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Francesca Toselli, Melanie Golding, Johan Nicolaï, Eric Gillent & Hugues Chanteux. (2022) Drug clearance by aldehyde oxidase: can we avoid clinical failure?. Xenobiotica 52:8, pages 890-903.
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Kristine Langthaler, Christopher R. Jones, Rasmus B. Christensen, Elin Eneberg, Birger Brodin & Christoffer Bundgaard. (2022) Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies. Xenobiotica 52:6, pages 591-607.
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Carl Petersson, Orestis Papasouliotis, Marc Lecomte, Lassina Badolo & Hugues Dolgos. (2020) Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery. Xenobiotica 50:3, pages 270-279.
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Adam J. Lucas, Joanne L. Sproston, Patrick Barton & Robert J. Riley. (2019) Estimating human ADME properties, pharmacokinetic parameters and likely clinical dose in drug discovery. Expert Opinion on Drug Discovery 14:12, pages 1313-1327.
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Tetsuo Yamagata, Ugo Zanelli, Dieter Gallemann, Dominique Perrin, Hugues Dolgos & Carl Petersson. (2017) Comparison of methods for the prediction of human clearance from hepatocyte intrinsic clearance for a set of reference compounds and an external evaluation set. Xenobiotica 47:9, pages 741-751.
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R. J. Riley, S. A. Foley, P. Barton, M. G. Soars & B. Williamson. (2016) Hepatic drug transporters: the journey so far. Expert Opinion on Drug Metabolism & Toxicology 12:2, pages 201-216.
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Norimasa Jinno, Mizuka Tagashira, Kazuyuki Tsurui & Shizuo Yamada. (2014) Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes. Xenobiotica 44:8, pages 677-686.
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C. Desbans, C. Hilgendorf, M. Lutz, P. Bachellier, T. Zacharias, J. C. Weber, H. Dolgos, L. Richert & A.-L. Ungell. (2014) Prediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors. Xenobiotica 44:1, pages 17-27.
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Anna-Karin Sohlenius-Sternbeck, Urban Fagerholm & Johan Bylund. (2013) The volume of distribution is an indicator of poor in vitro–in vivo extrapolation of clearance for acidic drugs in the rat. Xenobiotica 43:8, pages 671-678.
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Tjerk Bueters, Sanja Juric, Anna-Karin Sohlenius-Sternbeck, Yin Hu & Johan Bylund. (2013) Rat poorly predicts the combined non-absorbed and presystemically metabolized fractions in the human. Xenobiotica 43:7, pages 607-616.
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Articles from other publishers (66)
Lena Ripa, Jenny Sandmark, Glyn Hughes, Igor Shamovsky, Anders Gunnarsson, Julia Johansson, Antonio Llinas, Mia Collins, Bomi Jung, Anna Novén, Nils Pemberton, Mickael Mogemark, Yao Xiong, Qing Li, Stefan Tångefjord, Margareta Ek & Annika Åstrand. (2023) Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism. Journal of Medicinal Chemistry 66:20, pages 14188-14207.
Crossref
Crossref
Daniel Porat, Oleg Dukhno, Mazal Partook-Maccabi, Ella Vainer, Sandra Cvijić & Arik Dahan. (2023) Selective COX-2 inhibitors after bariatric surgery: Celecoxib, etoricoxib and etodolac post-bariatric solubility/dissolution and pharmacokinetics. International Journal of Pharmaceutics 645, pages 123347.
Crossref
Crossref
Nenad Manevski, Kenichi Umehara & Neil Parrott. (2023)
Drug Design and Success of Prospective Mouse In Vitro–In Vivo Extrapolation (IVIVE) for Predictions of Plasma Clearance (CL
p
) from Hepatocyte Intrinsic Clearance (CL
int
)
. Molecular Pharmaceutics 20:7, pages 3438-3459.
Crossref
Crossref
Dermot F. McGinnity & Ken Grime. 2023. The Handbook of Medicinal Chemistry. The Handbook of Medicinal Chemistry
298
323
.
Liu Liu, Yiming Liu, Xiaojie Zhou, Zhiwei Xu, Yehui Zhang, Liting Ji, Chunlan Hong & Changyu Li. (2022) Analyzing the metabolic fate of oral administration drugs: A review and state-of-the-art roadmap. Frontiers in Pharmacology 13.
Crossref
Crossref
Tien-Yu Chang, Hong-Jaan Wang, Shu-Hao Hsu, Ming-Ling Chang, Li-Ting Kao & Li-Heng Pao. (2022) Evidence of the need for modified well-stirred model in vitro to in vivo extrapolation. European Journal of Pharmaceutical Sciences 177, pages 106268.
Crossref
Crossref
Giuseppe Cecere, Laura Guasch, Andres M. Olivares-Morales, Kenichi Umehara & Antonia F. Stepan. (2022) LipMetE (Lipophilic Metabolism Efficiency) as a Simple Guide for Half-Life and Dosing Regimen Prediction of Oral Drugs. ACS Medicinal Chemistry Letters 13:9, pages 1444-1451.
Crossref
Crossref
Carl Petersson, Xin Zhou, Joerg Berghausen, David Cebrian, Michael Davies, Kevin DeMent, Peter Eddershaw, Arian Emami Riedmaier, Alix F. Leblanc, Nenad Manveski, Punit Marathe, Panteleimon D. Mavroudis, Robin McDougall, Neil Parrott, Andreas Reichel, Charles Rotter, David Tess, Laurie P. Volak, Guangqing Xiao, Zheng Yang & James Baker. (2022) Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey. The AAPS Journal 24:5.
Crossref
Crossref
Lena C. Preiss, Volker M. Lauschke, Katrin Georgi & Carl Petersson. (2022) Multi-Well Array Culture of Primary Human Hepatocyte Spheroids for Clearance Extrapolation of Slowly Metabolized Compounds. The AAPS Journal 24:2.
Crossref
Crossref
Philip Butler & Robert J. Riley. 2022. The ADME Encyclopedia. The ADME Encyclopedia
537
547
.
Ruirui Xu, Pingping Hu, Yuwen Li, Anran Tian, Jun Li & Chuanlong Zhu. (2021) Advances in HBV infection and replication systems in vitro. Virology Journal 18:1.
Crossref
Crossref
Timo Heinrich, Ada Sala-Hojman, Roberta Ferretti, Carl Petersson, Stefano Minguzzi, Andrzej Gondela, Shivapriya Ramaswamy, Anna Bartosik, Frank Czauderna, Lindsey Crowley, Pamela Wahra, Heike Schilke, Pia Böpple, Łukasz Dudek, Marcin Leś, Paulina Niedziejko, Kamila Olech, Henryk Pawlik, Łukasz Włoszczak, Karol Zuchowicz, Jose Ramon Suarez Alvarez, Justyna Martyka, Ewa Sitek, Maciej Mikulski, Joanna Szczęśniak, Sven Jäckel, Mireille Krier, Marcin Król, Ansgar Wegener, Michał Gałęzowski, Mateusz Nowak, Frank Becker & Christian Herhaus. (2021) Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology. Journal of Medicinal Chemistry 64:16, pages 11904-11933.
Crossref
Crossref
Jasleen K. Sodhi & Leslie Z. Benet. (2021) Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization. Journal of Medicinal Chemistry 64:7, pages 3546-3559.
Crossref
Crossref
Kajsa P. Kanebratt, Annika Janefeldt, Liisa Vilén, Anna Vildhede, Kristin Samuelsson, Lucas Milton, Anders Björkbom, Marie Persson, Carina Leandersson, Tommy B. Andersson & Constanze Hilgendorf. (2021) Primary Human Hepatocyte Spheroid Model as a 3D In Vitro Platform for Metabolism Studies. Journal of Pharmaceutical Sciences 110:1, pages 422-431.
Crossref
Crossref
Philip Butler & Robert J. Riley. 2021. The ADME Encyclopedia. The ADME Encyclopedia
1
11
.
Beth Williamson, Stephanie Harlfinger & Dermot F. McGinnity. (2020) Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance. Drug Metabolism and Disposition 48:11, pages 1137-1146.
Crossref
Crossref
John Weeks, Albert P. Li, Utkarsh Doshi, Karla Johanning & Patrick D. Guiney. (2020) In vitro evaluation of the metabolic stability of nine fragrance chemicals in trout and human hepatocytes. Journal of Applied Toxicology 40:10, pages 1421-1434.
Crossref
Crossref
Venkatesh Pilla Reddy, Rana Anjum, Michael Grondine, Aaron Smith, Deepa Bhavsar, Evan Barry, Sylvie M. Guichard, Wenlin Shao, Jason G. Kettle, Crystal Brown, Erica Banks & Rhys D.O. Jones. (2020) The Pharmacokinetic–Pharmacodynamic (PKPD) Relationships of AZD3229, a Novel and Selective Inhibitor of KIT, in a Range of Mouse Xenograft Models of GIST. Clinical Cancer Research 26:14, pages 3751-3759.
Crossref
Crossref
Beth Williamson, Nicola Colclough, Adrian John Fretland, Barry Christopher Jones, Rhys Dafydd Owen Jones & Dermot Francis McGinnity. (2020) Further Considerations Towards an Effective and Efficient Oncology Drug Discovery DMPK Strategy. Current Drug Metabolism 21:2, pages 145-162.
Crossref
Crossref
Michael Davies, Rhys D.O. Jones, Ken Grime, Rasmus Jansson-Löfmark, Adrian J. Fretland, Susanne Winiwarter, Paul Morgan & Dermot F. McGinnity. (2020) Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades. Trends in Pharmacological Sciences 41:6, pages 390-408.
Crossref
Crossref
Jochem Louisse, Martin Alewijn, Ad A.C.M. Peijnenburg, Nicole H.P. Cnubben, Minne B. Heringa, Sandra Coecke & Ans Punt. (2020) Towards harmonization of test methods for in vitro hepatic clearance studies. Toxicology in Vitro 63, pages 104722.
Crossref
Crossref
Venkatesh Pilla Reddy & Andy Z.X. Zhu. 2020. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters
633
655
.
Ravindra Varma Alluri & Manthena V.S. Varma. 2020. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters
609
631
.
Magnus Munck af Rosenschöld, Petra Johannesson, Antonios Nikitidis, Christian Tyrchan, Hui-Fang Chang, Robert Rönn, Dave Chapman, Victoria Ullah, Grigorios Nikitidis, Pernilla Glader, Helena Käck, Britta Bonn, Fredrik Wågberg, Eva Björkstrand, Ulf Andersson, Linda Swedin, Mattias Rohman, Theresa Andreasson, Eva Lamm Bergström, Fanyi Jiang, Xiao-Hong Zhou, Anders J. Lundqvist, Anna Malmberg, Margareta Ek, Euan Gordon, Anna Pettersen, Lena Ripa & Andrew M. Davis. (2019)
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1
S
,2
S
)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma
. Journal of Medicinal Chemistry 62:17, pages 7769-7787.
Crossref
Crossref
Philip Gardiner, Rhona J. Cox & Ken Grime. (2019) Plasma Protein Binding as an Optimizable Parameter for Acidic Drugs. Drug Metabolism and Disposition 47:8, pages 865-873.
Crossref
Crossref
Christine M. Bowman & Leslie Z. Benet. (2019) Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties. Pharmaceutical Research 36:8.
Crossref
Crossref
Gregory S. Honda, Robert G. Pearce, Ly L. Pham, R. W. Setzer, Barbara A. Wetmore, Nisha S. Sipes, Jon Gilbert, Briana Franz, Russell S. Thomas & John F. Wambaugh. (2019) Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions. PLOS ONE 14:5, pages e0217564.
Crossref
Crossref
Masahiro Yahata, Yuji Ishii, Tetsuya Nakagawa, Takao Watanabe & Kiyoko Bando. (2019) Species differences in metabolism of a new antiepileptic drug candidate, DSP‐0565 [2‐(2′‐fluoro[1,1′‐biphenyl]‐2‐yl)acetamide]. Biopharmaceutics & Drug Disposition 40:5-6, pages 165-175.
Crossref
Crossref
D. Hallifax & J.B. Houston. (2019) Use of Segregated Hepatocyte Scaling Factors and Cross-Species Relationships to Resolve Clearance Dependence in the Prediction of Human Hepatic Clearance. Drug Metabolism and Disposition 47:3, pages 320-327.
Crossref
Crossref
Kevin M. FooteJ. Willem M. Nissink, Thomas McGuirePaul TurnerSylvie GuichardJames W. T. YatesAlan LauKevin BladesDan HeathcoteRajesh OdedraGary WilkinsonZena WilsonChristine M. WoodPhilip J. Jewsbury. (2018) Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent. Journal of Medicinal Chemistry 61:22, pages 9889-9907.
Crossref
Crossref
C.M. Bowman & L.Z. Benet. (2018) An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation. European Journal of Pharmaceutical Sciences 123, pages 502-514.
Crossref
Crossref
Ulf Bredberg. 2018. Early Drug Development. Early Drug Development
399
432
.
Paul Lancett, Beth Williamson, Patrick Barton & Robert J. Riley. (2018) Development and Characterization of a Human Hepatocyte Low Intrinsic Clearance Assay for Use in Drug Discovery. Drug Metabolism and Disposition 46:8, pages 1169-1178.
Crossref
Crossref
Franck Da-silva, Xavier Boulenc, Hélène Vermet, Pauline Compigne, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Sylvie Klieber & Patrick Poulin. (2018) Improving Prediction of Metabolic Clearance Using Quantitative Extrapolation of Results Obtained From Human Hepatic Micropatterned Cocultures Model and by Considering the Impact of Albumin Binding. Journal of Pharmaceutical Sciences 107:7, pages 1957-1972.
Crossref
Crossref
John F Wambaugh, Michael F Hughes, Caroline L Ring, Denise K MacMillan, Jermaine Ford, Timothy R Fennell, Sherry R Black, Rodney W Snyder, Nisha S Sipes, Barbara A Wetmore, Joost Westerhout, R Woodrow Setzer, Robert G Pearce, Jane Ellen Simmons & Russell S Thomas. (2018) Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics. Toxicological Sciences 163:1, pages 152-169.
Crossref
Crossref
F. L. Wood, J. B. Houston & D. Hallifax. (2017) Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology. Drug Metabolism and Disposition 45:11, pages 1178-1188.
Crossref
Crossref
P Gennemark, M Trägårdh, D Lindén, K Ploj, A Johansson, A Turnbull, B Carlsson & M Antonsson. (2017) Translational Modeling to Guide Study Design and Dose Choice in Obesity Exemplified by AZD1979, a Melanin-concentrating Hormone Receptor 1 Antagonist. CPT: Pharmacometrics & Systems Pharmacology 6:7, pages 458-468.
Crossref
Crossref
Sofia Chen, Luna Prieto Garcia, Fredrik Bergström, Pär Nordell & Ken Grime. (2017) Intrinsic Clearance Assay Incubational Binding: A Method Comparison. Drug Metabolism and Disposition 45:4, pages 342-345.
Crossref
Crossref
Nicole A. Kratochwil, Christophe Meille, Stephen Fowler, Florian Klammers, Aynur Ekiciler, Birgit Molitor, Sandrine Simon, Isabelle Walter, Claudia McGinnis, Johanna Walther, Brian Leonard, Miriam Triyatni, Hassan Javanbakht, Christoph Funk, Franz Schuler, Thierry Lavé & Neil J. Parrott. (2017) Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling. The AAPS Journal 19:2, pages 534-550.
Crossref
Crossref
H. Tsui, Q. Zeng, K. Chen & X. Zhang. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III
408
446
.
D.F. McGinnity & K. Grime. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III
34
44
.
C. M. Bowman & L. Z. Benet. (2016) Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System. Drug Metabolism and Disposition 44:11, pages 1731-1735.
Crossref
Crossref
Daniel Scotcher, Christopher Jones, Amin Rostami-Hodjegan & Aleksandra Galetin. (2016) Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance. European Journal of Pharmaceutical Sciences 94, pages 59-71.
Crossref
Crossref
Robert H. BradburyRowena CallisGregory R. CarrHuawei Chen, Edwin Clark, Lyman FeronSteve GlossopMark A. GrahamMaureen Hattersley, Chris JonesScott G. LamontGilles Ouvry, Anil PatelJoe Patel, Alfred A. RabowCraig A. RobertsStephen StokesNatalie StrattonGraeme E. WalkerLara WardDavid WhalleyDavid WhittakerGail WrigleyMichael J. Waring. (2016)
Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3
R
)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-
b
]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)
. Journal of Medicinal Chemistry 59:17, pages 7801-7817.
Crossref
Crossref
Ia Hultman, Charlotta Vedin, Anna Abrahamsson, Susanne Winiwarter & Malin Darnell. (2016) Use of HμREL Human Coculture System for Prediction of Intrinsic Clearance and Metabolite Formation for Slowly Metabolized Compounds. Molecular Pharmaceutics 13:8, pages 2796-2807.
Crossref
Crossref
Christopher R. Jones, Oliver J. D. Hatley, Anna-Lena Ungell, Constanze Hilgendorf, Sheila Annie Peters & Amin Rostami-Hodjegan. (2016) Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination. The AAPS Journal 18:3, pages 589-604.
Crossref
Crossref
J. Willem M. Nissink, Sebastien Degorce & Ken Page. 2016. Lead Generation. Lead Generation
451
486
.
B. Bonn, P. Svanberg, A. Janefeldt, I. Hultman & K. Grime. (2016) Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG. Drug Metabolism and Disposition 44:4, pages 527-533.
Crossref
Crossref
Qingbei Zeng, Jiabing Wang, Ziqiang Cheng, Kan Chen, Peter Johnström, Katarina Varnäs, David Yunzhi Li, Zhen Fan Yang & Xiaolin Zhang. (2015) Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor. Journal of Medicinal Chemistry 58:20, pages 8200-8215.
Crossref
Crossref
Susanne Winiwarter, Brian Middleton, Barry Jones, Paul Courtney, Bo Lindmark, Ken M. Page, Alan Clark & Claire Landqvist. (2015) Time dependent analysis of assay comparability: a novel approach to understand intra- and inter-site variability over time. Journal of Computer-Aided Molecular Design 29:9, pages 795-807.
Crossref
Crossref
Marcel Geyer, Eric Wellner, Ulrik Jurva, Sebastian Saloman, Duncan Armstrong & Reinhold Tacke. (2015) Can Silicon Make an Excellent Drug Even Better? An in vitro and in vivo Head-to-Head Comparison between Loperamide and Its Silicon Analogue Sila-Loperamide. ChemMedChem 10:5, pages 911-924.
Crossref
Crossref
M Sundqvist, A Lundahl, MB Någård, U Bredberg & P Gennemark. (2015) Quantifying and Communicating Uncertainty in Preclinical Human Dose-Prediction. CPT: Pharmacometrics & Systems Pharmacology 4:4, pages 243-254.
Crossref
Crossref
Susan M. Jenkins & Dawn D. Parker. 2015. Discovering and Developing Molecules with Optimal Drug-Like Properties. Discovering and Developing Molecules with Optimal Drug-Like Properties
141
175
.
Monalisa Chatterji, Radha Shandil, M. R. Manjunatha, Suresh Solapure, Vasanthi Ramachandran, Naveen Kumar, Ramanatha Saralaya, Vijender Panduga, Jitendar Reddy, Prabhakar KR, Sreevalli Sharma, Claire Sadler, Christopher B. Cooper, Khisi Mdluli, Pravin S. Iyer, Shridhar Narayanan & Pravin S. Shirude. (2014) 1,4-Azaindole, a Potential Drug Candidate for Treatment of Tuberculosis. Antimicrobial Agents and Chemotherapy 58:9, pages 5325-5331.
Crossref
Crossref
Maruti Naik, Vaishali Humnabadkar, Subramanyam J. Tantry, Manoranjan Panda, Ashwini Narayan, Supreeth Guptha, Vijender Panduga, Praveena Manjrekar, Lalit kumar Jena, Krishna Koushik, Gajanan Shanbhag, Sandesh Jatheendranath, M. R. Manjunatha, Gopinath Gorai, Chandramohan Bathula, Suresh Rudrapatna, Vijayashree Achar, Sreevalli Sharma, Anisha Ambady, Naina Hegde, Jyothi Mahadevaswamy, Parvinder Kaur, Vasan K. Sambandamurthy, Disha Awasthy, Chandan Narayan, Sudha Ravishankar, Prashanti Madhavapeddi, Jitendar Reddy, KR Prabhakar, Ramanatha Saralaya, Monalisa Chatterji, James Whiteaker, Bob McLaughlin, Laurent R. Chiarelli, Giovanna Riccardi, Maria Rosalia Pasca, Claudia Binda, João Neres, Neeraj Dhar, François Signorino-Gelo, John D. McKinney, Vasanthi Ramachandran, Radha Shandil, Ruben Tommasi, Pravin S. Iyer, Shridhar Narayanan, Vinayak Hosagrahara, Stefan Kavanagh, Neela Dinesh & Sandeep R. Ghorpade. (2014) 4-Aminoquinolone Piperidine Amides: Noncovalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity. Journal of Medicinal Chemistry 57:12, pages 5419-5434.
Crossref
Crossref
Patrik Lundquist, Johan Lööf, Anna-Karin Sohlenius-Sternbeck, Eva Floby, Jenny Johansson, Johan Bylund, Janet Hoogstraate, Lovisa Afzelius & Tommy B. Andersson. (2014) The Impact of Solute Carrier (SLC) Drug Uptake Transporter Loss in Human and Rat Cryopreserved Hepatocytes on Clearance Predictions. Drug Metabolism and Disposition 42:3, pages 469-480.
Crossref
Crossref
Patrik Lundquist, Gunilla Englund, Cristine Skogastierna, Johan Lööf, Jenny Johansson, Janet Hoogstraate, Lovisa Afzelius & Tommy B. Andersson. (2014) Functional ATP-Binding Cassette Drug Efflux Transporters in Isolated Human and Rat Hepatocytes Significantly Affect Assessment of Drug Disposition. Drug Metabolism and Disposition 42:3, pages 448-458.
Crossref
Crossref
Yoshihiro Shibata, Jiro Kuze & Masato Chiba. (2014) Utility of Cryopreserved Hepatocytes Suspended in Serum to Predict Hepatic Clearance in Dogs and Monkeys. Drug Metabolism and Pharmacokinetics 29:2, pages 168-176.
Crossref
Crossref
Pär Nordell, Susanne Winiwarter & Constanze Hilgendorf. (2013) Resolving the Distribution–Metabolism Interplay of Eight OATP Substrates in the Standard Clearance Assay with Suspended Human Cryopreserved Hepatocytes. Molecular Pharmaceutics 10:12, pages 4443-4451.
Crossref
Crossref
Patrick Poulin & Sami Haddad. (2013) Toward a new paradigm for the efficient in vitro–in vivo extrapolation of metabolic clearance in humans from hepatocyte data. Journal of Pharmaceutical Sciences 102:9, pages 3239-3251.
Crossref
Crossref
Patrick Poulin. (2013) Prediction of Total Hepatic Clearance by Combining Metabolism, Transport, and Permeability Data in the In Vitro–In Vivo Extrapolation Methods: Emphasis on an Apparent Fraction Unbound in Liver for Drugs. Journal of Pharmaceutical Sciences 102:7, pages 2085-2095.
Crossref
Crossref
Alexandre R.R. Péry, Céline Brochot, Florence A. Zeman, Enrico Mombelli, Sophie Desmots, Manuela Pavan, Elena Fioravanzo & José-Manuel Zaldívar. (2013) Prediction of dose-hepatotoxic response in humans based on toxicokinetic/toxicodynamic modeling with or without in vivo data: A case study with acetaminophen. Toxicology Letters 220:1, pages 26-34.
Crossref
Crossref
Pär Nordell, Petter Svanberg, James Bird & Ken Grime. (2013) Predicting Metabolic Clearance for Drugs That Are Actively Transported into Hepatocytes: Incubational Binding as a Consequence of in Vitro Hepatocyte Concentration Is a Key Factor. Drug Metabolism and Disposition 41:4, pages 836-843.
Crossref
Crossref
Kenneth H. Grime, Patrick Barton & Dermot F. McGinnity. (2013) Application of In Silico, In Vitro and Preclinical Pharmacokinetic Data for the Effective and Efficient Prediction of Human Pharmacokinetics. Molecular Pharmaceutics 10:4, pages 1191-1206.
Crossref
Crossref
Ken Grime & Stuart W. Paine. (2013) Species Differences in Biliary Clearance and Possible Relevance of Hepatic Uptake and Efflux Transporters Involvement. Drug Metabolism and Disposition 41:2, pages 372-378.
Crossref
Crossref
Patrick Poulin, Cornelis E.C.A. Hop, Quynh Ho, Jason S. Halladay, Sami Haddad & Jane R. Kenny. (2012) Comparative Assessment of In Vitro–In Vivo Extrapolation Methods used for Predicting Hepatic Metabolic Clearance of Drugs. Journal of Pharmaceutical Sciences 101:11, pages 4308-4326.
Crossref
Crossref