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Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 8
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Animal Pharmacokinetics and Metabolism

Pharmacokinetic determination of ephedrine in Herba Ephedrae and Wu Tou Tang decoctions in rats using ultra performance liquid chromatography tandem mass spectrometry

Zhijie ZhengLaboratory of Molecular Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
,
Tongmeng YanLaboratory of Molecular Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
,
Weiying ChenLaboratory of Molecular Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
,
Ling YeLaboratory of Molecular Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
,
Lan TangLaboratory of Molecular Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
&
Zhongqiu LiuLaboratory of Molecular Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, ChinaCorrespondence[email protected]
Pages 775-783 | Received 06 Dec 2011, Accepted 16 Jan 2012, Published online: 21 Feb 2012

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Hongye Pan, Lei Wang, Qing Zhang, Lingyan Tao, Guoquan Chen, Jiale Chen, Yilun Ding & Longhu Wang. (2018) Quality Evaluation of Ephedrae herba by near Infrared Spectroscopy. Analytical Letters 51:18, pages 2849-2859.
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Mei Zeng, Lan Yang, Dan He, Yao Li, Mingxin Shi & Jingqing Zhang. (2017) Metabolic pathways and pharmacokinetics of natural medicines with low permeability. Drug Metabolism Reviews 49:4, pages 464-476.
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Huilian Huang, Min Liu & Pei Chen. (2014) Recent Advances in Ultra-High Performance Liquid Chromatography for the Analysis of Traditional Chinese Medicine. Analytical Letters 47:11, pages 1835-1851.
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Qian Wang, Yu Bian, Yuan Zhang, De-mei Sun, Wei-lai Wang, Yu Zhou, Zhi-fei Liu, Xue-song Feng & Zhen-wei He. (2023) Development of sampling, pretreatment and detection methods for ephedrine and related substances in complex samples. Microchemical Journal 189, pages 108538.
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Kyoung-Moon Han, Jinwoo Hwang, Sun Hee Lee, Boreum Park, Hyungil Kim & Sun Young Baek. (2022) Quantitative Analysis and Enantiomeric Separation of Ephedra Alkaloids in Ma Huang Related Products by HPLC-DAD and UPLC-MS/MS. Natural Product Sciences 28:4, pages 168-180.
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Yousef A. Bin Jardan, Khaled Mohamed, Nagwan Abbas, Manal El-Gendy, Nawaf Alsaif, Mohammed Alanazi, Mostafa Mohammed, Mohammed Abounassif & Mohamed Hefnawy. (2021) Development and validation of GC–MS method for determination of methcathinone and its main metabolite in mice plasma and brain tissue after SPE: Pharmacokinetic and distribution study. Journal of Pharmaceutical and Biomedical Analysis 194, pages 113798.
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Chunyan Zhu, Qionghong Xu, Zhiyun Mao & Na Lin. (2018) The Chinese Medicine Wu-Tou Decoction Relieves Neuropathic Pain by Inhibiting Hippocampal Microglia Activation. Scientific Reports 8:1.
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Chunyan Zhu, Qionghong Xu, Chao Wang, Zhiyun Mao & Na Lin. (2017) Evidence that CA3 is Underling the Comorbidity Between Pain and Depression and the Co-curation by Wu-Tou decoction in Neuropathic Pain. Scientific Reports 7:1.
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Tengfei Xu, Shizhe Li, Yufei Sun, Zifeng Pi, Shu Liu, Fengrui Song & Zhiqiang Liu. (2017) Systematically characterize the absorbed effective substances of Wutou Decoction and their metabolic pathways in rat plasma using UHPLC-Q-TOF-MS combined with a target network pharmacological analysis. Journal of Pharmaceutical and Biomedical Analysis 141, pages 95-107.
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Qingqing Guo, Kang Zheng, Danping Fan, Yukun Zhao, Li Li, Yanqin Bian, Xuemei Qiu, Xue Liu, Ge Zhang, Chaoying Ma, Xiaojuan He & Aiping Lu. (2017) Wu-Tou Decoction in Rheumatoid Arthritis: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation. Frontiers in Pharmacology 8.
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Mengkai Zheng, Huifen Zhou, Haitong Wan, Yu-Lin Chen & Yu He. (2015) Effects of herbal drugs in Mahuang decoction and their main components on intestinal transport characteristics of Ephedra alkaloids evaluated by a Caco-2 cell monolayer model. Journal of Ethnopharmacology 164, pages 22-29.
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Yanqiong Zhang, Ming Bai, Bo Zhang, Chunfang Liu, Qiuyan Guo, Yanqun Sun, Danhua Wang, Chao Wang, Yini Jiang, Na Lin & Shao Li. (2015) Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: drug-target prediction, network analysis and experimental validation. Scientific Reports 5:1.
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Tengfei Xu, Shu Liu, Jiadi Zhao, Guifang Feng, Zifeng Pi, Fengrui Song & Zhiqiang Liu. (2015) A study on the effective substance of the Wu-tou formula based on the metabonomic method using UPLC-Q-TOF-HDMS. Molecular BioSystems 11:11, pages 3081-3091.
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Daniel Radiloff, Yulin Zhao, Alina Boico, Gert Blueschke, Gregory Palmer, Andrew Fontanella, Mark Dewhirst, Claude A. Piantadosi, Robert Noveck, David Irwin, Karyn Hamilton, Bruce Klitzman & Thies Schroeder. (2014) Anti-Hypotensive Treatment and Endothelin Blockade Synergistically Antagonize Exercise Fatigue in Rats under Simulated High Altitude. PLoS ONE 9:6, pages e99309.
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Fangyuan Gao, Yongsheng Hu, Gao Fang, Guang Yang, Zihua Xu, Lili Dou, Zhao Chen & Guorong Fan. (2014) Recent developments in the field of the determination of constituents of TCMs in body fluids of animals and human. Journal of Pharmaceutical and Biomedical Analysis 87, pages 241-260.
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. (2013) Scientific Opinion on safety evaluation of Ephedra species for use in food. EFSA Journal 11:11.
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Yanqiong Zhang, Danhua Wang, Shufang Tan, Haiyu Xu, Chunfang Liu & Na Lin. (2013) A Systems Biology-Based Investigation into the Pharmacological Mechanisms of Wu Tou Tang Acting on Rheumatoid Arthritis by Integrating Network Analysis. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-12.
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