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Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 3
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General Xenobiochemistry

Ilaprazole, a new proton pump inhibitor, is primarily metabolized to ilaprazole sulfone by CYP3A4 and 3A5

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Pages 278-284 | Received 19 Jul 2011, Accepted 07 Sep 2011, Published online: 24 Oct 2011

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Hongyun Wang, Ning Ou, Liwei Lang, Ruihua Shi, Pei Hu & Ji Jiang. (2016) Pharmacokinetics and pharmacodynamics of intravenous ilaprazole in healthy subjects after single ascending doses. Xenobiotica 46:12, pages 1133-1141.
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J. W. Xuan, R. L. Song, G. X. Xu, W. Q. Lu, Y. J. Lu & Z. Liu. (2016) Modeling the cost-effectiveness of ilaprazole versus omeprazole for the treatment of newly diagnosed duodenal ulcer patients in China. Journal of Medical Economics 19:11, pages 1056-1060.
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Dhananjay D. Shinde, Min-Jung Kim, Eun-Sook Jeong, Yang-Weon Kim, Ji-Woo Lee, Jae-Gook Shin & Dong-Hyun Kim. (2014) Enantioselective N-Demethylation and Hydroxylation of Sibutramine in Human Liver Microsomes and Recombinant Cytochrome P-450 Isoforms. Journal of Toxicology and Environmental Health, Part A 77:22-24, pages 1419-1430.
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Articles from other publishers (20)

Xiao-Dong Zhang, Da-Ya Zhang, Run-Xiang Chen, Shi-Ju Chen, Chen Chen, Fan Zeng, Shi-Mei Huang, Da Li & Fei-Hu Bai. (2023) Ilaprazole-amoxicillin dual therapy at high dose as a first-line treatment for helicobacter pylori infection in Hainan: a single-center, open-label, noninferiority, randomized controlled trial. BMC Gastroenterology 23:1.
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Fadian Ding, Yuxin Liu, Jintong Chen, Youzhu Li, Xinxin Guo, Jianmin Wu & Qicai Liu. (2023) Proton pump inhibitors affect sperm parameters by regulating aquaporins. Heliyon 9:7, pages e17911.
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Jie He, Leixuan Luo, Shidi Xu, Feiyi Yang & Wufu Zhu. (2022) Pyrrole‐based EGFR inhibitors for the treatment of NCSLC : Binding modes and SARs investigations . Chemical Biology & Drug Design 101:1, pages 195-217.
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Saurav Howlader, Min-Jung Kim, M. Rasheduzzaman Jony, Nguyen Phuoc Long, Yong-Soon Cho, Dong-Hyun Kim & Jae-Gook Shin. (2022) Characterization of Clofazimine Metabolism in Human Liver Microsomal Incubation In Vitro . Antimicrobial Agents and Chemotherapy 66:10.
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Zekang Ye, Pengsheng Chen, Chuchu Tan, Xiaoxuan Gong, Ran Li, Zhou Dong, Inam Ullah, Chen Zhou, Sufeng Zhou, Lijun Xie, Xuemei Hou, Zhihui Han, Qian Gu, Jiazheng Ma, Jianzhen Teng, Yingdan Tang, Zhuanxia Zhang, Haitang Hu, Quankun Zhuang, Juan Chen, Bei Zhu, Feng Shao & Chunjian Li. (2022) Effects of ilaprazole on the steady-state pharmacodynamics of clopidogrel in healthy volunteers: An open-label randomized crossover study. Frontiers in Pharmacology 13.
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Petra Bořilová Linhartová, Ondřej Zendulka, Jaroslav Janošek, Natálie Mlčůchová, Michaela Cvanová, Zdeněk Daněk, Radek Kroupa, Ladislava Bartošová & Břetislav Lipový. (2022) CYP2C19 Gene Profiling as a Tool for Personalized Stress Ulcer Prophylaxis With Proton Pump Inhibitors in Critically Ill Patients - Recommendations Proposal. Frontiers in Medicine 9.
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Ranran Jia, Fan Zhang, Ni Wu, Wen Xu, Huitao Gao, Bo Liu & Hongyun Wang. (2021) Accelerating Development of Benziamidazole-Class Proton Pump Inhibitors: A Mechanism-Based PK/PD Model to Optimize Study Design with Ilaprazole as a Case Drug. Pharmaceutics 13:3, pages 392.
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Guiqiu Zhang, Kaijing Guo, Pengfei Wang, Yingbo Shan & Chen Ma. (2021) Identification of the New In Vivo Metabolites of Ilaprazole in Rat Plasma after Oral Administration by LC-MS: In Silico Prediction of the H+/K+-ATPase Inhibitor. Molecules 26:2, pages 459.
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Fengting Ou, Ying Zhou, Jinxiu Lei, Su Zeng, Fuhai Wu, Ning Zhang & Lushan Yu. (2020) Development of a UHPLC-MS/MS method for the quantification of ilaprazole enantiomers in rat plasma and its pharmacokinetic application. Journal of Pharmaceutical Analysis 10:6, pages 617-623.
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Young Suk Kwon, Jun Woo Choi, Ho Seok Lee, Jong Ho Kim, Youngmi Kim & Jae Jun Lee. (2020) Effect of a Preoperative Proton Pump Inhibitor and Gastroesophageal Reflux Disease on Postoperative Nausea and Vomiting. Journal of Clinical Medicine 9:3, pages 825.
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Hongyun Wang, Feng Shao, Xuemei Liu, Wen Xu, Ning Ou, Xianghong Qin, Fang Liu, Xuemei Hou, Haitang Hu & Ji Jiang. (2019) Efficacy, safety and pharmacokinetics of ilaprazole infusion in healthy subjects and patients with esomeprazole as positive control. British Journal of Clinical Pharmacology 85:11, pages 2547-2558.
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Daeun Yim, Min Jung Kim, Yumi Shin, Su-Jun Lee, Jae Gook Shin & Dong Hyun Kim. (2019) Inhibition of Cytochrome P450 Activities by Sophora flavescens Extract and Its Prenylated Flavonoids in Human Liver Microsomes . Evidence-Based Complementary and Alternative Medicine 2019, pages 1-10.
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Jie Pu, Fen Wang, Wei Tang & Mingshe Zhu. (2018) Biotransformation of Ilaprazole in Human Liver Microsomes and Human: Role of CYP3A4 in Ilaprazole Clearance and Drug-Drug Interaction. Drug Metabolism and Disposition 46:10, pages 1453-1461.
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Byung Hak Jin, Byung Won Yoo, Jungsin Park, Jung Hye Kim, Jun Yeon Lee, Jae Soo Shin & Min Soo Park. (2018) Pharmacokinetic drug interaction and safety after coadministration of clarithromycin, amoxicillin, and ilaprazole: a randomised, open-label, one-way crossover, two parallel sequences study. European Journal of Clinical Pharmacology 74:9, pages 1149-1157.
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Arun Karyampudi, Uday C Ghoshal, Rajan Singh, Abhai Verma, Asha Misra & Vivek A Saraswat. (2017) Esophageal Acidification During Nocturnal Acid-breakthrough with Ilaprazole Versus Omeprazole in Gastroesophageal Reflux Disease. Journal of Neurogastroenterology and Motility 23:2, pages 208-217.
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J. S. Shin, J. Y. Lee, K. H. Cho, H. L. Park, M. Kukulka, J.-T. Wu, D. Y. Kim & S.-H. Park. (2014) The pharmacokinetics, pharmacodynamics and safety of oral doses of ilaprazole 10, 20 and 40 mg and esomeprazole 40 mg in healthy subjects: a randomised, open-label crossover study. Alimentary Pharmacology & Therapeutics, pages n/a-n/a.
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Min-Jung Kim, Eun Sook Jeong, Jung-Soon Park, Su-Jun Lee, Jong Lyul Ghim, Chang-Soo Choi, Jae-Gook Shin & Dong-Hyun Kim. (2014) Multiple Cytochrome P450 Isoforms Are Involved in the Generation of a Pharmacologically Active Thiol Metabolite, whereas Paraoxonase 1 and Carboxylesterase 1 Catalyze the Formation of a Thiol Metabolite Isomer from Ticlopidine. Drug Metabolism and Disposition 42:1, pages 141-152.
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Xin Zhou. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Lakshmi Narayana Chennuru, Thirupathi Choppari, Subrahmanyam Duvvuri & Pramod Kumar Dubey. (2013) Enantiomeric separation of proton pump inhibitors on new generation chiral columns using LC and supercritical fluid chromatography. Journal of Separation Science 36:18, pages 3004-3010.
Crossref
Fen Jiang & Jae-Gook Shin. (2013) Reply to: Letter to the Editor “Impact of the CYP2C19*17 Polymorphism on the Pharmacokinetics and Pharmacodynamics of Proton Pump Inhibitors”. The Journal of Clinical Pharmacology 53:3, pages 360-360.
Crossref

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