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Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 12
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General Xenobiochemistry

Glutathione conjugation of busulfan produces a hydroxyl radical-trapping dehydroalanine metabolite

Cody J. PeerDepartment of Basic Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, USA
,
Islam R. Younis
,
Stephen S. LeonardPathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
,
Peter M. GannettDepartment of Basic Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, USA
,
Valerie C. MinarchickPathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
,
Allison J. KenyonPathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
,
Yon RojanasakulDepartment of Basic Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, USA
&
Patrick S. CalleryDepartment of Basic Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, USACorrespondence[email protected]
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Pages 1170-1177 | Received 20 Apr 2012, Accepted 21 May 2012, Published online: 22 Jun 2012

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David Combarel, Julie Tran, Julia Delahousse, Gilles Vassal & Angelo Paci. (2023) Individualizing busulfan dose in specific populations and evaluating the risk of pharmacokinetic drug-drug interactions. Expert Opinion on Drug Metabolism & Toxicology 19:2, pages 75-90.
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Alan L. Myers, Jitesh D. Kawedia, Richard E. Champlin, Mark A. Kramer, Yago Nieto, Romi Ghose & Borje S. Andersson. (2017) Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review. Expert Opinion on Drug Metabolism & Toxicology 13:9, pages 901-923.
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Articles from other publishers (4)

Stephanie Hoang, Nhu Dao & Alan L. Myers. (2020) Electrophilic reactivity of the Busulfan metabolite, EdAG, towards cellular thiols and inhibition of human thioredoxin-1. Biochemical and Biophysical Research Communications 533:3, pages 325-331.
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Bo LiXin HeMengru ZhuangBowen NiuChongyang WuHailong MuFurong TangYanhua CuiWeishuai LiuBaoyu ZhaoSha PengGuangpeng LiJinlian Hua. (2018) Melatonin Ameliorates Busulfan-Induced Spermatogonial Stem Cell Oxidative Apoptosis in Mouse Testes. Antioxidants & Redox Signaling 28:5, pages 385-400.
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Jeanne Palmer, Jeannine S. McCune, Miguel-Angel Perales, David Marks, Joseph Bubalo, Mohamad Mohty, John R. Wingard, Angelo Paci, Moustapha Hassan, Christopher Bredeson, Joseph Pidala, Nina Shah, Paul Shaughnessy, Navneet Majhail, Jeff Schriber, Bipin N. Savani & Paul A. Carpenter. (2016) Personalizing Busulfan-Based Conditioning: Considerations from the American Society for Blood and Marrow Transplantation Practice Guidelines Committee. Biology of Blood and Marrow Transplantation 22:11, pages 1915-1925.
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Danyelle M. Townsend, Volodymyr I. Lushchak & Arthur J.L. Cooper. 2014. Redox and Cancer Part A. Redox and Cancer Part A 177 198 .

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