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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 10
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General Xenobiochemistry

A comparison of hepatic in vitro metabolism of T-2 toxin in rats, pigs, chickens, and carp

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Pages 863-873 | Received 05 Apr 2011, Accepted 30 May 2011, Published online: 11 Jul 2011

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Zhao‐Ying Liu. (2012) An introduction to hybrid ion trap/time‐of‐flight mass spectrometry coupled with liquid chromatography applied to drug metabolism studies. Journal of Mass Spectrometry 47:12, pages 1627-1642.
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. (2011) Scientific Opinion on the risks for animal and public health related to the presence of T-2 and HT-2 toxin in food and feed. EFSA Journal 9:12, pages 2481.
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