Citations (39)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (3)
Naoyuki Nakada & Kazuo Oda. (2015) Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans. Xenobiotica 45:9, pages 757-765.
Read now
Read now
Ronald E. White, David C. Evans, Cornelis E. C. A. Hop, David J. Moore, Chandra Prakash, Sekhar Surapaneni & Francis L. S. Tse. (2013) Radiolabeled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary. Xenobiotica 43:2, pages 219-225.
Read now
Read now
Debra Luffer-Atlas. (2012) The early estimation of circulating drug metabolites in humans. Expert Opinion on Drug Metabolism & Toxicology 8:8, pages 985-997.
Read now
Read now
Articles from other publishers (35)
R. Lock, P. J. H. Webborn, C. W. Vose & R. M. J. Ings. 2023. The Handbook of Medicinal Chemistry. The Handbook of Medicinal Chemistry
265
297
.
Mahbuba Rahman, Rizwan Qureshi, Estevan Bruginski, Meshari Alazmi, Othman Soufan, Kabir H. Biswas & Tanvir Alam. 2023. Metabolomics. Metabolomics
239
260
.
Simon G. Wong & Shuguang Ma. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development
137
174
.
Christina Kovar, Lukas Kovar, Simeon Rüdesheim, Dominik Selzer, Boian Ganchev, Patrick Kröner, Svitlana Igel, Reinhold Kerb, Elke Schaeffeler, Thomas E. Mürdter, Matthias Schwab & Thorsten Lehr. (2022) Prediction of Drug–Drug–Gene Interaction Scenarios of (E)-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling. Pharmaceutics 14:12, pages 2604.
Crossref
Crossref
Xiaoxuan Li, Sheng Hui, Emily T. Mirek, William O. Jonsson, Tracy G. Anthony, Won Dong Lee, Xianfeng Zeng, Cholsoon Jang & Joshua D. Rabinowitz. (2022) Circulating metabolite homeostasis achieved through mass action. Nature Metabolism 4:1, pages 141-152.
Crossref
Crossref
Erkka Järvinen, Feng Deng, Wilma Kiander, Alli Sinokki, Heidi Kidron & Noora Sjöstedt. (2022) The Role of Uptake and Efflux Transporters in the Disposition of Glucuronide and Sulfate Conjugates. Frontiers in Pharmacology 12.
Crossref
Crossref
Yue Pan. 2021. The Medicinal Chemist's Guide to Solving ADMET Challenges. The Medicinal Chemist's Guide to Solving ADMET Challenges
278
302
.
Simone Schadt, Filipe Lopes, Simon Hauri, Axel Pähler & Andreas Brink. 2020. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters
419
438
.
Erkka Järvinen, Noora Sjöstedt, Jan B. Koenderink, Heidi Kidron & Moshe Finel. (2019)
Efflux transport of nicotine, cotinine and
trans
‐3′‐hydroxycotinine glucuronides by human hepatic transporters
. Basic & Clinical Pharmacology & Toxicology 125:6, pages 490-498.
Crossref
Crossref
Simone Schadt, Bojan Bister, Swapan K. Chowdhury, Christoph Funk, Cornelis E. C. A. Hop, W. Griffith Humphreys, Fumihiko Igarashi, Alexander D. James, Mark Kagan, S. Cyrus Khojasteh, Angus N. R. Nedderman, Chandra Prakash, Frank Runge, Holger Scheible, Douglas K. Spracklin, Piet Swart, Susanna Tse, Josh Yuan & R. Scott Obach. (2018) A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the “Metabolites in Safety Testing” Regulatory Guidance. Drug Metabolism and Disposition 46:6, pages 865-878.
Crossref
Crossref
Jin-Zi Ji, Ting Tai, Bei-Bei Huang, Tong-Tong Gu, Qiong-Yu Mi & Hong-Guang Xie. (2018) Mrp3 Transports Clopidogrel Acyl Glucuronide from the Hepatocytes into Blood. Drug Metabolism and Disposition 46:2, pages 151-154.
Crossref
Crossref
Erkka Järvinen, Johanna Troberg, Heidi Kidron & Moshe Finel. (2017) Selectivity in the Efflux of Glucuronides by Human Transporters: MRP4 Is Highly Active toward 4-Methylumbelliferone and 1-Naphthol Glucuronides, while MRP3 Exhibits Stereoselective Propranolol Glucuronide Transport. Molecular Pharmaceutics 14:10, pages 3299-3311.
Crossref
Crossref
Hoa Q. Nguyen, Jian Lin, Emi Kimoto, Ernesto Callegari, Susanna Tse & R. Scott Obach. (2017) Prediction of Losartan-Active Carboxylic Acid Metabolite Exposure Following Losartan Administration Using Static and Physiologically Based Pharmacokinetic Models. Journal of Pharmaceutical Sciences 106:9, pages 2758-2770.
Crossref
Crossref
Naoyuki Nakada. (2017) Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2. Pharmaceutical Research 34:4, pages 874-886.
Crossref
Crossref
Sang Keun Ha, Jin-Ah Lee, Eun Jung Cho & Inwook Choi. (2017)
Effects of Catechol
O
-Methyl Transferase Inhibition on Anti-Inflammatory Activity of Luteolin Metabolites
. Journal of Food Science 82:2, pages 545-552.
Crossref
Crossref
Ting Tai, Qiong-Yu Mi, Jin-Zi Ji, Qian Yin, Yu-Qin Pan, Meng-Ran Zhang, Bei-Bei Huang & Hong-Guang Xie. (2016) Enhanced Platelet Response to Clopidogrel in Abcc3-deficient Mice Due to Its Increased Bioactivation. Journal of Cardiovascular Pharmacology 68:6, pages 433-440.
Crossref
Crossref
Lu Gaohua, Howard Burt, Helen Humphries, Amin Rostami-Hodjegan & Masoud Jamei. 2016. Metabolite Safety in Drug Development. Metabolite Safety in Drug Development
213
237
.
Vibeke Hougaard Sunesen. 2016. Metabolite Safety in Drug Development. Metabolite Safety in Drug Development
177
211
.
Lars Weidolf & Ian D. Wilson. 2016. Metabolite Safety in Drug Development. Metabolite Safety in Drug Development
141
176
.
S.-E. W. Huskey, C.-q. Zhu, M. M. Lin, R. R. Forseth, H. Gu, O. Simon, F. K. Eggimann, M. Kittelmann, A. Luneau, A. Vargas, H. Li, L. Wang, H. J. Einolf, J. Zhang, S. Favara, H. He & J. B. Mangold. (2016) Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans. Drug Metabolism and Disposition 44:5, pages 653-664.
Crossref
Crossref
Naoyuki Nakada, Akio Kawamura, Hidetaka Kamimura, Koya Sato, Yasuhiro Kazuki, Masakazu Kakuni, Masato Ohbuchi, Kota Kato, Chise Tateno, Mitsuo Oshimura & Takashi Usui. (2016)
Murine
Cyp3a
knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans
. Biopharmaceutics & Drug Disposition 37:1, pages 3-14.
Crossref
Crossref
Thomas A. Baillie. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics
202
226
.
Yu-Qin Pan, Qiong-Yu Mi, Bang-Shun He, Shu-Li Zhao, Ting Tai & Hong-Guang Xie. (2015) The molecular mechanism underlying the induction of hepatic MRP3 expression and function by omeprazole. Biopharmaceutics & Drug Disposition 36:4, pages 232-244.
Crossref
Crossref
Raman Sharma, John Litchfield, Arthur Bergman, Karen Atkinson, David Kazierad, Stephanie M. Gustavson, Li Di, Jeffrey A. Pfefferkorn & Amit S. Kalgutkar. (2015) Comparison of the Circulating Metabolite Profile of PF-04991532, a Hepatoselective Glucokinase Activator, Across Preclinical Species and Humans: Potential Implications in Metabolites in Safety Testing Assessment. Drug Metabolism and Disposition 43:2, pages 190-198.
Crossref
Crossref
Yuan Chen, Jialin Mao & Cornelis E. C. A. Hop. (2015) Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of Amiodarone. Drug Metabolism and Disposition 43:2, pages 182-189.
Crossref
Crossref
Bernard Testa. 2014. Drug Metabolism Prediction. Drug Metabolism Prediction
1
26
.
Maciej J. Zamek-Gliszczynski, Xiaoyan Chu, Joseph W. Polli, Mary F. Paine & Aleksandra Galetin. (2014) Understanding the Transport Properties of Metabolites: Case Studies and Considerations for Drug Development. Drug Metabolism and Disposition 42:4, pages 650-664.
Crossref
Crossref
F. Peter Guengerich. 2014. Predictive ADMET. Predictive ADMET
523
534
.
Jian-Jun Zou, Hong-Wei Fan, Shao-Liang Chen, Jie Tan, Bang-Shun He & Hong-Guang Xie. (2013)
Efffect of the
ABCC3
-211
C/T
polymorphism on clopidogrel responsiveness in patients with percutaneous coronary intervention
. Clinical and Experimental Pharmacology and Physiology 40:8, pages 504-509.
Crossref
Crossref
Jens Atzrodt & Volker Derdau. (2013) Selected Scientific Topics of the 11th International Isotope Symposium on the Synthesis and Applications of Isotopes and Isotopically Labeled Compounds. Journal of Labelled Compounds and Radiopharmaceuticals 56:9-10, pages 408-416.
Crossref
Crossref
Cho-Ming Loi, Dennis A. Smith & Deepak Dalvie. (2013) Which Metabolites Circulate?. Drug Metabolism and Disposition 41:5, pages 933-951.
Crossref
Crossref
R. Scott Obach. (2013) Pharmacologically Active Drug Metabolites: Impact on Drug Discovery and Pharmacotherapy. Pharmacological Reviews 65:2, pages 578-640.
Crossref
Crossref
Dennis A. Smith. (2013) Evolution of ADME Science: Where Else Can Modeling and Simulation Contribute?. Molecular Pharmaceutics 10:4, pages 1162-1170.
Crossref
Crossref
Malcolm Rowland, Christian R. Noe, Dennis A. Smith, G.T. Tucker, Daan J.A. Crommelin, Carl C. Peck, Mario L. Rocci Jr.Luc Besançon & Vinod P. Shah. (2012) Impact of the Pharmaceutical Sciences on Health Care: A Reflection over the Past 50 Years. Journal of Pharmaceutical Sciences 101:11, pages 4075-4099.
Crossref
Crossref
Bernard Testa, Alessandro Pedretti & Giulio Vistoli. (2012) Reactions and enzymes in the metabolism of drugs and other xenobiotics. Drug Discovery Today 17:11-12, pages 549-560.
Crossref
Crossref