Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 8
570
Views
26
CrossRef citations to date
0
Altmetric
Topics in Xenobiochemistry

Understanding substrate selectivity of human UDP-glucuronosyltransferases through QSAR modeling and analysis of homologous enzymes

, , &
Pages 808-820 | Received 15 Dec 2011, Accepted 31 Jan 2012, Published online: 02 Mar 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Nikhilesh V. Dhuria, Bianka Haro, Amit Kapadia, Khadjia A. Lobo, Bernice Matusow, Mary A. Schleiff, Christina Tantoy & Jasleen K. Sodhi. (2021) Recent developments in predicting CYP-independent metabolism. Drug Metabolism Reviews 53:2, pages 188-206.
Read now
Zhufeng Wu, Xingwang Zhang, Zhiguo Ma & Baojian Wu. (2015) Establishment of pharmacophore and VolSurf models to predict the substrates of UDP-glucuronosyltransferase1A3. Xenobiotica 45:8, pages 653-662.
Read now

Articles from other publishers (24)

Chester J. J. Wrobel & Frank C. Schroeder. (2023) Repurposing degradation pathways for modular metabolite biosynthesis in nematodes. Nature Chemical Biology 19:6, pages 676-686.
Crossref
Vladimir N. Uversky. 2023. Structure and Intrinsic Disorder in Enzymology. Structure and Intrinsic Disorder in Enzymology 303 325 .
Tamara Božina, Ena Karačić, Lana Ganoci, Silvija Čuković-Čavka, Jozefina Palić, Nada Božina & Livija Šimičević. (2022) UGT2B7 c.-161C>T polymorphism frequency in Croatian population . Archives of Industrial Hygiene and Toxicology 73:4, pages 303-307.
Crossref
Janek Szychowski, Robert Papp, Evelyne Dietrich, Bingcan Liu, Frédéric Vallée, Marie-Eve Leclaire, Jimmy Fourtounis, Giovanni Martino, Alexander L. Perryman, Victor Pau, Shou Yun Yin, Pavel Mader, Anne Roulston, Jean-Francois Truchon, C. Gary Marshall, Mohamed Diallo, Nicole M. Duffy, Rino Stocco, Claude Godbout, Alexanne Bonneau-Fortin, Rosie Kryczka, Vivek Bhaskaran, Daniel Mao, Stephen Orlicky, Patrick Beaulieu, Pascal Turcotte, Igor Kurinov, Frank Sicheri, Yael Mamane, Michel Gallant & W. Cameron Black. (2022) Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. Journal of Medicinal Chemistry 65:15, pages 10251-10284.
Crossref
Michael J. Osborne, Amanda K. Rahardjo, Laurent Volpon & Katherine L. B. Borden. (2021) 1H, 13C and 15N chemical shift assignments of the C-terminal domain of human UDP-Glucuronosyltransferase 2B7 (UGT2B7-C). Biomolecular NMR Assignments 15:2, pages 323-328.
Crossref
Attila Almási, Pál Perjési & Emil Fischer. (2020) The Relative Importance of the Small Intestine and the Liver in Phase II Metabolic Transformations and Elimination of p-Nitrophenol Administered in Different Doses in the Rat. Scientia Pharmaceutica 88:4, pages 51.
Crossref
E. E. J. Kasteel, K. Darney, N. I. Kramer, J. L. C. M. Dorne & L. S. Lautz. (2020) Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors. Archives of Toxicology 94:8, pages 2637-2661.
Crossref
Alexander D. Smith, Brent D. G. Page, Abby C. Collier & Michael W. H. Coughtrie. (2020) Homology Modeling of Human Uridine-5′-diphosphate-glucuronosyltransferase 1A6 Reveals Insights into Factors Influencing Substrate and Cosubstrate Binding. ACS Omega 5:12, pages 6872-6887.
Crossref
P. Lafite, S. Marroun, G. Coadou, S. Montaut, S. Marquès, M. Schuler, P. Rollin, A. Tatibouët, R. Daniellou & H. Oulyadi. (2019) S-glycosyltransferase UGT74B1 can glycosylate both S- and O-acceptors: mechanistic insights through substrate specificity. Molecular Catalysis 479, pages 110631.
Crossref
Noémi-Piroska KovácsAttila AlmásiKitti GaraiMónika KuzmaSzende VanceaEmil FischerPál Perjési. (2019) Investigation of intestinal elimination and biliary excretion of ibuprofen in hyperglycemic rats. Canadian Journal of Physiology and Pharmacology 97:11, pages 1080-1089.
Crossref
Lydia Woelflingseder, Benedikt Warth, Immina Vierheilig, Heidi Schwartz-Zimmermann, Christian Hametner, Veronika Nagl, Barbara Novak, Bojan Šarkanj, Franz Berthiller, Gerhard Adam & Doris Marko. (2019) The Fusarium metabolite culmorin suppresses the in vitro glucuronidation of deoxynivalenol. Archives of Toxicology 93:6, pages 1729-1743.
Crossref
Stefan Bäurle, Jens Nagel, Olaf Peters, Nico Bräuer, Antonius ter Laak, Cornelia Preusse, Antje Rottmann, Dieter Heldmann, Ulrich Bothe, Thorsten Blume, Ludwig Zorn, Daryl WalterThomas M. Zollner, Andreas Steinmeyer & Gernot Langer. (2019) Identification of a Benzimidazolecarboxylic Acid Derivative ( BAY 1316957 ) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis . Journal of Medicinal Chemistry 62:5, pages 2541-2563.
Crossref
Michael J. Osborne, Luciana Coutinho de Oliveira, Laurent Volpon, Hiba Ahmad Zahreddine & Katherine L.B. Borden. (2019) Overcoming Drug Resistance through the Development of Selective Inhibitors of UDP-Glucuronosyltransferase Enzymes. Journal of Molecular Biology 431:2, pages 258-272.
Crossref
Xia Lv, Jian-Bin Zhang, Jie Hou, Tong-Yi Dou, Guang-Bo Ge, Wen-Zhong Hu & Ling Yang. (2019) Chemical Probes for Human UDP-Glucuronosyltransferases: A Comprehensive Review. Biotechnology Journal 14:1, pages 1800002.
Crossref
Min Yang, Charlie Fehl, Karen V. Lees, Eng-Kiat Lim, Wendy A. Offen, Gideon J. Davies, Dianna J. Bowles, Matthew G. Davidson, Stephen J. Roberts & Benjamin G. Davis. (2018) Functional and informatics analysis enables glycosyltransferase activity prediction. Nature Chemical Biology 14:12, pages 1109-1117.
Crossref
Laura Righetti, Marie Fenclova, Luca Dellafiora, Jana Hajslova, Milena Stranska-Zachariasova & Chiara Dall'Asta. (2018) High resolution-ion mobility mass spectrometry as an additional powerful tool for structural characterization of mycotoxin metabolites. Food Chemistry 245, pages 768-774.
Crossref
Xiaokang Wang, Caiyun Jiang, Xiaosong Wu, Peng Zou & Zhufeng Wu. (2018) Substrate Selectivity for UDP-glucuronosyltransferase1A8 using the Pharmacophore Approach. International Journal of Pharmacology 14:3, pages 320-328.
Crossref
Ming Hu, Baojian Wu & Zhongqiu Liu. (2017) Bioavailability of Polyphenols and Flavonoids in the Era of Precision Medicine. Molecular Pharmaceutics 14:9, pages 2861-2863.
Crossref
Sheng-Kuo Hsieh, Tse-Yu Chung, Yue-Chiun Li, Yuan-Hao Lo, Nan-Hei Lin, Ping-Chung Kuo, Wen-Ying Chen & Jason T.C. Tzen. (2016) Ginkgoghrelins, unique acylated flavonoid diglycosides in Folium Ginkgo, stimulate growth hormone secretion via activation of the ghrelin receptor. Journal of Ethnopharmacology 193, pages 237-247.
Crossref
C. D. van Beusekom, J. Fink-Gremmels & J. A. Schrickx. (2014) Comparing the glucuronidation capacity of the feline liver with substrate-specific glucuronidation in dogs. Journal of Veterinary Pharmacology and Therapeutics 37:1, pages 18-24.
Crossref
Ryan W. Dellinger, Angela M. Gomez Garcia & Frank L. MeyskensJr.Jr.. (2014) Differences in the Glucuronidation of Resveratrol and Pterostilbene: Altered Enzyme Specificity and Potential Gender Differences. Drug Metabolism and Pharmacokinetics 29:2, pages 112-119.
Crossref
Matthew T. Honaker, Mauro Acchione, Wei Zhang, Bengt Mannervik & William M. Atkins. (2013) Enzymatic Detoxication, Conformational Selection, and the Role of Molten Globule Active Sites. Journal of Biological Chemistry 288:25, pages 18599-18611.
Crossref
Scott A. Robotham & Jennifer S. Brodbelt. (2013) Identification of Flavone Glucuronide Isomers by Metal Complexation and Tandem Mass Spectrometry: Regioselectivity of Uridine 5′-Diphosphate–Glucuronosyltransferase Isozymes in the Biotransformation of Flavones. Journal of Agricultural and Food Chemistry 61:7, pages 1457-1463.
Crossref
Baojian Wu & Dong Dong. (2012) Human cytosolic glutathione transferases: structure, function, and drug discovery. Trends in Pharmacological Sciences 33:12, pages 656-668.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.