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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 1
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General Xenobiochemistry

In vitro metabolism, glutathione conjugation, and CYP isoform specificity of epoxidation of 4-vinylphenol

Fagen ZhangToxicology and Environmental Research & Consulting, The Dow Chemical Company, Midland, Michigan, USACorrespondence[email protected]
,
Ezra R. LoweToxicology and Environmental Research & Consulting, The Dow Chemical Company, Midland, Michigan, USA
,
David.L. RickToxicology and Environmental Research & Consulting, The Dow Chemical Company, Midland, Michigan, USA
,
Xiaohua QiuToxicology and Environmental Research & Consulting, The Dow Chemical Company, Midland, Michigan, USA
,
E. LeiboldBASF Aktiengesellschaft, Ludwigshafen/Rhein, Germany
,
George CruzanToxWorks, Bridgeton, NJ, USA
&
Michael J. BartelsToxicology and Environmental Research & Consulting, The Dow Chemical Company, Midland, Michigan, USA
 show all
Pages 6-23 | Received 22 Jul 2010, Accepted 10 Sep 2010, Published online: 07 Oct 2010

Citations (7)

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Patricia I. Mathias & Clayton B’hymer. (2016) Mercapturic acids: recent advances in their determination by liquid chromatography/mass spectrometry and their use in toxicant metabolism studies and in occupational and environmental exposure studies. Biomarkers 21:4, pages 293-315.
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Articles from other publishers (6)

Carr J Smith & Thomas A Perfetti. (2020) High-dose exposure to synthetic chemicals, hormones, or homeostatic substances in experimental animals or humans can induce artefactual pathology. Toxicology Research and Application 4, pages 239784732094055.
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George Cruzan, James S. Bus, Melvin E. Andersen, Gary P. Carlson, Marcy I. Banton, Satinder S. Sarang & Robbie Waites. (2018) Based on an analysis of mode of action, styrene-induced mouse lung tumors are not a human cancer concern. Regulatory Toxicology and Pharmacology 95, pages 17-28.
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Carr J Smith, Thomas A Perfetti & Judy A King. (2018) Bronchioloalveolar lung tumors induced in “mice only” by non-genotoxic chemicals are not useful for quantitative assessment of pulmonary adenocarcinoma risk in humans. Toxicology Research and Application 2, pages 239784731881661.
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George Cruzan, James S. Bus, Marcy I. Banton, Satinder S. Sarang, Robbie Waites, Debra B. Layko, James Raymond, Darol DoddMelvin E. Andersen. (2017) Editor’s Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance. Toxicological Sciences 159:2, pages 413-421.
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Shuijie Shen, Lei Li, Xinxin Ding & Jiang Zheng. (2013) Metabolism of Styrene to Styrene Oxide and Vinylphenols in Cytochrome P450 2F2- and P450 2E1-Knockout Mouse Liver and Lung Microsomes. Chemical Research in Toxicology 27:1, pages 27-33.
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G. Cruzan, J. Bus, J. Hotchkiss, R. Sura, C. Moore, G. Yost, M. Banton & S. Sarang. (2013) Studies of styrene, styrene oxide and 4-hydroxystyrene toxicity in CYP2F2 knockout and CYP2F1 humanized mice support lack of human relevance for mouse lung tumors. Regulatory Toxicology and Pharmacology 66:1, pages 24-29.
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