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Keiichi Morita, Motohiro Kato, Toshiyuki Kudo & Kiyomi Ito. (2020) In vitro–in vivo extrapolation of metabolic clearance using human liver microsomes: factors showing variability and their normalization. Xenobiotica 50:9, pages 1064-1075.
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Eliane Alexandre, Audrey Baze, Céline Parmentier, Coraline Desbans, Dumrongsak Pekthong, Brigitte Gerin, Claudine Wack, Philippe Bachellier, Bruno Heyd, Jean-Christophe Weber & Lysiane Richert. (2012) Plateable cryopreserved human hepatocytes for the assessment of cytochrome P450 inducibility: experimental condition-related variables affecting their response to inducers. Xenobiotica 42:10, pages 968-979.
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Tashinga E. Bapiro, Scott Martin, Stephen D. Wilkinson, Alexandra L. Orton, Niresh Hariparsad, Stephanie Harlfinger & Dermot F. McGinnity. (2023) The Disconnect in Intrinsic Clearance Determined in Human Hepatocytes and Liver Microsomes Results from Divergent Cytochrome P450 Activities. Drug Metabolism and Disposition 51:7, pages 892-901.
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Christine Wegler, Pär Matsson, Veronica Krogstad, Jozef Urdzik, Hege Christensen, Tommy B. Andersson & Per Artursson. (2021) Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes. Molecular Pharmaceutics 18:4, pages 1792-1805.
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Daniela Schneider, Dirk Bier, Marcus Holschbach, Andreas Bauer & Bernd Neumaier. (2021) Species Differences in Microsomal Metabolism of Xanthine-Derived A1 Adenosine Receptor Ligands. Pharmaceuticals 14:3, pages 277.
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Beth Williamson, Stephanie Harlfinger & Dermot F. McGinnity. (2020) Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance. Drug Metabolism and Disposition 48:11, pages 1137-1146.
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Johannes Matthaei, Wagner Hugo Bonat, Reinhold Kerb, Mladen Vassilev Tzvetkov, Jakob Strube, Stefanie Brunke, Cordula Sachse-Seeboth, Daniel Sehrt, Ute Hofmann, Jacob von Bornemann Hjelmborg, Matthias Schwab & Jürgen Brockmöller. (2020) Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans. Frontiers in Genetics 11.
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Christine M. Bowman & Leslie Z. Benet. (2019) In Vitro–In Vivo Inaccuracy: The CYP3A4 Anomaly. Drug Metabolism and Disposition 47:12, pages 1368-1371.
Crossref
Crossref
Christine M. Bowman & Leslie Z. Benet. (2019) Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties. Pharmaceutical Research 36:8.
Crossref
Crossref
Christine M. Bowman & Leslie Z. Benet. (2019) In Vitro-In Vivo Extrapolation and Hepatic Clearance-Dependent Underprediction. Journal of Pharmaceutical Sciences 108:7, pages 2500-2504.
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Crossref
D. Hallifax & J.B. Houston. (2019) Use of Segregated Hepatocyte Scaling Factors and Cross-Species Relationships to Resolve Clearance Dependence in the Prediction of Human Hepatic Clearance. Drug Metabolism and Disposition 47:3, pages 320-327.
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Crossref
Francesca L. Wood, J. Brian Houston & David Hallifax. (2018) Importance of the Unstirred Water Layer and Hepatocyte Membrane Integrity In Vitro for Quantification of Intrinsic Metabolic Clearance. Drug Metabolism and Disposition 46:3, pages 268-278.
Crossref
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F. L. Wood, J. B. Houston & D. Hallifax. (2017) Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology. Drug Metabolism and Disposition 45:11, pages 1178-1188.
Crossref
Crossref
Saki Izumi, Yoshitane Nozaki, Takafumi Komori, Osamu Takenaka, Kazuya Maeda, Hiroyuki Kusuhara & Yuichi Sugiyama. (2017) Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro–In Vivo Extrapolation Approaches. Journal of Pharmaceutical Sciences 106:9, pages 2678-2687.
Crossref
Crossref
Kellie A. Fay, Patrick N. Fitzsimmons, Alex D. Hoffman & John W. Nichols. (2017) Comparison of trout hepatocytes and liver S9 fractions as in vitro models for predicting hepatic clearance in fish. Environmental Toxicology and Chemistry 36:2, pages 463-471.
Crossref
Crossref
Andrés Olivares-Morales, Avijit Ghosh, Leon Aarons & Amin Rostami-Hodjegan. (2016) Development of a Novel Simplified PBPK Absorption Model to Explain the Higher Relative Bioavailability of the OROS® Formulation of Oxybutynin. The AAPS Journal 18:6, pages 1532-1549.
Crossref
Crossref
Souzan B. Yanni. 2015. Translational ADMET for Drug Therapy. Translational ADMET for Drug Therapy
63
110
.
J. Nicolaï, T. De Bruyn, P. P. Van Veldhoven, J. Keemink, P. Augustijns & P. Annaert. (2015) Verapamil hepatic clearance in four preclinical rat models: towards activity-based scaling. Biopharmaceutics & Drug Disposition 36:7, pages 462-480.
Crossref
Crossref
Iwona Wilk-Zasadna, Camilla Bernasconi, Olavi Pelkonen & Sandra Coecke. (2015) Biotransformation in vitro: An essential consideration in the quantitative in vitro-to-in vivo extrapolation (QIVIVE) of toxicity data. Toxicology 332, pages 8-19.
Crossref
Crossref
Arianna Silva-Trujillo, José Correa-Basurto, Aurelio Romero-Castro, Arnulfo Albores & Jessica Elena Mendieta-Wejebe. (2015) A simple validated RP-HPLC bioanalytical method for the quantitative determination of a novel valproic acid arylamide derivative in rat hepatic microsomes. Biomedical Chromatography 29:4, pages 523-528.
Crossref
Crossref
Huybrecht T’jollyn, Jan Snoeys, Pieter Colin, Jan Van Bocxlaer, Pieter Annaert, Filip Cuyckens, An Vermeulen, Achiel Van Peer, Karel Allegaert, Geert Mannens & Koen Boussery. (2014) Physiology-Based IVIVE Predictions of Tramadol from in Vitro Metabolism Data. Pharmaceutical Research 32:1, pages 260-274.
Crossref
Crossref
Patrik Lundquist, Johan Lööf, Anna-Karin Sohlenius-Sternbeck, Eva Floby, Jenny Johansson, Johan Bylund, Janet Hoogstraate, Lovisa Afzelius & Tommy B. Andersson. (2014) The Impact of Solute Carrier (SLC) Drug Uptake Transporter Loss in Human and Rat Cryopreserved Hepatocytes on Clearance Predictions. Drug Metabolism and Disposition 42:3, pages 469-480.
Crossref
Crossref
Céline Parmentier, Germaine L. Truisi, Konrad Moenks, Sven Stanzel, Arno Lukas, Annette Kopp-Schneider, Eliane Alexandre, Philip G. Hewitt, Stefan O. Mueller & Lysiane Richert. (2013) Transcriptomic Hepatotoxicity Signature of Chlorpromazine after Short- and Long-Term Exposure in Primary Human Sandwich Cultures. Drug Metabolism and Disposition 41:10, pages 1835-1842.
Crossref
Crossref
Patricio Godoy, Nicola J. Hewitt, Ute Albrecht, Melvin E. Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes Georg Bode, Jennifer Bolleyn, Christoph Borner, Jan Böttger, Albert Braeuning, Robert A. Budinsky, Britta Burkhardt, Neil R. Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J. Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, María Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Chris E. P. Goldring, María José Gómez-Lechón, Geny M. M. Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann-Georg Holzhütter, J. Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens M. Kelm, B. Kevin Park, Claus Kordes, Gerd A. Kullak-Ublick, Edward L. LeCluyse, Peng Lu, Jennifer Luebke-Wheeler, Anna Lutz, Daniel J. Maltman, Madlen Matz-Soja, Patrick McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J. Naisbitt, Andreas K. Nussler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan A. Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H. K. Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E. Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S. Weiss, Agata Widera, Courtney G. Woods, Jinghai James Xu, Kathy M. Yarborough & Jan G. Hengstler. (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology 87:8, pages 1315-1530.
Crossref
Crossref
Kimberley Lentz, Joseph Raybon & Michael W. Sinz. 2013. Drug Discovery. Drug Discovery
99
139
.
Jian YinHongxia QiuJing DaiYanhua LuRong ZhaoLi ChenQin Meng. (2013) Prediction of hepatic plasma clearance in vivo from gel-entrapped rat and human hepatocytes. Canadian Journal of Physiology and Pharmacology 91:2, pages 178-186.
Crossref
Crossref
J. Brian Houston, Karen Rowland-Yeo & Ugo Zanelli. (2012) Evaluation of the novel in vitro systems for hepatic drug clearance and assessment of their predictive utility. Toxicology in Vitro 26:8, pages 1265-1271.
Crossref
Crossref
Li Di, Christopher Keefer, Dennis O. Scott, Timothy J. Strelevitz, George Chang, Yi-An Bi, Yurong Lai, Jonathon Duckworth, Katherine Fenner, Matthew D. Troutman & R. Scott Obach. (2012) Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design. European Journal of Medicinal Chemistry 57, pages 441-448.
Crossref
Crossref
Patrick Poulin, Cornelis E.C.A. Hop, Quynh Ho, Jason S. Halladay, Sami Haddad & Jane R. Kenny. (2012) Comparative Assessment of In Vitro–In Vivo Extrapolation Methods used for Predicting Hepatic Metabolic Clearance of Drugs. Journal of Pharmaceutical Sciences 101:11, pages 4308-4326.
Crossref
Crossref
David Hallifax & J. Brian Houston. (2012) Evaluation of Hepatic Clearance Prediction Using In Vitro Data: Emphasis on Fraction Unbound in Plasma and Drug Ionisation Using a Database of 107 Drugs. Journal of Pharmaceutical Sciences 101:8, pages 2645-2652.
Crossref
Crossref
Alexander V. LyubimovMichael A. Sinz. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
31
.
David Hallifax, Elisa Turlizzi, Ugo Zanelli & J. Brian Houston. (2012) Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs. European Journal of Pharmaceutical Sciences 45:5, pages 570-574.
Crossref
Crossref
Patrick Poulin, Jane R. Kenny, Cornelis E.C.A. Hop & Sami Haddad. (2012) In Vitro–In Vivo Extrapolation of Clearance: Modeling Hepatic Metabolic Clearance of Highly Bound Drugs and Comparative Assessment with Existing Calculation Methods. Journal of Pharmaceutical Sciences 101:2, pages 838-851.
Crossref
Crossref
Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi & J. Brian Houston. (2012) Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs. Drug Metabolism and Disposition 40:1, pages 104-110.
Crossref
Crossref
Patrick Poulin & Sami Haddad. (2011) Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes. Journal of Pharmaceutical Sciences 100:10, pages 4501-4517.
Crossref
Crossref