Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 4
Submit an article Journal homepage
883
Views
15
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Assessment of cytochrome P450 (1A2, 2B6, 2C9 and 3A4) induction in cryopreserved human hepatocytes cultured in 48-well plates using the cocktail strategy

Brigitte GerinUCB Pharma SA, Non Clinical DMPK, B-1420 Braine l’Alleud, Belgium
,
Sylvie Dell’AieraUCB Pharma SA, Non Clinical DMPK, B-1420 Braine l’Alleud, Belgium
,
Lysiane RichertKaly-Cell, Bioparc, Boulevard Sébastien Brant, 67400 Illkirch, France
,
Steven SmithUCB Pharma SA, Non Clinical DMPK, B-1420 Braine l’Alleud, Belgium
&
Hugues ChanteuxUCB Pharma SA, Non Clinical DMPK, B-1420 Braine l’Alleud, BelgiumCorrespondence[email protected]
Pages 320-335 | Received 06 Jun 2012, Accepted 03 Aug 2012, Published online: 15 Nov 2012

Citations (15)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Yufei He, Zihong Wei, Xiaoyan Ci, Ying Xie, Xiulin Yi, Yong Zeng, Yazhuo Li & Changxiao Liu. (2019) Effects of liquorice on pharmacokinetics of aconitine in rats. Xenobiotica 49:12, pages 1485-1493.
Read now
Yong-Yeon Cho, Hyeon-Uk Jeong, Jeong-Han Kim & Hye Suk Lee. (2014) Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes. Drug Design, Development and Therapy 8, pages 2137-2145.
Read now

Articles from other publishers (13)

Sandra Grañana-Castillo, Angharad Williams, Thao Pham, Saye Khoo, Daryl Hodge, Asangaedem Akpan, Rachel Bearon & Marco Siccardi. (2023) General Framework to Quantitatively Predict Pharmacokinetic Induction Drug–Drug Interactions Using In Vitro Data. Clinical Pharmacokinetics 62:5, pages 737-748.
Crossref
Wei Qu, David M. Crizer, Michael J. DeVito, Suramya Waidyanatha, Menghang Xia, Keith Houck & Stephen S. Ferguson. (2021) Exploration of xenobiotic metabolism within cell lines used for Tox21 chemical screening. Toxicology in Vitro 73, pages 105109.
Crossref
Adrian Hall, Hugues Chanteux, Karelle MénochetMarie Ledecq & Monika-Sarah E. D. Schulze. (2021) Designing Out PXR Activity on Drug Discovery Projects: A Review of Structure-Based Methods, Empirical and Computational Approaches. Journal of Medicinal Chemistry 64:10, pages 6413-6522.
Crossref
Marie-Lynn Cuypers, Hugues Chanteux, Eric Gillent, Pierre Bonnaillie, Kenneth Saunders, Claire Beckers, Claude Delatour, Sylvie Dell’Aiera, Anna-Lena Ungell & Johan Nicolaï. (2020) (–)- N -3-Benzylphenobarbital Is Superior to Omeprazole and (+)- N -3-Benzylnirvanol as a CYP2C19 Inhibitor in Suspended Human Hepatocytes . Drug Metabolism and Disposition 48:11, pages 1121-1128.
Crossref
Hugues Chanteux, Maria Rosa, Claude Delatour, Johan Nicolaï, Eric Gillent, Sylvie Dell’Aiera & Anna-Lena Ungell. (2020) Application of Azamulin to Determine the Contribution of CYP3A4/5 to Drug Metabolic Clearance Using Human Hepatocytes. Drug Metabolism and Disposition 48:9, pages 778-787.
Crossref
Lihui Qiu, Qian Li, Jiangeng Huang, Qi Wu, Kun Tu, Ya Wu, Xin Zhang, Junyi Qian, Ran Zhang, Gao Li, Minghui Sun & Luqin Si. (2018) In vitro effect of mPEG2k-PCLx micelles on rat liver cytochrome P450 enzymes. International Journal of Pharmaceutics 552:1-2, pages 99-110.
Crossref
Shalenie P. den Braver-Sewradj, Michiel W. den Braver, Nico P.E. Vermeulen, Jan N.M. Commandeur, Lysiane Richert & J. Chris Vos. (2016) Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer. Toxicology in Vitro 33, pages 71-79.
Crossref
A. Stockis, S. Watanabe, A. J. Scheen, D. Tytgat, B. Gerin, M. Rosa, H. Chanteux & J.-M. Nicolas. (2016) Effect of Rifampin on the Disposition of Brivaracetam in Human Subjects: Further Insights into Brivaracetam Hydrolysis. Drug Metabolism and Disposition 44:6, pages 792-799.
Crossref
Alexander V. LyubimovAlbert P. Li. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 15 .
Albert P. Li. (2015) Evaluation of Adverse Drug Properties with Cryopreserved Human Hepatocytes and the Integrated Discrete Multiple Organ Co-culture (IdMOC TM ) System . Toxicological Research 31:2, pages 137-149.
Crossref
F. Peter Guengerich. 2015. Cytochrome P450. Cytochrome P450 523 785 .
Mandy B. Esch, Alec S.T. Smith, Jean-Matthieu Prot, Carlota Oleaga, James J. Hickman & Michael L. Shuler. (2014) How multi-organ microdevices can help foster drug development. Advanced Drug Delivery Reviews 69-70, pages 158-169.
Crossref
Albert P Li. (2014) Biomarkers and human hepatocytes. Biomarkers in Medicine 8:2, pages 173-183.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.