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Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 6
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General Xenobiochemistry

Carbonyl reduction of bupropion in human liver

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Pages 550-561 | Received 30 Sep 2011, Accepted 19 Nov 2011, Published online: 20 Feb 2012

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Ranjeet Prasad Dash, Rana Rais & Nuggehally R. Srinivas. (2018) Chirality and neuropsychiatric drugs: an update on stereoselective disposition and clinical pharmacokinetics of bupropion. Xenobiotica 48:9, pages 945-957.
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Raghava Choudary Palacharla, Ramakrishna Nirogi, Venkatesham Uthukam, Arunkumar Manoharan, Ranjith Kumar Ponnamaneni & Ilayaraja Kalaikadhiban. (2018) Quantitative in vitro phenotyping and prediction of drug interaction potential of CYP2B6 substrates as victims. Xenobiotica 48:7, pages 663-675.
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Sophia M. Shi & Li Di. (2017) The role of carbonyl reductase 1 in drug discovery and development. Expert Opinion on Drug Metabolism & Toxicology 13:8, pages 859-870.
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Iva Boušová, Lenka Skálová, Pavel Souček & Petra Matoušková. (2015) The modulation of carbonyl reductase 1 by polyphenols. Drug Metabolism Reviews 47:4, pages 520-533.
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Petra Malátková & Vladimír Wsól. (2014) Carbonyl reduction pathways in drug metabolism. Drug Metabolism Reviews 46:1, pages 96-123.
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Articles from other publishers (14)

Nadia O Bamfo, Jessica BL Lu & Zeruesenay Desta. (2023) Stereoselective Metabolism of Bupropion to Active Metabolites in Cellular Fractions of Human Liver and Intestine. Drug Metabolism and Disposition 51:1, pages 54-66.
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Mohamed‐Eslam F. Mohamed, Mukul Minocha, Sheryl Trueman, Tian Feng, Jeffrey Enejosa, Ogert Fisniku & Ahmed A. Othman. (2020) Characterization of the Effect of Upadacitinib on the Pharmacokinetics of Bupropion, a Sensitive Cytochrome P450 2B6 Probe Substrate. Clinical Pharmacology in Drug Development 10:3, pages 299-306.
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Xin Yang, Wenyi Hua, Sangwoo Ryu, Phillip Yates, Cheng Chang, Hui Zhang & Li Di. (2018) 11 β -Hydroxysteroid Dehydrogenase 1 Human Tissue Distribution, Selective Inhibitor, and Role in Doxorubicin Metabolism . Drug Metabolism and Disposition 46:7, pages 1023-1029.
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Jamie N. Connarn, Stephanie Flowers, Marisa Kelly, Ruijuan Luo, Kristen M. Ward, Gloria Harrington, Ila Moncion, Masoud Kamali, Melivin McInnis, Meihua R. Feng, Vicki Ellingrod, Andrew Babiskin, Xinyuan Zhang & Duxin Sun. (2017) Pharmacokinetics and Pharmacogenomics of Bupropion in Three Different Formulations with Different Release Kinetics in Healthy Human Volunteers. The AAPS Journal 19:5, pages 1513-1522.
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T.D. Nolin. 2017. Drug Metabolism in Diseases. Drug Metabolism in Diseases 91 113 .
Jamie N. Connarn, Ruijuan Luo, Jim Windak, Xinyuan Zhang, Andrew Babiskin, Marisa Kelly, Gloria Harrington, Vicki L. Ellingrod, Masoud Kamali, Melvin McInnis & Duxin Sun. (2016) Identification of non‐reported bupropion metabolites in human plasma. Biopharmaceutics & Drug Disposition 37:9, pages 550-560.
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V. M. Fokina, M. Xu, E. Rytting, S. Z. Abdel-Rahman, H. West, C. Oncken, S. M. Clark, M. S. Ahmed, G. D. V. Hankins & T. N. Nanovskaya. (2016) Pharmacokinetics of Bupropion and Its Pharmacologically Active Metabolites in Pregnancy. Drug Metabolism and Disposition 44:11, pages 1832-1838.
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Valentina M. Fokina, Holly West, Cheryl Oncken, Shannon M. Clark, Mahmoud S. Ahmed, Gary D.V. Hankins & Tatiana N. Nanovskaya. (2016) Bupropion therapy during pregnancy: the drug and its major metabolites in umbilical cord plasma and amniotic fluid. American Journal of Obstetrics and Gynecology 215:4, pages 497.e1-497.e7.
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O. A. Fahmi, M. Shebley, J. Palamanda, M. W. Sinz, D. Ramsden, H. J. Einolf, L. Chen & H. Wang. (2016) Evaluation of CYP2B6 Induction and Prediction of Clinical Drug-Drug Interactions: Considerations from the IQ Consortium Induction Working Group--An Industry Perspective. Drug Metabolism and Disposition 44:10, pages 1720-1730.
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B. T. Gufford, J. B. L. Lu, I. F. Metzger, D. R. Jones & Z. Desta. (2016) Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo. Drug Metabolism and Disposition 44:4, pages 544-553.
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Jamie N. Connarn, Xinyuan Zhang, Andrew Babiskin & Duxin Sun. (2015) Metabolism of Bupropion by Carbonyl Reductases in Liver and Intestine. Drug Metabolism and Disposition 43:7, pages 1019-1027.
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Osama Y. Alshogran, Judith Naud, Andrew J. Ocque, François A. Leblond, Vincent Pichette & Thomas D. Nolin. (2015) Effect of Experimental Kidney Disease on the Functional Expression of Hepatic Reductases. Drug Metabolism and Disposition 43:1, pages 100-106.
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Lucie Skarydova, Radana Tomanova, Lucie Havlikova, Hana Stambergova, Petr Solich & Vladimir Wsol. (2014) Deeper Insight into the Reducing Biotransformation of Bupropion in the Human Liver. Drug Metabolism and Pharmacokinetics 29:2, pages 177-184.
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Arne Meyer, Anna Vuorinen, Agnieszka E. Zielinska, Petra Strajhar, Gareth G. Lavery, Daniela Schuster & Alex Odermatt. (2013) Formation of Threohydrobupropion from Bupropion Is Dependent on 11 β -Hydroxysteroid Dehydrogenase 1 . Drug Metabolism and Disposition 41:9, pages 1671-1678.
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