Citations (71)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (12)
Weijia Han & Zhongping Duan. (2021) Different drug metabolism behavior between species in drug-induced hepatotoxicity: limitations and novel resolutions. Toxin Reviews 40:4, pages 420-431.
Read now
Read now
Takeshi Hirota, Yuito Fujita & Ichiro Ieiri. (2020) An updated review of pharmacokinetic drug interactions and pharmacogenetics of statins. Expert Opinion on Drug Metabolism & Toxicology 16:9, pages 809-822.
Read now
Read now
Weijia Han, Mei Ding, Shuang Liu, Yu Chen & Zhongping Duan. (2019) Evaluation of 3D re-cellularized tissue engineering: a drug-induced hepatotoxicity model for hepatoprotectant research. Toxicology Mechanisms and Methods 29:9, pages 654-664.
Read now
Read now
Mingxiang Liao, Qing Zhu, Andy Zhu, Christopher Gemski, Bingli Ma, Emily Guan, Albert P. Li, Guangqing Xiao & Cindy Q. Xia. (2019) Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans. Xenobiotica 49:7, pages 852-862.
Read now
Read now
Jae H. Chang, Xiaolin Zhang, Kirsten Messick, Yi-Chen Chen, Eugene Chen, Jonathan Cheong & Justin Ly. (2019) Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse. Xenobiotica 49:5, pages 602-610.
Read now
Read now
Paul Chan, Li Shao, Brian Tomlinson, Yuzhen Zhang & Zhong-Min Liu. (2019) An evaluation of pitavastatin for the treatment of hypercholesterolemia. Expert Opinion on Pharmacotherapy 20:1, pages 103-113.
Read now
Read now
Ursula Gundert-Remy, Ulrike Bernauer, Brunhilde Blömeke, Barbara Döring, Eric Fabian, Carsten Goebel, Stefanie Hessel, Christine Jäckh, Alfonso Lampen, Franz Oesch, Ernst Petzinger, Wolfgang Völkel & Peter H. Roos. (2014) Extrahepatic metabolism at the body's internal–external interfaces. Drug Metabolism Reviews 46:3, pages 291-324.
Read now
Read now
Miao Hu & Brian Tomlinson. (2014) Evaluation of the pharmacokinetics and drug interactions of the two recently developed statins, rosuvastatin and pitavastatin. Expert Opinion on Drug Metabolism & Toxicology 10:1, pages 51-65.
Read now
Read now
Amit S. Kalgutkar, Danny Chen, Manthena V. Varma, Bo Feng, Steven G. Terra, Renato J. Scialis, Charles J. Rotter, Kosea S. Frederick, Mark A. West, Theunis C. Goosen, James R. Gosset, Robert L. Walsky & Omar L. Francone. (2013) Elucidation of the biochemical basis for a clinical drug–drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778 875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha. Xenobiotica 43:11, pages 963-972.
Read now
Read now
Miao Hu & Brian Tomlinson. (2013) Lipid-lowing pharmacogenomics in Chinese patients. Expert Review of Cardiovascular Therapy 11:8, pages 985-997.
Read now
Read now
Chang-Ik Choi, Yun-Jeong Lee, Hye-In Lee, Bo-Hye Kim, Mi-Jeong Kim, Choon-Gon Jang, Jung-Woo Bae & Seok-Yong Lee. (2012) Effects of the SLCO1B1*15 allele on the pharmacokinetics of pitavastatin. Xenobiotica 42:5, pages 496-501.
Read now
Read now
Grant T. Generaux, Fiorenza M. Bonomo, Marta Johnson & Kelly M. Mahar Doan. (2011) Impact of SLCO1B1 (OATP1B1) and ABCG2 (BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins. Xenobiotica 41:8, pages 639-651.
Read now
Read now
Articles from other publishers (59)
Vanessa Zhu, Jürgen Burhenne, Johanna Weiss, Mathias Haag, Ute Hofmann, Matthias Schwab, Stephan Urban, Gerd Mikus, David Czock, Walter E. Haefeli & Antje Blank. (2023) Evaluation of the drug-drug interaction potential of the novel hepatitis B and D virus entry inhibitor bulevirtide at OATP1B in healthy volunteers. Frontiers in Pharmacology 14.
Crossref
Crossref
Solène Marie, Kayla L. Frost, Raymond K. Hau, Lucy Martinez-Guerrero, Jailyn M. Izu, Cassandra M. Myers, Stephen H. Wright & Nathan J. Cherrington. (2023) Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients. Acta Pharmaceutica Sinica B 13:1, pages 1-28.
Crossref
Crossref
M. Gharehbeglou, S. Yazdani, K. White, M. R. Haeri & N. Masoumzadeh. (2022) Atorvastatin Rapidly Reduces Hepatitis B Viral Load in Combination with Tenofovir: A Prospective Clinical Trial. Canadian Journal of Infectious Diseases and Medical Microbiology 2022, pages 1-5.
Crossref
Crossref
Dariusz Zakrzewicz & Joachim Geyer. (2022) Multitasking Na+/Taurocholate Cotransporting Polypeptide (NTCP) as a Drug Target for HBV Infection: From Protein Engineering to Drug Discovery. Biomedicines 10:1, pages 196.
Crossref
Crossref
Liangliang Yao, Muhammad Farrukh Nisar, Tingdong Yan & Chunpeng (Craig) Wan. (2021) Potential Effects of Dietary Isoflavones on Drug-Induced Liver Injury. Journal of Food Quality 2021, pages 1-10.
Crossref
Crossref
Ying Wang, Matthew Wilkerson, Jibin Li, Wei Zhang, Albert Owens, Stephen Wright & Ismael Hidalgo. (2020) Assessment of Statin Interactions With the Human NTCP Transporter Using a Novel Fluorescence Assay. International Journal of Toxicology 39:6, pages 518-529.
Crossref
Crossref
Benjamin J. Burwitz, Zhongmin Zhou & Wenhui Li. (2020) Animal models for the study of human hepatitis B and D virus infection: New insights and progress. Antiviral Research 182, pages 104898.
Crossref
Crossref
James J. Beaudoin, Kim L.R. Brouwer & Melina M. Malinen. (2020) Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside. Pharmacology & Therapeutics 211, pages 107542.
Crossref
Crossref
Yiting Yang & Xiaodong Liu. (2020) Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance. Pharmaceutics 12:4, pages 348.
Crossref
Crossref
Guruprasad P. Aithal & Gerd A. Kullak‐Ublick. 2020. The Liver. The Liver
1050
1057
.
Rui Li. (2019) Estimating In Vivo Fractional Contribution of OATP1B1 to Human Hepatic Active Uptake by Mechanistically Modeling Pharmacogenetic Data. The AAPS Journal 21:4.
Crossref
Crossref
Xiaoyang Lu, Lin Liu, Wenya Shan, Limin Kong, Na Chen, Yan Lou & Su Zeng. (2019) The Role of the Sodium-taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) in Related Liver Disease. Current Drug Metabolism 20:5, pages 377-389.
Crossref
Crossref
Connie B. Newman, David Preiss, Jonathan A. Tobert, Terry A. Jacobson, Robert L. PageIIII, Larry B. Goldstein, Clifford Chin, Lisa R. Tannock, Michael Miller, Geetha Raghuveer, P. Barton Duell, Eliot A. Brinton, Amy Pollak, Lynne T. Braun & Francine K. Welty. (2019) Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association. Arteriosclerosis, Thrombosis, and Vascular Biology 39:2.
Crossref
Crossref
Lin Chen, Lu Liao, Ting Zhai, Xiangtao Huang & Yong Chen. (2018) Influence of Orally Administered Borneol on the Expression of Hepatic Transporters in Rats. European Journal of Drug Metabolism and Pharmacokinetics 44:1, pages 103-109.
Crossref
Crossref
Weijia Han, Qiao Wu, Xiaohui Zhang & Zhongping Duan. (2019) Innovation for hepatotoxicity in vitro research models: A review. Journal of Applied Toxicology 39:1, pages 146-162.
Crossref
Crossref
Cheynne C. McLean, Wendy A. Teft, Bridget L. Morse, Steven E. Gryn, Robert A. Hegele & Richard B. Kim. (2018) Food Effect on Rosuvastatin Disposition and Low-Density Lipoprotein Cholesterol. Clinical Pharmacology & Therapeutics 104:3, pages 525-533.
Crossref
Crossref
Issey Takehara, Takashi Yoshikado, Keiko Ishigame, Daiki Mori, Ken-ichi Furihata, Nobuaki Watanabe, Osamu Ando, Kazuya Maeda, Yuichi Sugiyama & Hiroyuki Kusuhara. (2018) Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers. Pharmaceutical Research 35:7.
Crossref
Crossref
Rui Li & Hugh A. Barton. (2017) Explaining Ethnic Variability of Transporter Substrate Pharmacokinetics in Healthy Asian and Caucasian Subjects with Allele Frequencies of OATP1B1 and BCRP: A Mechanistic Modeling Analysis. Clinical Pharmacokinetics 57:4, pages 491-503.
Crossref
Crossref
Michelle Schaefer, Gaku Morinaga, Akiko Matsui, Gerhard Schänzle, Daniel Bischoff & Roderich D. Süssmuth. (2018) Quantitative Expression of Hepatobiliary Transporters and Functional Uptake of Substrates in Hepatic Two-Dimensional Sandwich Cultures: A Comparative Evaluation of Upcyte and Primary Human Hepatocytes. Drug Metabolism and Disposition 46:2, pages 166-177.
Crossref
Crossref
J.E. Manautou & C.I. Ghanem. 2018. Comprehensive Toxicology. Comprehensive Toxicology
215
276
.
R.H. Ho & R.B. Kim. 2018. Comprehensive Toxicology. Comprehensive Toxicology
574
616
.
Hye Won Lee, Hye Jung Park, Bora Jin, Mehrangiz Dezhbord, Do Young Kim, Kwang-Hyub Han, Wang-Shick Ryu, Seungtaek Kim & Sang Hoon Ahn. (2017) Effect of S267F variant of NTCP on the patients with chronic hepatitis B. Scientific Reports 7:1.
Crossref
Crossref
Simone Kersseboom, Anja L. M van Gucht, Alies van Mullem, Giulia Brigante, Stefania Farina, Bo Carlsson, Joanne M Donkers, Stan F. J van de Graaf, Robin P Peeters & Theo J Visser. (2017) Role of the Bile Acid Transporter SLC10A1 in Liver Targeting of the Lipid-Lowering Thyroid Hormone Analog Eprotirome. Endocrinology 158:10, pages 3307-3318.
Crossref
Crossref
Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment
387
430
.
Alexander D. Roth & Moo-Yeal Lee. (2017) Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays. BioMed Research International 2017, pages 1-23.
Crossref
Crossref
Ting Xiang, Zhangbin Yang, Baoguo Sun, Haoxuan Luo, Shijun Zhang, Bin Ren, Xiaoling Chen, Xin Zhou & Zexiong Chen. (2016) Traditional Chinese medicine: Pivotal role of the spleen in the metabolism of aristolochic acid I in rats is dependent on oatp2a1. Molecular Medicine Reports 14:4, pages 3243-3250.
Crossref
Crossref
H. J. Burt, A. E. Riedmaier, M. D. Harwood, H. K. Crewe, K. L. Gill & S. Neuhoff. (2016) Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis. Drug Metabolism and Disposition 44:10, pages 1550-1561.
Crossref
Crossref
Jeremiah D. Momper, Shirley M. Tsunoda & Joseph D. Ma. (2016) Evaluation of Proposed In Vivo Probe Substrates and Inhibitors for Phenotyping Transporter Activity in Humans. The Journal of Clinical Pharmacology 56, pages S82-S98.
Crossref
Crossref
William Brian, Larry M Tremaine, Million Arefayene, Ruben de Kanter, Raymond Evers, Yingying Guo, James Kalabus, Wen Lin, Cho-Ming Loi & Guangqing Xiao. (2016) Assessment of drug metabolism enzyme and transporter pharmacogenetics in drug discovery and early development: perspectives of the I-PWG. Pharmacogenomics 17:6, pages 615-631.
Crossref
Crossref
Bruno Stieger & Gerd A. Kullak‐Ublick. 2015. Antitargets and Drug Safety. Antitargets and Drug Safety
159
172
.
Zhongqi Dong, Sean Ekins & James E. Polli. (2015) A substrate pharmacophore for the human sodium taurocholate co-transporting polypeptide. International Journal of Pharmaceutics 478:1, pages 88-95.
Crossref
Crossref
Richard D. Finkelman, Tzung-Dau Wang, Yi Wang, Connie T. Azumaya, Bruce K. Birmingham, Jenny Wissmar & Rogelio Mosqueda-Garcia. (2015) Effect of CYP2C19 polymorphism on the pharmacokinetics of rosuvastatin in healthy Taiwanese subjects. Clinical Pharmacology in Drug Development 4:1, pages 33-40.
Crossref
Crossref
R Li, H A Barton & T S Maurer. (2014) Toward Prospective Prediction of Pharmacokinetics in OATP1B1 Genetic Variant Populations. CPT: Pharmacometrics & Systems Pharmacology 3:12, pages 1-9.
Crossref
Crossref
Wen Jin Hua, Wei Xiao Hua, Fu Yong Nan, Wang An Jiang & Chen Yan. (2014) The influence of herbal medicine ursolic acid on the uptake of rosuvastatin mediated by OATP1B1*1a and *5. European Journal of Drug Metabolism and Pharmacokinetics 39:3, pages 221-230.
Crossref
Crossref
Anna Vildhede, Maria Karlgren, Elin K. Svedberg, Jacek R. Wisniewski, Yurong Lai, Agneta Norén & Per Artursson. (2014)
Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions
. Drug Metabolism and Disposition 42:7, pages 1210-1218.
Crossref
Crossref
Christine Y. Yu, Stuart E. Campbell, Craig A. Sponseller, David S. Small, Matthew M. Medlock & Roger E. Morgan. (2014) Steady-State Pharmacokinetics of Darunavir/Ritonavir and Pitavastatin when Co-administered to Healthy Adult Volunteers. Clinical Drug Investigation 34:7, pages 475-482.
Crossref
Crossref
Na LiPingping ZhangCuiling YangQianqian ZhuZhu LiFang LiQunying HanYawen WangYi LvPing WeiZhengwen Liu. (2014) Association of Genetic Variation of Sodium Taurocholate Cotransporting Polypeptide with Chronic Hepatitis B Virus Infection. Genetic Testing and Molecular Biomarkers 18:6, pages 425-429.
Crossref
Crossref
Anna Baghdasaryan, Peter Chiba & Michael Trauner. (2014) Clinical application of transcriptional activators of bile salt transporters. Molecular Aspects of Medicine 37, pages 57-76.
Crossref
Crossref
Yi‐an Bi, Xi Qiu, Charles J. Rotter, Emi Kimoto, Mary Piotrowski, Manthena V. Varma, Ayman F. EI‐Kattan & Yurong Lai. (2013) Quantitative assessment of the contribution of sodium‐dependent taurocholate co‐transporting polypeptide (NTCP) to the hepatic uptake of rosuvastatin, pitavastatin and fluvastatin. Biopharmaceutics & Drug Disposition 34:8, pages 452-461.
Crossref
Crossref
Xi Qiu, Yi-An Bi, Larissa M. Balogh & Yurong Lai. (2013) Absolute measurement of species differences in sodium taurocholate cotransporting polypeptide (NTCP/Ntcp) and its modulation in cultured hepatocytes. Journal of Pharmaceutical Sciences 102:9, pages 3252-3263.
Crossref
Crossref
Hon-Kit Lee, Miao Hu, Sandra SH Lui, Chung-Shun Ho, Chun-Kwok Wong & Brian Tomlinson. (2013)
Effects of polymorphisms in
ABCG2
,
SLCO1B1
,
SLC10A1
and
CYP2C9
/
19
on plasma concentrations of rosuvastatin and lipid response in Chinese patients
. Pharmacogenomics 14:11, pages 1283-1294.
Crossref
Crossref
Dilek Iusuf, Anita van Esch, Michael Hobbs, Maxine Taylor, Kathryn E. Kenworthy, Evita van de Steeg, Els Wagenaar & Alfred H. Schinkel. (2013) Murine Oatp1a/1b Uptake Transporters Control Rosuvastatin Systemic Exposure Without Affecting Its Apparent Liver Exposure. Molecular Pharmacology 83:5, pages 919-929.
Crossref
Crossref
Mariëtte Y.M. van der Wulp, Henkjan J. Verkade & Albert K. Groen. (2013) Regulation of cholesterol homeostasis. Molecular and Cellular Endocrinology 368:1-2, pages 1-16.
Crossref
Crossref
Tatiana Claro da Silva, James E. Polli & Peter W. Swaan. (2013) The solute carrier family 10 (SLC10): Beyond bile acid transport. Molecular Aspects of Medicine 34:2-3, pages 252-269.
Crossref
Crossref
Zhongqi Dong, Sean Ekins & James E. Polli. (2013) Structure–Activity Relationship for FDA Approved Drugs As Inhibitors of the Human Sodium Taurocholate Cotransporting Polypeptide (NTCP). Molecular Pharmaceutics 10:3, pages 1008-1019.
Crossref
Crossref
E. van de Steeg, R. Greupink, M. Schreurs, I.H.G. Nooijen, K.C.M. Verhoeckx, R. Hanemaaijer, D. Ripken, M. Monshouwer, M.L.H. Vlaming, J. DeGroot, M. Verwei, F.G.M. Russel, M.T. Huisman & H.M. Wortelboer. (2013) Drug-Drug Interactions between Rosuvastatin and Oral Antidiabetic Drugs Occurring at the Level of OATP1B1. Drug Metabolism and Disposition 41:3, pages 592-601.
Crossref
Crossref
Kenta YoshidaKazuya MaedaYuichi Sugiyama. (2013) Hepatic and Intestinal Drug Transporters: Prediction of Pharmacokinetic Effects Caused by Drug-Drug Interactions and Genetic Polymorphisms. Annual Review of Pharmacology and Toxicology 53:1, pages 581-612.
Crossref
Crossref
Miao Hu, Valiant Wah Lun Mak, Ophelia Qi Ping Yin, Tanya Ten Wah Chu & Brian Tomlinson. (2013) Effects of Grapefruit Juice and SLCO1B1 388A>G Polymorphism on the Pharmacokinetics of Pitavastatin. Drug Metabolism and Pharmacokinetics 28:2, pages 104-108.
Crossref
Crossref
Yurong Lai. 2013. Transporters in Drug Discovery and Development. Transporters in Drug Discovery and Development
353
454
.
Anne T Nies, Mikko Niemi, Oliver Burk, Stefan Winter, Ulrich M Zanger, Bruno Stieger, Matthias Schwab & Elke Schaeffeler. (2013) Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1. Genome Medicine 5:1, pages 1.
Crossref
Crossref
Hiroyuki Kusuhara, Kenta Yoshida & Yuichi Sugiyama. 2013. Transporters in Drug Development. Transporters in Drug Development
67
97
.
Jibin Li, Ying Wang, Wei Zhang, Yuehua Huang, Kristin Hein & Ismael J. Hidalgo. (2012) The Role of a Basolateral Transporter in Rosuvastatin Transport and Its Interplay with Apical Breast Cancer Resistance Protein in Polarized Cell Monolayer Systems. Drug Metabolism and Disposition 40:11, pages 2102-2108.
Crossref
Crossref
Yi-an Bi, Emi Kimoto, Samantha Sevidal, Hannah M. Jones, Hugh A. Barton, Sarah Kempshall, Kevin M. Whalen, Hui Zhang, Chengjie Ji, Katherine S. Fenner, Ayman F. El-Kattan & Yurong Lai. (2012) In Vitro Evaluation of Hepatic Transporter-Mediated Clinical Drug-Drug Interactions: Hepatocyte Model Optimization and Retrospective Investigation. Drug Metabolism and Disposition 40:6, pages 1085-1092.
Crossref
Crossref
Lan-Xiang Wu, Cheng-Xian Guo, Wang-Qing Chen, Jing Yu, Qiang Qu, Yao Chen, Zhi-Rong Tan, Guo Wang, Lan Fan, Qing Li, Wei Zhang & Hong-Hao Zhou. (2012) Inhibition of the organic anion-transporting polypeptide 1B1 by quercetin: an in vitro and in vivo assessment. British Journal of Clinical Pharmacology 73:5, pages 750-757.
Crossref
Crossref
Jean Davignon. (2012) Pleiotropic effects of pitavastatin. British Journal of Clinical Pharmacology 73:4, pages 518-535.
Crossref
Crossref
Min‐Koo Choi & Im‐Sook Song. (2012) Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake. Biopharmaceutics & Drug Disposition 33:3, pages 170-178.
Crossref
Crossref
Barbara Döring, Thomas Lütteke, Joachim Geyer & Ernst Petzinger. 2012. Co-Transport Systems. Co-Transport Systems
105
168
.
Rick Greupink, Lieve Dillen, Mario Monshouwer, Maarten T. Huisman & Frans G.M. Russel. (2011) Interaction of fluvastatin with the liver-specific Na+-dependent taurocholate cotransporting polypeptide (NTCP). European Journal of Pharmaceutical Sciences 44:4, pages 487-496.
Crossref
Crossref
Fabian MüllerMartin F Fromm. (2011) Transporter-mediated drug–drug interactions. Pharmacogenomics 12:7, pages 1017-1037.
Crossref
Crossref