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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 6
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Clinical Pharmacokinetics and Metabolism

Absorption, metabolism and excretion of darexaban (YM150), a new direct factor Xa inhibitor in humans

Tadashi HashimotoDrug Metabolism Research Laboratories, Drug Discovery Research, Astellas Pharma, Inc., Osaka, JapanCorrespondence[email protected]
,
Katsuhiro SuzukiDrug Metabolism Research Laboratories, Drug Discovery Research, Astellas Pharma, Inc., Osaka, Japan
,
Yukie KiharaDrug Metabolism and Analysis Department, Kumamoto Laboratory, Mitsubishi Chemical Medience Corporation, Kumamoto, Japan
,
Takafumi IwatsuboDrug Metabolism Research Laboratories, Drug Discovery Research, Astellas Pharma, Inc., Osaka, Japan
,
Aiji MiyashitaDrug Metabolism Research Laboratories, Drug Discovery Research, Astellas Pharma, Inc., Osaka, Japan
,
Marten HeeringaAstellas Pharma Global Development Europe, Leiderdorp, The Netherlands
,
Hartmut OnkelsAstellas Pharma Global Development Europe, Leiderdorp, The Netherlands
,
Dorien GroenendaalAstellas Pharma Global Development Europe, Leiderdorp, The Netherlands
,
Frank VerheggenAstellas Pharma Global Development Europe, Leiderdorp, The Netherlands
,
Sjoerd van MarlePRA International, Zuidlaren, The Netherlands
&
Takashi UsuiDrug Metabolism Research Laboratories, Drug Discovery Research, Astellas Pharma, Inc., Osaka, Japan
 show all
Pages 534-547 | Received 21 Aug 2012, Accepted 29 Sep 2012, Published online: 20 Nov 2012

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Gerasimos Dimitropoulos, S. M. Zubair Rahim, Alexandra Sophie Moss & Gregory Y. H. Lip. (2018) New anticoagulants for venous thromboembolism and atrial fibrillation: what the future holds. Expert Opinion on Investigational Drugs 27:1, pages 71-86.
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Andrew Blann. (2015) Nonvitamin K antagonist oral anticoagulants (NOACs): the tide continues to come in. Vascular Health and Risk Management 11, pages 489-492.
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Articles from other publishers (10)

Anna Zatloukalová. (2020) New direct oral anticoagulances - new molecules in research. Klinická farmakologie a farmacie 34:2, pages 84-88.
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Nicolás E. Núñez-Navarro, Fabián M. Santana, Loreto P. Parra & Flavia C. Zacconi. (2019) Surfing the Blood Coagulation Cascade: Insight into the Vital Factor Xa. Current Medicinal Chemistry 26:17, pages 3175-3200.
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Flavia C. Zacconi. 2018. Anticoagulant Drugs. Anticoagulant Drugs.
G.Y.H. Lip, J.L. Halperin, P. Petersen, G.M. Rodgers, D. Pall & R.W. Renfurm. (2015) A Phase II, double‐blind, randomized, parallel group, dose‐finding study of the safety and tolerability of darexaban compared with warfarin in patients with non‐valvular atrial fibrillation: the oral factor Xa inhibitor for prophylaxis of stroke in atrial fibrillation study 2 (OPAL‐2). Journal of Thrombosis and Haemostasis 13:8, pages 1405-1413.
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Yazan Daaboul, Rim Halaby, Serge Korjian, Hesham Bahaa Eldin, Alejandro Lemor, Kiran Singh, Ammu Thampi Susheela, Vignesh Ponnusamy, Deepika Beereddy, Jesús R. Hernández-Elenes, Mugilan Poongkunran, Ogheneochuko W. Ajari, Alonso Alvarado & C. Michael Gibson. (2015) Dual Pathway Therapy for Secondary Prevention Following Acute Coronary Syndrome. Current Cardiovascular Risk Reports 9:2.
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Dorien Groenendaal, Gregory Strabach, Alberto Garcia-Hernandez, Takeshi Kadokura, Marten Heeringa, Roelof Mol, Charlotte Eltink & Hartmut Onkels. (2014) The pharmacokinetics of darexaban (YM150), an oral direct factor Xa inhibitor, are not affected by ketoconazole, a strong inhibitor of CYP3A and P-glycoprotein. Clinical Pharmacology in Drug Development 3:3, pages 194-201.
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Takeshi Kadokura, Dorien Groenendaal, Marten Heeringa, Roelof Mol, Frank Verheggen, Alberto Garcia-Hernandez & Hartmut Onkels. (2013) Darexaban (YM150), an oral direct factor Xa inhibitor, has no effect on the pharmacokinetics of digoxin. European Journal of Drug Metabolism and Pharmacokinetics 39:1, pages 1-9.
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Bengt Eriksson, Giancarlo Agnelli, Alexander Gallus, Michael Lassen, Martin Prins, Ronny Renfurm, Makoto Kashiwa & Alexander Turpie. (2017) Darexaban (YM150) versus enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a randomised phase IIb dose confirmation study (ONYX-3). Thrombosis and Haemostasis 111:02, pages 213-225.
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Takeshi Kadokura, Makoto Kashiwa, Dorien Groenendaal, Marten Heeringa, Roelof Mol, Frank Verheggen, Alberto Garcia‐Hernandez & Hartmut Onkels. (2013) Clinical pharmacokinetics, pharmacodynamics, safety and tolerability of darexaban, an oral direct factor Xa inhibitor, in healthy Caucasian and Japanese subjects. Biopharmaceutics & Drug Disposition 34:8, pages 431-441.
Crossref
Takeshi Kadokura, Keishi Oikawa, Koji Miyata, Toshinobu Murase & Mashio Nakamura. (2013) Clinical Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Darexaban, an Oral Direct Factor Xa Inhibitor, in Healthy Elderly Japanese Subjects. Clinical Pharmacology in Drug Development 2:4, pages 328-335.
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