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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 1
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General Xenobiochemistry

Characterization of metabolites and human P450 isoforms involved in the microsomal metabolism of mesaconitine

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Pages 46-58 | Received 24 Jul 2010, Accepted 15 Sep 2010, Published online: 24 Nov 2010

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Yufei He, Zihong Wei, Xiaoyan Ci, Ying Xie, Xiulin Yi, Yong Zeng, Yazhuo Li & Changxiao Liu. (2019) Effects of liquorice on pharmacokinetics of aconitine in rats. Xenobiotica 49:12, pages 1485-1493.
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Wenqin Liu, Jian Shi, Lijun Zhu, Lingna Dong, Feifei Luo, Min Zhao, Ying Wang, Ming Hu, Linlin Lu & Zhongqiu Liu. (2015) Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4. Drug Design, Development and Therapy 9, pages 5771-5783.
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Xiaocui Li, Yu Fu, Huawei Qiu, Xueyu Xu, Tingting Lin, Weiqing Hou, Weiying Chen, Rong Zhang, Zhongqiu Liu & Lijun Zhu. (2023) Clinical poisoning events involving yunaconitine may be highly correlated with metabolism-based interactions: A critical role of CYP3A4. Food and Chemical Toxicology 179, pages 113989.
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Qian Chen, Xinqi Deng, Kai Zhang, Yingquan Kang, Mingjie Jiao, Jia Zhang, Chunguo Wang & Fei Li. (2023) Changes to PUFA-PPAR pathway during mesaconitine induced myocardial coagulative necrosis. Food and Chemical Toxicology 177, pages 113831.
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Qian Chen, Kai Zhang, Mingjie Jiao, Jiakang Jiao, Dongling Chen, Yihui Yin, Jia Zhang & Fei Li. (2022) Study on the Mechanism of Mesaconitine-Induced Hepatotoxicity in Rats Based on Metabonomics and Toxicology Network. Toxins 14:7, pages 486.
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Xiaocui Li, Xiaowen Ou, Jiadong Ni, Yihong Xu, Huilin Zuo, Yu Fu, Caihua Yang, Zhongxiang Zhao, Na Li, Hua Zhou, Rong Zhang, Zhongqiu Liu, Ling Fu & Lijun Zhu. (2022) Bulleyaconitine A is a sensitive substrate and competitive inhibitor of CYP3A4: One of the possible explanations for clinical adverse reactions. Toxicology and Applied Pharmacology 445, pages 116024.
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Ashraf M. A. Qasem, Ziyu Zeng, Michael G. Rowan & Ian S. Blagbrough. (2022) Norditerpenoid alkaloids from Aconitum and Delphinium : structural relevance in medicine, toxicology, and metabolism . Natural Product Reports 39:3, pages 460-473.
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Li MI, Yu-Chen LI, Meng-Ru SUN, Pei-Lin ZHANG, Yi LI & Hua YANG. (2021) A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids. Chinese Journal of Natural Medicines 19:7, pages 505-520.
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Wei Zhou, Hong Liu, Li‐Zhen Qiu, Lan‐Xin Yue, Guang‐Jie Zhang, Hui‐Fang Deng, Yu‐Hao Ni & Yue Gao. (2021) Cardiac efficacy and toxicity of aconitine: A new frontier for the ancient poison. Medicinal Research Reviews 41:3, pages 1798-1811.
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Zhihui Sun, Limin Yang, Lihong Zhao, Ranji Cui & Wei Yang. (2020) Neuropharmacological Effects of Mesaconitine: Evidence from Molecular and Cellular Basis of Neural Circuit. Neural Plasticity 2020, pages 1-10.
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Yufei He, Zihong Wei, Ying Xie, Xiulin Yi, Yong Zeng, Yazhuo Li & Changxiao Liu. (2020) Potential synergic mechanism of Wutou-Gancao herb-pair by inhibiting efflux transporter P-glycoprotein. Journal of Pharmaceutical Analysis 10:2, pages 178-186.
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Zemin Yang, Yanke Lin, Lu Gao, Ziyue Zhou, Shuai Wang, Dong Dong & Baojian Wu. (2020) Circadian clock regulates metabolism and toxicity of Fuzi(lateral root of Aconitum carmichaeli Debx) in mice. Phytomedicine 67, pages 153161.
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Da-Cheng Hao. 2019. Ranunculales Medicinal Plants. Ranunculales Medicinal Plants 125 173 .
Mengbi Yang, Xiaoyu Ji & Zhong Zuo. (2018) Relationships between the Toxicities of Radix Aconiti Lateralis Preparata (Fuzi) and the Toxicokinetics of Its Main Diester-Diterpenoid Alkaloids. Toxins 10:10, pages 391.
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Jin-jun Wu, Zhen-zhen Guo, Yuan-feng Zhu, Zhi-jian Huang, Xia Gong, Yu-huan Li, Wen-jie Son, Xiao-yan Li, Yan-mei Lou, Li-jun Zhu, Lin-lin Lu, Zhong-qiu Liu & Liang Liu. (2018) A systematic review of pharmacokinetic studies on herbal drug Fuzi : Implications for Fuzi as personalized medicine. Phytomedicine 44, pages 187-203.
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Min Zhang, Chong-sheng Peng & Xiao-bo Li. (2017) Human intestine and liver microsomal metabolic differences between C19-diester and monoester diterpenoid alkaloids from the roots of Aconitum carmichaelii Debx.. Toxicology in Vitro 45, pages 318-333.
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Tengfei Xu, Shu Liu, Lulu Meng, Zifeng Pi, Fengrui Song & Zhiqiang Liu. (2016) Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional Chinese medicines. Journal of Chromatography B 1026, pages 56-66.
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Jinjun Wu, Na Lin, Fangyuan Li, Guiyu Zhang, Shugui He, Yuanfeng Zhu, Rilan Ou, Na Li, Shuqiang Liu, Lizhi Feng, Liang Liu, Zhongqiu Liu & Linlin Lu. (2016) Induction of P-glycoprotein expression and activity by Aconitum alkaloids: Implication for clinical drug–drug interactions. Scientific Reports 6:1.
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Janne T. Backman, Anne M. Filppula, Mikko Niemi & Pertti J. Neuvonen. (2015) Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions. Pharmacological Reviews 68:1, pages 168-241.
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Na Zhang, Jun Li, Qingqing Song, Shepo Shi, Chun Li, Yunfang Zhao, Yuelin Song & Pengfei Tu. (2016) Direct stability characterization of aconite alkaloids in different media by autosampler-mediated incubation-online solid phase extraction-LC-MS/MS. Analytical Methods 8:8, pages 1942-1949.
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Yunfeng Bi, Xiaoyu Zhuang, Hongbin Zhu, Fengrui Song, Zhiqiang Liu & Shuying Liu. (2015) Studies on metabolites and metabolic pathways of bulleyaconitine A in rat liver microsomes using LC-MS n combined with specific inhibitors . Biomedical Chromatography 29:7, pages 1027-1034.
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Shupeng Yang, Huiyan Zhang, Ross C. Beier, Feifei Sun, Xingyuan Cao, Jianzhong Shen, Zhanhui Wang & Suxia Zhang. (2015) Comparative metabolism of Lappaconitine in rat and human liver microsomes and in vivo of rat using ultra high-performance liquid chromatography–quadrupole/time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 110, pages 1-11.
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Peimin Dai, Lijun Zhu, Xiaoshan Yang, Min Zhao, Jian Shi, Ying Wang, Linlin Lu & Zhongqiu Liu. (2015) Multidrug resistance-associated protein 2 is involved in the efflux of Aconitum alkaloids determined by MRP2-MDCKII cells. Life Sciences 127, pages 66-72.
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Min Zhang, Chong-sheng Peng & Xiao-bo Li. (2015) In Vivo and In Vitro Metabolites from the Main Diester and Monoester Diterpenoid Alkaloids in a Traditional Chinese Herb, the Aconitum Species . Evidence-Based Complementary and Alternative Medicine 2015, pages 1-23.
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Jin-Ming Zhang, Wan Liao, Yu-xin He, Yao He, Dong Yan & Chao-Mei Fu. (2013) Study on intestinal absorption and pharmacokinetic characterization of diester diterpenoid alkaloids in precipitation derived from Fuzi–Gancao herb-pair decoction for its potential interaction mechanism investigation. Journal of Ethnopharmacology 147:1, pages 128-135.
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Ling Ye, Xiao-Shan Yang, Lin-lin Lu, Wei-Ying Chen, Shan Zeng, Tong-Meng Yan, Ling-Na Dong, Xiao-Juan Peng, Jian Shi & Zhong-Qiu Liu. (2013) Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5 . Evidence-Based Complementary and Alternative Medicine 2013, pages 1-24.
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Lijun Zhu, Xiaoshan Yang, Juan Zhou, Lan Tang, Bijun Xia, Ming Hu, Fuyuan Zhou & Zhongqiu Liu. (2013) The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography–tandem mass spectrometric method of a specific probe buspirone. Food and Chemical Toxicology 51, pages 396-403.
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Ling Ye, Tao Wang, Caihua Yang, Lan Tang, Juan Zhou, Chang Lv, Yun Gong, Zhihong Jiang & Zhongqiu Liu. (2011) Microsomal cytochrome P450-mediated metabolism of hypaconitine, an active and highly toxic constituent derived from Aconitum species. Toxicology Letters 204:1, pages 81-91.
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