Shao, Xiaoming Wang, Linlin Sun, Xianjun Fu & Qingcong Wei. (2020) Research progress on nanotechnology for delivery of active ingredients from traditional Chinese medicines. Journal of Materials Chemistry B 8:30, pages 6333-6351.
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Yaqing Zhang, Mei Zhang, Guangnan Hu, Zunjian Zhang & Rui Song. (2020) Elevated system exposures of baicalin after combinatory oral administration of rhein and baicalin: Mainly related to breast cancer resistance protein (ABCG2), not UDP-glucuronosyltransferases. Journal of Ethnopharmacology 250, pages 112528.
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Jin Liu, Yinglin Yuan, Xia Gong, Liangke Zhang, Qin Zhou, Shengwang Wu, Xue Zhang, Jun Hu, Ge Kuang, Xinru Yin, Jingyuan Wan & Yonghua Yuan. (2020) Baicalin and its nanoliposomes ameliorates nonalcoholic fatty liver disease via suppression of TLR4 signaling cascade in mice. International Immunopharmacology 80, pages 106208.
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Jing Wang, Wuwen Feng, Fei Tang, Hui Ao & Cheng Peng. (2019) Gut microbial transformation, a potential improving factor in the therapeutic activities of four groups of natural compounds isolated from herbal medicines. Fitoterapia 138, pages 104293.
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Yu Liu, Wenhua Zhao, Jianfeng Xu, Xiaolin Yu, Chun Ye, Shulin Fu & Yinsheng Qiu. (2019) Pharmacokinetics of sodium baicalin following intravenous and intramuscular administration to piglets. Journal of Veterinary Pharmacology and Therapeutics 42:5, pages 580-584.
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Riham I. El-Gogary, Sara A. Abdel Gaber & Maha Nasr. (2019) Polymeric nanocapsular baicalin: Chemometric optimization, physicochemical characterization and mechanistic anticancer approaches on breast cancer cell lines. Scientific Reports 9:1.
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Nuggehally R Srinivas. (2019) Combination of flavonoids with azole drugs for fungal infections: key pharmacokinetic challenges. Future Microbiology 14:9, pages 733-738.
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Cahit Muderrisoglu & Ozlem Yesil-Celiktas. (2019) High-Yield Biocatalysis of Baicalein 7-O-β-d-Glucuronide to Baicalein Using Soluble Helix pomatia-Derived β-Glucuronidase in a Chemically Defined Acidic Medium. Catalysis Letters 149:6, pages 1701-1709.
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Silvia Mir-Palomo, Amparo Nácher, M.A. Ofelia Vila Busó, Carla Caddeo, Maria Letizia Manca, Maria Manconi & Octavio Díez-Sales. (2019) Baicalin and berberine ultradeformable vesicles as potential adjuvant in vitiligo therapy. Colloids and Surfaces B: Biointerfaces 175, pages 654-662.
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Wenjuan Guo, Jie Yu, Zhao Dai & Weizhao Hou. (2019) A New Method for Enriching baicalin in Scutellaria baicalensis Georgi by Metal Organic Framework Material ZIF-8. Acta Chimica Sinica 77:11, pages 1203.
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Gen Chen, Xiangjuan Chen, Chao Niu, Xiaozhong Huang, Ning An, Jia Sun, Shuai Huang, Weijian Ye, Santie Li, Yingjie Shen, Jiaojiao Liang, Weitao Cong & Litai Jin. (2019) Baicalin alleviates hyperglycemia-induced endothelial impairment via Nrf2. Journal of Endocrinology 240:1, pages 81-98.
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Peng Xu, Hua Zhou, Ya-Zhuo Li, Zhong-Wen Yuan, Chang-Xiao Liu, Liang Liu & Ying Xie. (2018) Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2. Frontiers in Pharmacology 9.
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Berenice Fernández-Rojas & Gloria Gutiérrez-Venegas. (2018) Flavonoids exert multiple periodontic benefits including anti-inflammatory, periodontal ligament-supporting, and alveolar bone-preserving effects. Life Sciences 209, pages 435-454.
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Yaqing Zhang, Zunjian Zhang & Rui Song. (2017) The Influence of Compatibility of Rhubarb and Radix Scutellariae on the Pharmacokinetics of Anthraquinones and Flavonoids in Rat Plasma. European Journal of Drug Metabolism and Pharmacokinetics 43:3, pages 291-300.
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Liang Shi, Zhanxia Hao, Shaobo Zhang, Mengjuan Wei, Bin Lu, Zhengtao Wang & Lili Ji. (2018) Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC. Biochemical Pharmacology 150, pages 9-23.
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Qingwen Zhang, Jinxia Sun, Yuli Wang, Weigang He, Lixin Wang, Yuejuan Zheng, Jing Wu, Ying Zhang & Xin Jiang. (2017) Antimycobacterial and Anti-inflammatory Mechanisms of Baicalin via Induced Autophagy in Macrophages Infected with Mycobacterium tuberculosis. Frontiers in Microbiology 8.
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Juan J. Martínez Medina, Evelina G. Ferrer, Patricia A.M. Williams & Nora B. Okulik. (2017) Theoretical investigation of the conformational space of baicalin. Journal of Molecular Graphics and Modelling 76, pages 181-191.
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Jing Li, Qihua Jiang, Ping Deng, Qian Chen, Mingan Yu, Jingchuan Shang & Wei Li. (2017) The formation of a host-guest inclusion complex system between β-cyclodextrin and baicalin and its dissolution characteristics. Journal of Pharmacy and Pharmacology 69:6, pages 663-674.
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Shihua Xing, Mengyue Wang, Ying Peng & Xiaobo Li. (2017) Effects of Intestinal Microecology on Metabolism and Pharmacokinetics of Oral Wogonoside and Baicalin. Natural Product Communications 12:4, pages 1934578X1701200.
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A. A. Fouad, H. O. Qutub & I. Jresat. (2017) Dose-dependent protective effect of baicalin against testicular torsion-detorsion in rats. Andrologia 49:1, pages e12580.
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Xiao Ling, Yuqiang Xiang, Qingfa Tang, Feilong Chen & Xiaomei Tan. (2017) Comparative pharmacokinetics of eight major bioactive components in normal and bacterial diarrhea mini-pigs after oral administration of Gegen Qinlian Decoction. Journal of Chromatography B 1044-1045, pages 132-141.
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Wei Liang, Xiaobo Huang & Wenqiang Chen. (2017) The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review. Aging and disease 8:6, pages 850.
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Xianqing Shi, Yongjian Fu, SongSong Zhang, Hao Ding & Jin Chen. (2017) Baicalin Attenuates Subarachnoid Hemorrhagic Brain Injury by Modulating Blood-Brain Barrier Disruption, Inflammation, and Oxidative Damage in Mice. Oxidative Medicine and Cellular Longevity 2017, pages 1-9.
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Wei-yi Gong, Zheng-xiao Zhao, Bao-jun Liu, Lin-wei Lu & Jing-cheng Dong. (2017) Exploring the chemopreventive properties and perspectives of baicalin and its aglycone baicalein in solid tumors. European Journal of Medicinal Chemistry 126, pages 844-852.
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Nuggehally R. Srinivas. (2016) Is There Saturation in the Conversion of Baicalein to Baicalin After Oral Chewable Tablets: Retrospective Evaluation of the Human Pharmacokinetic Data?. Clinical Drug Investigation 36:12, pages 1075-1076.
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