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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 4
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General Xenobiochemistry

Quantitation of UGT1A1 in human liver microsomes using stable isotope-labelled peptides and mass spectrometry based proteomic approaches

Chitra SridarDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, USA
,
Imad HannaNovartis Institutes for Biomedical Research, East Hanover, NJ, USA
&
Paul F. HollenbergDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, USACorrespondence[email protected]
Pages 336-345 | Received 13 Jun 2012, Accepted 03 Aug 2012, Published online: 03 Sep 2012

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Dong Gui Hu, Robyn Meech, Ross A. McKinnon & Peter I. Mackenzie. (2014) Transcriptional regulation of human UDP-glucuronosyltransferase genes. Drug Metabolism Reviews 46:4, pages 421-458.
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Li Di. (2014) The role of drug metabolizing enzymes in clearance. Expert Opinion on Drug Metabolism & Toxicology 10:3, pages 379-393.
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Haeyoung Zhang, Abdul Basit & Bhagwat Prasad. 2020. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters 359 385 .
Justine Badée, Stephen Fowler, Saskia N. de Wildt, Abby C. Collier, Stephan Schmidt & Neil Parrott. (2018) The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling. Clinical Pharmacokinetics 58:2, pages 189-211.
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Xia Lv, Jian-Bin Zhang, Jie Hou, Tong-Yi Dou, Guang-Bo Ge, Wen-Zhong Hu & Ling Yang. (2019) Chemical Probes for Human UDP-Glucuronosyltransferases: A Comprehensive Review. Biotechnology Journal 14:1, pages 1800002.
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Jiamei Chen, Lijun Zhu, Xiaoyan Li, Haihui Zheng, Tongmeng Yan, Cong Xie, Sijing Zeng, Jia Yu, Huangyu Jiang, Linlin Lu, Xiaoxiao Qi, Ying Wang, Ming Hu & Zhongqiu Liu. (2017) High-Throughput and Reliable Isotope Label-free Approach for Profiling 24 Metabolic Enzymes in FVB Mice and Sex Differences. Drug Metabolism and Disposition 45:6, pages 624-634.
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T. Bohnert, A. Patel, I. Templeton, Y. Chen, C. Lu, G. Lai, L. Leung, S. Tse, H. J. Einolf, Y.-H. Wang, M. Sinz, R. Stearns, R. Walsky, W. Geng, S. Sudsakorn, D. Moore, L. He, J. Wahlstrom, J. Keirns, R. Narayanan, D. Lang & X. Yang. (2016) Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions--an Industry Perspective. Drug Metabolism and Disposition 44:8, pages 1399-1423.
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J. Matthew Hutzler & Michael A. Zientek. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 79 130 .
Michael A. Zientek & Kuresh Youdim. (2015) Reaction Phenotyping: Advances in the Experimental Strategies Used to Characterize the Contribution of Drug-Metabolizing Enzymes. Drug Metabolism and Disposition 43:1, pages 163-181.
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Brahim Achour, Amin Rostami-Hodjegan & Jill Barber. (2014) Protein expression of various hepatic uridine 5′-diphosphate glucuronosyltransferase (UGT) enzymes and their inter-correlations: a meta-analysis. Biopharmaceutics & Drug Disposition 35:6, pages 353-361.
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Brahim Achour, Matthew R. Russell, Jill Barber & Amin Rostami-Hodjegan. (2014) Simultaneous Quantification of the Abundance of Several Cytochrome P450 and Uridine 5′-Diphospho-Glucuronosyltransferase Enzymes in Human Liver Microsomes Using Multiplexed Targeted Proteomics. Drug Metabolism and Disposition 42:4, pages 500-510.
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Adam Laycock, Björn Stolpe, Isabella Römer, Agnieszka Dybowska, Eugenia Valsami-Jones, Jamie R. Lead & Mark Rehkämper. (2014) Synthesis and characterization of isotopically labeled silver nanoparticles for tracing studies. Environ. Sci.: Nano 1:3, pages 271-283.
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John K. Fallon, Hendrik Neubert, Ruth Hyland, Theunis C. Goosen & Philip C. Smith. (2013) Targeted Quantitative Proteomics for the Analysis of 14 UGT1As and -2Bs in Human Liver Using NanoUPLC–MS/MS with Selected Reaction Monitoring. Journal of Proteome Research 12:10, pages 4402-4413.
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