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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 11
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General Xenobiochemistry

The mechanism of enzymatic and non-enzymatic N-oxide reductive metabolism of cyadox in pig liver

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Pages 964-971 | Received 07 Apr 2011, Accepted 30 May 2011, Published online: 11 Jul 2011

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Xu Wang, María-Aránzazu Martínez, Guyue Cheng, Zhaoying Liu, Lingli Huang, Menghong Dai, Dongmei Chen, María-Rosa Martínez-Larrañaga, Arturo Anadón & Zonghui Yuan. (2016) The critical role of oxidative stress in the toxicity and metabolism of quinoxaline 1,4-di-N-oxides in vitro and in vivo. Drug Metabolism Reviews 48:2, pages 159-182.
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Lingli Huang, Zhoumeng Lin, Xuan Zhou, Meiling Zhu, Ronette Gehring, Jim E. Riviere & Zonghui Yuan. (2015) Estimation of residue depletion of cyadox and its marker residue in edible tissues of pigs using physiologically based pharmacokinetic modelling. Food Additives & Contaminants: Part A 32:12, pages 2002-2017.
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Articles from other publishers (20)

Chongyang Huang, Hehua Lei, Chaoyang Liu & Yulan Wang. (2022) Acute and subchronic exposure of cyadox induced metabolic and transcriptomic disturbances in Wistar rats. Toxicology 482, pages 153367.
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Xiaoyan Pang, Chongzhuang Tang, Runcong Guo & Xiaoyan Chen. (2022) Non-cytochrome P450 enzymes involved in the oxidative metabolism of xenobiotics: Focus on the regulation of gene expression and enzyme activity. Pharmacology & Therapeutics 233, pages 108020.
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Sechenchogt Harnud, Shishan Fu, Yulian Wang, Yuanhu Pan, Aiqun Zhang & Lingli Huang. (2021) Pharmacokinetics of cyadox and its main metabolites in rats, pigs, chickens, and carps following oral administration at three dosage. Regulatory Toxicology and Pharmacology 124, pages 104971.
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Muhammad Kashif Maan, Zhifei Weng, Menghong Dai, Zhenli Liu, Haihong Hao, Guyue Cheng, Yulian Wang, Xu Wang & Lingli Huang. (2021) The Spectrum of Antimicrobial Activity of Cyadox against Pathogens Collected from Pigs, Chicken, and Fish in China. Antibiotics 10:2, pages 153.
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Qiang Li, Wenbin Zhou, Yuyan Wang, Fang Kou, Chunming Lyu & Hai Wei. (2020) Metabolic mechanism and anti-inflammation effects of sinomenine and its major metabolites N-demethylsinomenine and sinomenine-N-oxide. Life Sciences 261, pages 118433.
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Adeel Sattar, Mian Abdul Hafeez, Qin Wu, Adnan Hassan Tahir, Muhammad Abu Bakr Shabbir, Dongmei Chen, Lingli Huang, Shuyu Xie & Zonghui Yuan. (2020) Disposition of cyadox in domesticated cats following oral, intramuscular, and intravenous administration. Journal of Veterinary Pharmacology and Therapeutics 43:2, pages 97-107.
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Qianying Liu, Zhixin Lei, Kaixiang Zhou, Huiru Yu, Shenhe Liu, Qiliang Sun, Xu Wang, Menghong Dai & Zonghui Yuan. (2018) N–O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox. Chemical Research in Toxicology 31:11, pages 1219-1229.
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Feng Li, Nenggang Zhang, Siddharth Gorantla, Scott R. Gilbertson & Debananda Pati. (2018) The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes. Frontiers in Pharmacology 9.
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Hailey J. Knox, Jamila Hedhli, Tae Wook Kim, Kian Khalili, Lawrence W. Dobrucki & Jefferson Chan. (2017) A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia. Nature Communications 8:1.
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Ashok K. Sharma, Shubham K. Jaiswal, Nikhil Chaudhary & Vineet K. Sharma. (2017) A novel approach for the prediction of species-specific biotransformation of xenobiotic/drug molecules by the human gut microbiota. Scientific Reports 7:1.
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Fanfan Xu, Guyue Cheng, Haihong Hao, Yulian Wang, Xu Wang, Dongmei Chen, Dapeng Peng, Zhenli Liu, Zonghui Yuan & Menghong Dai. (2016) Mechanisms of Antibacterial Action of Quinoxaline 1,4-di-N-oxides against Clostridium perfringens and Brachyspira hyodysenteriae. Frontiers in Microbiology 7.
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Adeel Sattar, Shuyu Xie, Lingli Huang, Zahid Iqbal, Wei Qu, Muhammad A. Shabbir, Yuanhu Pan, Hafiz I. Hussain, Dongmei Chen, Yanfei Tao, Zhenli Liu, Mujahid Iqbal & Zonghui Yuan. (2016) Pharmacokinetics and Metabolism of Cyadox and Its Main Metabolites in Beagle Dogs Following Oral, Intramuscular, and Intravenous Administration. Frontiers in Pharmacology 7.
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S. Merel & C. Zwiener. 2016. Assessing Transformation Products of Chemicals by Non-Target and Suspect Screening − Strategies and Workflows Volume 2. Assessing Transformation Products of Chemicals by Non-Target and Suspect Screening − Strategies and Workflows Volume 2 3 27 .
Lingli Huang, Fujun Yin, Yuanhu Pan, Dongmei Chen, Juan Li, Dan Wan, Zhenli Liu & Zonghui Yuan. (2015) Metabolism, Distribution, and Elimination of Mequindox in Pigs, Chickens, and Rats. Journal of Agricultural and Food Chemistry 63:44, pages 9839-9849.
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Huang Lingli, Xu Ning, Sechenchogt Harnud, Pan Yuanhu, Chen Dongmei, Tao Yanfei, Liu Zhenli & Yuan Zonghui. (2015) Metabolic Disposition and Elimination of Cyadox in Pigs, Chickens, Carp, and Rats. Journal of Agricultural and Food Chemistry 63:22, pages 5557-5569.
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Juan Li, Lingli Huang, Xu Wang, Yuanhu Pan, Zhaoying Liu, Dongmei Chen, Yanfei Tao, Qinghua Wu & Zonghui Yuan. (2014) Metabolic disposition and excretion of quinocetone in rats, pigs, broilers, and carp. Food and Chemical Toxicology 69, pages 109-119.
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Peiqiang Mu, Ming Zheng, Ming Xu, Yuanming Zheng, Xianqing Tang, Yufan Wang, Kaixin Wu, Qingmei Chen, Lijuan Wang & Yiqun Deng. (2014) N -Oxide Reduction of Quinoxaline-1,4-Dioxides Catalyzed by Porcine Aldehyde Oxidase SsAOX1 . Drug Metabolism and Disposition 42:4, pages 511-519.
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Chigang Chen, Guyue Cheng, Haihong Hao, Menghong Dai, Xu Wang, Lingli Huang, Zhenli Liu & Zonghui Yuan. (2013) Mechanism of Porcine Liver Xanthine Oxidoreductase Mediated N-Oxide Reduction of Cyadox as Revealed by Docking and Mutagenesis Studies. PLoS ONE 8:9, pages e73912.
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Jiaheng Zhang, Min Li, Linxia Li, Yubo Li, Bing Peng, Suxia Zhang, Haixiang Gao & Wenfeng Zhou. (2012) Investigation of the ultrasound effect and target analyte selectivity of dispersive liquid–liquid microextraction and its application to a quinocetone pharmacokinetic study. Journal of Chromatography A 1268, pages 1-8.
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Xianqing Tang, Peiqiang Mu, Jun Wu, Jun Jiang, Caihui Zhang, Ming Zheng & Yiqun Deng. (2012) Carbonyl Reduction of Mequindox by Chicken and Porcine Cytosol and Cloned Carbonyl Reductase 1. Drug Metabolism and Disposition 40:4, pages 788-795.
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