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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 5
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Animal Pharmacokinetics and Metabolism

Absorption, excretion, and metabolism of a potential GABA-Aα2/3 receptor modulator in rats

Jian GuoClinical Pharmacology & DMPK, AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE, USACorrespondence[email protected]
,
Patty C. DavisClinical Pharmacology & DMPK, AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE, USA
,
Chungang GuClinical Pharmacology & DMPK, AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE, USA
&
Scott W. GrimmClinical Pharmacology & DMPK, AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE, USA
Pages 385-399 | Received 09 Nov 2010, Accepted 02 Dec 2010, Published online: 06 Jan 2011

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Roberto Mandrioli & Laura Mercolini. (2015) Discontinued anxiolytic drugs (2009 – 2014). Expert Opinion on Investigational Drugs 24:4, pages 557-573.
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Articles from other publishers (6)

Lee Kingston, Chungang Gu, Jian Guo, Steve Swallow & Charles S. Elmore. (2021) The impact of radiochemistry in drug projects: The use of C‐14 label in the AZD8529, AZD7325, and AZD6280 projects. Journal of Labelled Compounds and Radiopharmaceuticals 64:2, pages 65-72.
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Markus Artelsmair, Chungang Gu, Richard J. Lewis & Charles S. Elmore. (2018) Synthesis of C‐14 labeled GABA A α2/α3 selective partial agonists and the investigation of late‐occurring and long‐circulating metabolites of GABA A receptor modulator AZD7325 . Journal of Labelled Compounds and Radiopharmaceuticals 61:5, pages 415-426.
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Erik T. te Beek, Xia Chen, Gabriël E. Jacobs, Kimberly J. Nahon, Marieke L. de Kam, Jaakko Lappalainen, Alan J. Cross, Joop M. A. van Gerven & Justin L. Hay. (2015) The effects of the nonselective benzodiazepine lorazepam and the α 2 /α 3 subunit-selective GABA A receptor modulators AZD7325 and AZD6280 on plasma prolactin levels . Clinical Pharmacology in Drug Development 4:2, pages 149-154.
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Xia Chen, Gabriel Jacobs, Marieke L. de Kam, Judith Jaeger, Jaakko Lappalainen, Paul Maruff, Mark A. Smith, Alan J. Cross, Adam Cohen & Joop van Gerven. (2015) AZD6280, a Novel Partial γ-Aminobutyric Acid A Receptor Modulator, Demonstrates a Pharmacodynamically Selective Effect Profile in Healthy Male Volunteers. Journal of Clinical Psychopharmacology 35:1, pages 22-33.
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Jian Guo, Minli Zhang, Charles S. Elmore & Karthick Vishwanathan. (2013) An integrated strategy for in vivo metabolite profiling using high-resolution mass spectrometry based data processing techniques. Analytica Chimica Acta 780, pages 55-64.
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Markus R. Meyer & Hans H. Maurer. (2012) Current applications of high-resolution mass spectrometry in drug metabolism studies. Analytical and Bioanalytical Chemistry 403:5, pages 1221-1231.
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