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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 1
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General Xenobiochemistry

Transport and metabolism of (±)-praeruptorin A in Caco-2 cell monolayers

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Pages 71-81 | Received 08 Aug 2010, Accepted 21 Sep 2010, Published online: 27 Oct 2010

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Xiong-Fei Wang, Yi-Kun Sun, Ke Sun, Yue-Zhu Ding & Rui-Juan Yuan. (2017) Review: Separation and Pharmacology of Chiral Compounds in Traditional Chinese Medicine. Analytical Letters 50:1, pages 33-49.
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Yue-Lin Song, Wang-Hui Jing, Peng-Fei Tu & Yi-Tao Wang. (2014) Enantiomeric separation of angular-type pyranocoumarins from Peucedani Radix using AD-RH chiral column. Natural Product Research 28:8, pages 545-550.
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Y. L. Song, W. H. Jing, H. Y. Zhao, R. Yan, P. T. Li & Y. T. Wang. (2012) Stereoselective metabolism of (±)-praeruptorin A, a calcium channel blocker from Peucedani Radix, in pooled liver microsomes of rats and humans. Xenobiotica 42:3, pages 231-237.
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Articles from other publishers (14)

Zhuicheng Xu, An Kang, Jinjun Shan, Mengmeng Song & Tong Xie. (2022) An LC-MS/MS Method for the Pharmacokinetic and In Vitro Metabolism Studies of Praeruptorin A in Rat . Current Pharmaceutical Analysis 18:5, pages 520-527.
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Hong Shen, Xue-Jiao Gao, Ting Li, Wang-Hui Jing, Bei-Lei Han, Yu-Meng Jia, Nan Hu, Zhi-Xiang Yan, Song-Lin Li & Ru Yan. (2018) Ginseng polysaccharides enhanced ginsenoside Rb1 and microbial metabolites exposure through enhancing intestinal absorption and affecting gut microbial metabolism. Journal of Ethnopharmacology 216, pages 47-56.
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An Kang, Tong Xie, Dong Zhu, Yu Dong, Hongmei Wen, Yuqiong Pei, Jinjun Shan & Liuqing Di. (2017) Comparative pharmacokinetic study of pyranocoumarins and khellactone in normal and acute lung injury rats after oral administration of Peucedanum praeruptorum Dunn extracts using a rapid and sensitive liquid chromatography-tandem mass spectrometry method . Biomedical Chromatography 31:10, pages e3977.
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Wanghui Jing, Ruilin Liu, Wei Du, Zhimin Luo, Pengqi Guo, Ting Zhang, Aiguo Zeng, Chun Chang & Qiang Fu. (2016) Pharmacokinetic and Metabolic Characteristics of Herb-Derived Khellactone Derivatives, A Class of Anti-HIV and Anti-Hypertensive: A Review. Molecules 21:3, pages 314.
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Y.L. Song, W.H. Jing, G. Du, F.Q. Yang, R. Yan & Y.T. Wang. (2014) Qualitative analysis and enantiospecific determination of angular-type pyranocoumarins in Peucedani Radix using achiral and chiral liquid chromatography coupled with tandem mass spectrometry. Journal of Chromatography A 1338, pages 24-37.
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Yue-Lin Song, Wang-Hui Jing, Ru Yan & Yi-Tao Wang. (2014) Metabolic characterization of (±)-praeruptorin A in vitro and in vivo by high performance liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry and time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 90, pages 98-110.
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Yuelin Song, Wanghui Jing, Pengfei Tu & Yitao Wang. (2014) Characterization of Peucedani Radix extract-derived angular-type pyranocoumarins in rats using ultra-high performance liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry. Anal. Methods 6:14, pages 5198-5206.
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Yuelin Song, Wanghui Jing, Pengfei Tu & Yitao Wang. (2014) Development of enantiospecific and chemoselective methods for the determination of praeruptorin A enantiomers and their metabolites in rat plasma using chiral and achiral LC-MS/MS. Anal. Methods 6:13, pages 4831-4839.
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Yuelin Song, Wanghui Jing, Ru Yan & Yitao Wang. (2014) A pretreatment free method for the determination of seven natural products in a high-salt matrix by online guard column extraction coupled with tandem mass spectrometry. Anal. Methods 6:2, pages 623-628.
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Yuelin Song, Wanghui Jing, Fengqing Yang, Zhan Shi, Meicun Yao, Ru Yan & Yitao Wang. (2014) Simultaneously enantiospecific determination of (+)-trans-khellactone, (+/−)-praeruptorin A, (+/−)-praeruptorin B, (+)-praeruptorin E, and their metabolites, (+/−)-cis-khellactone, in rat plasma using online solid phase extraction–chiral LC–MS/MS. Journal of Pharmaceutical and Biomedical Analysis 88, pages 269-277.
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Wang-Hui Jing, Yue-Lin Song, Ru Yan & Yi-Tao Wang. (2013) Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 77, pages 175-188.
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Parisa Sarkhail, Abbas Shafiee & Pantea Sarkheil. (2013) Biological Activities and Pharmacokinetics of Praeruptorins from Peucedanum Species: A Systematic Review . BioMed Research International 2013, pages 1-14.
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Taigang Liang, Wenyan Yue, Xue Du, Luhui Ren & Qingshan Li. (2012) Pharmacokinetics and Tissue Distribution Study of Praeruptorin D from Radix Peucedani in Rats by High-Performance Liquid Chromatography (HPLC). International Journal of Molecular Sciences 13:7, pages 9129-9141.
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Yue-Lin Song, Qing-Wen Zhang, Ya-Ping Li, Ru Yan & Yi-Tao Wang. (2012) Enantioseparation and Absolute Configuration Determination of Angular-Type Pyranocoumarins from Peucedani Radix Using Enzymatic Hydrolysis and Chiral HPLC-MS/MS Analysis. Molecules 17:4, pages 4236-4251.
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