Citations (163)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (11)
Nobumitsu Hanioka, Takashi Isobe, Toshiko Tanaka-Kagawa, Hideto Jinno & Susumu Ohkawara. (2022) In vitro glucuronidation of bisphenol A in liver and intestinal microsomes: interspecies differences in humans and laboratory animals. Drug and Chemical Toxicology 45:4, pages 1565-1569.
Read now
Read now
Dong Gui Hu, Peter I. Mackenzie, Julie-Ann Hulin, Ross A. McKinnon & Robyn Meech. (2022) Regulation of human UDP-glycosyltransferase (UGT) genes by miRNAs. Drug Metabolism Reviews 54:2, pages 120-140.
Read now
Read now
Guiyuan He, Johanna Troberg, Xia Lv, Yang-Liu Xia, Liang-Liang Zhu, Jing Ning, Guang-Bo Ge, Moshe Finel & Ling Yang. (2018) Identification and characterization of human UDP-glucuronosyltransferases responsible for xanthotoxol glucuronidation. Xenobiotica 48:2, pages 109-116.
Read now
Read now
Christina M. Street, Zhaohui Zhu, Moshe Finel & Michael H. Court. (2017) Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms. Xenobiotica 47:1, pages 1-10.
Read now
Read now
Larry House, Jacqueline Ramirez, Michael Seminerio, Snezana Mirkov & Mark J. Ratain. (2015) In vitro glucuronidation of aprepitant: a moderate inhibitor of UGT2B7. Xenobiotica 45:11, pages 990-998.
Read now
Read now
Darja Gramec Skledar, Johanna Troberg, Jason Lavdas, Lucija Peterlin Mašič & Moshe Finel. (2015) Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10. Xenobiotica 45:6, pages 511-519.
Read now
Read now
Jolantha Beyerle, Eva Frei, Marie Stiborova, Nina Habermann & Cornelia M. Ulrich. (2015) Biotransformation of xenobiotics in the human colon and rectum and its association with colorectal cancer. Drug Metabolism Reviews 47:2, pages 199-221.
Read now
Read now
Dong Gui Hu, Robyn Meech, Ross A. McKinnon & Peter I. Mackenzie. (2014) Transcriptional regulation of human UDP-glucuronosyltransferase genes. Drug Metabolism Reviews 46:4, pages 421-458.
Read now
Read now
Dongxue Sun, Liangliang Zhu, Ling Xiao, Yangliu Xia, Guangbo Ge, Yunfeng Cao, Yan Wu, Jun Yin & Ling Yang. (2014) In vitro glucuronidation of Armillarisin A: UDP-glucuronosyltransferase 1A9 acts as a major contributor and significant species differences. Xenobiotica 44:11, pages 988-995.
Read now
Read now
Ursula Gundert-Remy, Ulrike Bernauer, Brunhilde Blömeke, Barbara Döring, Eric Fabian, Carsten Goebel, Stefanie Hessel, Christine Jäckh, Alfonso Lampen, Franz Oesch, Ernst Petzinger, Wolfgang Völkel & Peter H. Roos. (2014) Extrahepatic metabolism at the body's internal–external interfaces. Drug Metabolism Reviews 46:3, pages 291-324.
Read now
Read now
Tuomas Rahikainen, Merja R. Häkkinen, Moshe Finel, Markku Pasanen & Risto O. Juvonen. (2013) A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes. Xenobiotica 43:10, pages 853-861.
Read now
Read now
Articles from other publishers (152)
Jean Dinh, Trevor N. Johnson, Manuela Grimstein & Tamorah Lewis. (2023) Physiologically Based Pharmacokinetics Modeling in the Neonatal Population—Current Advances, Challenges, and Opportunities. Pharmaceutics 15:11, pages 2579.
Crossref
Crossref
Fernanda de Lima Moreira, Tiago Antunes Paz, Patrícia Pereira dos Santos Melli, Matheus de Lucca Thomaz, Maria Paula Marques, Adriana Rocha, Geraldo Duarte & Vera Lucia Lanchote. (2023) Total, Unbound, Renal, and Hepatic Clearances of Raltegravir and the Formation and Elimination Clearances of Raltegravir Glucuronide in Pregnant Women. The Journal of Clinical Pharmacology 63:9, pages 1053-1060.
Crossref
Crossref
Jun Matsumoto, Anzu Nishimoto, Shogo Watari, Hideo Ueki, Shoya Shiromizu, Naohiro Iwata, Tatsuaki Takeda, Soichiro Ushio, Makoto Kajizono, Masachika Fujiyoshi, Toshihiro Koyama, Motoo Araki, Koichiro Wada, Yoshito Zamami, Yasutomo Nasu & Noritaka Ariyoshi. (2022) Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma. Molecular and Cellular Biochemistry 478:8, pages 1779-1790.
Crossref
Crossref
Ravneel R. Chand, Mhairi Nimick, Belinda Cridge & Rhonda J. Rosengren. (2023) Investigating the Contribution of Major Drug-Metabolising Enzymes to Possum-Specific Fertility Control. International Journal of Molecular Sciences 24:11, pages 9424.
Crossref
Crossref
Abigail M. Wheeler, Benjamin C. Orsburn & Namandjé N. Bumpus. (2023) Biotransformation of Efavirenz and Proteomic Analysis of Cytochrome P450s and UDP-Glucuronosyltransferases in Mouse, Macaque, and Human Brain-Derived In Vitro Systems. Drug Metabolism and Disposition 51:4, pages 521-531.
Crossref
Crossref
Abigail M. Wheeler, Colten D. Eberhard, Eric P. Mosher, Yuting Yuan, Hannah N. Wilkins, Herana Kamal Seneviratne, Benjamin C. Orsburn & Namandjé N. Bumpus. (2023) Achieving a Deeper Understanding of Drug Metabolism and Responses Using Single-Cell Technologies. Drug Metabolism and Disposition 51:3, pages 350-359.
Crossref
Crossref
Wenyu Liu, Jing Li, Rui Zhao, Yao Lu & Panpan Huang. (2023) The Uridine diphosphate (UDP)-glycosyltransferases (UGTs) superfamily: the role in tumor cell metabolism. Frontiers in Oncology 12.
Crossref
Crossref
Le-Yuan Shang, Ming-Hao Zhou, Si-Yuan Cao, Min Zhang, Peng-Jiao Wang, Shuo Zhang, Xiao-Xia Meng, Qi-Mei Yang & Xiu-Li Gao. (2023) Effect of polyethylene glycol 400 on the pharmacokinetics and tissue distribution of baicalin by intravenous injection based on the enzyme activity of UGT1A8/1A9. European Journal of Pharmaceutical Sciences 180, pages 106328.
Crossref
Crossref
Dong Gui Hu, Shashikanth Marri, Julie-Ann Hulin, Ross A. McKinnon, Peter I. Mackenzie & Robyn Meech. (2022) The Somatic Mutation Landscape of UDP-Glycosyltransferase (UGT) Genes in Human Cancers. Cancers 14:22, pages 5708.
Crossref
Crossref
Ankit Balhara, Aditya R. Kumar & Jashvant D. Unadkat. (2022) Predicting Human Fetal Drug Exposure Through Maternal‐Fetal PBPK Modeling and In Vitro or Ex Vivo Studies. The Journal of Clinical Pharmacology 62:S1.
Crossref
Crossref
Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao & Xingxing Diao. (2022)
Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [
14
C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
. Drug Metabolism and Disposition 50:6, pages 798-808.
Crossref
Crossref
Weili Mao, Lingling Mao, Nan Zhao, Yingying Zhang, Meirong Zhao & Hangbiao Jin. (2022) Disposition of Bisphenol S metabolites in Sprague-Dawley rats. Science of The Total Environment 811, pages 152288.
Crossref
Crossref
Yasuhiro Uno, Shotaro Uehara & Hiroshi Yamazaki. (2022) Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans. Biochemical Pharmacology 197, pages 114887.
Crossref
Crossref
Norio Suzuki, Yuma Iwamura, Taku Nakai, Koichiro Kato, Akihito Otsuki, Akira Uruno, Daisuke Saigusa, Keiko Taguchi, Mikiko Suzuki, Ritsuko Shimizu, Akane Yumoto, Risa Okada, Masaki Shirakawa, Dai Shiba, Satoru Takahashi, Takafumi Suzuki & Masayuki Yamamoto. (2022) Gene expression changes related to bone mineralization, blood pressure and lipid metabolism in mouse kidneys after space travel. Kidney International 101:1, pages 92-105.
Crossref
Crossref
James Akingbasote, Sandra Szlapinski, Elora Hilmas, Patrik Miller & Natalie Rine. 2022. Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology. Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology
197
232
.
Cui-Lan Meng, Wei Zhao & Dan-Ni Zhong. (2021) Epigenetics and microRNAs in UGT1As. Human Genomics 15:1.
Crossref
Crossref
Qi‐Hang Zhou, Guang‐Hao Zhu, Yun‐Qing Song, Yuan‐Fang Que, Qing‐Qing He, Dong‐Zhu Tu, Hai‐Rong Zeng, Wei‐Wei Qin, Chun‐Zhi Ai & Guang‐Bo Ge. (2021) Methylophiopogonanone A is a naturally occurring broad‐spectrum inhibitor against human UDP‐glucuronosyltransferases: Inhibition behaviours and implication in herb‐drug interactions. Basic & Clinical Pharmacology & Toxicology 129:6, pages 437-449.
Crossref
Crossref
Min Li, Qingfeng He, Li Yao, Xiaofeng Wang, Zhijia Tang, Xiao Zhu, Hai-Shu Lin & Xiaoqiang Xiang. (2021) Simultaneous Quantification of Propylthiouracil and Its N-β-d Glucuronide by HPLC-MS/MS: Application to a Metabolic Study. Pharmaceuticals 14:11, pages 1194.
Crossref
Crossref
Lei Feng, Yi Wang, Jiasheng Qin, Yu Fu, Zeyi Guo, Jianmin Zhang, Guolin He, Zesheng Jiang, Xiaoping Xu, Chenjie Zhou & Yi Gao. (2021) UGT1A Gene Family Members Serve as Potential Targets and Prognostic Biomarkers for Pancreatic Cancer. BioMed Research International 2021, pages 1-20.
Crossref
Crossref
Dong Gui Hu, Shashikanth Marri, Peter I. Mackenzie, Julie-Ann Hulin, Ross A. McKinnon & Robyn Meech. (2021) The Expression Profiles and Deregulation of UDP-Glycosyltransferase (UGT) Genes in Human Cancers and Their Association with Clinical Outcomes. Cancers 13:17, pages 4491.
Crossref
Crossref
Daniela Silva-Adaya, Carla Garza-Lombó & María E. Gonsebatt. (2021) Xenobiotic transport and metabolism in the human brain. NeuroToxicology 86, pages 125-138.
Crossref
Crossref
Anna Bogacz, Adam Kamiński, Małgorzata Łochyńska, Izabela Uzar, Jarosław Gorący, Daniel Kotrych, Agnieszka Seremak-Mrozikiewicz & Bogusław Czerny. (2021) The importance of the UGT1A1 variants in the development of osteopenia and osteoporosis in postmenopausal women. Scientific Reports 11:1.
Crossref
Crossref
Xiaoyu Wang, Zhe Wang, Xiaoyu Fan, Mingrui Yan, Lili Jiang, Yangliu Xia, Jun Cao & Yong Liu. (2021) Comparison of the drug-drug interactions potential of ibrutinib and acalabrutinib via inhibition of UDP-glucuronosyltransferase. Toxicology and Applied Pharmacology 424, pages 115595.
Crossref
Crossref
Yazun Jarrar & Su-Jun Lee. (2021) The Functionality of UDP-Glucuronosyltransferase Genetic Variants and their Association with Drug Responses and Human Diseases. Journal of Personalized Medicine 11:6, pages 554.
Crossref
Crossref
Ya-Nan Zhu, Shuo Zhang, Min Zhang, Xiao-Xia Meng, Peng-Jiao Wang, Rong-Ping Zhang & Xiu-Li Gao. (2021) Study of Pharmaceutical Excipient PEG400 Alteration of Pharmacokinetics and Tissue Distribution of Main Flavonoids Metabolites of Baicalin. Current Pharmaceutical Analysis 17:5, pages 609-623.
Crossref
Crossref
Daniela Poblete, Fernando Bernal, Gabriel Llull, Sebastian Archiles, Patricia Vasquez, Leonardo Chanqueo, Nicole Soto, María A. Lavanderos, Luis A. Quiñones & Nelson M. Varela. (2021) Pharmacogenetic Associations Between Atazanavir/UGT1A1*28 and Efavirenz/rs3745274 (CYP2B6) Account for Specific Adverse Reactions in Chilean Patients Undergoing Antiretroviral Therapy. Frontiers in Pharmacology 12.
Crossref
Crossref
Anna Mieszkowska, Anna M. Nowicka, Agata Kowalczyk, Agnieszka Potęga, Monika Pawłowska, Michał Kosno, Ewa Augustin & Zofia Mazerska. (2021) Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells. Pharmaceuticals 14:4, pages 317.
Crossref
Crossref
Fabrice Neiers, David Jarriault, Franck Menetrier, Loïc Briand & Jean-Marie Heydel. (2021) The odorant metabolizing enzyme UGT2A1: Immunolocalization and impact of the modulation of its activity on the olfactory response. PLOS ONE 16:3, pages e0249029.
Crossref
Crossref
Herana Kamal Seneviratne, Allyson N. Hamlin, Sue Li, Beatriz Grinsztejn, Halima Dawood, Albert Y. Liu, Irene Kuo, Mina C. Hosseinipour, Ravindre Panchia, Leslie Cottle, Gordon Chau, Adeola Adeyeye, Alex R. Rinehart, Marybeth McCauley, Joseph S. Eron, Myron S. Cohen, Raphael J. Landovitz, Craig W. Hendrix & Namandjé N. Bumpus. (2021) Identification of Novel UGT1A1 Variants Including UGT1A1 454C>A through the Genotyping of Healthy Participants of the HPTN 077 Study. ACS Pharmacology & Translational Science 4:1, pages 226-239.
Crossref
Crossref
Huan Liu, Xiong Zhou, Shaowen Huang, Jie Yang, Ruijing Liu & Chunhong Liu. (2021) Lycium Barbarum Polysaccharides and Wolfberry Juice Prevent DEHP-Induced Hepatotoxicity via PXR-Regulated Detoxification Pathway. Molecules 26:4, pages 859.
Crossref
Crossref
Aarzoo Thakur, Md Masud Parvez, J. Steven Leeder & Bhagwat Prasad. 2021. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism
551
593
.
You Gao, Chunmiao Yang, Lingchao Wang, Yanan Xiang, Wenpeng Zhang, Yunfeng Li & Xiaomei Zhuang. (2020) Comparable Intestinal and Hepatic First-Pass Effect of YL-IPA08 on the Bioavailability and Effective Brain Exposure, a Rapid Anti-PTSD and Anti-Depression Compound. Frontiers in Pharmacology 11.
Crossref
Crossref
Steffen Landerer, Sandra Kalthoff, Stefan Paulusch & Christian P. Strassburg. (2020) UDP‐glucuronosyltransferase polymorphisms affect diethylnitrosamine‐induced carcinogenesis in humanized transgenic mice. Cancer Science 111:11, pages 4266-4275.
Crossref
Crossref
Chloé Hugbart, Yann Verres, Brendan Le Daré, Simon Bucher, Elise Vène, Aude Bodin, Vincent Lagente, Bernard Fromenty, Renaud Bouvet, Isabelle Morel, Pascal Loyer & Thomas Gicquel. (2020) Non-oxidative ethanol metabolism in human hepatic cells in vitro: Involvement of uridine diphospho-glucuronosyltransferase 1A9 in ethylglucuronide production. Toxicology in Vitro 66, pages 104842.
Crossref
Crossref
Dimosthenis Α. Sarigiannis, Spyros P. Karakitsios, Evangelos Handakas & Alberto Gotti. (2020) Development of a generic lifelong physiologically based biokinetic model for exposome studies. Environmental Research 185, pages 109307.
Crossref
Crossref
Parul Patel, Zhengyu Xue, Karen S King, Laura Parham, Susan Ford, Yu Lou, Kalpana K Bakshi, Kenneth Sutton, David Margolis, Arlene R Hughes & William R Spreen. (2020) Evaluation of the effect of UGT1A1 polymorphisms on the pharmacokinetics of oral and long-acting injectable cabotegravir. Journal of Antimicrobial Chemotherapy.
Crossref
Crossref
Gaëlle Magliocco, Frédérique Rodieux, Jules Desmeules, Caroline Flora Samer & Youssef Daali. (2019) Toward precision medicine in pediatric population using cytochrome P450 phenotyping approaches and physiologically based pharmacokinetic modeling. Pediatric Research 87:3, pages 441-449.
Crossref
Crossref
Yasuhiro Uno, Shotaro Uehara, Takashi Inoue, Shu Kawamura, Norie Murayama, Miyu Nishikawa, Shinichi Ikushiro, Erika Sasaki & Hiroshi Yamazaki. (2020) Molecular characterization of functional UDP-glucuronosyltransferases 1A and 2B in common marmosets. Biochemical Pharmacology 172, pages 113748.
Crossref
Crossref
Stephanie E. Martinez, Marie C. Andresen, Zhaohui Zhu, Ioannis Papageorgiou & Michael H. Court. (2020) Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization. Scientific Reports 10:1.
Crossref
Crossref
Risto O. Juvonen, Aki T. Heikkinen, Olli Kärkkäinen, Rabia Jehangir, Juhani Huuskonen, Johanna Troberg, Hannu Raunio, Olli T. Pentikäinen & Moshe Finel. (2020) In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs. European Journal of Pharmaceutical Sciences 141, pages 105118.
Crossref
Crossref
Dong Gui Hu, J.ulie-Ann Hulin, Pramod C. Nair, Alex Z. Haines, Ross A. McKinnon, Peter I. Mackenzie & Robyn Meech. (2019) The UGTome: The expanding diversity of UDP glycosyltransferases and its impact on small molecule metabolism. Pharmacology & Therapeutics 204, pages 107414.
Crossref
Crossref
Jin-Bo Fang, Dejan Nikolić, David C. Lankin, Charlotte Simmler, Shao-Nong Chen, Rene F. Ramos Alvarenga, Yang Liu, Guido F. Pauli & Richard B. van Breemen. (2019)
Formation of (2
R
)- and (2
S
)-8-Prenylnaringenin Glucuronides by Human UDP-Glucuronosyltransferases
. Journal of Agricultural and Food Chemistry 67:42, pages 11650-11656.
Crossref
Crossref
Sinjini Sikdar, Roby Joehanes, Bonnie R Joubert, Cheng-Jian Xu, Marta Vives-Usano, Faisal I Rezwan, Janine F Felix, James M Ward, Weihua Guan, Rebecca C Richmond, Jennifer A Brody, Leanne K Küpers, Nour Baïz, Siri E Håberg, Jennifer A Smith, Sarah E Reese, Stella Aslibekyan, Cathrine Hoyo, Radhika Dhingra, Christina A Markunas, Tao Xu, Lindsay M Reynolds, Allan C Just, Pooja R Mandaviya, Akram Ghantous, Brian D Bennett, Tianyuan Wang, The BIOS Consortium, Kelly M Bakulski, Erik Melen, Shanshan Zhao, Jianping Jin, Zdenko Herceg, Joyce van Meurs, Jack A Taylor, Andrea A Baccarelli, Susan K Murphy, Yongmei Liu, Monica Cheng Munthe-Kaas, Ian J Deary, Wenche Nystad, Melanie Waldenberger, Isabella Annesi-Maesano, Karen Conneely, Vincent WV Jaddoe, Donna Arnett, Harold Snieder, Sharon LR Kardia, Caroline L Relton, Ken K Ong, Susan Ewart, Hortensia Moreno-Macias, Isabelle Romieu, Nona Sotoodehnia, Myriam Fornage, Alison Motsinger-Reif, Gerard H Koppelman, Mariona Bustamante, Daniel Levy & Stephanie J London. (2019) Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics 11:13, pages 1487-1500.
Crossref
Crossref
Dandan Zhou, Linghua Kong, Yiguo Jiang, Cheng Wang, Yao Ni, Yedong Wang, Hongjian Zhang & Jianqing Ruan. (2019) UGT-dependent regioselective glucuronidation of ursodeoxycholic acid and obeticholic acid and selective transport of the consequent acyl glucuronides by OATP1B1 and 1B3. Chemico-Biological Interactions 310, pages 108745.
Crossref
Crossref
Mitesh Patel, H. Christian Eberl, Andrea Wolf, Esaie Pierre, Joseph W. Polli & Maciej J. Zamek-Gliszczynski. (2019) Mechanistic Basis of Cabotegravir–Glucuronide Disposition in Humans. Journal of Pharmacology and Experimental Therapeutics 370:2, pages 269-277.
Crossref
Crossref
Yangliu Xia & Huilin Pang. (2019) Glucuronidation of d-Luciferin In Vitro: Isoform Selectivity and Kinetics Characterization. European Journal of Drug Metabolism and Pharmacokinetics 44:4, pages 549-556.
Crossref
Crossref
Elizabeth A. Hausner, Susan A. Elmore & Xi Yang. (2019) Overview of the Components of Cardiac Metabolism. Drug Metabolism and Disposition 47:6, pages 673-688.
Crossref
Crossref
Lydia Woelflingseder, Benedikt Warth, Immina Vierheilig, Heidi Schwartz-Zimmermann, Christian Hametner, Veronika Nagl, Barbara Novak, Bojan Šarkanj, Franz Berthiller, Gerhard Adam & Doris Marko. (2019) The Fusarium metabolite culmorin suppresses the in vitro glucuronidation of deoxynivalenol. Archives of Toxicology 93:6, pages 1729-1743.
Crossref
Crossref
David Rodrigues & Andrew Rowland. (2019) From Endogenous Compounds as Biomarkers to Plasma‐Derived Nanovesicles as Liquid Biopsy; Has the Golden Age of Translational Pharmacokinetics‐Absorption, Distribution, Metabolism, Excretion‐Drug–Drug Interaction Science Finally Arrived?. Clinical Pharmacology & Therapeutics 105:6, pages 1407-1420.
Crossref
Crossref
Aimee K. Sutliff, Christy J. W. Watson, Gang Chen & Philip Lazarus. (2019) Regulation of UGT2A1 by miR-196a-5p and miR-196b-5p. Journal of Pharmacology and Experimental Therapeutics 369:2, pages 234-243.
Crossref
Crossref
Stephanie N. Liu, Jessica Bo Li Lu, Christy J. W. Watson, Philip Lazarus, Zeruesenay Desta & Brandon T. Gufford. (2019) Mechanistic Assessment of Extrahepatic Contributions to Glucuronidation of Integrase Strand Transfer Inhibitors. Drug Metabolism and Disposition 47:5, pages 535-544.
Crossref
Crossref
Dimosthenis A. Sarigiannis, Spyros Karakitsios, Elena Dominguez-Romero, Krystalia Papadaki, Celine Brochot, Vikas Kumar, Marta Schuhmacher, Moustapha Sy, Hans Mielke, Mathias Greiner, Marcel Mengelers & Martin Scheringer. (2019) Physiology-based toxicokinetic modelling in the frame of the European Human Biomonitoring Initiative. Environmental Research 172, pages 216-230.
Crossref
Crossref
Yasuhiro Uno, Rika Takahira, Norie Murayama, Shunsuke Onozeki, Shu Kawamura, Shotaro Uehara, Yoshinori Ikenaka, Mayumi Ishizuka, Shinichi Ikushiro & Hiroshi Yamazaki. (2019) Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques. Biochemical Pharmacology 163, pages 335-344.
Crossref
Crossref
Robyn Meech, Dong Gui Hu, Ross A. McKinnon, Siti Nurul Mubarokah, Alex Z. Haines, Pramod C. Nair, Andrew Rowland & Peter I. Mackenzie. (2019) The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms. Physiological Reviews 99:2, pages 1153-1222.
Crossref
Crossref
Kangle Shi, Shan Li & Qinggang Meng. (2019) Identification and interspecies characterization of UDP-glucuronosyltransferase isoforms catalyzing acacetin glucuronidation using recombinant UGT enzymes and microsomes. Journal of Traditional Chinese Medical Sciences 6:2, pages 155-163.
Crossref
Crossref
Xin-Yu Liu, Xia Lv, Ping Wang, Chun-Zhi Ai, Qi-Hang Zhou, Moshe Finel, Bin Fan, Yun-Feng Cao, Hui Tang & Guang-Bo Ge. (2019) Inhibition of UGT1A1 by natural and synthetic flavonoids. International Journal of Biological Macromolecules 126, pages 653-661.
Crossref
Crossref
Ahmed A. Albassam & Reginald F. Frye. (2019) Effect of pterostilbene on in vitro drug metabolizing enzyme activity. Saudi Pharmaceutical Journal 27:3, pages 406-412.
Crossref
Crossref
Dimosthenis A. Sarigiannis, Janja Snoj Tratnik, Darja Mazej, Tina Kosjek, Ester Heath, Milena Horvat, Ourania Anesti & Spyros P. Karakitsios. (2019) Risk characterization of bisphenol-A in the Slovenian population starting from human biomonitoring data. Environmental Research 170, pages 293-300.
Crossref
Crossref
Heli Routti, Béatrice Diot, Cristina Panti, Nur Duale, Maria Cristina Fossi, Mikael Harju, Kit M. Kovacs, Christian Lydersen, Sophie E. Scotter, Gro D. Villanger & Sophie Bourgeon. (2019) Contaminants in Atlantic walruses in Svalbard Part 2: Relationships with endocrine and immune systems. Environmental Pollution 246, pages 658-667.
Crossref
Crossref
Yasuhiro Kazuki, Kaoru KobayashiMasumi HirabayashiSatoshi AbeNaoyo KajitaniKanako KazukiShoko TakeharaMasato TakiguchiDaisuke SatohJiro KuzeTetsushi SakumaTakehito KanekoTomoji MashimoMinori OsamuraMari HashimotoRiko WakatsukiRika HirashimaRyoichi FujiwaraTsuneo DeguchiAtsushi KuriharaYasuko TsukazakiNaoto SendaTakashi YamamotoNico Scheer & Mitsuo Oshimura. (2019) Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism. Proceedings of the National Academy of Sciences 116:8, pages 3072-3081.
Crossref
Crossref
Justine Badée, Stephen Fowler, Saskia N. de Wildt, Abby C. Collier, Stephan Schmidt & Neil Parrott. (2018) The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling. Clinical Pharmacokinetics 58:2, pages 189-211.
Crossref
Crossref
Pil Joung Cho, Ju-Hyun Kim, Hye Suk Lee, Jeong Ah Kim & Sangkyu Lee. (2019) Identification of specific UGT1A9-mediated glucuronidation of licoricidin in human liver microsomes. Biopharmaceutics & Drug Disposition 40:2, pages 94-98.
Crossref
Crossref
Dimosthenis Sarigiannis & Spyros Karakitsios. (2019) Advancing Chemical Risk Assessment through Human Physiology-Based Biochemical Process Modeling. Fluids 4:1, pages 4.
Crossref
Crossref
Takaya Kutsukake, Yoichi Furukawa, Kyoko Ondo, Saki Gotoh, Tatsuki Fukami & Miki Nakajima. (2019) Quantitative Analysis of UDP-Glucuronosyltransferase Ugt1a and Ugt2b mRNA Expression in the Rat Liver and Small Intestine: Sex and Strain Differences. Drug Metabolism and Disposition 47:1, pages 38-44.
Crossref
Crossref
Peng Chen, Ke-Wei Zhu, Dao-Yu Zhang, Han Yan, Han Liu, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao, Jing Yang & Xiao-Ping Chen. (2018) Influence of UGT1A1 polymorphisms on the outcome of acute myeloid leukemia patients treated with cytarabine-base regimens. Journal of Translational Medicine 16:1.
Crossref
Crossref
Anna Mróz, Izabela Ryska, Hanna Sominko, Anna Bejrowska & Zofia Mazerska. (2018) Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7. Pharmacological Reports 70:5, pages 972-980.
Crossref
Crossref
Matthew W. Linakis, Sarah F. Cook, Shaun S. Kumar, Xiaoxi Liu, Diana G. Wilkins, Roger Gaedigk, Andrea Gaedigk, Catherine M. T. Sherwin & John N. van den Anker. (2018) Polymorphic Expression of UGT1A9 is Associated with Variable Acetaminophen Glucuronidation in Neonates: A Population Pharmacokinetic and Pharmacogenetic Study. Clinical Pharmacokinetics 57:10, pages 1325-1336.
Crossref
Crossref
John van den Anker, Michael D. Reed, Karel Allegaert & Gregory L. Kearns. (2018) Developmental Changes in Pharmacokinetics and Pharmacodynamics. The Journal of Clinical Pharmacology 58, pages S10-S25.
Crossref
Crossref
Yasuhiro Uno, Rika Takahira, Norie Murayama, Yu Ishii, Yoshinori Ikenaka, Mayumi Ishizuka, Hiroshi Yamazaki & Shinichi Ikushiro. (2018) Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques. Biochemical Pharmacology 155, pages 172-181.
Crossref
Crossref
Naoyuki Tatsumi, Shinsaku Tokumitsu, Masataka Nakano, Tatsuki Fukami & Miki Nakajima. (2018) miR-141-3p commonly regulates human UGT1A isoforms via different mechanisms. Drug Metabolism and Pharmacokinetics 33:4, pages 203-210.
Crossref
Crossref
Suramya Waidyanatha, Sherry R. Black, Rodney W. Snyder, Yun Lan Yueh, Vicki Sutherland, Purvi R. Patel, Scott L. Watson & Timothy R. Fennell. (2018) Disposition and metabolism of the bisphenol analogue, bisphenol S, in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans. Toxicology and Applied Pharmacology 351, pages 32-45.
Crossref
Crossref
Anna Bejrowska, Monika Pawłowska, Anna Mróz & Zofia Mazerska. (2018) Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems. Pharmacological Reports 70:3, pages 470-475.
Crossref
Crossref
Kentaro Konishi, Daisuke Tenmizu & Shin Takusagawa. (2017) Identification of Uridine 5′-Diphosphate-Glucuronosyltransferases Responsible for the Glucuronidation of Mirabegron, a Potent and Selective β3-Adrenoceptor Agonist, in Human Liver Microsomes. European Journal of Drug Metabolism and Pharmacokinetics 43:3, pages 301-309.
Crossref
Crossref
Adrien Labriet, Eric P. Allain, Michèle Rouleau, Yannick Audet-Delage, Lyne Villeneuve & Chantal Guillemette. (2018) Post-transcriptional Regulation of UGT2B10 Hepatic Expression and Activity by Alternative Splicing. Drug Metabolism and Disposition 46:5, pages 514-524.
Crossref
Crossref
A Tourancheau, M Rouleau, S Guauque-Olarte, L Villeneuve, I Gilbert, A Droit & C Guillemette. (2017) Quantitative profiling of the UGT transcriptome in human drug-metabolizing tissues. The Pharmacogenomics Journal 18:2, pages 251-261.
Crossref
Crossref
Risto O. Juvonen, Sanna Rauhamäki, Sami Kortet, Sanna Niinivehmas, Johanna Troberg, Aleksanteri Petsalo, Juhani Huuskonen, Hannu Raunio, Moshe Finel & Olli T. Pentikäinen. (2018) Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10. Molecular Pharmaceutics 15:3, pages 923-933.
Crossref
Crossref
Na Yang, Sijia Li, Caixia Yan, Runbin Sun, Jun He, Yuan Xie, Ying Peng, Guangji Wang & Jiye Aa. (2018) Inhibitory Effects of Endogenous Linoleic Acid and Glutaric Acid on the Renal Glucuronidation of Berberrubine in Mice and on Recombinant Human UGT1A7, 1A8, and 1A9. Molecular Pharmacology 93:3, pages 216-227.
Crossref
Crossref
Pei Wang, Ya-li Nie, Shu-jie Wang, Lin-lin Yang, Wei-hong Yang, Jiang-feng Li, Xiao-tian Li & Li-rong Zhang. (2018)
Regulation of
UGT1A
expression by miR-298 in human livers from the Han Chinese population and in human cell lines
. Epigenomics 10:1, pages 43-57.
Crossref
Crossref
K.K. Wolf & M.F. Paine. 2018. Comprehensive Toxicology. Comprehensive Toxicology
74
98
.
Johanna Troberg, Erkka Järvinen, Guang-Bo Ge, Ling Yang & Moshe Finel. (2016) UGT1A10 Is a High Activity and Important Extrahepatic Enzyme: Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated?. Molecular Pharmaceutics 14:9, pages 2875-2883.
Crossref
Crossref
Shingo Oda, Yukiko Kato, Masahiko Hatakeyama, Atsushi Iwamura, Tatsuki Fukami, Toshiyuki Kume, Tsuyoshi Yokoi & Miki Nakajima. (2017) Evaluation of Expression and Glycosylation Status of UGT1A10 in Supersomes and Intestinal Epithelial Cells with a Novel Specific UGT1A10 Monoclonal Antibody. Drug Metabolism and Disposition 45:9, pages 1027-1034.
Crossref
Crossref
Shuqiang Liu, Haihui Zheng, Rongjin Sun, Huangyu Jiang, Jiamei Chen, Jia Yu, Qisong Zhang, Qingwei Chen, Lijun Zhu, Ming Hu, Linlin Lu & Zhongqiu Liu. (2017) Disposition of Flavonoids for Personal Intake. Current Pharmacology Reports 3:4, pages 196-212.
Crossref
Crossref
Na Yang, Runbin Sun, Xiaoying Liao, Jiye Aa & Guangji Wang. (2017) UDP-glucuronosyltransferases (UGTs) and their related metabolic cross-talk with internal homeostasis: A systematic review of UGT isoforms for precision medicine. Pharmacological Research 121, pages 169-183.
Crossref
Crossref
J. E. Slovak, K. Mealey & M. H. Court. (2017) Comparative metabolism of mycophenolic acid by glucuronic acid and glucose conjugation in human, dog, and cat liver microsomes. Journal of Veterinary Pharmacology and Therapeutics 40:2, pages 123-129.
Crossref
Crossref
Jean-Marie Nicolas, François Bouzom, Chanteux Hugues & Anna-Lena Ungell. (2017) Oral drug absorption in pediatrics: the intestinal wall, its developmental changes and current tools for predictions. Biopharmaceutics & Drug Disposition 38:3, pages 209-230.
Crossref
Crossref
E.H.J. Krekels, J.E. Rower, J.E. Constance, C.A.J. Knibbe & C.M.T. Sherwin. 2017. Drug Metabolism in Diseases. Drug Metabolism in Diseases
181
206
.
Dimosthenis A. Sarigiannis, Spyros P. Karakitsios, Evangelos Handakas, Konstantina Simou, Ermioni Solomou & Alberto Gotti. (2016) Integrated exposure and risk characterization of bisphenol-A in Europe. Food and Chemical Toxicology 98, pages 134-147.
Crossref
Crossref
Daniel Scotcher, Christopher Jones, Maria Posada, Amin Rostami-Hodjegan & Aleksandra Galetin. (2016) Key to Opening Kidney for In Vitro–In Vivo Extrapolation Entrance in Health and Disease: Part I: In Vitro Systems and Physiological Data. The AAPS Journal 18:5, pages 1067-1081.
Crossref
Crossref
Michèle Rouleau, Alan Tourancheau, Camille Girard-Bock, Lyne Villeneuve, Jonathan Vaucher, Anne-Marie Duperré, Yannick Audet-Delage, Isabelle Gilbert, Ion Popa, Arnaud Droit & Chantal Guillemette. (2016) Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing. Cell Reports 17:1, pages 114-124.
Crossref
Crossref
Darja Gramec Skledar, Jan Schmidt, Anja Fic, Ivana Klopčič, Jurij Trontelj, Marija Sollner Dolenc, Moshe Finel & Lucija Peterlin Mašič. (2016) Influence of metabolism on endocrine activities of bisphenol S. Chemosphere 157, pages 152-159.
Crossref
Crossref
Kathleen M. Knights, Shane M. Spencer, John K. Fallon, Nuy Chau, Philip C. Smith & John O. Miners. (2016)
Scaling factors for the
in vitro
-
in vivo
extrapolation (IV-IVE) of renal drug and xenobiotic glucuronidation clearance
. British Journal of Clinical Pharmacology 81:6, pages 1153-1164.
Crossref
Crossref
Tingting Cai, Lihua Yao & Robert J. Turesky. (2016) Bioactivation of Heterocyclic Aromatic Amines by UDP Glucuronosyltransferases. Chemical Research in Toxicology 29:5, pages 879-891.
Crossref
Crossref
Xuan Qin, Mingyao Liu & Xin Wang. (2016) New insights into the androgen biotransformation in prostate cancer: A regulatory network among androgen, androgen receptors and UGTs. Pharmacological Research 106, pages 114-122.
Crossref
Crossref
RS Gammal, MH Court, CE Haidar, OF Iwuchukwu, AH Gaur, M Alvarellos, C Guillemette, JL Lennox, M Whirl-Carrillo, SS Brummel, MJ Ratain, TE Klein, BR Schackman, KE Caudle & DW Haas. (2016)
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for
UGT1A1
and Atazanavir Prescribing
. Clinical Pharmacology & Therapeutics 99:4, pages 363-369.
Crossref
Crossref
Zofia Mazerska, Anna Mróz, Monika Pawłowska & Ewa Augustin. (2016) The role of glucuronidation in drug resistance. Pharmacology & Therapeutics 159, pages 35-55.
Crossref
Crossref
Abby C. Collier, Audrey D. Thévenon, William Goh, Mark Hiraoka & Claire E. Kendal-Wright. (2014) Placental profiling of UGT1A enzyme expression and activity and interactions with preeclampsia at term. European Journal of Drug Metabolism and Pharmacokinetics 40:4, pages 471-480.
Crossref
Crossref
J. Matthew Hutzler & Michael A. Zientek. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics
79
130
.
Johanna Troberg & Moshe Finel. (2015) The Polymorphic Variant P24T of UDP-Glucuronosyltransferase 1A4 and Its Unusual Consequences. Drug Metabolism and Disposition 43:11, pages 1769-1772.
Crossref
Crossref
Porntipa Korprasertthaworn, Thomas M. Polasek, Michael J. Sorich, Andrew J. McLachlan, John O. Miners, Geoffrey T. Tucker & Andrew Rowland. (2015) In Vitro Characterization of the Human Liver Microsomal Kinetics and Reaction Phenotyping of Olanzapine Metabolism. Drug Metabolism and Disposition 43:11, pages 1806-1814.
Crossref
Crossref
Roope A. Kallionpää, Erkka Järvinen & Moshe Finel. (2015) Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7. The Journal of Steroid Biochemistry and Molecular Biology 154, pages 104-111.
Crossref
Crossref
Dhilushi D. Wijayakumara, Dong Gui Hu, Robyn Meech, Ross A. McKinnon & Peter I. Mackenzie. (2015) Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines. Journal of Pharmacology and Experimental Therapeutics 354:3, pages 417-425.
Crossref
Crossref
Guillaume Margaillan, Michèle Rouleau, Kathrin Klein, John K. Fallon, Patrick Caron, Lyne Villeneuve, Philip C. Smith, Ulrich M. Zanger & Chantal Guillemette. (2015) Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential. Drug Metabolism and Disposition 43:9, pages 1331-1335.
Crossref
Crossref
Masaya Sakamoto, Tomoo Itoh, Robert H. Tukey & Ryoichi Fujiwara. (2015) Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain. Drug Metabolism and Pharmacokinetics 30:4, pages 269-275.
Crossref
Crossref
Jessica Lawrence, David Cameron & David Argyle. (2015) Species differences in tumour responses to cancer chemotherapy. Philosophical Transactions of the Royal Society B: Biological Sciences 370:1673, pages 20140233.
Crossref
Crossref
Yuki Kutsuno, Rika Hirashima, Masaya Sakamoto, Hiroko Ushikubo, Hirofumi Michimae, Tomoo Itoh, Robert H. Tukey & Ryoichi Fujiwara. (2015)
Expression of
UDP-Glucuronosyltransferase 1
(
UGT1
) and Glucuronidation Activity toward Endogenous Substances in Humanized
UGT1
Mouse Brain
. Drug Metabolism and Disposition 43:7, pages 1071-1076.
Crossref
Crossref
Jacqueline Ramírez, Snezana Mirkov, Larry K. House & Mark J. Ratain. (2015) Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10. Drug Metabolism and Disposition 43:7, pages 928-935.
Crossref
Crossref
Kathleen G. Barrett, Hailin Fang, Daniela Cukovic, Alan A. Dombkowski, Thomas A. Kocarek & Melissa Runge-Morris. (2015) Upregulation of UGT2B4 Expression by 3′-Phosphoadenosine-5′-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation. Drug Metabolism and Disposition 43:7, pages 1061-1070.
Crossref
Crossref
Karl Walter Bock. (2015) Roles of human UDP-glucuronosyltransferases in clearance and homeostasis of endogenous substrates, and functional implications. Biochemical Pharmacology 96:2, pages 77-82.
Crossref
Crossref
Shingo Oda, Ryoichi Fujiwara, Yuki Kutsuno, Tatsuki Fukami, Tomoo Itoh, Tsuyoshi Yokoi & Miki Nakajima. (2015) Targeted Screen for Human UDP-Glucuronosyltransferases Inhibitors and the Evaluation of Potential Drug-Drug Interactions with Zafirlukast. Drug Metabolism and Disposition 43:6, pages 812-818.
Crossref
Crossref
Xinxin Ding & Fang Xie. 2015. Handbook of Olfaction and Gustation. Handbook of Olfaction and Gustation
63
92
.
Guillaume Margaillan, Michèle Rouleau, John K. Fallon, Patrick Caron, Lyne Villeneuve, Véronique Turcotte, Philip C. Smith, Melanie S. Joy & Chantal Guillemette. (2015) Quantitative Profiling of Human Renal UDP-glucuronosyltransferases and Glucuronidation Activity: A Comparison of Normal and Tumoral Kidney Tissues. Drug Metabolism and Disposition 43:4, pages 611-619.
Crossref
Crossref
Yang-Liu Xia, Guang-Bo Ge, Ping Wang, Si-Cheng Liang, Yu-Qi He, Jing Ning, Xing-Kai Qian, Yan Li & Ling Yang. (2015) Structural Modifications at the C-4 Position Strongly Affect the Glucuronidation of 6,7-Dihydroxycoumarins. Drug Metabolism and Disposition 43:4, pages 553-560.
Crossref
Crossref
Julieta Gradinaru, Stéphanie Romand, Laurent Geiser, Pierre-Alain Carrupt, Dany Spaggiari & Serge Rudaz. (2015) Inhibition screening method of microsomal UGTs using the cocktail approach. European Journal of Pharmaceutical Sciences 71, pages 35-45.
Crossref
Crossref
Bin Guo, Zhongze Fang, Lu Yang, Ling Xiao, Yangliu Xia, Frank J. Gonzalez, Liangliang Zhu, Yunfeng Cao, Guangbo Ge, Ling Yang & Hongzhi Sun. (2015) Tissue and species differences in the glucuronidation of glabridin with UDP-glucuronosyltransferases. Chemico-Biological Interactions 231, pages 90-97.
Crossref
Crossref
Kerstin Ziegler, Sarka Tumova, Asimina Kerimi & Gary Williamson. (2015) Cellular Asymmetric Catalysis by UDP-glucuronosyltransferase 1A8 Shows Functional Localization to the Basolateral Plasma Membrane. Journal of Biological Chemistry 290:12, pages 7622-7633.
Crossref
Crossref
Isabelle Laverdière, Christine Flageole, Étienne Audet-Walsh, Patrick Caron, Yves Fradet, Louis Lacombe, Éric Lévesque & Chantal Guillemette. (2015) The UGT1 locus is a determinant of prostate cancer recurrence after prostatectomy. Endocrine-Related Cancer 22:1, pages 77-85.
Crossref
Crossref
Stephen Fowler, Heidemarie Kletzl, Moshe Finel, Nenad Manevski, Paul Schmid, Dietrich Tuerck, Roger D. Norcross, Marius C. Hoener, Olivia Spleiss & Victor A. Iglesias. (2015) A UGT2B10 Splicing Polymorphism Common in African Populations May Greatly Increase Drug Exposure. Journal of Pharmacology and Experimental Therapeutics 352:2, pages 358-367.
Crossref
Crossref
Shingo Oda, Tatsuki Fukami, Tsuyoshi Yokoi & Miki Nakajima. (2015) A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development. Drug Metabolism and Pharmacokinetics 30:1, pages 30-51.
Crossref
Crossref
Michel Kranendonk, Mónica Alves, Pedro Antunes & José Rueff. (2014) Human Sulfotransferase 1A1-Dependent Mutagenicity of 12-Hydroxy-nevirapine: The Missing Link?. Chemical Research in Toxicology 27:11, pages 1967-1971.
Crossref
Crossref
Mohamed Ouzzine, Sandrine Gulberti, Nick Ramalanjaona, Jacques Magdalou & Sylvie Fournel-Gigleux. (2014) The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication. Frontiers in Cellular Neuroscience 8.
Crossref
Crossref
Brandon T. Gufford, Gang Chen, Philip Lazarus, Tyler N. Graf, Nicholas H. Oberlies & Mary F. Paine. (2014) Identification of Diet-Derived Constituents as Potent Inhibitors of Intestinal Glucuronidation. Drug Metabolism and Disposition 42:10, pages 1675-1683.
Crossref
Crossref
Karthika Divakaran, Ronald N. Hines & D Gail McCarver. (2014) Human Hepatic UGT2B15 Developmental Expression. Toxicological Sciences 141:1, pages 292-299.
Crossref
Crossref
C Guillemette, É Lévesque & M Rouleau. (2014) Pharmacogenomics of Human Uridine Diphospho-Glucuronosyltransferases and Clinical Implications. Clinical Pharmacology & Therapeutics 96:3, pages 324-339.
Crossref
Crossref
Tsai-Yu Lin, Chang Seok Ki & Chien-Chi Lin. (2014) Manipulating hepatocellular carcinoma cell fate in orthogonally cross-linked hydrogels. Biomaterials 35:25, pages 6898-6906.
Crossref
Crossref
Verena Christen & Karl Fent. (2014) Tissue-, sex- and development-specific transcription profiles of eight UDP-glucuronosyltransferase genes in zebrafish (Danio rerio) and their regulation by activator of aryl hydrocarbon receptor. Aquatic Toxicology 150, pages 93-102.
Crossref
Crossref
Leo Ghemtio, Anne Soikkeli, Marjo Yliperttula, Jouni Hirvonen, Moshe Finel & Henri Xhaard. (2014) SVM Classification and CoMSIA Modeling of UGT1A6 Interacting Molecules. Journal of Chemical Information and Modeling 54:4, pages 1011-1026.
Crossref
Crossref
Nathan R. Jones & Philip Lazarus. (2014) UGT2B Gene Expression Analysis in Multiple Tobacco Carcinogen-Targeted Tissues. Drug Metabolism and Disposition 42:4, pages 529-536.
Crossref
Crossref
Shingo Oda, Tatsuki Fukami, Tsuyoshi Yokoi & Miki Nakajima. (2014) Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10. Biochemical Pharmacology 87:4, pages 660-667.
Crossref
Crossref
J.C. Stingl, H. Bartels, R. Viviani, M.L. Lehmann & J. Brockmöller. (2014) Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review. Pharmacology & Therapeutics 141:1, pages 92-116.
Crossref
Crossref
B.S. Raccor, A.M. Teitelbaum, J.C. Dinh & R.A. Totah. 2014. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.
Michael H. Court. 2014. Optimization in Drug Discovery. Optimization in Drug Discovery
117
136
.
Vincent Ménard, Pierre Collin, Guillaume Margaillan & Chantal Guillemette. (2013) Modulation of the UGT2B7 Enzyme Activity by C-Terminally Truncated Proteins Derived from Alternative Splicing. Drug Metabolism and Disposition 41:12, pages 2197-2205.
Crossref
Crossref
Fredrik H. Karlsson, Salim Bouchene, Constanze Hilgendorf, Hugues Dolgos & Sheila Annie Peters. (2013) Utility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical Development. Drug Metabolism and Disposition 41:12, pages 2033-2046.
Crossref
Crossref
Shingo Oda, Tatsuki Fukami, Tsuyoshi Yokoi & Miki Nakajima. (2013) Epigenetic Regulation Is a Crucial Factor in the Repression of UGT1A1 Expression in the Human Kidney. Drug Metabolism and Disposition 41:10, pages 1738-1743.
Crossref
Crossref
X‐L Jiang, P Zhao, JS Barrett, LJ Lesko & S Schmidt. (2013) Application of Physiologically Based Pharmacokinetic Modeling to Predict Acetaminophen Metabolism and Pharmacokinetics in Children. CPT: Pharmacometrics & Systems Pharmacology 2:10, pages 1-9.
Crossref
Crossref
Michael H. Court. (2013) Feline Drug Metabolism and Disposition. Veterinary Clinics of North America: Small Animal Practice 43:5, pages 1039-1054.
Crossref
Crossref
Tina Suominen, Päivi Uutela, Raimo A. Ketola, Jonas Bergquist, Lars Hillered, Moshe Finel, Hongbo Zhang, Aki Laakso & Risto Kostiainen. (2013) Determination of Serotonin and Dopamine Metabolites in Human Brain Microdialysis and Cerebrospinal Fluid Samples by UPLC-MS/MS: Discovery of Intact Glucuronide and Sulfate Conjugates. PLoS ONE 8:6, pages e68007.
Crossref
Crossref
Andrew Rowland, John O. Miners & Peter I. Mackenzie. (2013) The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification. The International Journal of Biochemistry & Cell Biology 45:6, pages 1121-1132.
Crossref
Crossref
Jennifer Lee, Selina Moy, John Meijer, Walter Krauwinkel, Taiji Sawamoto, Virginie Kerbusch, Donna Kowalski, Michael Roy, Alan Marion, Shin Takusagawa, Marcel van Gelderen & James Keirns. (2013) Role of Cytochrome P450 Isoenzymes 3A and 2D6 in the In Vivo Metabolism of Mirabegron, a β3-Adrenoceptor Agonist. Clinical Drug Investigation 33:6, pages 429-440.
Crossref
Crossref
Umit Yasar, David J Greenblatt, Chantal Guillemette & Michael H Court. (2013) Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers. Journal of Pharmacy and Pharmacology 65:6, pages 874-883.
Crossref
Crossref
Michael H. Court, Marina Freytsis, Xueding Wang, Inga Peter, Chantal Guillemette, Suwagmani Hazarika, Su X. Duan, David J. Greenblatt & William M. Lee. (2013) The UDP-Glucuronosyltransferase (UGT) 1A Polymorphism c.2042C>G (rs8330) Is Associated with Increased Human Liver Acetaminophen Glucuronidation, Increased UGT1A Exon 5a/5b Splice Variant mRNA Ratio, and Decreased Risk of Unintentional Acetaminophen-Induced Acute Liver Failure. Journal of Pharmacology and Experimental Therapeutics 345:2, pages 297-307.
Crossref
Crossref
Katherine L. Gill, Michael Gertz, J. Brian Houston & Aleksandra Galetin. (2013) Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data. Drug Metabolism and Disposition 41:4, pages 744-753.
Crossref
Crossref
Nina Sneitz, Mikko Vahermo, Johanna Mosorin, Liisa Laakkonen, Donald Poirier & Moshe Finel. (2013) Regiospecificity and Stereospecificity of Human UDP-Glucuronosyltransferases in the Glucuronidation of Estriol, 16-Epiestriol, 17-Epiestriol, and 13-Epiestradiol. Drug Metabolism and Disposition 41:3, pages 582-591.
Crossref
Crossref
Alaa Al Saabi, Delphine Allorge, François-Ludovic Sauvage, Gilles Tournel, Jean-michel Gaulier, Pierre Marquet & Nicolas Picard. (2013) Involvement of UDP-Glucuronosyltransferases UGT1A9 and UGT2B7 in Ethanol Glucuronidation, and Interactions with Common Drugs of Abuse. Drug Metabolism and Disposition 41:3, pages 568-574.
Crossref
Crossref
Lena Ekström, Maria Johansson & Anders Rane. (2013) Tissue Distribution and Relative Gene Expression of UDP-Glucuronosyltransferases (2B7, 2B15, 2B17) in the Human Fetus. Drug Metabolism and Disposition 41:2, pages 291-295.
Crossref
Crossref
Mitsuhiro Nishihara, Yuto Hiura, Naohiro Kawaguchi, Junzo Takahashi & Satoru Asahi. (2013) UDP-glucuronosyltransferase 2B15 (UGT2B15) Is the Major Enzyme Responsible for Sipoglitazar Glucuronidation in Humans: Retrospective Identification of the UGT Isoform by In Vitro Analysis and the Effect of UGT2B15*2 Mutation. Drug Metabolism and Pharmacokinetics 28:6, pages 475-484.
Crossref
Crossref
Liangliang Zhu, Guangbo Ge, Yong Liu, Zhimou Guo, Chengcheng Peng, Feng Zhang, Yunfeng Cao, Jingjing Wu, Zhongze Fang, Xinmiao Liang & Ling Yang. (2012) Characterization of UDP-Glucuronosyltransferases Involved in Glucuronidation of Diethylstilbestrol in Human Liver and Intestine. Chemical Research in Toxicology 25:12, pages 2663-2669.
Crossref
Crossref
Hongbo Zhang, Anne Soikkeli, Ari Tolonen, Timo Rousu, Jouni Hirvonen & Moshe Finel. (2012) Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases. Toxicology in Vitro 26:8, pages 1286-1293.
Crossref
Crossref
Nenad Manevski, Jari Yli-Kauhaluoma & Moshe Finel. (2012) UDP-Glucuronic Acid Binds First and the Aglycone Substrate Binds Second to Form a Ternary Complex in UGT1A9-Catalyzed Reactions, in Both the Presence and Absence of Bovine Serum Albumin. Drug Metabolism and Disposition 40:11, pages 2192-2203.
Crossref
Crossref
Karl Walter Bock. (2012) Human UDP-glucuronosyltransferases: Feedback loops between substrates and ligands of their transcription factors. Biochemical Pharmacology 84:8, pages 1000-1006.
Crossref
Crossref
Karl Walter Bock. (2012) Fremdstoffmetabolismus und Toxizität von Dioxinen. BIOspektrum 18:6, pages 593-595.
Crossref
Crossref
Stephanie Haller, Franz Schuler, Stanley E. Lazic, Dalila Bachir-Cherif, Stefanie D. Krämer, Neil J. Parrott, Guido Steiner & Sara Belli. (2012) Expression Profiles of Metabolic Enzymes and Drug Transporters in the Liver and along the Intestine of Beagle Dogs. Drug Metabolism and Disposition 40:8, pages 1603-1611.
Crossref
Crossref