Citations (36)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (10)
Siva Nageswara Rao Gajula, Tanaaz Navin Nathani, Rashmi Madhukar Patil, Sasikala Talari & Rajesh Sonti. (2022) Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development. Drug Metabolism Reviews 54:4, pages 427-448.
Read now
Read now
Klarissa D. Jackson, Upendra A. Argikar, Sungjoon Cho, Rachel D. Crouch, James P. Driscoll, Carley J. S. Heck, Lloyd King, Hlaing (Holly) Maw, Grover P. Miller, Herana Kamal Seneviratne, Shuai Wang, Cong Wei, Donglu Zhang & S. Cyrus Khojasteh. (2022) Bioactivation and reactivity research advances – 2021 year in review. Drug Metabolism Reviews 54:3, pages 246-281.
Read now
Read now
Daigo Asano, Takahiro Shibayama, Hideyuki Shiozawa, Shin-ichi Inoue, Tsuyoshi Shinozuka, Shinji Murata, Nobuaki Watanabe & Kouichi Yoshinari. (2021) Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase. Xenobiotica 51:9, pages 1060-1070.
Read now
Read now
Christine Beedham. (2020) Aldehyde oxidase; new approaches to old problems. Xenobiotica 50:1, pages 34-50.
Read now
Read now
Narges Cheshmazar, Siavoush Dastmalchi, Mineko Terao, Enrico Garattini & Maryam Hamzeh-Mivehroud. (2019) Aldehyde oxidase at the crossroad of metabolism and preclinical screening. Drug Metabolism Reviews 51:4, pages 428-452.
Read now
Read now
Austin C. Li, Donghui Cui, Erya Yu, Kyle Dobson, Edward T. Hellriegel & Philmore Robertson Jr. (2019) Identification and human exposure prediction of two aldehyde oxidase-mediated metabolites of a methylquinoline-containing drug candidate. Xenobiotica 49:3, pages 302-312.
Read now
Read now
Rachel D. Crouch, J. Matthew Hutzler & J. Scott Daniels. (2018) A novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry. Xenobiotica 48:3, pages 219-231.
Read now
Read now
Maki Miyamoto, Shinji Iwasaki, Ikumi Chisaki, Sayaka Nakagawa, Nobuyuki Amano & Hideki Hirabayashi. (2017) Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver. Xenobiotica 47:12, pages 1052-1063.
Read now
Read now
Mohammad-Reza Rashidi & Somaieh Soltani. (2017) An overview of aldehyde oxidase: an enzyme of emerging importance in novel drug discovery. Expert Opinion on Drug Discovery 12:3, pages 305-316.
Read now
Read now
Li Di. (2014) The role of drug metabolizing enzymes in clearance. Expert Opinion on Drug Metabolism & Toxicology 10:3, pages 379-393.
Read now
Read now
Articles from other publishers (26)
Nihan Izat, Jayaprakasam Bolleddula, Armina Abbasi, Lionel Cheruzel, Robert S. Jones, Darren Moss, Fatima Ortega-Muro, Yannick Parmentier, Vincent C. Peterkin, Dan-Dan Tian, Karthik Venkatakrishnan, Michael A. Zientek, Jill Barber, J. Brian Houston, Aleksandra Galetin & Daniel Scotcher. (2023) Challenges and Opportunities for In Vitro–In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation. Drug Metabolism and Disposition 51:12, pages 1591-1606.
Crossref
Crossref
Kazuko Inoue, Kiyomi Kikuchi, Kazumi Takahashi, Seiji Hitaoka, Kazutomi Kusano & Takafumi Komori. (2023) In Vitro Metabolism of 2-Methoxy-N-[3-[4-[3-methyl-4-[(6-methyl- 3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide (CP-724,714) by Aldehyde Oxidase and Predicting Its Percent Contribution Relative to CYP-Mediated Metabolism. Drug Metabolism and Disposition 51:8, pages 962-969.
Crossref
Crossref
Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
Crossref
Crossref
Xiaoyan Pang, Chongzhuang Tang, Runcong Guo & Xiaoyan Chen. (2022) Non-cytochrome P450 enzymes involved in the oxidative metabolism of xenobiotics: Focus on the regulation of gene expression and enzyme activity. Pharmacology & Therapeutics 233, pages 108020.
Crossref
Crossref
Nobumitsu Hanioka, Keita Saito, Takashi Isobe, Susumu Ohkawara, Hideto Jinno & Toshiko Tanaka‐Kagawa. (2021) Favipiravir biotransformation in liver cytosol: Species and sex differences in humans, monkeys, rats, and mice. Biopharmaceutics & Drug Disposition 42:5, pages 218-225.
Crossref
Crossref
Armina Abbasi, Carolyn A. Joswig-Jones & Jeffrey P. Jones. (2020) Site-Directed Mutagenesis at the Molybdenum Pterin Cofactor Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey. Drug Metabolism and Disposition 48:12, pages 1364-1371.
Crossref
Crossref
Mailys De Sousa Mendes, Alexandra L. Orton, Helen E. Humphries, Barry Jones, Iain Gardner, Sibylle Neuhoff & Venkatesh Pilla Reddy. (2020) A Laboratory-Specific Scaling Factor to Predict the In Vivo Human Clearance of Aldehyde Oxidase Substrates. Drug Metabolism and Disposition 48:11, pages 1231-1238.
Crossref
Crossref
Yandi Zhang, Yu Yang, Guanwang Shen, Xueqin Mao, Mengyao Jiao & Ying Lin. (2020) Identification and Characterization of Aldehyde Oxidase 5 in the Pheromone Gland of the Silkworm (Lepidoptera: Bombycidae). Journal of Insect Science 20:6.
Crossref
Crossref
Nam Ah Kim, Sungyoul Hong, Ki Hyun Kim, Du Hyung Choi, Joo Seok Kim, Kyung Eui Park, Jun Young Choi, Young Kee Shin & Seong Hoon Jeong. (2020) New Preclinical Development of a c-Met Inhibitor and Its Combined Anti-Tumor Effect in c-Met-Amplified NSCLC. Pharmaceutics 12:2, pages 121.
Crossref
Crossref
Nenad Manevski, Lloyd King, William R. Pitt, Fabien Lecomte & Francesca Toselli. (2019) Metabolism by Aldehyde Oxidase: Drug Design and Complementary Approaches to Challenges in Drug Discovery. Journal of Medicinal Chemistry 62:24, pages 10955-10994.
Crossref
Crossref
Deepak Dalvie & Li Di. (2019) Aldehyde oxidase and its role as a drug metabolizing enzyme. Pharmacology & Therapeutics 201, pages 137-180.
Crossref
Crossref
Elias C. Padilha, Jianyao Wang, Ed Kerns, Arthur Lee, Wenwei Huang, Jian-kang Jiang, John McKew, Abdul Mutlib, Rosangela G. Peccinini, Paul B. Yu, Philip Sanderson & Xin Xu. (2019) Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP). Frontiers in Pharmacology 10.
Crossref
Crossref
Xin Yang, Nathaniel Johnson & Li Di. (2019) Evaluation of Cytochrome P450 Selectivity for Hydralazine as an Aldehyde Oxidase Inhibitor for Reaction Phenotyping. Journal of Pharmaceutical Sciences 108:4, pages 1627-1630.
Crossref
Crossref
Rachel D. Crouch, Anna L. Blobaum, Andrew S. Felts, P. Jeffrey Conn & Craig W. Lindsley. (2017)
Species-Specific Involvement of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of the Pyrimidine-Containing mGlu
5
-Negative Allosteric Modulator VU0424238 (Auglurant)
. Drug Metabolism and Disposition 45:12, pages 1245-1259.
Crossref
Crossref
Yuan Xu, Liang Li, Yulan Wang, Jing Xing, Lei Zhou, Dafang Zhong, Xiaomin Luo, Hualiang Jiang, Kaixian Chen, Mingyue Zheng, Pan Deng & Xiaoyan Chen. (2017) Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: A Combined Computational and Experimental Study. Journal of Medicinal Chemistry 60:7, pages 2973-2982.
Crossref
Crossref
Lionel Sebbag, Sara M. Thomasy, Andrew P. Woodward, Heather K. Knych & David J. Maggs. (2016) Pharmacokinetic modeling of penciclovir and BRL42359 in the plasma and tears of healthy cats to optimize dosage recommendations for oral administration of famciclovir. American Journal of Veterinary Research 77:8, pages 833-845.
Crossref
Crossref
R. D. Crouch, R. D. Morrison, F. W. Byers, C. W. Lindsley, K. A. Emmitte & J. S. Daniels. (2016) Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity. Drug Metabolism and Disposition 44:8, pages 1296-1303.
Crossref
Crossref
Mineko Terao, Maria João Romão, Silke Leimkühler, Marco Bolis, Maddalena Fratelli, Catarina Coelho, Teresa Santos-Silva & Enrico Garattini. (2016) Structure and function of mammalian aldehyde oxidases. Archives of Toxicology 90:4, pages 753-780.
Crossref
Crossref
Kanika V. Choughule, Carolyn A. Joswig-Jones & Jeffrey P. Jones. (2015) Interspecies differences in the metabolism of methotrexate: An insight into the active site differences between human and rabbit aldehyde oxidase. Biochemical Pharmacology 96:3, pages 288-295.
Crossref
Crossref
Seigo Sanoh, Yoshitaka Tayama, Kazumi Sugihara, Shigeyuki Kitamura & Shigeru Ohta. (2015) Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy. Drug Metabolism and Pharmacokinetics 30:1, pages 52-63.
Crossref
Crossref
David G. Baker & Neil S. Lipman. 2015. Laboratory Animal Medicine. Laboratory Animal Medicine
1441
1496
.
Nenad Manevski, Kamal Kumar Balavenkatraman, Barbara Bertschi, Piet Swart, Markus Walles, Gian Camenisch, Hilmar Schiller, Olivier Kretz, Barbara Ling, Reto Wettstein, Dirk J. Schaefer, Francois Pognan, Armin Wolf & Karine Litherland. (2014) Aldehyde Oxidase Activity in Fresh Human Skin. Drug Metabolism and Disposition 42:12, pages 2049-2057.
Crossref
Crossref
J. Matthew Hutzler, Matthew A. Cerny, Young-Sun Yang, Constance Asher, Diane Wong, Kosea Frederick & Kyle Gilpin. (2014) Cynomolgus Monkey as a Surrogate for Human Aldehyde Oxidase Metabolism of the EGFR Inhibitor BIBX1382. Drug Metabolism and Disposition 42:10, pages 1751-1760.
Crossref
Crossref
Kanika V. Choughule, Carlo Barnaba, Carolyn A. Joswig-Jones & Jeffrey P. Jones. (2014) In Vitro Oxidative Metabolism of 6-Mercaptopurine in Human Liver: Insights into the Role of the Molybdoflavoenzymes Aldehyde Oxidase, Xanthine Oxidase, and Xanthine Dehydrogenase. Drug Metabolism and Disposition 42:8, pages 1334-1340.
Crossref
Crossref
Allyson D. Groth, Marcos T. Contreras, Helen K. Kado-Fong, Kyvan Q. Nguyen, Sara M. Thomasy & David J. Maggs. (2014)
In vitro
cytotoxicity and antiviral efficacy against feline herpesvirus type 1 of famciclovir and its metabolites
. Veterinary Ophthalmology 17:4, pages 268-274.
Crossref
Crossref
Kanika V. Choughule, John T. Barr & Jeffrey P. Jones. (2013) Evaluation of Rhesus Monkey and Guinea Pig Hepatic Cytosol Fractions as Models for Human Aldehyde Oxidase. Drug Metabolism and Disposition 41:10, pages 1852-1858.
Crossref
Crossref