Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 7
236
Views
17
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Intestinal transport of scutellarein and scutellarin and first-pass metabolism by UDP-glucuronosyltransferase-mediated glucuronidation of scutellarein and hydrolysis of scutellarin

, , &
Pages 538-548 | Received 17 Feb 2011, Accepted 04 Apr 2011, Published online: 11 May 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Xinran Wang, Cai Zhang, Ning Han, Juyuan Luo, Shuofeng Zhang, Chunguo Wang, Zhanhong Jia & Shouying Du. (2021) Triglyceride-mimetic prodrugs of scutellarin enhance oral bioavailability by promoting intestinal lymphatic transport and avoiding first-pass metabolism. Drug Delivery 28:1, pages 1664-1672.
Read now
Mei Zeng, Lan Yang, Dan He, Yao Li, Mingxin Shi & Jingqing Zhang. (2017) Metabolic pathways and pharmacokinetics of natural medicines with low permeability. Drug Metabolism Reviews 49:4, pages 464-476.
Read now

Articles from other publishers (15)

Natalie Vivien Gunter & Siau Hui Mah. 2023. Handbook of Dietary Flavonoids. Handbook of Dietary Flavonoids 1 73 .
Tao Li, Dirong Wu, Yang Yang, Tao Xiao, Yilin Han, Jing Li, Ting Liu, Li Li, Zeqin Dai, Yongjun Li & Xiaozhong Fu. (2020) Synthesis, pharmacological evaluation and mechanistic study of scutellarin methyl ester -4′-dipeptide conjugates for the treatment of hypoxic-ischemic encephalopathy (HIE) in rat pups. Bioorganic Chemistry 101, pages 103980.
Crossref
Jinxin Shi, Chengpeng Sun, Huilian Huang, Wenhui Lin, Jian Gao, Yanhe Lin, Zhanjun Zhang, Xiaokui Huo, Xiangge Tian, Zhenlong Yu, Baojing Zhang & Xiaochi Ma. (2020) β ‐Glucuronidase‐ and OATP2B1 ‐mediated drug interaction of scutellarin in Dengzhan Xixin Injection: A formulation aspect . Drug Development Research 81:5, pages 609-619.
Crossref
Liping Wang & Qiang Ma. (2018) Clinical benefits and pharmacology of scutellarin: A comprehensive review. Pharmacology & Therapeutics 190, pages 105-127.
Crossref
Jingnan Wang, Jiayun Tan, Jiahao Luo, Peilin Huang, Wuyi Zhou, Luming Chen, Lingli Long, Li-ming Zhang, Banghao Zhu, Liqun Yang & David Y. B. Deng. (2017) Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy. Journal of Nanobiotechnology 15:1.
Crossref
Lu Xiao, Tao Yi, Min Chen, Christopher Wai Kei Lam & Hua Zhou. (2016) A new mechanism for increasing the oral bioavailability of scutellarin with Cremophor EL: Activation of MRP3 with concurrent inhibition of MRP2 and BCRP. European Journal of Pharmaceutical Sciences 93, pages 456-467.
Crossref
Yu Ou, Min Luo, Yong-Xi Dong, Hang Su, Xiao-Zhong Fu, Yu-Feng Cha, Shun Zhang, Yong-Long Zhao, Yong-Jun Li & Yong-Lin Wang. (2016) Permeability of novel 4′-N-substituted (aminomethyl) benzoate-7-substituted nicotinic acid ester derivatives of scutellarein in Caco-2 cells and in an in vitro model of the blood-brain barrier. Medicinal Chemistry Research 25:10, pages 2205-2213.
Crossref
Jihong Chu, Chong Zou, Changyin Li, Jun Zhang, Yang Zhao, Meijuan Xu, Ting Wu & Wenzheng Ju. (2016) Determination of scutellarein in human plasma by enzymatic hydrolysis and liquid chromatograph-triple quadrupole tandem mass spectrometer analysis: Its use in determining the bioequivalence of scutellarin in Chinese volunteers. European Journal of Integrative Medicine 8:4, pages 519-525.
Crossref
Yu-Feng Cha, Shun Zhang, Hang Su, Yu Ou, Xiao-Zhong Fu, Feng-Jie Jiang, Yong-Long Zhao, Yong-Xi Dong, Min Luo, Yong Huang, Yan-Yu Lan, Ai-Min Wang & Yong-Lin Wang. (2014) l-Amino acid carbamate prodrugs of scutellarin: synthesis, physiochemical property, Caco-2 cell permeability, and in vitro anti-oxidative activity. Medicinal Chemistry Research 24:5, pages 2238-2246.
Crossref
Wen-Zheng Ju, Yang Zhao, Fang Liu, Ting Wu, Jun Zhang, Shi-Jia Liu, Ling Zhou, Guo-Liang Dai, Ning-Ning Xiong & Zhu-Yuan Fang. (2015) Clinical tolerability and pharmacokinetics of Erigerontis hydroxybenzene injection: Results of a randomized phase I study in healthy Chinese volunteers. Phytomedicine 22:2, pages 319-325.
Crossref
Xiao Yang, Xiaoqing Miao, Fangrui Cao, Shang Li, Nana Ai, Qi Chang, Simon M.Y. Lee & Ying Zheng. (2014) Nanosuspension Development of Scutellarein as an Active and Rapid Orally Absorbed Precursor of its BCS Class IV Glycoside Scutellarin. Journal of Pharmaceutical Sciences 103:11, pages 3576-3584.
Crossref
Hai-Sheng You, Jian-Feng Xing, Jun Lu, Wei-Hua Dong, Jun-Tian Liu & Ya-Lin Dong. (2014) Influence of the Gastrointestinal Microflora and Efflux Transporters on the Absorption of Scutellarin and Scutellarein. Phytotherapy Research 28:9, pages 1295-1300.
Crossref
Guang-You Ma, Yun-Feng Cao, Cui-Min Hu, Zhong-Ze Fang, Xiao-Yu Sun, Mo Hong & Zhi-Tu Zhu. (2014) Comparison of Inhibition Capability of Scutellarein and Scutellarin Towards Important Liver UDP-Glucuronosyltransferase (UGT) Isoforms. Phytotherapy Research 28:3, pages 382-386.
Crossref
Alexander V. LyubimovShalu Jhajra, Ninad Ramesh Varkhede, Deepak Suresh Ahire, Bukke Vidyasagar Naik, Bhagwat Prasad, Jyoti Paliwal & Saranjit Singh. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 99 .
Chunying Gao, Hongjian Zhang, Zitao Guo, Tiangeng You, Xiaoyan Chen & Dafang Zhong. (2012) Mechanistic Studies on the Absorption and Disposition of Scutellarin in Humans: Selective OATP2B1-Mediated Hepatic Uptake Is a Likely Key Determinant for Its Unique Pharmacokinetic Characteristics. Drug Metabolism and Disposition 40:10, pages 2009-2020.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.