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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 5
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Animal Pharmacokinetics and Metabolism

Dalcetrapib pharmacokinetics and metabolism in the cynomolgus monkey

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Pages 430-436 | Received 19 Nov 2010, Accepted 24 Dec 2010, Published online: 24 Feb 2011

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Hiroaki Takubo, Tomohiro Ishikawa, Olaf Kuhlmann, Hiroyuki Nemoto, Tomoyuki Noguchi, Toyomichi Nanayama, Hiroshi Komura & Motohiro Kogayu. (2014) Pharmacokinetics and disposition of dalcetrapib in rats and monkeys. Xenobiotica 44:12, pages 1117-1126.
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Amit S. Kalgutkar, Kosea S. Frederick, Heather L. Hatch, Catherine M. Ambler, David A. Perry, Ravi S. Garigipati, George C. Chang, Bruce A. Lefker, Ronald W. Clark, Lee A. Morehouse, Omar Francone & Xiao Hu. (2014) Identification of a novel, non-tetrahydroquinoline variant of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, with improved aqueous solubility. Xenobiotica 44:7, pages 591-605.
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Günter Gross, Joseph Tardio & Olaf Kuhlmann. (2012) Solubility and stability of dalcetrapib in vehicles and biological media. International Journal of Pharmaceutics 437:1-2, pages 103-109.
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David RhaindsBenoit J ArsenaultMathieu R BrodeurJean-Claude Tardif. (2012) An update on the clinical development of dalcetrapib (RO4607381), a cholesteryl ester transfer protein modulator that increases HDL cholesterol levels. Future Cardiology 8:4, pages 513-531.
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Katja Heinig, Franz Bucheli, Olaf Kuhlmann, Manfred Zell, Axel Pähler, Elke Zwanziger, Günter Gross, Joseph Tardio, Tomohiro Ishikawa & Tomoko Yamashita. (2012) Determination of dalcetrapib by liquid chromatography–tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 66, pages 314-324.
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D E Gutstein, R Krishna, D Johns, H K Surks, H M Dansky, S Shah, Y B Mitchel, J Arena & J A Wagner. (2011) Anacetrapib, a Novel CETP Inhibitor: Pursuing a New Approach to Cardiovascular Risk Reduction. Clinical Pharmacology & Therapeutics 91:1, pages 109-122.
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Michael Derks, Hitoshi Kawamura, Markus Abt, Georgina Meneses-Lorente, Mary Phelan & Tomohiro Ishikawa. (2011) Effects of Food Intake on the Pharmacokinetic Properties of Dalcetrapib: Findings From Three Phase I, Single-Dose Crossover Studies in Healthy Volunteers. Clinical Therapeutics 33:6, pages 754-765.
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