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Xenobiotica

the fate of foreign compounds in biological systems

Volume 41, 2011 - Issue 1

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General Xenobiochemistry

Application of cytochrome P450 BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone

Jelle ReinenLACDR-Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

Livia L. KalmaLACDR-Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

Selina BegheijnLACDR-Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

Ferry HeusLACDR-Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

Jan N.M. CommandeurLACDR-Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

Nico P.E. VermeulenLACDR-Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The NetherlandsCorrespondence[email protected]

Pages 59-70 | Received 29 Jul 2010, Accepted 19 Sep 2010, Published online: 18 Nov 2010

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https://doi.org/10.3109/00498254.2010.525762

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Barbara M. A. van Vugt-Lussenburg, Liliana Capinha, Jelle Reinen, Martijn Rooseboom, Michel Kranendonk, Rob C. A. Onderwater & Paul Jennings. (2022) “ Commandeuring ” Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism . Chemical Research in Toxicology 35:7, pages 1184-1201.
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Min Zhou, Lijie Yang, Minghui Shao, Yuxi Wang, Weiren Yang, Libo Huang, Xuemei Zhou, Shuzhen Jiang & Zaibin Yang. (2018) Effects of Zearalenone Exposure on the TGF-β1/Smad3 Signaling Pathway and the Expression of Proliferation or Apoptosis Related Genes of Post-Weaning Gilts. Toxins 10:2, pages 49.
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Jelle Reinen, Geert Postma, Cornelis Tump, Tom Bloemberg, Jasper Engel, Nico P. E. Vermeulen, Jan N. M. Commandeur & Maarten Honing. (2016) Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity. Analytical and Bioanalytical Chemistry 408:5, pages 1425-1443.
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Jelle Reinen, Galvin Vredenburg, Karoline Klaering, Nico P.E. Vermeulen, Jan N.M. Commandeur, Maarten Honing & J. Chris Vos. (2015) Selective whole-cell biosynthesis of the designer drug metabolites 15- or 16-betahydroxynorethisterone by engineered Cytochrome P450 BM3 mutants. Journal of Molecular Catalysis B: Enzymatic 121, pages 64-74.
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Herman Autrup, Frank A. Barile, Bas J. Blaauboer, Gisela H. Degen, Wolfgang Dekant, Daniel Dietrich, Jose L. Domingo, Gio Batta Gori, Helmuth Greim, Jan G. Hengstler, Sam Kacew, Hans Marquardt, Olavi Pelkonen, Kai Savolainen & Nico P. Vermeulen. (2015) Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System. Toxicological Sciences 146:1, pages 11-15.
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James B.Y.H. Behrendorff, Weiliang Huang & Elizabeth M.J. Gillam. (2015) Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity. Biochemical Journal 467:1, pages 1-15.
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Qing Liu, Yajun Wang, Jianhong Gu, Yan Yuan, Xuezhong Liu, Wanglong Zheng, Qinyi Huang, Zongping Liu & Jianchun Bian. (2014) Zearalenone inhibits testosterone biosynthesis in mouse Leydig cells via the crosstalk of estrogen receptor signaling and orphan nuclear receptor Nur77 expression. Toxicology in Vitro 28:4, pages 647-656.
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Vanina Rea, David Falck, Jeroen Kool, Frans J. J. de Kanter, Jan N. M. Commandeur, Nico P. E. Vermeulen, Wilfried M. A. Niessen & Maarten Honing. (2013) Combination of biotransformation by P450 BM3 mutants with on-line post-column bioaffinity and mass spectrometric profiling as a novel strategy to diversify and characterize p38α kinase inhibitors. Med. Chem. Commun. 4:2, pages 371-377.
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Kim Thoa Nguyen, Cornelia Virus, Nils Günnewich, Frank Hannemann & Rita Bernhardt. (2012) Changing the Regioselectivity of a P450 from C15 to C11 Hydroxylation of Progesterone. ChemBioChem 13:8, pages 1161-1166.
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Andreas A. Hildebrand, Erika Pfeiffer, Georg Damm & Manfred Metzler. (2012) Combination of LC-MS 2 and GC-MS as a Tool to Differentiate Oxidative Metabolites of Zearalenone with Different Chemical Structures . International Journal of Spectroscopy 2012, pages 1-10.
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Christopher J. C. Whitehouse, Stephen G. Bell & Luet-Lok Wong. (2012) P450 BM3 (CYP102A1): connecting the dots . Chem. Soc. Rev. 41:3, pages 1218-1260.
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Michael Erkelenz, Chi-Hsien Kuo & Christof M. Niemeyer. (2011) DNA-Mediated Assembly of Cytochrome P450 BM3 Subdomains. Journal of the American Chemical Society 133:40, pages 16111-16118.
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Application of cytochrome P450 BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone

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Application of cytochrome P450 BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone

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