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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 5
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Animal Pharmacokinetics and Metabolism

In vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases

Liyue HuangPharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, MA, USA
,
Xuhai BePharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, MA, USA
,
Loren BerryPharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, MA, USA
,
Earl MoorePharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, MA, USA
,
Brett JanoskyPharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, MA, USA
,
Mary WellsPharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, MA, USA
,
Wei-Jian PanPharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, MA, USA
,
Zhiyang ZhaoPharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, MA, USA
&
Min-Hwa Jasmine LinPharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, MA, USACorrespondence[email protected]
 show all
Pages 400-408 | Received 29 Oct 2010, Accepted 14 Dec 2010, Published online: 04 Feb 2011

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Francesca Toselli, Melanie Golding, Johan Nicolaï, Eric Gillent & Hugues Chanteux. (2022) Drug clearance by aldehyde oxidase: can we avoid clinical failure?. Xenobiotica 52:8, pages 890-903.
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Lenisa Geron, Kleiton Silva Borges, Augusto Faria Andrade, Veridiana Kill Suazo, Carlos Alberto Scrideli & Luiz Gonzaga Tone. (2015) Antitumour activity of AMG 900 alone or in combination with histone deacetylase inhibitor SaHa on medulloblastoma cell lines. Neurological Research 37:8, pages 703-711.
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Chun Hei Antonio Cheung, Sailu Sarvagalla, Jane Ying-Chieh Lee, Yi-Chun Huang & Mohane Selvaraj Coumar. (2014) Aurora kinase inhibitor patents and agents in clinical testing: an update (2011 – 2013). Expert Opinion on Therapeutic Patents 24:9, pages 1021-1038.
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Articles from other publishers (8)

Nidhi Varshney, Annu Rani, Dharmendra Kashyap, Deeksha Tiwari & Hem Chandra Jha. 2022. Protein Kinase Inhibitors. Protein Kinase Inhibitors 261 322 .
Hardik Bhatt, Keerti Vishwakarma & Suman Shaw. 2022. Protein Kinase Inhibitors. Protein Kinase Inhibitors 323 360 .
Ankit C. Borisa & Hardik G. Bhatt. (2017) A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies. European Journal of Medicinal Chemistry 140, pages 1-19.
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Min Yan, Chunli Wang, Bin He, Mengying Yang, Mengying Tong, Zijie Long, Bing Liu, Fei Peng, Lingzhi Xu, Yan Zhang, Dapeng Liang, Haixin Lei, Sen Subrata, Keith W. Kelley, Eric W.-F. Lam, Bilian Jin & Quentin Liu. (2016) Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy. Medicinal Research Reviews 36:6, pages 1036-1079.
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Stephanie Geuns-Meyer, Victor J. Cee, Holly L. Deak, Bingfan Du, Brian L. Hodous, Hanh Nho Nguyen, Philip R. Olivieri, Laurie B. Schenkel, Karina R. Vaida, Paul Andrews, Annette Bak, Xuhai Be, Pedro J. Beltran, Tammy L. Bush, Mary K. Chaves, Grace Chung, Yang Dai, Patrick Eden, Kelly Hanestad, Liyue Huang, Min-Hwa Jasmine Lin, Jin Tang, Beth Ziegler, Robert Radinsky, Richard Kendall, Vinod F. Patel & Marc Payton. (2015) Discovery of N -(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), A Highly Selective, Orally Bioavailable Inhibitor of Aurora Kinases with Activity against Multidrug-Resistant Cancer Cell Lines . Journal of Medicinal Chemistry 58:13, pages 5189-5207.
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Gloria Juan, Tammy L Bush, Connie Ma, Raffi Manoukian, Grace Chung, Jennifer M Hawkins, Stephen Zoog, Richard Kendall, Robert Radinsky, Robert Loberg, Greg Friberg & Marc Payton. (2014) AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor xenografts and proliferating mouse tissues. Journal of Translational Medicine 12:1.
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Xuhai Be, Earl S. Moore, Zhiyang Zhao & Mary C. Wells. (2013) LC–MS/MS bioanalytical method development for AMG 900: Resolution of an isobaric interference in rodent in vivo studies. Journal of Pharmaceutical and Biomedical Analysis 74, pages 171-177.
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Laurie B. Schenkel, Xin Huang, Alan Cheng, Holly L. Deak, Elizabeth Doherty, Renee Emkey, Yan Gu, Hakan Gunaydin, Joseph L. Kim, Josie Lee, Robert Loberg, Philip Olivieri, Jeanne Pistillo, Jin Tang, Qian Wan, Hui-Ling Wang, Shen-Wu Wang, Mary C. Wells, Bin Wu, Violeta Yu, Liqin Liu & Stephanie Geuns-Meyer. (2011) Discovery of Potent and Highly Selective Thienopyridine Janus Kinase 2 Inhibitors. Journal of Medicinal Chemistry 54:24, pages 8440-8450.
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