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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 5
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Animal Pharmacokinetics and Metabolism

Isolation and identification of phase I metabolites of resibufogenin in rats

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Pages 479-485 | Received 13 Aug 2012, Accepted 06 Sep 2012, Published online: 15 Nov 2012

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Xiu-Lan Xin, Pei-Pei Dong, Xiao-Hong Sun, Sa Deng, Ning Zhang, Chao Wang, Xiao-Kui Huo, Ye Li, Rong Lan, Liang Chen & Guang-Jun Fan. (2016) Identification of the hydroxylated derivatives of bufalin: phase I metabolites in rats. Journal of Asian Natural Products Research 18:3, pages 239-247.
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Li-Yan Mou, Xiu-Lan Xin, Liang Chen, Pei-Pei Dong, Rong Lan, Dong-Hai Su, Jian Huang, Jin-Hui Wang & Li-Bin Zhan. (2014) Biotransformation of resibufogenin by Actinomucor elegans. Journal of Asian Natural Products Research 16:6, pages 623-628.
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Wen-long Wei, Ya-ling An, Zhen-wei Li, Ying-ying Wang, Hong-jian Ji, Jin-jun Hou, Wan-ying Wu & De-an Guo. (2019) Simultaneous determination of resibufogenin and its eight metabolites in rat plasma by LC–MS/MS for metabolic profiles and pharmacokinetic study. Phytomedicine 60, pages 152971.
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Wen-Long Wei, Jin-Jun Hou, Xia Wang, Yang Yu, Hao-Jv Li, Zhen-Wei Li, Zi-Jin Feng, Hua Qu, Wan-Ying Wu & De-An Guo. (2019) Venenum bufonis: An overview of its traditional use, natural product chemistry, pharmacology, pharmacokinetics and toxicology. Journal of Ethnopharmacology 237, pages 215-235.
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Wen Hou, Zhi-Xing Huang, Hong-Gui Xu, Jing Lin, Dong-Mei Zhang, Qun-Long Peng, Hui Lin, Yi-Qun Chang, Long-Hai Wang, Zhe Yao, Ping-Hua Sun & Wei-Min Chen. (2018) Hybrids of arenobufagin and benzoisoselenazol reducing the cardiotoxicity of arenobufagin. Bioorganic & Medicinal Chemistry Letters 28:20, pages 3391-3394.
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Jing Ning, Zhen-Long Yu, Liang-Hai Hu, Chao Wang, Xiao-Kui Huo, Sa Deng, Jie Hou, Jing-Jing Wu, Guang-Bo Ge, Xiao-Chi Ma & Ling Yang. (2015) Characterization of Phase I Metabolism of Resibufogenin and Evaluation of the Metabolic Effects on Its Antitumor Activity and Toxicity. Drug Metabolism and Disposition 43:3, pages 299-308.
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