Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 40, 2010 - Issue 8
935
Views
99
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae

, , , , , , & show all
Pages 547-557 | Received 24 Feb 2010, Accepted 13 May 2010, Published online: 09 Jun 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Luís Félix, Ana Maria Coimbra, Ana Maria Valentim & Luís Antunes. (2019) Review on the use of zebrafish embryos to study the effects of anesthetics during early development. Critical Reviews in Toxicology 49:4, pages 357-370.
Read now
Katsuhisa Kurogi, Tzu-An Liu, Yoichi Sakakibara, Masahito Suiko & Ming-Cheh Liu. (2013) The use of zebrafish as a model system for investigating the role of the SULTs in the metabolism of endogenous compounds and xenobiotics. Drug Metabolism Reviews 45:4, pages 431-440.
Read now
S. Scholz, P. Renner, S. E. Belanger, F. Busquet, R. Davi, B. A. Demeneix, J. S. Denny, M. Léonard, M. E. McMaster, D. L. Villeneuve & M. R. Embry. (2013) Alternatives to in vivo tests to detect endocrine disrupting chemicals (EDCs) in fish and amphibians – screening for estrogen, androgen and thyroid hormone disruption. Critical Reviews in Toxicology 43:1, pages 45-72.
Read now
Huw S. Jones, Henry T. Trollope, Thomas H. Hutchinson, Grace H. Panter & J. Kevin Chipman. (2012) Metabolism of ibuprofen in zebrafish larvae. Xenobiotica 42:11, pages 1069-1075.
Read now
Guang Hu, Shiu On Siu, Shang Li, Ivan Keung Chu, Yiu Wa Kwan, Shun Wan Chan, George Pak-Heng Leung, Ru Yan & Simon Ming-Yuen Lee. (2012) Metabolism of calycosin, an isoflavone from Astragali Radix, in zebrafish larvae. Xenobiotica 42:3, pages 294-303.
Read now
Adrian Hill, Natalie Mesens, Margino Steemans, Jinghai James Xu & Michael D. Aleo. (2012) Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development. Drug Metabolism Reviews 44:1, pages 127-140.
Read now
Hendrian Sukardi, Hui Ting Chng, Eric Chun Yong Chan, Zhiyuan Gong & Siew Hong Lam. (2011) Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models. Expert Opinion on Drug Metabolism & Toxicology 7:5, pages 579-589.
Read now

Articles from other publishers (92)

Nobuyuki Shimizu, Hiroshi Shiraishi & Toshikatsu Hanada. (2023) Zebrafish as a Useful Model System for Human Liver Disease. Cells 12:18, pages 2246.
Crossref
A. Małkowska, K. Ługowska, K. Grucza, W. Małkowska & D. Kwiatkowska. (2023) Ethyl glucuronide and ethyl sulfate in the zebrafish after ethanol exposure. Alcohol.
Crossref
Chrisna Matthee, Andrew Ross Brown, Anke Lange & Charles R. Tyler. (2023) Factors Determining the Susceptibility of Fish to Effects of Human Pharmaceuticals. Environmental Science & Technology 57:24, pages 8845-8862.
Crossref
Jiye Zhang, Ying Huang, Youjun Pei, Yuyang Wang, Mingwan Li, Huihui Chen, Xuefang Liang & Christopher J. Martyniuk. (2023) Biotransformation, metabolic response, and toxicity of UV-234 and UV-326 in larval zebrafish (Danio rerio). Environment International 174, pages 107896.
Crossref
John C Achenbach, Joseph P M Hui, Fabrice Berrue, Cindy Woodland & Lee D Ellis. (2022) Evaluation of the Uptake, Metabolism, and Secretion of Toxicants by Zebrafish Larvae. Toxicological Sciences 190:2, pages 133-145.
Crossref
Chellapandi Bhuvaneswari, Karuppaiya Palpandi, Natarajan Raman & Sundaram Ganesh Babu. (2022) Sustainable architecting of Co2SnO4/CE-BN-based electrochemical platform for highly selective and ultrasensitive detection of 2-nitroaniline in life samples. Microchimica Acta 189:10.
Crossref
Daniel Cerveny, Petr Cisar, Tomas Brodin, Erin S. McCallum & Jerker Fick. (2022) Environmentally relevant concentration of caffeine—effect on activity and circadian rhythm in wild perch. Environmental Science and Pollution Research 29:36, pages 54264-54272.
Crossref
Derrick M. Glasco, Zhidong Wang, Seonwoo Kang & Avery T. Funkhouser. (2022) Acetaminophen Disrupts the Development of Pharyngeal Arch-Derived Cartilage and Muscle in Zebrafish. Journal of Developmental Biology 10:3, pages 30.
Crossref
Zunera Chauhdary, Kanwal Rehman, Muhammad Sajid Hamid Akash, Shaleem Suhail, Momina Shahid & Sardar Sindhu. 2022. Biochemistry of Drug Metabolizing Enzymes. Biochemistry of Drug Metabolizing Enzymes 323 345 .
Dan Cao, Chongjun Zhao, Zhiqi Li, Qiqi Fan, Meilin Chen, Yangyu Jiang, Haiyan Wang, Hanjun Ning, Ruichao Lin & Jian Li. (2021) Combined Metabolomics and Network Toxicology to Explore the Molecular Mechanism of Phytolacca acinose Roxb-Induced Hepatotoxicity in Zebrafish Larvae in Vivo. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-13.
Crossref
Chloé Bars, Jente Hoyberghs, Allan Valenzuela, Laura Buyssens, Miriam Ayuso, Chris Van Ginneken, Alain J. Labro, Kenn Foubert & Steven J. Van Cruchten. (2021) Developmental Toxicity and Biotransformation of Two Anti-Epileptics in Zebrafish Embryos and Early Larvae. International Journal of Molecular Sciences 22:23, pages 12696.
Crossref
Ann-Kathrin Loerracher & Thomas Braunbeck. (2021) Cytochrome P450-dependent biotransformation capacities in embryonic, juvenile and adult stages of zebrafish (Danio rerio)—a state-of-the-art review. Archives of Toxicology 95:7, pages 2299-2334.
Crossref
Yao Zhang, Yang Cai, Shi-Ru Zhang, Chong-Yong Li, Ling-Ling Jiang, Pin Wei & Ming-Fang He. (2021) Mechanism of hepatotoxicity of first-line tyrosine kinase inhibitors: Gefitinib and afatinib. Toxicology Letters 343, pages 1-10.
Crossref
Petrus Siregar, Gilbert Audira, Ling-Yi Feng, Jia-Hau Lee, Fiorency Santoso, Wen-Hao Yu, Yu-Heng Lai, Jih-Heng Li, Ying-Ting Lin, Jung-Ren Chen & Chung-Der Hsiao. (2021) Pharmaceutical Assessment Suggests Locomotion Hyperactivity in Zebrafish Triggered by Arecoline Might Be Associated with Multiple Muscarinic Acetylcholine Receptors Activation. Toxins 13:4, pages 259.
Crossref
Izuru Miyawaki. (2021) Current status of drug safety evaluation using zebrafishゼブラフィッシュを用いた安全性評価の現状. Folia Pharmacologica Japonica 156:1, pages 31-36.
Crossref
Swati Katoch & Vikram Patial. (2020) Zebrafish: An emerging model system to study liver diseases and related drug discovery. Journal of Applied Toxicology 41:1, pages 33-51.
Crossref
Tasuku Nawaji, Natsumi Yamashita, Haruka Umeda, Shuangyi Zhang, Naohiro Mizoguchi, Masanori Seki, Takio Kitazawa & Hiroki Teraoka. (2020) Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish. Pharmaceuticals 13:12, pages 456.
Crossref
Zhaoxian Zhang, Jing Zhang, Xuejun Zhao, Beibei Gao, Zongzhe He, Lianshan Li, Haiyan Shi & Minghua Wang. (2020) Stereoselective uptake and metabolism of prothioconazole caused oxidative stress in zebrafish (Danio rerio). Journal of Hazardous Materials 396, pages 122756.
Crossref
Maria Zoupa, Edwin P. Zwart, Eric R. Gremmer, Ananditya Nugraha, Sharon Compeer, Wout Slob & Leo T.M. van der Ven. (2020) Dose addition in chemical mixtures inducing craniofacial malformations in zebrafish (Danio rerio) embryos. Food and Chemical Toxicology 137, pages 111117.
Crossref
Izuru Miyawaki. (2020) Application of zebrafish to safety evaluation in drug discovery. Journal of Toxicologic Pathology 33:4, pages 197-210.
Crossref
Ludivine Raby, Pamela Völkel, Xuefen Le Bourhis & Pierre-Olivier Angrand. (2020) La transplantation de cellules tumorales chez le poisson zèbre : de la recherche translationnelle à la médecine personnalisée. Bulletin du Cancer 107:1, pages 30-40.
Crossref
Chongjun Zhao, Zhe Jia, Erwen Li, Xia Zhao, Ting Han, Jinghuan Tian, Farong Li, Dixin Zou & Ruichao Lin. (2019) Hepatotoxicity evaluation of Euphorbia kansui on zebrafish larvae in vivo. Phytomedicine 62, pages 152959.
Crossref
Gabriela Klein Couto, Natália Vieira Segatto, Thaís Larré Oliveira, Fabiana Kömmling Seixas, Kyle M. Schachtschneider & Tiago Collares. (2019) The Melding of Drug Screening Platforms for Melanoma. Frontiers in Oncology 9.
Crossref
Bonifasius Putera Sampurna, Fiorency Santoso, Jia-Hau Lee, Wen-Hao Yu, Chin-Chung Wu, Gilbert Audira, Stevhen Juniardi, Jung-Ren Chen, Ying-Ting Lin & Chung-Der Hsiao. (2019) Cardiac Rhythm and Molecular Docking Studies of Ion Channel Ligands with Cardiotoxicity in Zebrafish. Cells 8:6, pages 566.
Crossref
Arianna Giusti, Xuan-Bac Nguyen, Stanislav Kislyuk, Mélanie Mignot, Cecilia Ranieri, Johan Nicolaï, Marlies Oorts, Xiao Wu, Pieter Annaert, Noémie De Croze, Marc Léonard, Annelii Ny, Deirdre Cabooter & Peter de Witte. (2019) Safety Assessment of Compounds after In Vitro Metabolic Conversion Using Zebrafish Eleuthero Embryos. International Journal of Molecular Sciences 20:7, pages 1712.
Crossref
Xingxing Diao & Marilyn A. Huestis. (2019) New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites. Frontiers in Chemistry 7.
Crossref
Rongling Zhong, Ying Chen, Jie Ling, Zhi Xia, Yang Zhan, E. Sun, Ziqi Shi, Liang Feng, Xiaobin Jia, Jie Song & Yingjie Wei. (2019) The Toxicity and Metabolism Properties of Herba Epimedii Flavonoids on Laval and Adult Zebrafish . Evidence-Based Complementary and Alternative Medicine 2019, pages 1-9.
Crossref
Evy Verbueken, Chloé Bars, Jonathan S. Ball, Jelena Periz-Stanacev, Waleed F. A. Marei, Anna Tochwin, Isabelle J. Gabriëls, Ellen D. G. Michiels, Evelyn Stinckens, Lucia Vergauwen, Dries Knapen, Chris J. Van Ginneken & Steven J. Van Cruchten. (2018) From mRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation during Zebrafish Embryonic and Larval Development. International Journal of Molecular Sciences 19:12, pages 3976.
Crossref
Patricia Letrado, Irene de Miguel, Iranzu Lamberto, Roberto Díez-Martínez & Julen Oyarzabal. (2018) Zebrafish: Speeding Up the Cancer Drug Discovery Process. Cancer Research 78:21, pages 6048-6058.
Crossref
Carina de Souza Anselmo, Vinicius Figueiredo Sardela, Valeria Pereira de Sousa & Henrique Marcelo Gualberto Pereira. (2018) Zebrafish ( Danio rerio ): A valuable tool for predicting the metabolism of xenobiotics in humans?. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 212, pages 34-46.
Crossref
Dimitrios E. Damalas, Anna A. Bletsou, Adamantia Agalou, Dimitris Beis & Nikolaos S. Thomaidis. (2018) Assessment of the Acute Toxicity, Uptake and Biotransformation Potential of Benzotriazoles in Zebrafish ( Danio rerio ) Larvae Combining HILIC- with RPLC-HRMS for High-Throughput Identification . Environmental Science & Technology 52:10, pages 6023-6031.
Crossref
Muhammad Imran, Odile Sergent, Arnaud Tête, Isabelle Gallais, Martine Chevanne, Dominique Lagadic-Gossmann & Normand Podechard. (2018) Membrane Remodeling as a Key Player of the Hepatotoxicity Induced by Co-Exposure to Benzo[a]pyrene and Ethanol of Obese Zebrafish Larvae. Biomolecules 8:2, pages 26.
Crossref
Marta Sobanska, Stefan Scholz, Anna-Maija Nyman, Romanas Cesnaitis, Simon Gutierrez Alonso, Nils Klüver, Ralph Kühne, Henrik Tyle, Joop de Knecht, Zhichao Dang, Ivar Lundbergh, Claudio Carlon & Wim De Coen. (2018) Applicability of the fish embryo acute toxicity (FET) test (OECD 236) in the regulatory context of Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH). Environmental Toxicology and Chemistry 37:3, pages 657-670.
Crossref
Oh Kwang Kwon, Sun Joo Kim & Sangkyu Lee. (2018) First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos. Scientific Reports 8:1.
Crossref
Lucia Vergauwen, Steven Van Cruchten & Dries Knapen. 2018. A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment. A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment 43 73 .
Pushkar Kulkarni, Raghavender Medishetti, Nagaraju Nune, Swapna Yellanki, Vijaykumar Sripuram, Pallavi Rao, Dharmarajan Sriram, Uday Saxena, Srinivas Oruganti & Perumal Yogeeswari. (2017) Correlation of pharmacokinetics and brain penetration data of adult zebrafish with higher mammals including humans. Journal of Pharmacological and Toxicological Methods 88, pages 147-152.
Crossref
Agnes Kühnert, Carolina Vogs, Bettina Seiwert, Silke Aulhorn, Rolf Altenburger, Henner Hollert, Eberhard Küster & Wibke Busch. (2017) Biotransformation in the zebrafish embryo –temporal gene transcription changes of cytochrome P450 enzymes and internal exposure dynamics of the AhR binding xenobiotic benz[a]anthracene. Environmental Pollution 230, pages 1-11.
Crossref
Carina de Souza Anselmo, Vinicius Figueiredo Sardela, Bernardo Fonseca Matias, Amanda Reis de Carvalho, Valeria Pereira de Sousa, Henrique Marcelo Gualberto Pereira & Francisco Radler de Aquino Neto. (2017) Is zebrafish ( Danio rerio ) a tool for human‐like metabolism study? . Drug Testing and Analysis 9:11-12, pages 1685-1694.
Crossref
Moayad Saad, An Matheeussen, Sebastiaan Bijttebier, Evy Verbueken, Casper Pype, Christophe Casteleyn, Chris Van Ginneken, Sandra Apers, Louis Maes, Paul Cos & Steven Van Cruchten. (2017) In vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds. Toxicology in Vitro 42, pages 329-336.
Crossref
Vincent Le Fol, Selim Aït-Aïssa, Manoj Sonavane, Jean-Marc Porcher, Patrick Balaguer, Jean-Pierre Cravedi, Daniel Zalko & François Brion. (2017) In vitro and in vivo estrogenic activity of BPA, BPF and BPS in zebrafish-specific assays. Ecotoxicology and Environmental Safety 142, pages 150-156.
Crossref
Consuelo J. Perez, Alessandra Tata, Michel L. de Campos, Chun Peng & Demian R. Ifa. (2016) Monitoring Toxic Ionic Liquids in Zebrafish ( Danio rerio ) with Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI) . Journal of the American Society for Mass Spectrometry 28:6, pages 1136-1148.
Crossref
Normand Podechard, Martine Chevanne, Morgane Fernier, Arnaud Tête, Aurore Collin, Doris Cassio, Olivier Kah, Dominique Lagadic-Gossmann & Odile Sergent. (2017) Zebrafish larva as a reliable model for in vivo assessment of membrane remodeling involvement in the hepatotoxicity of chemical agents . Journal of Applied Toxicology 37:6, pages 732-746.
Crossref
Vincent Le Fol, François Brion, Anne Hillenweck, Elisabeth Perdu, Sandrine Bruel, Selim Aït-Aïssa, Jean-Pierre Cravedi & Daniel Zalko. (2017) Comparison of the In Vivo Biotransformation of Two Emerging Estrogenic Contaminants, BP2 and BPS, in Zebrafish Embryos and Adults. International Journal of Molecular Sciences 18:4, pages 704.
Crossref
Yun Zhang, Liwen Han, Qiuxia He, Weiyun Chen, Chen Sun, Xue Wang, Xiqiang Chen, Rongchun Wang, Chung-Der Hsiao & Kechun Liu. (2017) A rapid assessment for predicting drug-induced hepatotoxicity using zebrafish. Journal of Pharmacological and Toxicological Methods 84, pages 102-110.
Crossref
Zhengxin Xie, Guanghua Lu, Zhenhua Yan, Jianchao Liu, Peifang Wang & Yonghua Wang. (2017) Bioaccumulation and trophic transfer of pharmaceuticals in food webs from a large freshwater lake. Environmental Pollution 222, pages 356-366.
Crossref
Kar Lai Poon, Xingang Wang, Ashley S. Ng, Wei Huang Goh, Claudia McGinnis, Stephen Fowler, Tom J. Carney, Haishan Wang & Phillip W. Ingham. (2016) Humanizing the zebrafish liver shifts drug metabolic profiles and improves pharmacokinetics of CYP3A4 substrates. Archives of Toxicology 91:3, pages 1187-1197.
Crossref
Xuan-Bac Nguyen, Stanislav Kislyuk, Duc-Hung Pham, Angela Kecskés, Jan Maes, Deirdre Cabooter, Pieter Annaert, Peter De Witte & Annelii Ny. (2017) Cell Imaging Counting as a Novel Ex Vivo Approach for Investigating Drug-Induced Hepatotoxicity in Zebrafish Larvae. International Journal of Molecular Sciences 18:2, pages 356.
Crossref
Evy Verbueken, Derek Alsop, Moayad Saad, Casper Pype, Els Van Peer, Christophe Casteleyn, Chris Van Ginneken, Joanna Wilson & Steven Van Cruchten. (2017) In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development. International Journal of Molecular Sciences 18:1, pages 217.
Crossref
R.S. Settivari, J.C. Rowlands, D.M. Wilson, S.M. Arnold & P.J. Spencer. 2017. A Comprehensive Guide to Toxicology in Nonclinical Drug Development. A Comprehensive Guide to Toxicology in Nonclinical Drug Development 843 873 .
Vasudev KantaeElke H.J. KrekelsAnita OrdasOskar GonzálezRob C. van WijkAmy C. HarmsPeter I. RaczPiet H. van der GraafHerman P. SpainkThomas Hankemeier. (2016) Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude. Zebrafish 13:6, pages 504-510.
Crossref
Stephan Brox, Bettina Seiwert, Eberhard Küster & Thorsten Reemtsma. (2016) Toxicokinetics of Polar Chemicals in Zebrafish Embryo ( Danio rerio ): Influence of Physicochemical Properties and of Biological Processes . Environmental Science & Technology 50:18, pages 10264-10272.
Crossref
Moayad Saad, Evy Verbueken, Casper Pype, Christophe Casteleyn, Chris Van Ginneken, Louis Maes, Paul Cos & Steven Van Cruchten. (2016) In vitro CYP1A activity in the zebrafish: temporal but low metabolite levels during organogenesis and lack of gender differences in the adult stage. Reproductive Toxicology 64, pages 50-56.
Crossref
Qian Li, Peipei Wang, Ling Chen, Hongwen Gao & Lingling Wu. (2016) Acute toxicity and histopathological effects of naproxen in zebrafish (Danio rerio) early life stages. Environmental Science and Pollution Research 23:18, pages 18832-18841.
Crossref
Sandra Verstraelen, Bernard Peers, Walid Maho, Karen Hollanders, Sylvie Remy, Pascale Berckmans, Adrian Covaci & Hilda Witters. (2016) Phenotypic and biomarker evaluation of zebrafish larvae as an alternative model to predict mammalian hepatotoxicity. Journal of Applied Toxicology 36:9, pages 1194-1206.
Crossref
Stephan Brox, Bettina Seiwert, Nora Haase, Eberhard Küster & Thorsten Reemtsma. (2016) Metabolism of clofibric acid in zebrafish embryos ( Danio rerio ) as determined by liquid chromatography–high resolution–mass spectrometry. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 185-186, pages 20-28.
Crossref
Jingying Chen, Jianbo He, Li Li, Deqin Yang & Lingfei Luo. (2016) Cyp2aa9 regulates haematopoietic stem cell development in zebrafish. Scientific Reports 6:1.
Crossref
J. Gerry Kenna, Mikael Persson, Scott Q. Siler, Ke Yu, Chuchu Hu, Minjun Chen, Joshua Xu, Weida Tong, Yvonne Will & Michael D. Aleo. 2016. Drug Discovery Toxicology. Drug Discovery Toxicology 93 129 .
Christoph Steinbach, Roman Grabic, Ganna Fedorova, Olga Koba, Oksana Golovko, Katerina Grabicova & Hana Kocour Kroupova. (2016) Bioconcentration, metabolism and half-life time of the human therapeutic drug diltiazem in rainbow trout Oncorhynchus mykiss. Chemosphere 144, pages 154-159.
Crossref
Moayad Saad, Kate Cavanaugh, Evy Verbueken, Casper Pype, Christophe Casteleyn, Chris Van Ginneken & Steven Van Cruchten. (2016) Xenobiotic metabolism in the zebrafish: a review of the spatiotemporal distribution, modulation and activity of Cytochrome P450 families 1 to 3. The Journal of Toxicological Sciences 41:1, pages 1-11.
Crossref
Jinfeng Liang, Wangdong Jin, Haibin Wei, Hongwen Li, Fei Jia, Jing Qian, Hongcui Liu, Yanfeng Huang, Chunqi Li, Li Zhou & Thomas Efferth. (2016) Acute hepatotoxicity induced by quetiapine fumarate in larval zebrafish. Fundamental Toxicological Sciences 3:3, pages 127-135.
Crossref
Barrie M. Peake, Rhiannon Braund, Alfred Y.C. Tong & Louis A. Tremblay. 2016. The Life-Cycle of Pharmaceuticals in the Environment. The Life-Cycle of Pharmaceuticals in the Environment 109 152 .
Thomas Braunbeck, Britta Kais, Eva Lammer, Jens Otte, Katharina Schneider, Daniel Stengel & Ruben Strecker. (2014) The fish embryo test (FET): origin, applications, and future. Environmental Science and Pollution Research 22:21, pages 16247-16261.
Crossref
Nic Bury. 2015. Freshwater Fisheries Ecology. Freshwater Fisheries Ecology 695 716 .
Natalie Mesens, Alexander D. Crawford, Aswin Menke, Pham Duc Hung, Freddy Van Goethem, Rik Nuyts, Erik Hansen, Andre Wolterbeek, Jacky Van Gompel, Peter De Witte & Camila V. Esguerra. (2015) Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?. Journal of Applied Toxicology 35:9, pages 1017-1029.
Crossref
Nils Klüver, Maria König, Julia Ortmann, Riccardo Massei, Albrecht Paschke, Ralph Kühne & Stefan Scholz. (2015) Fish Embryo Toxicity Test: Identification of Compounds with Weak Toxicity and Analysis of Behavioral Effects To Improve Prediction of Acute Toxicity for Neurotoxic Compounds. Environmental Science & Technology 49:11, pages 7002-7011.
Crossref
Ellen Fritsche, Henrik Alm, Jenny Baumann, Lieve Geerts, Helen Håkansson, Stefan Masjosthusmann & Hilda Witters. (2015) Literature review on in vitro and alternative Developmental Neurotoxicity (DNT) testing methods. EFSA Supporting Publications 12:4.
Crossref
Vincent Le Fol, Selim Aït-Aïssa, Nicolas Cabaton, Laurence Dolo, Marina Grimaldi, Patrick Balaguer, Elisabeth Perdu, Laurent Debrauwer, François Brion & Daniel Zalko. (2015) Cell-Specific Biotransformation of Benzophenone-2 and Bisphenol-S in Zebrafish and Human in Vitro Models Used for Toxicity and Estrogenicity Screening. Environmental Science & Technology 49:6, pages 3860-3868.
Crossref
Wietske van der Ent, Claudia Burrello, Mark J. de Lange, Pieter A. van der Velden, Aart G. Jochemsen, Martine J. Jager & B. Ewa Snaar-Jagalska. (2015) Embryonic Zebrafish: Different Phenotypes after Injection of Human Uveal Melanoma Cells. Ocular Oncology and Pathology 1:3, pages 170-181.
Crossref
A. D. Bastiaan Vliegenthart, Carl S. Tucker, Jorge Del Pozo & James W. Dear. (2014) Zebrafish as model organisms for studying drug-induced liver injury. British Journal of Clinical Pharmacology 78:6, pages 1217-1227.
Crossref
Jonnalagadda Padma Sridevi, Hasitha Shilpa Anantaraju, Pushkar Kulkarni, Perumal Yogeeswari & Dharmarajan Sriram. (2014) Optimization and validation of Mycobacterium marinum-induced adult zebrafish model for evaluation of oral anti-tuberculosis drugs. International Journal of Mycobacteriology 3:4, pages 259-267.
Crossref
Natalie Mesens. 2014. Predictive Toxicology. Predictive Toxicology 217 240 .
Marja Driessen, Anne S. Kienhuis, Alexa P. Vitins, Jeroen L.A. Pennings, Tessa E. Pronk, Evert-Jan van den Brandhof, Marianne Roodbergen, Bob van de Water & Leo T.M.van der Ven. (2014) Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans. Toxicology Letters 230:1, pages 48-56.
Crossref
Pieter Spincemaille, Duc-Hung Pham, Gursimran Chandhok, Jef Verbeek, Andree Zibert, Louis Libbrecht, Hartmut Schmidt, Camila V. Esguerra, Peter A.M. de Witte, Bruno P.A. Cammue, David Cassiman & Karin Thevissen. (2014) The plant decapeptide OSIP108 prevents copper-induced toxicity in various models for Wilson disease. Toxicology and Applied Pharmacology 280:2, pages 345-351.
Crossref
Stephan Brox, Axel P. Ritter, Eberhard Küster & Thorsten Reemtsma. (2014) A quantitative HPLC–MS/MS method for studying internal concentrations and toxicokinetics of 34 polar analytes in zebrafish (Danio rerio) embryos. Analytical and Bioanalytical Chemistry 406:20, pages 4831-4840.
Crossref
Nils Klüver, Julia Ortmann, Heidrun Paschke, Patrick Renner, Axel P. Ritter & Stefan Scholz. (2014) Transient Overexpression of adh8a Increases Allyl Alcohol Toxicity in Zebrafish Embryos. PLoS ONE 9:3, pages e90619.
Crossref
Pushkar Kulkarni, Girish Hari Chaudhari, Vijaykumar Sripuram, Rakesh Kumar Banote, Krishna Tulasi Kirla, Razia Sultana, Pallavi Rao, Srinivas Oruganti & Kiranam Chatti. (2014) Oral dosing in adult zebrafish: Proof-of-concept using pharmacokinetics and pharmacological evaluation of carbamazepine. Pharmacological Reports 66:1, pages 179-183.
Crossref
Bhaskar C DasLaura McCormick, Pritam Thapa, Radha Karki & Todd Evans. (2013) Use of zebrafish in chemical biology and drug discovery. Future Medicinal Chemistry 5:17, pages 2103-2116.
Crossref
Anna C.K. Tse, Karen Y.T. Lau, Wei Ge & Rudolf S.S. Wu. (2013) A rapid screening test for endocrine disrupting chemicals using primary cell culture of the marine medaka. Aquatic Toxicology 144-145, pages 50-58.
Crossref
Angeleen Fleming, Heike Diekmann & Paul Goldsmith. (2013) Functional Characterisation of the Maturation of the Blood-Brain Barrier in Larval Zebrafish. PLoS ONE 8:10, pages e77548.
Crossref
Christoph Steinbach, Ganna Fedorova, Miroslav Prokes, Katerina Grabicova, Jana Machova, Roman Grabic, Olga Valentova & Hana Kocour Kroupova. (2013) Toxic effects, bioconcentration and depuration of verapamil in the early life stages of common carp (Cyprinus carpio L.). Science of The Total Environment 461-462, pages 198-206.
Crossref
Kristin A. Connors, Bowen Du, Patrick N. Fitzsimmons, Alex D. Hoffman, C. Kevin Chambliss, John W. Nichols & Bryan W. Brooks. (2013) Comparative pharmaceutical metabolism by rainbow trout ( Oncorhynchus mykiss ) liver S9 fractions . Environmental Toxicology and Chemistry 32:8, pages 1810-1818.
Crossref
Agnes Kühnert, Carolina Vogs, Rolf Altenburger & Eberhard Küster. (2013) The internal concentration of organic substances in fish embryos-A toxicokinetic approach. Environmental Toxicology and Chemistry 32:8, pages 1819-1827.
Crossref
Marja Driessen, Anne S. Kienhuis, Jeroen L. A. Pennings, Tessa E. Pronk, Evert-Jan van de Brandhof, Marianne Roodbergen, Herman P. Spaink, Bob van de Water & Leo T. M. van der Ven. (2013) Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling. Archives of Toxicology 87:5, pages 807-823.
Crossref
Rakesh Kumar Banote, Srinivas Koutarapu, Keerthana Sarma Chennubhotla, Kiranam Chatti & Pushkar Kulkarni. (2013) Oral gabapentin suppresses pentylenetetrazole-induced seizure-like behavior and cephalic field potential in adult zebrafish. Epilepsy & Behavior 27:1, pages 212-219.
Crossref
A. Fleming & W.K. Alderton. (2013) Zebrafish in pharmaceutical industry research: finding the best fit. Drug Discovery Today: Disease Models 10:1, pages e43-e50.
Crossref
H. Diekmann & A. Hill. (2013) ADMETox in zebrafish. Drug Discovery Today: Disease Models 10:1, pages e31-e35.
Crossref
Edward W. Carney & Raja Settivari. 2013. A Comprehensive Guide to Toxicology in Preclinical Drug Development. A Comprehensive Guide to Toxicology in Preclinical Drug Development 777 806 .
Adrian Hill. 2013. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays 605 629 .
Hui Ting Chng, Han Kiat Ho, Chun Wei Yap, Siew Hong Lam & Eric Chun Yong Chan. (2012) An Investigation of the Bioactivation Potential and Metabolism Profile of Zebrafish versus Human. SLAS Discovery 17:7, pages 974-986.
Crossref
Anna Mattsson, Erik Ullerås, Johan Patring & Agneta Oskarsson. (2012) Albendazole causes stage-dependent developmental toxicity and is deactivated by a mammalian metabolization system in a modified zebrafish embryotoxicity test. Reproductive Toxicology 34:1, pages 31-42.
Crossref
Philippe Vernier, Evan J. Kyzar, Caio Maximino, Keith Tierney, Michael Gebhardt, Merlin Lange, Suresh Jesuthasan, Adam Michael Stewart, Stephan C.F. Neuhauss, Kyle Robinson, William Norton, Anderson Manoel Herculano, Jonathan Cachat, Vincent Tropepe, Samuel Landsman, Brian Wisenden, Laure Bally-Cuif & Allan V. Kalueff. (2012) Time to recognize zebrafish ‘affective’ behavior. Behaviour 149:10-12, pages 1019-1036.
Crossref
Catherine W. McCollum, Nicole A. Ducharme, Maria Bondesson & Jan-Ake Gustafsson. (2011) Developmental toxicity screening in zebrafish. Birth Defects Research Part C: Embryo Today: Reviews 93:2, pages 67-114.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.