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Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 9
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Animal Pharmacokinetics and Metabolism

Extensive intestinal glucuronidation of raloxifene in vivo in pigs and impact for oral drug delivery

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Pages 917-928 | Received 18 Jan 2012, Accepted 04 Apr 2012, Published online: 04 May 2012

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Jing-Yi Ye, Zhong-Yun Chen, Chuan-Li Huang, Bei Huang, Yu-Rong Zheng, Ying-Feng Zhang, Ban-Yi Lu, Lin He, Chang-Shun Liu & Xiao-Ying Long. (2020) A Non-Lipolysis Nanoemulsion Improved Oral Bioavailability by Reducing the First-Pass Metabolism of Raloxifene, and Related Absorption Mechanisms Being Studied. International Journal of Nanomedicine 15, pages 6503-6518.
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N. Aditya, Punna Rao Ravi, Uday Sai Ranjan Avula & Rahul Vats. (2014) Poly (ε-caprolactone) nanocapsules for oral delivery of raloxifene: process optimization by hybrid design approach, in vitro and in vivo evaluation. Journal of Microencapsulation 31:5, pages 508-518.
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Anju SharmaJarriaun StreetsPriyanka Bhatt, Pranav PatelVijaykumar SutariyaSheeba Varghese Gupta. (2022) Formulation and Characterization of Raloxifene Nanostructured Lipid Carriers for Permeability and Uptake Enhancement Applications. ASSAY and Drug Development Technologies 20:4, pages 164-174.
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Dvora Izgelov, Irina Cherniakov, Gefen Aldouby Bier, Abraham J. Domb & Amnon Hoffman. (2018) The Effect of Piperine Pro-Nano Lipospheres on Direct Intestinal Phase II Metabolism: The Raloxifene Paradigm of Enhanced Oral Bioavailability. Molecular Pharmaceutics 15:4, pages 1548-1555.
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Erik Sjögren, Bertil Abrahamsson, Patrick Augustijns, Dieter Becker, Michael B. Bolger, Marcus Brewster, Joachim Brouwers, Talia Flanagan, Matthew Harwood, Christian Heinen, René Holm, Hans-Paul Juretschke, Marlies Kubbinga, Anders Lindahl, Viera Lukacova, Uwe Münster, Sibylle Neuhoff, Mai Anh Nguyen, Achiel van Peer, Christos Reppas, Amin Rostami Hodjegan, Christer Tannergren, Werner Weitschies, Clive Wilson, Patricia Zane, Hans Lennernäs & Peter Langguth. (2014) In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects. European Journal of Pharmaceutical Sciences 57, pages 99-151.
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Punna Rao Ravi, N. Aditya, Himanshu Kathuria, Srinivas Malekar & Rahul Vats. (2014) Lipid nanoparticles for oral delivery of raloxifene: Optimization, stability, in vivo evaluation and uptake mechanism. European Journal of Pharmaceutics and Biopharmaceutics 87:1, pages 114-124.
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Claudia Suenderhauf & Neil Parrott. (2012) A Physiologically Based Pharmacokinetic Model of the Minipig: Data Compilation and Model Implementation. Pharmaceutical Research 30:1, pages 1-15.
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