Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 6
376
Views
29
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Identification of human UGT isoforms responsible for glucuronidation of efavirenz and its three hydroxy metabolites

, , &
Pages 437-444 | Received 30 Nov 2010, Accepted 31 Dec 2010, Published online: 14 Feb 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Monpat Chamnanphon, Rattanaporn Sukprasong, Andrea Gaedigk, Weerawat Manosuthi, Pajaree Chariyavilaskul, Supeecha Wittayalertpanya, Napatrupron Koomdee, Thawinee Jantararoungtong, Apichaya Puangpetch & Chonlaphat Sukasem. (2021) Influence of SULT1A1*2 Polymorphism on Plasma Efavirenz Concentration in Thai HIV-1 Patients. Pharmacogenomics and Personalized Medicine 14, pages 915-926.
Read now

Articles from other publishers (27)

Urs Duthaler, Fabio Bachmann, Agustos C. Ozbey, Kenichi Umehara, Neil Parrott, Stephen Fowler & Stephan Krähenbühl. (2023) The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis. Clinical Pharmacokinetics 62:8, pages 1141-1155.
Crossref
Abigail M. Wheeler, Benjamin C. Orsburn & Namandjé N. Bumpus. (2023) Biotransformation of Efavirenz and Proteomic Analysis of Cytochrome P450s and UDP-Glucuronosyltransferases in Mouse, Macaque, and Human Brain-Derived In Vitro Systems. Drug Metabolism and Disposition 51:4, pages 521-531.
Crossref
Musa Otieno Ngayo, Margaret Oluka, Zachari Arochi Kwena, Wallace Dimbuson Bulimo & Faith Apolot Okalebo. (2022) Effects of cytochrome P450 2B6 and constitutive androstane receptor genetic variation on Efavirenz plasma concentrations among HIV patients in Kenya. PLOS ONE 17:3, pages e0260872.
Crossref
Zaikuan J. YuEric P. MosherNamandjé N. Bumpus. (2021) Pharmacogenomics of Antiretroviral Drug Metabolism and Transport. Annual Review of Pharmacology and Toxicology 61:1, pages 565-585.
Crossref
Ang Chen, Xiaojing Zhou, Yi Cheng, Shuowen Tang, Mingyao Liu & Xin Wang. (2018) Design and optimization of the cocktail assay for rapid assessment of the activity of UGT enzymes in human and rat liver microsomes. Toxicology Letters 295, pages 379-389.
Crossref
Tailah Bernardo de Almeida, Marcelo Costa Velho Mendes de Azevedo, Jorge Francisco da Cunha Pinto, Fernando Rafael de Almeida Ferry, Guilherme Almeida Rosa da Silva, Izana Junqueira de Castro, Paxton Baker, Amilcar Tanuri, David W Haas & Cynthia C Cardoso. (2018) Drug metabolism and transport gene polymorphisms and efavirenz adverse effects in Brazilian HIV-positive individuals. Journal of Antimicrobial Chemotherapy 73:9, pages 2460-2467.
Crossref
Litaty Céphanoée Mbatchi, Jean-Paul Brouillet & Alexandre Evrard. (2018) Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability. Pharmacogenomics 19:1, pages 61-77.
Crossref
Nádia M. Grilo, M. João Correia, Joana P. Miranda, Madalena Cipriano, Jacinta Serpa, M. Matilde Marques, Emília C. Monteiro, Alexandra M.M. Antunes, Lucília N. Diogo & Sofia A. Pereira. (2017) Unmasking efavirenz neurotoxicity: Time matters to the underlying mechanisms. European Journal of Pharmaceutical Sciences 105, pages 47-54.
Crossref
Nádia M. Grilo, M. João Correia, Catarina Sequeira, Shrika G. Harjivan, Umbelina Caixas, Lucília N. Diogo, M. Matilde Marques, Emília C. Monteiro, Alexandra M.M. Antunes & Sofia A. Pereira. (2016) Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients. Toxicology Letters 260, pages 28-35.
Crossref
Marelize Swart, Jonathan Evans, Michelle Skelton, Sandra Castel, Lubbe Wiesner, Peter J. Smith & Collet Dandara. (2016) An Expanded Analysis of Pharmacogenetics Determinants of Efavirenz Response that Includes 3′-UTR Single Nucleotide Polymorphisms among Black South African HIV/AIDS Patients. Frontiers in Genetics 6.
Crossref
Mônica M. Bastos, Carolina C.P. Costa, Talitha C. Bezerra, Fernando de C. da Silva & Núbia Boechat. (2016) Efavirenz a nonnucleoside reverse transcriptase inhibitor of first-generation: Approaches based on its medicinal chemistry. European Journal of Medicinal Chemistry 108, pages 455-465.
Crossref
Ellen M. McDonagh, Johnathan L. Lau, Maria L. Alvarellos, Russ B. Altman & Teri E. Klein. (2015) PharmGKB summary. Pharmacogenetics and Genomics 25:7, pages 363-376.
Crossref
Juhee Sim, Eunhwa Choi, Gil-Saeng Jeong & Sangkyu Lee. (2015) Characterization of in vitro metabolites of cudratricusxanthone A in human liver microsomes . Biopharmaceutics & Drug Disposition 36:5, pages 325-336.
Crossref
Shingo Oda, Tatsuki Fukami, Tsuyoshi Yokoi & Miki Nakajima. (2015) A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development. Drug Metabolism and Pharmacokinetics 30:1, pages 30-51.
Crossref
Jeongmin Joo, Boram Lee, Taeho Lee & Kwang-Hyeon Liu. (2014) Screening of six UGT enzyme activities in human liver microsomes using liquid chromatography/triple quadrupole mass spectrometry. Rapid Communications in Mass Spectrometry 28:22, pages 2405-2414.
Crossref
Kyung-Ah Seo, Hyo-Ji Kim, Eun Sook Jeong, Nagi Abdalla, Chang-Soo Choi, Dong-Hyun Kim & Jae-Gook Shin. (2014) In Vitro Assay of Six UDP-Glucuronosyltransferase Isoforms in Human Liver Microsomes, Using Cocktails of Probe Substrates and Liquid Chromatography–Tandem Mass Spectrometry. Drug Metabolism and Disposition 42:11, pages 1803-1810.
Crossref
V Michaud, Y Kreutz, T Skaar, E Ogburn, N Thong, D A Flockhart & Z Desta. (2013) Efavirenz-mediated induction of omeprazole metabolism is CYP2C19 genotype dependent. The Pharmacogenomics Journal 14:2, pages 151-159.
Crossref
J.C. Stingl, H. Bartels, R. Viviani, M.L. Lehmann & J. Brockmöller. (2014) Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review. Pharmacology & Therapeutics 141:1, pages 92-116.
Crossref
Andrew Owen & Paul Curley. 2014. Humanized Mice for HIV Research. Humanized Mice for HIV Research 339 360 .
Marco SiccardiRajith Kumar Reddy Rajoli, Paul Curley, Adeniyi Olagunju, Darren Moss & Andrew Owen. (2013) Physiologically based pharmacokinetic models for the optimization of antiretroviral therapy: recent progress and future perspective. Future Virology 8:9, pages 871-890.
Crossref
Fen Jiang, Zeruesenay Desta, Ji-Hong Shon, Chang-Woo Yeo, Ho-Sook Kim, Kwang-Hyeon Liu, Soo-Kyung Bae, Sang-Seop Lee, David A. Flockhart & Jae-Gook Shin. (2013) Effects of clopidogrel and itraconazole on the disposition of efavirenz and its hydroxyl metabolites: exploration of a novel CYP2B6 phenotyping index. British Journal of Clinical Pharmacology 75:1, pages 244-253.
Crossref
Adeniyi Olagunju, Andrew Owen & Tim R Cressey. (2012) Potential effect of pharmacogenetics on maternal, fetal and infant antiretroviral drug exposure during pregnancy and breastfeeding. Pharmacogenomics 13:13, pages 1501-1522.
Crossref
V Michaud, E Ogburn, N Thong, A O Aregbe, T C Quigg, D A Flockhart & Z Desta. (2012) Induction of CYP2C19 and CYP3A Activity Following Repeated Administration of Efavirenz in Healthy Volunteers. Clinical Pharmacology & Therapeutics 91:3, pages 475-482.
Crossref
Hye Young Ji, Hyeri Lee, Sae Rom Lim, Jeong Han Kim & Hye Suk Lee. (2012) Effect of Efavirenz on UDP-Glucuronosyltransferase 1A1, 1A4, 1A6, and 1A9 Activities in Human Liver Microsomes. Molecules 17:1, pages 851-860.
Crossref
Sofia A. Pereira, Riccardo Wanke, M. Matilde Marques, Emília C. Monteiro & Alexandra M.M. Antunes. 2012. Advances in Molecular Toxicology Volume 6. Advances in Molecular Toxicology Volume 6 1 39 .
Getnet Yimer, Nobuhisa Ueda, Abiy Habtewold, Wondwossen Amogne, Akira Suda, Klaus-Dieter Riedel, Jürgen Burhenne, Getachew Aderaye, Lars Lindquist, Eyasu Makonnen & Eleni Aklillu. (2011) Pharmacogenetic & Pharmacokinetic Biomarker for Efavirenz Based ARV and Rifampicin Based Anti-TB Drug Induced Liver Injury in TB-HIV Infected Patients. PLoS ONE 6:12, pages e27810.
Crossref
A. Habtewold, W. Amogne, E. Makonnen, G. Yimer, K.-D. Riedel, N. Ueda, A. Worku, W. E. Haefeli, L. Lindquist, G. Aderaye, J. Burhenne & E. Aklillu. (2011) Long-term effect of efavirenz autoinduction on plasma/peripheral blood mononuclear cell drug exposure and CD4 count is influenced by UGT2B7 and CYP2B6 genotypes among HIV patients. Journal of Antimicrobial Chemotherapy 66:10, pages 2350-2361.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.