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Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 6
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General Xenobiochemistry

Development and validation of a highly sensitive UPLC-MS/MS method for simultaneous determination of aconitine, mesaconitine, hypaconitine, and five of their metabolites in rat blood and its application to a pharmacokinetics study of aconitine, mesaconitine, and hypaconitine

Ling YeDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
,
Song GaoDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX, USA
,
Qian FengDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
,
Wei LiuDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
,
Zhen YangDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX, USA
,
Ming HuCorrespondence[email protected] [email protected]
&
Zhongqiu LiuDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
 show all
Pages 518-525 | Received 23 Sep 2011, Accepted 14 Nov 2011, Published online: 22 Dec 2011

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Huaxuan Fu, Zhifei Wang, Tao Zhang, Mingyue Du, Bo Lv, Song Yang & Ru Chen. (2022) Simultaneous detection of topramezon, atrazine, and atrazine metabolite residues in environmental water by large-volume SPE-UPLC-MS/MS. International Journal of Environmental Analytical Chemistry 0:0, pages 1-11.
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Xiuxiu Liu, Minghai Tang, Taohong Liu, Chunyan Wang, Qiaoxin Tang, Yaxin Xiao, Ruixin Yang & Ruobing Chao. (2019) The in vivo pharmacokinetics, tissue distribution and excretion investigation of mesaconine in rats and its in vitro intestinal absorption study using UPLC-MS/MS. Xenobiotica 49:1, pages 71-79.
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Panpan Zhang, Dezhi Kong, Qian Du, Jing Zhao, Qing Li, Jianghua Zhang, Tonghui Li & Leiming Ren. (2017) A conscious rat model involving bradycardia and hypotension after oral administration: a toxicokinetical study of aconitine. Xenobiotica 47:6, pages 515-525.
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Articles from other publishers (18)

Gelin Xiang, Sa Guo, Jing Qin, Huimin Gao, Yi Zhang & Shaohui Wang. (2024) Comprehensive insight into the pharmacology, pharmacokinetics, toxicity, detoxification and extraction of hypaconitine from Aconitum plants. Journal of Ethnopharmacology 321, pages 117505.
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Ming-Hai Tang, Fu-Li Peng, Xiu-Xiu Liu & Ruo-Bing Chao. (2023) Comparative Pharmacokinetic Investigation on Multiple Active Aminoalcohol-Diterpenoid Alkaloids after Single Oral Administrations of Monomers and Aqueous Extract of Fuzi (Aconiti Lateralis Radix Praeparata) by UFLC-MS/MS. Planta Medica 89:05, pages 561-570.
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Shiling Li, Liqiong Yu, Qian Shi, Yue Liu, Yi Zhang, Shaohui Wang & Xianrong Lai. (2022) An insight into current advances on pharmacology, pharmacokinetics, toxicity and detoxification of aconitine. Biomedicine & Pharmacotherapy 151, pages 113115.
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Liang Yang, Guanghui Xie, Yuguang Wang, Jian Li, Bin Zheng, Jinmiao Zhu, Xinsong Yuan, Qian Hong, Zengchun Ma & Yue Gao. (2022) Metabolic Behaviors of Aconitum Alkaloids in Different Concentrations of Aconiti Lateralis Radix Praeparata and Effects of Aconitine in Healthy Human and Long QT Syndrome Cardiomyocytes. Molecules 27:13, pages 4055.
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Guoquan You, Ruopeng Yang, Yingjie Wei, Wanyu Hu, Lili Gan, Cong Xie, Zhijie Zheng, Zhongqiu Liu, Rongxin Liao & Ling Ye. (2021) The detoxification effect of cytochrome P450 3A4 on gelsemine-induced toxicity. Toxicology Letters 353, pages 34-42.
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Xiaomin Yu, Huamin Liu, Xiaoxin Xu, Yujie Hu, Xianqin Wang & Congcong Wen. (2021) Pharmacokinetics of yunaconitine and indaconitine in mouse blood by UPLC-MS/MS. Journal of Chromatography B 1179, pages 122840.
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Jinzhao Yang, Guowu Zeng, Jianshe Ma, Xianqin Wang & Quan Zhou. (2021) Pharmacokinetics of 10-Hydroxy Mesaconitine in Rat Plasma by Ultra-Performance Liquid Chromatography-Tandem Quadrupole Mass Spectrometry. Journal of Analytical Methods in Chemistry 2021, pages 1-6.
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Kaiwen Ni, Xiaolu Cai, Yaling Chen, Linshui Zhou, Ruilin Chen, Suqun Zheng & Zhen Wang. (2020) Determining Pharmacological Mechanisms of Chinese Incompatible Herbs Fuzi and Banxia in Chronic Obstructive Pulmonary Disease: A Systems Pharmacology-Based Study. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-14.
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Zhihui Sun, Limin Yang, Lihong Zhao, Ranji Cui & Wei Yang. (2020) Neuropharmacological Effects of Mesaconitine: Evidence from Molecular and Cellular Basis of Neural Circuit. Neural Plasticity 2020, pages 1-10.
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Yida Zhang, Xingxing Zong, Jian-Lin Wu, Ying Liu, Zhongqiu Liu, Hua Zhou, Liang Liu & Na Li. (2020) Pharmacokinetics and tissue distribution of eighteen major alkaloids of Aconitum carmichaelii in rats by UHPLC-QQQ-MS. Journal of Pharmaceutical and Biomedical Analysis 185, pages 113226.
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Jin-jun Wu, Zhen-zhen Guo, Yuan-feng Zhu, Zhi-jian Huang, Xia Gong, Yu-huan Li, Wen-jie Son, Xiao-yan Li, Yan-mei Lou, Li-jun Zhu, Lin-lin Lu, Zhong-qiu Liu & Liang Liu. (2018) A systematic review of pharmacokinetic studies on herbal drug Fuzi : Implications for Fuzi as personalized medicine. Phytomedicine 44, pages 187-203.
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Dan Huang, Xinqing Zhao, Xiuxiu Liu & Ruobing Chao. (2017) Determination of Five Aminoalcohol-diterpenoid Alkaloids in the Lateral Root of Aconitum carmichaeli by HPLC–ELSD with SPE. Journal of Chromatographic Science 55:9, pages 940-945.
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Peimin Dai, Lijun Zhu, Xiaoshan Yang, Min Zhao, Jian Shi, Ying Wang, Linlin Lu & Zhongqiu Liu. (2015) Multidrug resistance-associated protein 2 is involved in the efflux of Aconitum alkaloids determined by MRP2-MDCKII cells. Life Sciences 127, pages 66-72.
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Min Zhang, Chong-sheng Peng & Xiao-bo Li. (2015) In Vivo and In Vitro Metabolites from the Main Diester and Monoester Diterpenoid Alkaloids in a Traditional Chinese Herb, the Aconitum Species . Evidence-Based Complementary and Alternative Medicine 2015, pages 1-23.
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H. Yang, Hua Yin, Z. Wang, L. Fan, Q. Li & X. Zhu. (2014) Multi-composition analysis in Radix Aconiti Lateralis by single marker quantitation . Acta Chromatographica 26:4, pages 727-737.
Crossref
Pei-Min Dai, Ying Wang, Ling Ye, Shan Zeng, Zhi-Jie Zheng, Qiang Li, Lin-Liu Lu & Zhong-Qiu Liu. (2014) Pharmacokinetic Comparisons of Benzoylmesaconine in Rats Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry after Administration of Pure Benzoylmesaconine and Wutou Decoction. Molecules 19:10, pages 16757-16769.
Crossref
Wen-Wen Peng, Wen Li, Jun-Song Li, Xiao-Bing Cui, Yong-xin Zhang, Guang-Ming Yang, Hong-Mei Wen & Bao-Chang Cai. (2013) The effects of Rhizoma Zingiberis on pharmacokinetics of six Aconitum alkaloids in herb couple of Radix Aconiti Lateralis−Rhizoma Zingiberis. Journal of Ethnopharmacology 148:2, pages 579-586.
Crossref
Ling Ye, Xiao-Shan Yang, Lin-lin Lu, Wei-Ying Chen, Shan Zeng, Tong-Meng Yan, Ling-Na Dong, Xiao-Juan Peng, Jian Shi & Zhong-Qiu Liu. (2013) Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5 . Evidence-Based Complementary and Alternative Medicine 2013, pages 1-24.
Crossref

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